{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:22:19Z","timestamp":1793190139259,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100001582","name":"Dermatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jid.2024.09.008","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T13:03:44Z","timestamp":1727355824000},"page":"1117-1126.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Single-Cell RNA Sequencing Reveals Molecular Signatures that Distinguish Allergic from Irritant Contact Dermatitis"],"prefix":"10.1016","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3397-9687","authenticated-orcid":false,"given":"Michael L.","family":"Frisoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-1519","authenticated-orcid":false,"given":"Wei-Che C.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9390-6033","authenticated-orcid":false,"given":"Nuria","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-7948","authenticated-orcid":false,"given":"Khashayar","family":"Afshari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1395-4984","authenticated-orcid":false,"given":"Yuqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-1293","authenticated-orcid":false,"given":"Manuel","family":"Garber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7815-6430","authenticated-orcid":false,"given":"John E.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2024.09.008_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2024.09.008_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s13671-023-00410-y","article-title":"Toward a molecular diagnosis: looking under the skin at allergic contact dermatitis","volume":"12","author":"Bahamon","year":"2023","journal-title":"Curr Derm Rep"},{"key":"10.1016\/j.jid.2024.09.008_bib3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/cod.13584","article-title":"Review of biologics in allergic contact dermatitis","volume":"83","author":"Bhatia","year":"2020","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2024.09.008_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaw2938","article-title":"A\u00a0key role for IL-13 signaling via the type 2 IL-4 receptor in experimental atopic dermatitis","volume":"5","author":"Bitton","year":"2020","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jid.2024.09.008_bib5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41592-019-0667-5","article-title":"NicheNet: modeling intercellular communication by linking ligands to target genes","volume":"17","author":"Browaeys","year":"2020","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2024.09.008_bib6","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/cea.13892","article-title":"Effects of dupilumab treatment on patch test reactions: a retrospective evaluation","volume":"51","author":"De Wijs","year":"2021","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jid.2024.09.008_bib7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jaci.2014.03.009","article-title":"Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response","volume":"134","author":"Dhingra","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2024.09.008_bib8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1365-2567.1999.00844.x","article-title":"Impaired contact hypersensitivity to trinitrochlorobenzene in interleukin-4-deficient mice","volume":"98","author":"Dieli","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.jid.2024.09.008_bib9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/(SICI)1097-0029(19970501)37:3<193::AID-JEMT4>3.0.CO;2-P","article-title":"Ultrastructure of the epidermal barrier after irritation","volume":"37","author":"Fartasch","year":"1997","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.jid.2024.09.008_bib10","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni.1760","article-title":"Foxp3+ regulatory T cells: differentiation, specification, subphenotypes","volume":"10","author":"Feuerer","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2024.09.008_bib11","doi-asserted-by":"crossref","first-page":"33474","DOI":"10.1073\/pnas.2009192117","article-title":"Machine-learning\u2013driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis","volume":"117","author":"Fortino","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2024.09.008_bib12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1523-1747.2001.01327.x","article-title":"Keratins and the keratinocyte activation cycle","volume":"116","author":"Freedberg","year":"2001","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jid.2024.09.008_bib13","first-page":"1","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J\u00a0Stat Softw"},{"key":"10.1016\/j.jid.2024.09.008_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1034\/j.1600-0536.2003.480209.x","article-title":"Patch testing with the irritant sodium lauryl sulfate (SLS) is useful in interpreting weak reactions to contact allergens as allergic or irritant","volume":"48","author":"Geier","year":"2003","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2024.09.008_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd8995","article-title":"scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T reg function","volume":"13","author":"Gellatly","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2024.09.008_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/dth.12701","article-title":"A\u00a0case series of dupilumab-treated allergic contact dermatitis patients","volume":"31","author":"Goldminz","year":"2018","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.jid.2024.09.008_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2230.2000.00577.x","article-title":"Evaluation","volume":"25","author":"Goulden","year":"2000","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jid.2024.09.008_bib18","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jid.2024.09.008_bib19","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/DER.0000000000000409","article-title":"Effective use of dupilumab in managing systemic allergic contact dermatitis","volume":"29","author":"Joshi","year":"2018","journal-title":"Dermatitis"},{"key":"10.1016\/j.jid.2024.09.008_bib20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nri3150","article-title":"Early