{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:52:26Z","timestamp":1784285546272,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY198"],"award-info":[{"award-number":["2022KY198"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ21H020002"],"award-info":[{"award-number":["LZ21H020002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY22H110002"],"award-info":[{"award-number":["LY22H110002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273560"],"award-info":[{"award-number":["82273560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272284"],"award-info":[{"award-number":["82272284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016799","name":"Natural Science Foundation of Guangzhou Municipality","doi-asserted-by":"publisher","award":["2023YZ32"],"award-info":[{"award-number":["2023YZ32"]}],"id":[{"id":"10.13039\/100016799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jid.2024.07.026","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T07:46:58Z","timestamp":1725695218000},"page":"842-853.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["FGF21 Ameliorates Fibroblasts Activation and Systemic Sclerosis by Inhibiting CK2\u03b1\/GLI2 Signaling Axis"],"prefix":"10.1016","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9349-3669","authenticated-orcid":false,"given":"Yeyi","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-6077","authenticated-orcid":false,"given":"Wenjie","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8907-0766","authenticated-orcid":false,"given":"Zhaohang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4834-6839","authenticated-orcid":false,"given":"Siyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3090-0195","authenticated-orcid":false,"given":"Nan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5882-974X","authenticated-orcid":false,"given":"Zhenyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7703-9890","authenticated-orcid":false,"given":"Yanni","family":"Shou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1276-6713","authenticated-orcid":false,"given":"Tianpeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7955-5313","authenticated-orcid":false,"given":"Yingjie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6556-6262","authenticated-orcid":false,"given":"Xiaokun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7598-5938","authenticated-orcid":false,"given":"Litai","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1033-291X","authenticated-orcid":false,"given":"Weitao","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-5012","authenticated-orcid":false,"given":"Zhongxin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2024.07.026_bib1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-\u03b2-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2024.07.026_bib2","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41584-018-0099-0","article-title":"New insights into the genetics and epigenetics of systemic sclerosis","volume":"14","author":"Angiolilli","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jid.2024.07.026_bib3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13046-019-1292-y","article-title":"Role of protein kinase CK2 in antitumor drug resistance","volume":"38","author":"Borgo","year":"2019","journal-title":"J\u00a0Exp Clin Cancer Res"},{"key":"10.1016\/j.jid.2024.07.026_bib4","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nrneph.2015.135","article-title":"Fibrosis: GLI2 inhibition reduces myofibroblast generation and kidney fibrosis","volume":"11","author":"Carney","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jid.2024.07.026_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz5506","article-title":"Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis","volume":"12","author":"Chakraborty","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2024.07.026_bib6","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/bph.15701","article-title":"FGF21 promotes migration and differentiation of epidermal cells during wound healing via SIRT1-dependent autophagy","volume":"179","author":"Chen","year":"2022","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jid.2024.07.026_bib7","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.1158\/0008-5472.CAN-07-0491","article-title":"Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in\u00a0vitro and in\u00a0vivo","volume":"67","author":"Dennler","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2024.07.026_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbapap.2007.08.017","article-title":"Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2","volume":"1784","author":"Duncan","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jid.2024.07.026_bib9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/bph.15945","article-title":"CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway","volume":"180","author":"Fan","year":"2023","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jid.2024.07.026_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/path.5226","article-title":"Fibroblast growth factor-21 protects against fibrosis in hypertensive heart disease","volume":"248","author":"Ferrer-Curriu","year":"2019","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jid.2024.07.026_bib11","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.cell.2022.03.011","article-title":"LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma","volume":"185","author":"Gur","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jid.2024.07.026_bib12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1124\/mol.114.095141","article-title":"An overview of hedgehog signaling in fibrosis","volume":"87","author":"Hu","year":"2015","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jid.2024.07.026_bib13","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/25785826.2020.1843267","article-title":"Protein kinase 2 (CK2): a potential regulator of immune cell development and function in cancer","volume":"44","author":"Husain","year":"2021","journal-title":"Immunol