{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:38:39Z","timestamp":1783107519316,"version":"3.54.6"},"reference-count":84,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jid.2024.08.003","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T16:25:02Z","timestamp":1726071902000},"page":"790-799","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Connexin Hemichannel Inhibition and Human Genodermatoses"],"prefix":"10.1016","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3751-1691","authenticated-orcid":false,"given":"Fabio","family":"Mammano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6187-6549","authenticated-orcid":false,"given":"Amy S.","family":"Paller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3285-7434","authenticated-orcid":false,"given":"Thomas W.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2024.08.003_bib1","doi-asserted-by":"crossref","first-page":"6594","DOI":"10.3390\/ijms25126594","article-title":"Calcium regulation of connexin hemichannels","volume":"25","author":"Bayraktar","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2024.08.003_bib2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1586\/eem.12.34","article-title":"Calcium regulation of keratinocyte differentiation","volume":"7","author":"Bikle","year":"2012","journal-title":"Expert Rev Endocrinol Metab"},{"key":"10.1016\/j.jid.2024.08.003_bib3","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/j.febslet.2015.05.047","article-title":"Altered epidermal lipid processing and calcium distribution in the KID syndrome mouse model Cx26S17F","volume":"589","author":"Bosen","year":"2015","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jid.2024.08.003_bib4","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.febslet.2014.03.040","article-title":"The Clouston syndrome mutation connexin30 A88V leads to hyperproliferation of sebaceous glands and hearing impairments in mice","volume":"588","author":"Bosen","year":"2014","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jid.2024.08.003_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1996.0001q.x","article-title":"Connections with connexins: the molecular basis of direct intercellular signaling","volume":"238","author":"Bruzzone","year":"1996","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jid.2024.08.003_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.166047","article-title":"Harnessing the therapeutic potential of antibodies targeting connexin hemichannels","volume":"1867","author":"Buratto","year":"2021","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.jid.2024.08.003_bib7","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/jid.2011.344","article-title":"Purinergic signaling in healthy and diseased skin","volume":"132","author":"Burnstock","year":"2012","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib8","doi-asserted-by":"crossref","first-page":"e219","DOI":"10.1111\/jdv.15405","article-title":"Hypotrichosis with keratosis follicular and hyperostosis: a new phenotype due to GJA1 mutation","volume":"33","author":"Bursztejn","year":"2019","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2024.08.003_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032531","article-title":"Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death","volume":"7","author":"Chi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2024.08.003_bib10","doi-asserted-by":"crossref","first-page":"6186","DOI":"10.3390\/ijms20246186","article-title":"Connexin 43 mutations lead to increased hemichannel functionality in skin disease","volume":"20","author":"Cocozzelli","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2024.08.003_bib11","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.3390\/ijms24032222","article-title":"Increased hemichannel activity displayed by a connexin43 mutation causing a familial connexinopathy exhibiting hypotrichosis with follicular keratosis and hyperostosis","volume":"24","author":"Crouthamel","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2024.08.003_bib12","doi-asserted-by":"crossref","first-page":"20911","DOI":"10.1074\/jbc.M111498200","article-title":"Targeted Gap junction protein constructs reveal connexin-specific differences in oligomerization","volume":"277","author":"Das Sarma","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2024.08.003_bib13","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1046\/j.0022-202x.2001.01468.x","article-title":"Multiple epidermal connexins are expressed in different keratinocyte subpopulations including connexin 31","volume":"117","author":"Di","year":"2001","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib14","article-title":"Calcium signaling in the photodamaged skin: in\u00a0vivo experiments and mathematical modelling [published correction appears in Function (Oxf) 2022;3:zqac003]","volume":"3","author":"Donati","year":"2022","journal-title":"Function (Oxf)"},{"key":"10.1016\/j.jid.2024.08.003_bib15","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1684\/ejd.2014.2452","article-title":"Calcium--a central regulator of keratinocyte differentiation in health and disease","volume":"24","author":"Elsholz","year":"2014","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00232-001-0115-0","article-title":"Inhibition