{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:58:49Z","timestamp":1777906729791,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danmarks Grundforskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000380","name":"Guy's & St Thomas' Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009362","name":"South London and Maudsley NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019418","name":"NIHR Maudsley Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019418","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013126","name":"Psoriasis Association","doi-asserted-by":"publisher","award":["RE18933\/BSTOP5"],"award-info":[{"award-number":["RE18933\/BSTOP5"]}],"id":[{"id":"10.13039\/100013126","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017751","name":"NIHR BioResource","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100024063","name":"National Health Service Corps","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012618","name":"NIHR Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009902","name":"Egmont Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009902","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012331","name":"LEO Foundation","doi-asserted-by":"publisher","award":["FL14005"],"award-info":[{"award-number":["FL14005"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012176","name":"Maudsley Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013376","name":"Institute of Psychiatry Psychology and Neuroscience","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000764","name":"King's College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000724","name":"Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jid.2025.02.007","type":"journal-article","created":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T11:48:16Z","timestamp":1739965696000},"page":"2340-2344.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic Risk Factors in Childhood Psoriasis"],"prefix":"10.1016","volume":"145","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-398X","authenticated-orcid":false,"given":"Christopher Willy","family":"Schwarz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0082-116X","authenticated-orcid":false,"given":"Christoffer","family":"Blegvad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-1286","authenticated-orcid":false,"given":"David","family":"Baudry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2638-8539","authenticated-orcid":false,"given":"Isabella","family":"Tosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5610-033X","authenticated-orcid":false,"given":"Sang-Hyuck","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-9564","authenticated-orcid":false,"given":"Raymond","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-8742","authenticated-orcid":false,"given":"Esteban","family":"Tato-Barcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2992-1941","authenticated-orcid":false,"given":"Charles J.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9918-1144","authenticated-orcid":false,"given":"Catherine H.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8539-8753","authenticated-orcid":false,"given":"Michael A.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4296-8488","authenticated-orcid":false,"given":"Anne-Marie","family":"Nybo Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9030-183X","authenticated-orcid":false,"given":"Jonathan N.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2066-7780","authenticated-orcid":false,"given":"Paola","family":"Di Meglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4784-9680","authenticated-orcid":false,"given":"Lone","family":"Skov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1805-6278","authenticated-orcid":false,"given":"Nick","family":"Dand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2025.02.007_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/pde.14896","article-title":"Link between childhood tobacco exposure and childhood psoriasis: a case-control study","volume":"39","author":"Atak","year":"2022","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.jid.2025.02.007_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-031448","article-title":"Cohort profile: the clinical \u2018Psoriasis in Adolescents\u2019 (PIA) cohort in Denmark","volume":"9","author":"Blegvad","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.jid.2025.02.007_bib3","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/bjd.14507","article-title":"The epidemiology of childhood psoriasis: a scoping review","volume":"174","author":"Burden-Teh","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2025.02.007_bib4","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/bjd.16083","article-title":"HLA-Cw6 and psoriasis","volume":"178","author":"Chen","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2025.02.007_bib5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13073-020-00742-5","article-title":"Polygenic risk scores: from research tools to clinical instruments","volume":"12","author":"Lewis","year":"2020","journal-title":"Genome Med"},{"key":"10.1016\/j.jid.2025.02.007_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2340\/00015555-1986","article-title":"Clinical characterisation at onset of childhood psoriasis - a cross sectional study in Sweden","volume":"95","author":"Lysell","year":"2015","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2025.02.007_bib7","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1186\/s12967-024-05591-z","article-title":"A partitioned polygenic risk score reveals distinct contributions to psoriasis clinical phenotypes across a multi-ethnic cohort","volume":"22","author":"Orcales","year":"2024","journal-title":"J Transl Med"},{"key":"10.1016\/j.jid.2025.02.007_bib8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1001\/jamadermatol.2013.1078","article-title":"Association of pediatric psoriasis severity with excess and central adiposity: an international cross-sectional study","volume":"149","author":"Paller","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2025.02.007_bib9","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1046\/j.1525-1470.2000.01746.x","article-title":"A comparative study of pediatric onset psoriasis with adult onset psoriasis","volume":"17","author":"Raychaudhuri","year":"2000","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.jid.2025.02.007_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15382","article-title":"Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants","volume":"8","author":"Tsoi","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2025.02.007_bib11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"Auton","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jid.2025.02.007_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.simpa.2021.100147","article-title":"InteractionR: An R package for full reporting of effect modification and interaction","volume":"10","author":"Alli","year":"2021","journal-title":"Softw Impacts"},{"key":"10.1016\/j.jid.2025.02.007_bib13","doi-asserted-by":"crossref","first-page":"giab008","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"key":"10.1016\/j.jid.2025.02.007_bib14","author":"Delaneau","year":"2021","journal-title":"shapeit4"},{"key":"10.1016\/j.jid.2025.02.007_bib15","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.1038\/s41467-019-13225-y","article-title":"Accurate, scalable, and integrative haplotype estimation","volume":"10","author":"Delaneau","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2025.02.007_bib16","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1534\/g3.111.001198","article-title":"Genotype imputation with thousands of genomes","volume":"1","author":"Howie","year":"2011","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.jid.2025.02.007_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"Howie","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jid.2025.02.007_bib18","article-title":"Imputing amino acid polymorphisms in human leukocyte antigens","volume":"8","author":"Jia","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2025.02.007_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biopsych.2013.09.006","article-title":"Gene \u00d7 environment interaction studies have not properly controlled for potential confounders: the problem and the (simple) solution","volume":"75","author":"Keller","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jid.2025.02.007_bib20","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/ije\/dym157","article-title":"Estimating interaction on an additive scale between continuous determinants in a logistic regression model","volume":"36","author":"Knol","year":"2007","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jid.2025.02.007_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/mpr.1608","article-title":"A tutorial on conducting genome-wide association studies: quality control and statistical analysis","volume":"27","author":"Marees","year":"2018","journal-title":"Int J Methods Psychiatr Res"},{"key":"10.1016\/j.jid.2025.02.007_bib24","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2025.02.007_bib25","series-title":"R: language and environment for statistical computing","year":"2022"},{"key":"10.1016\/j.jid.2025.02.007_bib26","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1093\/ije\/dys147","article-title":"Case-control studies: basic concepts","volume":"41","author":"Vandenbroucke","year":"2012","journal-title":"Int J Epidemiol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25001174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25001174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:22:53Z","timestamp":1777641773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X25001174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0022202X25001174"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2025.02.007","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic Risk Factors in Childhood Psoriasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2025.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}