Med"},{"key":"10.1016\/j.jid.2024.07.026_bib14","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: paradigms and principles","volume":"15","author":"Ingham","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.jid.2024.07.026_bib15","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1158\/0008-5472.CAN-11-1194","article-title":"TGF-\u03b2\/SMAD\/GLI2 signaling axis in cancer progression and metastasis","volume":"71","author":"Javelaud","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.jid.2024.07.026_bib16","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.4161\/cc.6.20.4808","article-title":"Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy","volume":"6","author":"Lauth","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jid.2024.07.026_bib17","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1038\/sj.emboj.7601818","article-title":"TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA","volume":"26","author":"Lee","year":"2007","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2024.07.026_bib18","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/annrheumdis-2016-209698","article-title":"The transcription factor GLI2 as a downstream mediator of transforming growth factor-\u03b2-induced fibroblast activation in SSc","volume":"76","author":"Liang","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jid.2024.07.026_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20021469","article-title":"Protein kinase CK2: structure, regulation and role in cellular decisions of life and death","volume":"369","author":"Litchfield","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.jid.2024.07.026_bib20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.canlet.2020.11.026","article-title":"FGF21 in obesity and cancer: new insights","volume":"499","author":"Lu","year":"2021","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jid.2024.07.026_bib21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00441-010-1068-3","article-title":"Cellular regulators of protein kinase CK2","volume":"342","author":"Montenarh","year":"2010","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jid.2024.07.026_bib22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tem.2014.10.002","article-title":"Tissue-specific actions of the metabolic hormones FGF15\/19 and FGF21","volume":"26","author":"Owen","year":"2015","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jid.2024.07.026_bib23","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.cmet.2018.04.002","article-title":"FGF21 prevents angiotensin II-induced hypertension and vascular dysfunction by activation of ACE2\/angiotensin-(1-7) axis in mice","volume":"27","author":"Pan","year":"2018","journal-title":"Cell Metab"},{"key":"10.1016\/j.jid.2024.07.026_bib24","doi-asserted-by":"crossref","first-page":"10846","DOI":"10.1074\/jbc.M608599200","article-title":"A\u00a0novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome","volume":"282","author":"Pan","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2024.07.026_bib25","doi-asserted-by":"crossref","first-page":"10853","DOI":"10.1073\/pnas.0904187106","article-title":"FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response","volume":"106","author":"Potthoff","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jid.2024.07.026_bib26","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/s41416-018-0280-x","article-title":"Fibroblast growth factor 21 as a circulating biomarker at various stages of colorectal carcinogenesis","volume":"119","author":"Qian","year":"2018","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jid.2024.07.026_bib27","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1136\/annrheumdis-2018-214865","article-title":"Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease","volume":"78","author":"Valenzi","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jid.2024.07.026_bib28","first-page":"32","article-title":"Feedback activation of basic fibroblast growth factor signaling via the Wnt\/\u03b2-catenin pathway in skin fibroblasts","volume":"8","author":"Wang","year":"2017","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jid.2024.07.026_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102131","article-title":"Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis","volume":"46","author":"Wu","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.jid.2024.07.026_bib30","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2024.07.026_bib31","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.7150\/ijbs.25026","article-title":"The role of FGF21 in type 1 diabetes and its complications","volume":"14","author":"Zhang","year":"2018","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jid.2024.07.026_bib32","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.biopha.2018.03.100","article-title":"FGF21 attenuates pulmonary fibrogenesis through ameliorating oxidative stress in\u00a0vivo and in\u00a0vitro","volume":"103","author":"Zhang","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jid.2024.07.026_bib33","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1136\/annrheumdis-2013-204256","article-title":"Inhibition of casein kinase II reduces TGF\u03b2 induced fibroblast activation and ameliorates experimental fibrosis","volume":"74","author":"Zhang","year":"2015","journal-title":"Ann Rheum Dis"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X2402058X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X2402058X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T01:53:51Z","timestamp":1775008431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X2402058X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0022202X2402058X"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2024.07.026","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FGF21 Ameliorates Fibroblasts Activation and Systemic Sclerosis by Inhibiting CK2\u03b1\/GLI2 Signaling Axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2024.07.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Society for Investigative Dermatology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}