of gap junction hemichannels by chloride channel blockers","volume":"185","author":"Eskandari","year":"2002","journal-title":"J\u00a0Membr Biol"},{"key":"10.1016\/j.jid.2024.08.003_bib17","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/hmg\/ddh191","article-title":"Connexin30 mutations responsible for hidrotic ectodermal dysplasia cause abnormal hemichannel activity","volume":"13","author":"Essenfelder","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2024.08.003_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20060175","article-title":"The gap junction cellular internet: connexin hemichannels enter the signalling limelight","volume":"397","author":"Evans","year":"2006","journal-title":"Biochem J"},{"key":"10.1016\/j.jid.2024.08.003_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-0716-3842-2_1","article-title":"Purification, reconstitution, and functional analysis of connexin hemichannels","volume":"2801","author":"Fiori","year":"2024","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jid.2024.08.003_bib20","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jid.2015.11.017","article-title":"From hyperactive connexin26 hemichannels to impairments in epidermal calcium gradient and permeability barrier in the keratitis-ichthyosis-deafness syndrome","volume":"136","author":"Garc\u00eda","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib21","doi-asserted-by":"crossref","first-page":"C337","DOI":"10.1152\/ajpcell.00626.2006","article-title":"Aberrant hemichannel properties of Cx26 mutations causing skin disease and deafness","volume":"293","author":"Gerido","year":"2007","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jid.2024.08.003_bib22","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrm1072","article-title":"Beyond the gap: functions of unpaired connexon channels","volume":"4","author":"Goodenough","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jid.2024.08.003_bib23","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1046\/j.1523-1747.2003.12567.x","article-title":"Purinergic receptors are part of a signaling system for keratinocyte proliferation, differentiation, and apoptosis in human fetal epidermis","volume":"121","author":"Greig","year":"2003","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib24","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0022-3565(24)29472-6","article-title":"Fenamates: a novel class of reversible gap junction blockers","volume":"298","author":"Harks","year":"2001","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.jid.2024.08.003_bib25","first-page":"325","article-title":"Emerging issues of connexin channels: biophysics fills the gap","volume":"34","author":"Harris","year":"2001","journal-title":"Q\u00a0Rev Biophys"},{"key":"10.1016\/j.jid.2024.08.003_bib26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(80)90406-7","article-title":"Calcium regulation of growth and differentiation of mouse epidermal cells in culture","volume":"19","author":"Hennings","year":"1980","journal-title":"Cell"},{"key":"10.1016\/j.jid.2024.08.003_bib27","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/nbt1142","article-title":"Engineered antibody fragments and the rise of single domains","volume":"23","author":"Holliger","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2024.08.003_bib28","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1073\/pnas.90.14.6444","article-title":"\u201cDiabodies\u201d: small bivalent and bispecific antibody fragments","volume":"90","author":"Holliger","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jid.2024.08.003_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ejmg.2007.09.005","article-title":"A\u00a0familial case of keratitis-ichthyosis-deafness (KID) syndrome with the GJB2 mutation G45E","volume":"51","author":"Jonard","year":"2008","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.jid.2024.08.003_bib30","first-page":"253","article-title":"Flufenamic acid and placebo compared in rheumatoid arthritis and osteoarthritis","volume":"9","author":"Kagan","year":"1981","journal-title":"J\u00a0Int Med Res"},{"key":"10.1016\/j.jid.2024.08.003_bib31","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0140-6736(78)91078-4","article-title":"Flufenamic acid in treatment of primary spasmodic dysmenorrhoea. A double-blind crossover study","volume":"1","author":"Kapadia","year":"1978","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2024.08.003_bib32","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1078\/0171-9335-00422","article-title":"Expression and function of connexins in the epidermis, analyzed with transgenic mouse mutants","volume":"83","author":"Kretz","year":"2004","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jid.2024.08.003_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102825","article-title":"A\u00a0potent antagonist antibody targeting connexin hemichannels alleviates Clouston syndrome symptoms in mutant mice","volume":"57","author":"Kuang","year":"2020","journal-title":"EBiomedicine"},{"key":"10.1016\/j.jid.2024.08.003_bib34","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1042\/BJ20051922","article-title":"Life