{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:02:41Z","timestamp":1793289761156,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2326-B-006-004-MY3"],"award-info":[{"award-number":["109-2326-B-006-004-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008212","name":"College of Medicine, Drexel University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 109-2326-B-006-004-MY3"],"award-info":[{"award-number":["NSTC 109-2326-B-006-004-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jid.2023.12.014","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T11:24:29Z","timestamp":1704972269000},"page":"1491-1504.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Profibrotic Subsets of SPP1+ Macrophages and POSTN+ Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis"],"prefix":"10.1016","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-9289","authenticated-orcid":false,"given":"Yi-Kai","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5139-3612","authenticated-orcid":false,"given":"Daw-Yang","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3897-6522","authenticated-orcid":false,"given":"Chao-Chun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-4220","authenticated-orcid":false,"given":"Siao Muk","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-1765","authenticated-orcid":false,"given":"Peng-Chieh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4557-1109","authenticated-orcid":false,"given":"Wilson Jr","family":"Aala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8222-5614","authenticated-orcid":false,"given":"Hans","family":"I-Chen Harn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-5704","authenticated-orcid":false,"given":"Spencer T.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-0431","authenticated-orcid":false,"given":"Alexandros","family":"Onoufriadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9971-7831","authenticated-orcid":false,"given":"Si-Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-8338","authenticated-orcid":false,"given":"Yu-Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-2542","authenticated-orcid":false,"given":"Yi-Han","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8590-361X","authenticated-orcid":false,"given":"Tzu-Kun","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4782-2362","authenticated-orcid":false,"given":"Kuo-Shu","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-183X","authenticated-orcid":false,"given":"Yi-Chao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-4363","authenticated-orcid":false,"given":"Ming-Jer","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8297-433X","authenticated-orcid":false,"given":"Kurt Q.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3708-9964","authenticated-orcid":false,"given":"John A.","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4365-4533","authenticated-orcid":false,"given":"Chao-Kai","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2023.12.014_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075600","article-title":"Site-specific keloid fibroblasts alter the behaviour of normal skin and normal scar fibroblasts through paracrine signalling","volume":"8","author":"Ashcroft","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2023.12.014_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3167037","article-title":"The role of periostin in capsule formation on silicone implants","volume":"2018","author":"Bae","year":"2018","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.jid.2023.12.014_bib3","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.18632\/oncotarget.13610","article-title":"Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts","volume":"8","author":"Bonan","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2023.12.014_bib4","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.ajpath.2019.02.006","article-title":"An overview of the derivation and function of multinucleated giant cells and their role in pathologic processes","volume":"189","author":"Brooks","year":"2019","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2023.12.014_bib5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2023.12.014_bib6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3892\/etm.2021.10011","article-title":"Transcriptomic analysis identifies upregulation of secreted phosphoprotein 1 in silicotic rats","volume":"21","author":"Cai","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jid.2023.12.014_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/1346-8138.15127","article-title":"\"Spade sign\" and inflammation\/fibrosis limited to the upper and mid-dermis as the pathognomonic features of acne keloidalis","volume":"47","author":"Cheng","year":"2020","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.jid.2023.12.014_bib8","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1038\/s41467-021-24110-y","article-title":"Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases","volume":"12","author":"Deng","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2023.12.014_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature12783","article-title":"Distinct fibroblast lineages determine dermal architecture in skin development and repair","volume":"504","author":"Driskell","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jid.2023.12.014_bib10","article-title":"Osteopontin regulates macrophage activation and osteoclast formation in hypertensive patients with vascular calcification","volume":"7","author":"Ge","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2023.12.014_bib11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nbt.2600","article-title":"All charged up about implanted