immune events in the induction of allergic contact dermatitis","volume":"12","author":"Kaplan","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2024.09.008_bib21","article-title":"rstatix: pipe-friendly framework for basic statistical tests","author":"Kassambara","year":"2023","journal-title":"rstatix"},{"key":"10.1016\/j.jid.2024.09.008_bib22","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/bjd.15163","article-title":"Stratum corneum profiles of inflammatory mediators in patch test reactions to common contact allergens and sodium lauryl sulfate","volume":"176","author":"Koppes","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2024.09.008_bib23","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1111\/all.14989","article-title":"Unique molecular signatures typify skin inflammation induced by chemical allergens and irritants","volume":"76","author":"Lefevre","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jid.2024.09.008_bib24","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.jaad.2016.12.043","article-title":"The burden of skin disease in the United States","volume":"76","author":"Lim","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2024.09.008_bib25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jaad.2018.07.043","article-title":"Dupilumab use in allergic contact dermatitis","volume":"80","author":"Machler","year":"2019","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2024.09.008_bib26","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.jaci.2006.12.654","article-title":"Chemokine responses distinguish chemical-induced allergic from irritant skin inflammation: memory T cells make the difference","volume":"119","author":"Meller","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2024.09.008_bib27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1040-0486(06)80006-2","article-title":"Practical problems in the use of patch testing in the evaluation of patients with contact dermatitis","volume":"2","author":"Nethercott","year":"1990","journal-title":"Curr Probl Dermatol"},{"key":"10.1016\/j.jid.2024.09.008_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1600-0536.1976.tb02993.x","article-title":"Squaric-acid-diethylester - a strong sensitizer","volume":"2","author":"Noster","year":"1976","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jid.2024.09.008_bib29","doi-asserted-by":"crossref","first-page":"R54","DOI":"10.1186\/gb-2006-7-7-r54","article-title":"Signatures of human regulatory T cells: an encounter with old friends and new players","volume":"7","author":"Pfoertner","year":"2006","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2024.09.008_bib30","series-title":"R: a language and environment for statistical computing","year":"2021"},{"key":"10.1016\/j.jid.2024.09.008_bib31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/jsre.2000.5892","article-title":"Bioactive interleukin-8 is expressed in wounds and enhances wound healing","volume":"93","author":"Rennekampff","year":"2000","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.jid.2024.09.008_bib32","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A\u00a0scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2024.09.008_bib33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41572-021-00271-4","article-title":"Contact dermatitis","volume":"7","author":"Scheinman","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jid.2024.09.008_bib34","article-title":"Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons","volume":"119","author":"Silva","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2024.09.008_bib35","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jaad.2016.12.021","article-title":"Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity","volume":"76","author":"Strassner","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jid.2024.09.008_bib36","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.jid.2024.09.008_bib37","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12864-020-6714-x","article-title":"DolphinNext: a distributed data processing platform for high throughput genomics","volume":"21","author":"Yukselen","year":"2020","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jid.2024.09.008_bib38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-2133.1983.tb04582.x","article-title":"Extensive pityriasis alba: a histological histochemical and ultrastructural study","volume":"108","author":"Zaynoun","year":"1983","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2024.09.008_bib39","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2016.154","article-title":"Single-cell barcoding and sequencing using droplet microfluidics","volume":"12","author":"Zilionis","year":"2017","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jid.2024.09.008_bib40","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni.1760","article-title":"Foxp3+ regulatory T cells: differentiation, specification, subphenotypes","volume":"10","author":"Feuerer","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2024.09.008_bib41","doi-asserted-by":"crossref","first-page":"R54","DOI":"10.1186\/gb-2006-7-7-r54","article-title":"Signatures of human regulatory T cells: an encounter with old friends and new players","volume":"7","author":"Pfoertner","year":"2006","journal-title":"Genome Biol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X24021523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X24021523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:59:41Z","timestamp":1777633181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X24021523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0022202X24021523"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2024.09.008","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-Cell RNA Sequencing Reveals Molecular Signatures that Distinguish Allergic from Irritant Contact Dermatitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2024.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Society for Investigative Dermatology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}