cycle of connexins in health and disease","volume":"394","author":"Laird","year":"2006","journal-title":"Biochem J"},{"key":"10.1016\/j.jid.2024.08.003_bib35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tcb.2021.07.007","article-title":"Cellular mechanisms of connexin-based inherited diseases","volume":"32","author":"Laird","year":"2022","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.jid.2024.08.003_bib36","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/jid.2008.335","article-title":"Connexin mutations causing skin disease and deafness increase hemichannel activity and cell death when expressed in Xenopus oocytes","volume":"129","author":"Lee","year":"2009","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib37","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.jid.2019.09.022","article-title":"Allele-specific small interfering RNA corrects aberrant cellular phenotype in keratitis-ichthyosis-deafness syndrome keratinocytes","volume":"140","author":"Lee","year":"2020","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib38","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1001\/jamadermatol.2014.5069","article-title":"A\u00a0somatic p.G45E GJB2 mutation causing porokeratotic eccrine ostial and dermal duct nevus","volume":"151","author":"Levinsohn","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib39","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/jid.2014.408","article-title":"Aberrant connexin26 hemichannels underlying keratitis-ichthyosis-deafness syndrome are potently inhibited by mefloquine","volume":"135","author":"Levit","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib40","doi-asserted-by":"crossref","DOI":"10.1172\/JCI168117","article-title":"Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments","volume":"133","author":"Leybaert","year":"2023","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jid.2024.08.003_bib41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.semcdb.2015.11.018","article-title":"Connexin channels in congenital skin disorders","volume":"50","author":"Lilly","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jid.2024.08.003_bib42","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ajmg.a.63005","article-title":"Keratitis-ichthyosis-deafness syndrome with lethal p.Ala88Val variant and severe hypercalcemia","volume":"191","author":"L\u00f3pez-Sundh","year":"2023","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jid.2024.08.003_bib43","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/hmg\/8.7.1237","article-title":"A\u00a0missense mutation in connexin26, D66H, causes mutilating keratoderma with sensorineural deafness (Vohwinkel\u2019s syndrome) in three unrelated families","volume":"8","author":"Maestrini","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2024.08.003_bib44","first-page":"505","article-title":"Molecular mechanisms and clinical phenotypes of GJB2 missense variants","volume":"12","author":"Mao","year":"2023","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.jid.2024.08.003_bib45","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.febslet.2014.02.048","article-title":"Connexins: sensors of epidermal integrity that are therapeutic targets","volume":"588","author":"Martin","year":"2014","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jid.2024.08.003_bib46","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/1523-1747.ep12273485","article-title":"Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry","volume":"84","author":"Menon","year":"1985","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib47","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1091\/mbc.e11-09-0778","article-title":"The Cx26-G45E mutation displays increased hemichannel activity in a mouse model of the lethal form of keratitis-ichthyosis-deafness syndrome","volume":"22","author":"Mese","year":"2011","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jid.2024.08.003_bib48","doi-asserted-by":"crossref","first-page":"C1150","DOI":"10.1152\/ajpcell.00374.2012","article-title":"The human Cx26-D50A and Cx26-A88V mutations causing keratitis-ichthyosis-deafness syndrome display increased hemichannel activity","volume":"304","author":"Mhaske","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.jid.2024.08.003_bib49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jaad.2003.12.042","article-title":"A\u00a0novel connexin 26 gene mutation associated with features of the keratitis-ichthyosis-deafness syndrome and the follicular occlusion triad","volume":"51","author":"Montgomery","year":"2004","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib50","doi-asserted-by":"crossref","first-page":"7337","DOI":"10.3390\/ijms23137337","article-title":"A\u00a0quantitative assay for Ca2+ uptake through normal and pathological hemichannels","volume":"23","author":"Nardin","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2024.08.003_bib51","first-page":"237","article-title":"The role of connexin hemichannels in inflammatory diseases","volume":"11","author":"Peng","year":"2022","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.jid.2024.08.003_bib52","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-1-0716-3842-2_13","article-title":"A\u00a0protocol