biomaterials","volume":"31","author":"Grainger","year":"2013","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2023.12.014_bib12","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2342-14-7","article-title":"Segmentation of epidermal tissue with histopathological damage in images of haematoxylin and eosin stained human skin","volume":"14","author":"Haggerty","year":"2014","journal-title":"BMC Med Imaging"},{"key":"10.1016\/j.jid.2023.12.014_bib13","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jid.2023.12.014_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112131","article-title":"Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner","volume":"42","author":"Hoeft","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2023.12.014_bib15","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3389\/fonc.2020.00787","article-title":"Biomechanical contributions to macrophage activation in the tumor microenvironment","volume":"10","author":"Hoffmann","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.jid.2023.12.014_bib16","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/srt.12776","article-title":"A\u00a0simple morphometric analysis method for dermal microstructure using color thresholding and moments","volume":"26","author":"Hong","year":"2020","journal-title":"Skin Res Technol"},{"key":"10.1016\/j.jid.2023.12.014_bib17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jid.2017.05.041","article-title":"Caveolin-1 controls hyperresponsiveness to mechanical stimuli and fibrogenesis-associated RUNX2 activation in keloid fibroblasts","volume":"138","author":"Hsu","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.12.014_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115559","article-title":"SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation","volume":"422","author":"Huang","year":"2021","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jid.2023.12.014_bib19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00403-021-02255-6","article-title":"Chronic itch in African Americans: an unmet need","volume":"314","author":"Ingrasci","year":"2022","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2023.12.014_bib20","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2023.12.014_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095893","article-title":"Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in\u00a0vivo","volume":"9","author":"Joshi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2023.12.014_bib22","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1007\/s00266-022-02935-2","article-title":"Efficacy of topical losartan in management of mammoplasty and abdominoplasty scars: a randomized, double-blind clinical trial","volume":"46","author":"Khodaei","year":"2022","journal-title":"Aesthetic Plast Surg"},{"key":"10.1016\/j.jid.2023.12.014_bib23","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1016\/j.jid.2022.06.014","article-title":"Different molecular features of epithelioid and giant cells in foreign body reaction identified by single-cell RNA sequencing","volume":"142","author":"Kim","year":"2022","journal-title":"J\u00a0Invest Dermatol"},{"issue":"Suppl 1","key":"10.1016\/j.jid.2023.12.014_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000210647","article-title":"Effects of corticosteroids on osteopontin expression in a murine model of allergic asthma","volume":"149","author":"Kurokawa","year":"2009","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jid.2023.12.014_bib25","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1161\/ATVBAHA.117.309385","article-title":"CD44 promotes inflammation and extracellular matrix production during arteriovenous fistula maturation","volume":"37","author":"Kuwahara","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jid.2023.12.014_bib26","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.4049\/jimmunol.1900789","article-title":"Collagen density modulates the immunosuppressive functions of macrophages","volume":"205","author":"Larsen","year":"2020","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2023.12.014_bib27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.2174\/18715281113129990053","article-title":"Anti-inflammatory treatments for chronic diseases: a review","volume":"12","author":"Laveti","year":"2013","journal-title":"Inflamm Allergy Drug Targets"},{"key":"10.1016\/j.jid.2023.12.014_bib28","doi-asserted-by":"crossref","first-page":"e1115","DOI":"10.1002\/ctm2.1115","article-title":"CTHRC1+ fibroblasts are stimulated by macrophage-secreted SPP1 to induce excessive collagen deposition in keloids","volume":"12","author":"Liu","year":"2022","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.jid.2023.12.014_bib29","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1165\/rcmb.2020-0499OC","article-title":"Noncanonical Wnt signaling promotes myofibroblast differentiation in pulmonary fibrosis","volume":"65","author":"Liu","year":"2021","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jid.2023.12.014_bib30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1172\/JCI93555","article-title":"Fibroblast heterogeneity: implications for human disease","volume":"128","author":"Lynch","year":"2018","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2023.12.014_bib31","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1189\/jlb.1008588","article-title":"Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9","volume":"85","author":"MacLauchlan","year":"2009","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jid.2023.12.014_bib32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s13555-016-0134-5","article-title":"Treatment of acne keloidalis nuchae: a systematic review of the