{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:22:31Z","timestamp":1793020951602,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HR20C0026"],"award-info":[{"award-number":["HR20C0026"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["2025IP0055"],"award-info":[{"award-number":["2025IP0055"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jid.2025.04.037","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T19:29:22Z","timestamp":1748374162000},"page":"103-115.e21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Spatial Transcriptome Analysis Reveals Factors Involved in Actinic Cheilosis Transformation to Squamous Cell Carcinoma of the Lip"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7514-7873","authenticated-orcid":false,"given":"Myoung Eun","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5877-7750","authenticated-orcid":false,"given":"Hee Joo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-8306","authenticated-orcid":false,"given":"Joon Min","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-464X","authenticated-orcid":false,"given":"Woo Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4669-9454","authenticated-orcid":false,"given":"Mi Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1997-2240","authenticated-orcid":false,"given":"Chong Hyun","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2025.04.037_bib1","article-title":"Integrative tumor and immune cell multi-omic analyses predict response to immune checkpoint blockade in melanoma","volume":"1","author":"Anagnostou","year":"2020","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.jid.2025.04.037_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2021.686337","article-title":"Cancer-associated fibroblasts in oral cancer: a current perspective on function and potential for therapeutic targeting","volume":"2","author":"Bienkowska","year":"2021","journal-title":"Front Oral Health"},{"key":"10.1016\/j.jid.2025.04.037_bib3","doi-asserted-by":"crossref","first-page":"12812","DOI":"10.18632\/oncotarget.14559","article-title":"High TMPRSS11D protein expression predicts poor overall survival in non-small cell lung cancer","volume":"8","author":"Cao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2025.04.037_bib4","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/s12105-023-01543-z","article-title":"Clinicopathological analysis of actinic cheilitis: a systematic review with meta-analyses","volume":"17","author":"Carneiro","year":"2023","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.jid.2025.04.037_bib5","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3892\/etm.2021.10142","article-title":"Autophagy-related signaling pathways are involved in cancer (Review)","volume":"22","author":"Chen","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jid.2025.04.037_bib6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.bbrc.2011.05.022","article-title":"Epigenetic activation of human kallikrein 13 enhances malignancy of lung adenocarcinoma by promoting N-cadherin expression and laminin degradation","volume":"409","author":"Chou","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jid.2025.04.037_bib7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/odi.12694","article-title":"Myofibroblasts in oral potentially malignant disorders: is it related to malignant transformation?","volume":"24","author":"Coletta","year":"2018","journal-title":"Oral Dis"},{"key":"10.1016\/j.jid.2025.04.037_bib8","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41580-023-00585-z","article-title":"Autophagy and autophagy-related pathways in cancer","volume":"24","author":"Debnath","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jid.2025.04.037_bib9","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1146\/annurev.biochem.78.081307.110540","article-title":"Mechanisms of endocytosis","volume":"78","author":"Doherty","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jid.2025.04.037_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/jop.12623","article-title":"Prognostic value of the immunohistochemical detection of cancer-associated fibroblasts in oral cancer: a systematic review and meta-analysis","volume":"47","author":"Dourado","year":"2018","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jid.2025.04.037_bib11","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1038\/s41598-019-39882-z","article-title":"Src in endosomal membranes promotes exosome secretion and tumor progression","volume":"9","author":"Hikita","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2025.04.037_bib12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s40425-019-0726-6","article-title":"Tumor-infiltrating B cells affect the progression of oropharyngeal squamous cell carcinoma via cell-to-cell interactions with CD8+ T cells","volume":"7","author":"Hlad\u00edkov\u00e1","year":"2019","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.jid.2025.04.037_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4103\/0019-509X.175580","article-title":"Stromal myofibroblasts in oral squamous cell carcinoma and potentially malignant disorders","volume":"52","author":"Jayaraj","year":"2015","journal-title":"Indian J Cancer"},{"key":"10.1016\/j.jid.2025.04.037_bib14","first-page":"746","article-title":"Probiotic-derived p8 protein induce apoptosis via regulation of RNF152 in colorectal cancer cells","volume":"11","author":"Kim","year":"2021","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.jid.2025.04.037_bib15","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s12276-023-00975-5","article-title":"TMPRSS4, a type II transmembrane serine protease, as a potential therapeutic target in cancer","volume":"55","author":"Kim","year":"2023","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jid.2025.04.037_bib16","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1158\/1078-0432.CCR-19-3211","article-title":"B cells improve overall survival in HPV-associated squamous cell carcinomas