for the automated assessment of cutaneous pathology in a mouse model of hemichannel dysfunction","volume":"2801","author":"Peres","year":"2024","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jid.2024.08.003_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104453","article-title":"Antibody gene transfer treatment drastically improves epidermal pathology in a keratitis ichthyosis deafness syndrome model using male mice","volume":"89","author":"Peres","year":"2023","journal-title":"EBiomedicine"},{"key":"10.1016\/j.jid.2024.08.003_bib54","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.3390\/biom13101521","article-title":"Functional consequences of pathogenic variants of the GJB2 gene (Cx26) localized in different Cx26 domains","volume":"13","author":"Posukh","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jid.2024.08.003_bib55","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3389\/fncel.2015.00267","article-title":"Diseases associated with leaky hemichannels","volume":"9","author":"Retamal","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jid.2024.08.003_bib56","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1365-2230.2003.01312.x","article-title":"Connexin gene pathology","volume":"28","author":"Richard","year":"2003","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib57","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1086\/339986","article-title":"Missense mutations in GJB2 encoding connexin-26 cause the ectodermal dysplasia keratitis-ichthyosis-deafness syndrome","volume":"70","author":"Richard","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2024.08.003_bib58","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s004390050839","article-title":"Functional defects of Cx26 resulting from a heterozygous missense mutation in a family with dominant deaf-mutism and palmoplantar keratoderma","volume":"103","author":"Richard","year":"1998","journal-title":"Hum Genet"},{"key":"10.1016\/j.jid.2024.08.003_bib59","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/1523-1747.ep12393218","article-title":"Topography of mammalian connexins in human skin","volume":"103","author":"Salomon","year":"1994","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib60","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1085\/jgp.201010433","article-title":"Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome","volume":"136","author":"S\u00e1nchez","year":"2010","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.jid.2024.08.003_bib61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1085\/jgp.201310962","article-title":"The D50N mutation and syndromic deafness: altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions","volume":"142","author":"Sanchez","year":"2013","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.jid.2024.08.003_bib62","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1399-0004.2009.01339.x","article-title":"Germline mosaicism in keratitis-ichthyosis-deafness syndrome: pre-natal diagnosis in a familial lethal form","volume":"77","author":"Sbidian","year":"2010","journal-title":"Clin Genet"},{"key":"10.1016\/j.jid.2024.08.003_bib63","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/hmg\/ddq429","article-title":"The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndrome","volume":"20","author":"Sch\u00fctz","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2024.08.003_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-03627-8","article-title":"Connexin hemichannel inhibition ameliorates epidermal pathology in a mouse model of keratitis ichthyosis deafness syndrome","volume":"11","author":"Sellitto","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2024.08.003_bib65","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-5793(89)81002-6","article-title":"An increase in intracellular free calcium is an early event during differentiation of cultured human keratinocytes","volume":"254","author":"Sharpe","year":"1989","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jid.2024.08.003_bib66","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/JID.2015.389","article-title":"Connexin26 mutations causing palmoplantar keratoderma and deafness interact with connexin43, modifying gap junction and hemichannel properties","volume":"136","author":"Shuja","year":"2016","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib67","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41598-018-37221-2","article-title":"Connexin43 mutations linked to skin disease have augmented hemichannel activity","volume":"9","author":"Srinivas","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2024.08.003_bib68","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1124\/mol.63.6.1389","article-title":"Closure of gap junction channels by arylaminobenzoates","volume":"63","author":"Srinivas","year":"2003","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jid.2024.08.003_bib69","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bbamem.2017.04.024","article-title":"Human diseases associated with connexin