literature","volume":"6","author":"Maranda","year":"2016","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.jid.2023.12.014_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.149426","article-title":"Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma","volume":"7","author":"Marangoni","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2023.12.014_bib34","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.jid.2016.01.036","article-title":"\u03b2-catenin stabilization in skin fibroblasts causes fibrotic lesions by preventing adipocyte differentiation of the reticular dermis","volume":"136","author":"Mastrogiannaki","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.12.014_bib35","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/01.HYP.0000128621.68160.dd","article-title":"Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy","volume":"43","author":"Matsui","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.jid.2023.12.014_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aas9944","article-title":"BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance","volume":"4","author":"Matsushita","year":"2018","journal-title":"Sci Adv"},{"key":"10.1016\/j.jid.2023.12.014_bib37","first-page":"975","article-title":"Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity","volume":"149","author":"McNally","year":"1996","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2023.12.014_bib38","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02441-2018","article-title":"Proliferating SPP1\/MERTK-expressing macrophages in idiopathic pulmonary fibrosis","volume":"54","author":"Morse","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jid.2023.12.014_bib39","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1007\/s00018-017-2647-1","article-title":"Periostin in the pathogenesis of skin diseases","volume":"74","author":"Murota","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jid.2023.12.014_bib40","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mehy.2016.09.024","article-title":"Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis - Keloids and hypertrophic scars may be vascular disorders","volume":"96","author":"Ogawa","year":"2016","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.jid.2023.12.014_bib41","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2147\/CCID.S99225","article-title":"Acne keloidalis nuchae: prevalence, impact, and management challenges","volume":"9","author":"Ogunbiyi","year":"2016","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"Suppl 2","key":"10.1016\/j.jid.2023.12.014_bib42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/bjd.13422","article-title":"Perceived aetiological factors of folliculitis keloidalis nuchae (acne keloidalis) and treatment options among Nigerian men","volume":"173","author":"Ogunbiyi","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2023.12.014_bib43","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jid.2018.01.016","article-title":"Spatial and single-cell transcriptional profiling identifies functionally distinct human dermal fibroblast subpopulations","volume":"138","author":"Philippeos","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.12.014_bib44","doi-asserted-by":"crossref","DOI":"10.1111\/dth.15515","article-title":"Losartan treatment improves recessive dystrophic epidermolysis bullosa: a case series","volume":"35","author":"Pourani","year":"2022","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.jid.2023.12.014_bib45","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1681\/ASN.2016070709","article-title":"NF\u03baB-induced periostin activates integrin-\u03b23 signaling to promote renal injury in GN","volume":"28","author":"Prakoura","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jid.2023.12.014_bib46","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2023.12.014_bib47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fcell.2017.00018","article-title":"CD44: a multifunctional cell surface adhesion receptor is a regulator of progression and metastasis of cancer cells","volume":"5","author":"Senbanjo","year":"2017","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jid.2023.12.014_bib48","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1016\/j.jid.2022.01.017","article-title":"Integrated analysis of single-cell and spatial transcriptomics in keloids: highlights on fibrovascular interactions in keloid pathogenesis","volume":"142","author":"Shim","year":"2022","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.12.014_bib49","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1111\/all.12240","article-title":"Cell type-dependent effects of corticosteroid on periostin production by primary human tissue cells","volume":"68","author":"Shoda","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jid.2023.12.014_bib50","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/j.ajpath.2011.01.045","article-title":"Lack of TNF-\u03b1-induced MMP-9 production and abnormal E-cadherin redistribution associated with compromised fusion in MCP-1-null macrophages","volume":"178","author":"Skokos","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2023.12.014_bib51","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/1346-8138.14217","article-title":"Primary scarring alopecia: a retrospective study of 89 patients in Taiwan","volume":"45","author":"Su","year":"2018","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.jid.2023.12.014_bib52","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A\u00a0next generation connectivity map: L1000 platform and the first 1,000,000 profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jid.2023.12.014_bib53","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1165\/ajrcmb.24.3.4293","article-title":"Role