{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:59:13Z","timestamp":1789840753167,"version":"4.0.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["172616"],"award-info":[{"award-number":["172616"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["165349"],"award-info":[{"award-number":["165349"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["530938"],"award-info":[{"award-number":["530938"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["479268"],"award-info":[{"award-number":["479268"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["152477"],"award-info":[{"award-number":["152477"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000142","name":"Arthritis Society","doi-asserted-by":"publisher","award":["23-0000000084"],"award-info":[{"award-number":["23-0000000084"]}],"id":[{"id":"10.13039\/501100000142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jid.2025.06.1592","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T15:21:34Z","timestamp":1752765694000},"page":"252-256.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Granzyme B Mediates Syndecan-1 (CD138) Shedding in Psoriatic Keratinocytes"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-2284","authenticated-orcid":false,"given":"Alexandre","family":"Aubert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-8558","authenticated-orcid":false,"given":"Katlyn C.","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1141-011X","authenticated-orcid":false,"given":"Martin","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0928-5298","authenticated-orcid":false,"given":"Amy","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3978-3597","authenticated-orcid":false,"given":"Jhunam","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7409-4386","authenticated-orcid":false,"given":"Christopher T.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7056-1768","authenticated-orcid":false,"given":"Wendy A.","family":"Boivin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8669-1898","authenticated-orcid":false,"given":"Richard I.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6985-2816","authenticated-orcid":false,"given":"David J.","family":"Granville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2025.06.1592_bib1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41584-024-01109-5","article-title":"Granzyme serine proteases in inflammation and rheumatic diseases","volume":"20","author":"Aubert","year":"2024","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.jid.2025.06.1592_bib2","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1080\/14728222.2022.2161890","article-title":"Granzyme B as a therapeutic target: an update in 2022","volume":"26","author":"Aubert","year":"2022","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.jid.2025.06.1592_bib3","doi-asserted-by":"crossref","first-page":"W208","DOI":"10.1093\/nar\/gki433","article-title":"GraBCas: a bioinformatics tool for score-based prediction of caspase- and granzyme B-cleavage sites in protein sequences","volume":"33","author":"Backes","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2025.06.1592_bib4","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.4049\/jimmunol.1800104","article-title":"Syndecan-1 regulates psoriasiform dermatitis by controlling homeostasis of IL-17-producing \u03b3\u03b4 T cells","volume":"201","author":"Jaiswal","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.06.1592_bib5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jdermsci.2016.09.009","article-title":"Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis","volume":"84","author":"Kamata","year":"2016","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jid.2025.06.1592_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.matbio.2021.08.002","article-title":"Syndecan-1 shedding by meprin \u03b2 impairs keratinocyte adhesion and differentiation in hyperkeratosis","volume":"102","author":"Peters","year":"2021","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2025.06.1592_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1398120","article-title":"Granzyme K mediates IL-23-dependent inflammation and keratinocyte proliferation in psoriasis","volume":"15","author":"Richardson","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2025.06.1592_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.matbio.2011.10.001","article-title":"Molecular functions of syndecan-1 in disease","volume":"31","author":"Teng","year":"2012","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jid.2025.06.1592_bib9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00403-008-0848-z","article-title":"The expression of syndecan-1 in psoriatic epidermis","volume":"300","author":"Tomas","year":"2008","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2025.06.1592_bib10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jid.2020.05.095","article-title":"Granzyme B contributes to barrier dysfunction in oxazolone-induced skin inflammation through E-cadherin and FLG cleavage","volume":"141","author":"Turner","year":"2021","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25022663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25022663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:21:36Z","timestamp":1778649696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X25022663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0022202X25022663"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2025.06.1592","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Granzyme B Mediates Syndecan-1 (CD138) Shedding in Psoriatic Keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2025.06.1592","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}