mutations","volume":"1860","author":"Srinivas","year":"2018","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10.1016\/j.jid.2024.08.003_bib70","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1097\/01.mlg.0000241944.77192.d2","article-title":"A\u00a0novel mechanism for connexin 26 mutation linked deafness: cell death caused by leaky gap junction hemichannels","volume":"116","author":"Stong","year":"2006","journal-title":"Laryngoscope"},{"issue":"Suppl","key":"10.1016\/j.jid.2024.08.003_bib71","first-page":"93","article-title":"A\u00a0controlled clinical trial of flufenamic acid in rheumatoid arthritis","author":"Sydnes","year":"1966","journal-title":"Ann Phys Med"},{"key":"10.1016\/j.jid.2024.08.003_bib72","doi-asserted-by":"crossref","first-page":"41079","DOI":"10.1074\/jbc.M107122200","article-title":"The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes","volume":"276","author":"Tu","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2024.08.003_bib73","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1074\/jbc.M708318200","article-title":"Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes","volume":"283","author":"Tu","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jid.2024.08.003_bib74","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ceca.2003.10.019","article-title":"The role of the calcium-sensing receptor in epidermal differentiation","volume":"35","author":"Tu","year":"2004","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jid.2024.08.003_bib75","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1046\/j.1523-1747.2002.01735.x","article-title":"A\u00a0novel connexin 26 mutation in a patient diagnosed with keratitis-ichthyosis-deafness syndrome","volume":"118","author":"van Steensel","year":"2002","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib76","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1007\/s00018-015-1958-3","article-title":"Introduction: connexins, pannexins and their channels as gatekeepers of organ physiology","volume":"72","author":"Vinken","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jid.2024.08.003_bib77","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/hmg\/ddu442","article-title":"Exome sequencing reveals mutation in GJA1 as a cause of keratoderma-hypotrichosis-leukonychia totalis syndrome [published correction appears in Hum Mol Genet 2015;24:6564]","volume":"24","author":"Wang","year":"2015","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2024.08.003_bib78","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0165-0173(99)00079-X","article-title":"Functional analysis of human Cx26 mutations associated with deafness","volume":"32","author":"White","year":"2000","journal-title":"Brain Res Brain Res Rev"},{"key":"10.1016\/j.jid.2024.08.003_bib79","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/10409238.2016.1204980","article-title":"Connexins and their channels in inflammation","volume":"51","author":"Willebrords","year":"2016","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.jid.2024.08.003_bib80","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1046\/j.1523-1747.2000.00043.x","article-title":"Differential expression of connexins during stratification of human keratinocytes","volume":"115","author":"Wiszniewski","year":"2000","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.08.003_bib81","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fnmol.2017.00298","article-title":"Design and characterization of a human monoclonal antibody that modulates mutant connexin 26 hemichannels implicated in deafness and skin disorders","volume":"10","author":"Xu","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.jid.2024.08.003_bib82","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1346971","article-title":"Connexins in epidermal health and diseases: insights into their mutations, implications, and therapeutic solutions","volume":"15","author":"Yasarbas","year":"2024","journal-title":"Front Physiol"},{"key":"10.1016\/j.jid.2024.08.003_bib83","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3389\/fphys.2019.00392","article-title":"A\u00a0human-derived monoclonal antibody targeting extracellular connexin domain selectively modulates hemichannel function","volume":"10","author":"Ziraldo","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.jid.2024.08.003_bib84","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-1-0716-3842-2_4","article-title":"Molecular dynamics simulation of permeation through connexin channels","volume":"2801","author":"Zonta","year":"2024","journal-title":"Methods Mol Biol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X24020530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X24020530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T01:52:28Z","timestamp":1775008348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X24020530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0022202X24020530"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2024.08.003","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Connexin Hemichannel Inhibition and Human Genodermatoses","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2024.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Society for Investigative Dermatology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}