of osteopontin in the pathogenesis of bleomycin-induced pulmonary fibrosis","volume":"24","author":"Takahashi","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jid.2023.12.014_bib54","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1007\/s11033-022-07184-9","article-title":"MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K\/AKT pathway","volume":"49","author":"Tian","year":"2022","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.jid.2023.12.014_bib55","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/labinvest.2008.101","article-title":"Deep dermal fibroblasts contribute to hypertrophic scarring","volume":"88","author":"Wang","year":"2008","journal-title":"Lab Invest"},{"key":"10.1016\/j.jid.2023.12.014_bib56","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jid.2023.07.028","article-title":"Aged skin cells nurture stem cells toward regeneration","volume":"144","author":"Wang","year":"2024","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.12.014_bib57","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/s41586-023-06172-8","article-title":"Signalling by senescent melanocytes hyperactivates hair growth","volume":"618","author":"Wang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jid.2023.12.014_bib58","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1093\/bioinformatics\/bty060","article-title":"L1000FWD: fireworks visualization of drug-induced transcriptomic signatures","volume":"34","author":"Wang","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2023.12.014_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-016-0016","article-title":"Implanted biomaterials: dissecting fibrosis","volume":"1","author":"Weigert","year":"2017","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.jid.2023.12.014_bib60","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/s41419-022-05215-8","article-title":"Cathepsin K regulates the tumor growth and metastasis by IL-17\/CTSK\/EMT axis and mediates M2 macrophage polarization in castration-resistant prostate cancer","volume":"13","author":"Wu","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jid.2023.12.014_bib61","article-title":"Periostin facilitates skin sclerosis via PI3K\/Akt dependent mechanism in a mouse model of scleroderma","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2023.12.014_bib62","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1365-2133.2008.08989.x","article-title":"Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts","volume":"160","author":"Zhang","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2023.12.014_bib63","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.4049\/jimmunol.1003626","article-title":"NF-\u03baB- and AP-1-mediated DNA looping regulates osteopontin transcription in endotoxin-stimulated murine macrophages","volume":"186","author":"Zhao","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jid.2023.12.014_bib64","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nmeth.4299","article-title":"Clustering","volume":"14","author":"Altman","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2023.12.014_bib65","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","article-title":"xCell: digitally portraying the tissue cellular heterogeneity landscape","volume":"18","author":"Aran","year":"2017","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2023.12.014_bib66","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2023.12.014_bib67","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2023.12.014_bib68","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jid.2017.05.041","article-title":"Caveolin-1 controls hyperresponsiveness to mechanical stimuli and fibrogenesis-associated RUNX2 activation in keloid fibroblasts","volume":"138","author":"Hsu","year":"2018","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2023.12.014_bib69","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2023.12.014_bib70","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in Ingenuity Pathway Analysis","volume":"30","author":"Kr\u00e4mer","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2023.12.014_bib71","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2023.12.014_bib72","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2023.12.014_bib73","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst"},{"key":"10.1016\/j.jid.2023.12.014_bib74","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2023.12.014_bib75","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.jid.2023.12.014_bib76","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1365-2133.2008.08989.x","article-title":"Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts","volume":"160","author":"Zhang","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2023.12.014_bib77","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1101\/gr.275193.120","article-title":"Rapid and accurate alignment of nucleotide conversion sequencing reads with HISAT-3N","volume":"31","author":"Zhang","year":"2021","journal-title":"Genome Res"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X24000071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X24000071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:57:35Z","timestamp":1777435055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X24000071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":77,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0022202X24000071"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2023.12.014","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Profibrotic Subsets of SPP1+ Macrophages and POSTN+ Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2023.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}