and are activated by radiation and PD-1 blockade","volume":"26","author":"Kim","year":"2020","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jid.2025.04.037_bib17","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jid.2021.07.172","article-title":"Genomic progression of precancerous actinic keratosis to squamous cell carcinoma","volume":"142","author":"Kim","year":"2022","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.04.037_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.565306","article-title":"Cancer-associated fibroblast density, prognostic characteristics, and recurrence in head and neck squamous cell carcinoma: a meta-analysis","volume":"10","author":"Knops","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.jid.2025.04.037_bib19","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/ijc.34957","article-title":"Cancer-associated fibroblast activation predicts progression, metastasis, and prognosis of cutaneous squamous cell carcinoma","volume":"155","author":"Knuutila","year":"2024","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jid.2025.04.037_bib20","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1749-6632.1997.tb52090.x","article-title":"Regulation of T and B cell responses by modulating interactions between CD28\/CTLA4 and their ligands, CD80 and CD86","volume":"815","author":"Lane","year":"1997","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jid.2025.04.037_bib21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s13046-021-02147-7","article-title":"TMPRSS4 promotes cancer stem-like properties in prostate cancer cells through upregulation of SOX2 by SLUG and TWIST1","volume":"40","author":"Lee","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.jid.2025.04.037_bib22","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41420-023-01555-2","article-title":"Cutaneous squamous cell carcinoma-derived extracellular vesicles exert an oncogenic role by activating cancer-associated fibroblasts","volume":"9","author":"Li","year":"2023","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.jid.2025.04.037_bib23","doi-asserted-by":"crossref","first-page":"23683","DOI":"10.1021\/acsomega.3c01782","article-title":"MGST1 expression is associated with poor prognosis, enhancing the Wnt\/\u03b2-catenin pathway via regulating AKT and inhibiting ferroptosis in gastric cancer","volume":"8","author":"Li","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.jid.2025.04.037_bib24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"10.1016\/j.jid.2025.04.037_bib25","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.urolonc.2011.05.011","article-title":"Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness","volume":"31","author":"Lose","year":"2013","journal-title":"Urol Oncol"},{"key":"10.1016\/j.jid.2025.04.037_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.658315","article-title":"The diverse roles of heme oxygenase-1 in tumor progression","volume":"12","author":"Luu Hoang","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2025.04.037_bib27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1601-0825.2004.01004.x","article-title":"Actinic cheilitis: clinical and pathologic characteristics in 65 cases","volume":"10","author":"Markopoulos","year":"2004","journal-title":"Oral Dis"},{"key":"10.1016\/j.jid.2025.04.037_bib28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/jop.13541","article-title":"Assessment of the association of myofibroblasts and structural components of the extracellular matrix with histopathological parameters of actinic cheilitis and lower lip squamous cell carcinoma","volume":"53","author":"Martinez","year":"2024","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jid.2025.04.037_bib29","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm3151","article-title":"Molecular mechanism and physiological functions of clathrin-mediated endocytosis","volume":"12","author":"McMahon","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jid.2025.04.037_bib30","first-page":"e62","article-title":"Actinic cheilitis and lip squamous cell carcinoma: literature review and new data from Brazil","volume":"11","author":"Mello","year":"2019","journal-title":"J Clin Exp Dent"},{"key":"10.1016\/j.jid.2025.04.037_bib31","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1007\/s00405-014-3415-6","article-title":"Squamous cell carcinoma of the lip: survival analysis with long-term follow-up","volume":"272","author":"Ozturk","year":"2015","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.jid.2025.04.037_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0714.2011.01057.x","article-title":"Increased fibroblast density in actinic cheilitis: association with tryptase-positive mast cells, actinic elastosis and epithelial p53 and COX-2 expression","volume":"41","author":"Rojas","year":"2012","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jid.2025.04.037_bib33","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.1038\/s41467-023-41141-9","article-title":"Functionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma","volume":"14","author":"Sch\u00fctz","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2025.04.037_bib34","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/jop.12559","article-title":"Incidence of lip malignancies in Germany-data from nine population-based cancer registries","volume":"46","author":"Singer","year":"2017","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jid.2025.04.037_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cpt.2023.04.001","article-title":"Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis","volume":"2","author":"Singhabahu","year":"2024","journal-title":"Cancer Pathog Ther"},{"key":"10.1016\/j.jid.2025.04.037_bib36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1365-2559.2011.03756.x","article-title":"Immunohistochemical analysis of p53, APE1, hMSH2 and ERCC1 proteins in actinic cheilitis and lip squamous cell carcinoma","volume":"58","author":"Souza","year":"2011","journal-title":"Histopathology"},{"key":"10.1016\/j.jid.2025.04.037_bib37","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/j.1365-2559.2010.03721.x","article-title":"Association of mast cell, eosinophil leucocyte and microvessel densities in actinic cheilitis and lip squamous cell carcinoma","volume":"57","author":"Souza","year":"2010","journal-title":"Histopathology"},{"key":"10.1016\/j.jid.2025.04.037_bib38","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2025.04.037_bib39","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/febs.13971","article-title":"The role of type II transmembrane serine protease-mediated signaling in cancer","volume":"284","author":"Tanabe","year":"2017","journal-title":"FEBS J"},{"key":"10.1016\/j.jid.2025.04.037_bib40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12920-023-01462-6","article-title":"Identification of gene profiles related to the development of oral cancer using a deep learning technique","volume":"16","author":"Tapak","year":"2023","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.jid.2025.04.037_bib41","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.oraloncology.2008.11.013","article-title":"Serine protease inhibitor (Serpin) B1 promotes oral cancer cell motility and is over-expressed in invasive oral squamous cell carcinoma","volume":"45","author":"Tseng","year":"2009","journal-title":"Oral Oncol"},{"key":"10.1016\/j.jid.2025.04.037_bib42","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/lary.26704","article-title":"Cutaneous squamous cell carcinoma of the lip: a population-based analysis","volume":"128","author":"Unsal","year":"2018","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jid.2025.04.037_bib43","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12935-021-01806-1","article-title":"Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression","volume":"21","author":"Wan","year":"2021","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.jid.2025.04.037_bib44","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/jamadermatol.2018.0792","article-title":"Association of nodal metastasis and mortality with vermilion vs cutaneous lip location in cutaneous squamous cell carcinoma of the lip","volume":"154","author":"Wang","year":"2018","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2025.04.037_bib45","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.biocel.2011.05.010","article-title":"Core signaling pathways of survival\/death in autophagy-related cancer networks","volume":"43","author":"Wang","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jid.2025.04.037_bib46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/19768354.2021.1944311","article-title":"Type II transmembrane serine proteases 4 (TMPRSS4) promotes proliferation, invasion and epithelial-mesenchymal transition in endometrial carcinoma cells (HEC1A and Ishikawa) via activation of MAPK and AKT","volume":"25","author":"Xiao","year":"2021","journal-title":"Anim Cells Syst (Seoul)"},{"key":"10.1016\/j.jid.2025.04.037_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2019.105537","article-title":"SerpinB1 promotes the proliferation of porcine pancreatic stem cells through the STAT3 signaling pathway","volume":"198","author":"Xu","year":"2020","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jid.2025.04.037_bib48","doi-asserted-by":"crossref","first-page":"21591","DOI":"10.1039\/C9RA02482D","article-title":"Retracted Article: Knockdown of TMPRSS11D inhibits the proliferation, migration and invasion of cervical cancer cells","volume":"9","author":"Yan","year":"2019","journal-title":"RSC Adv"},{"key":"10.1016\/j.jid.2025.04.037_bib49","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40364-023-00460-1","article-title":"Roles and mechanisms of tumour-infiltrating B cells in human cancer: a new force in immunotherapy","volume":"11","author":"Zhang","year":"2023","journal-title":"Biomark Res"},{"key":"10.1016\/j.jid.2025.04.037_bib50","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/bs.acr.2023.05.001","article-title":"Microsomal glutathione transferase 1 in cancer and the regulation of ferroptosis","volume":"160","author":"Zhang","year":"2023","journal-title":"Adv Cancer Res"},{"key":"10.1016\/j.jid.2025.04.037_bib51","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/17246008211046368","article-title":"TMPRSS4 overexpression promotes the metastasis of colorectal cancer and predicts poor prognosis of stage III-IV colorectal cancer","volume":"36","author":"Zhao","year":"2021","journal-title":"Int J Biol Markers"},{"key":"10.1016\/j.jid.2025.04.037_bib52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jid.2025.04.037_bib53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41368-023-00265-w","article-title":"Genomic alterations in oral multiple primary cancers","volume":"16","author":"Zhou","year":"2024","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.jid.2025.04.037_bib54","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.ajpath.2023.06.014","article-title":"RNF152 suppresses fatty acid oxidation and metastasis of lung adenocarcinoma by inhibiting IRAK1-mediated AKR1B10 expression","volume":"193","author":"Zhu","year":"2023","journal-title":"Am J Pathol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25005287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25005287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:36:02Z","timestamp":1774859762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X25005287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0022202X25005287"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2025.04.037","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spatial Transcriptome Analysis Reveals Factors Involved in Actinic Cheilosis Transformation to Squamous Cell Carcinoma of the Lip","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2025.04.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}