{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T05:05:45Z","timestamp":1779944745072,"version":"3.53.1"},"reference-count":17,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1P30AR075043"],"award-info":[{"award-number":["1P30AR075043"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR080662"],"award-info":[{"award-number":["R01AR080662"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UC2 AR081033"],"award-info":[{"award-number":["UC2 AR081033"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01AR072129"],"award-info":[{"award-number":["K01AR072129"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003185","name":"National Psoriasis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031234","name":"Michigan Medicine, University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008456","name":"A. Alfred Taubman Medical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008456","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001582","name":"Dermatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jid.2025.07.030","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T23:12:25Z","timestamp":1755904345000},"page":"858-862.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endothelin-2 from Keratinocytes and its Association with Itch in Skin Diseases"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9190-5902","authenticated-orcid":false,"given":"Yumeng","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8505-4259","authenticated-orcid":false,"given":"Mrinal K.","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianying","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Patrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-8537","authenticated-orcid":false,"given":"Bo","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2177-2427","authenticated-orcid":false,"given":"Mehrnaz","family":"Gharaee-Kermani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Julia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Weidinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-8945","authenticated-orcid":false,"given":"J. Michelle","family":"Kahlenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-0812","authenticated-orcid":false,"given":"Johann E.","family":"Gudjonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-5722","authenticated-orcid":false,"given":"Lam C.","family":"Tsoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2025.07.030_bib1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/00015559850135779","article-title":"Endothelin-1 levels are increased in sera and lesional skin extracts of psoriatic patients and correlate with disease severity","volume":"78","author":"Bonifati","year":"1998","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2025.07.030_bib2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1124\/pr.115.011833","article-title":"Endothelin","volume":"68","author":"Davenport","year":"2016","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jid.2025.07.030_bib3","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1128\/MCB.20.4.1436-1447.2000","article-title":"Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics","volume":"20","author":"Dickson","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jid.2025.07.030_bib4","first-page":"839","article-title":"The neurogenic vasodilator response to endothelin-1: a study in human skin in vivo","volume":"85","author":"Katugampola","year":"2000","journal-title":"Exp Physiol"},{"key":"10.1016\/j.jid.2025.07.030_bib5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1476-5381.2011.01786.x","article-title":"Endothelin-2, the forgotten isoform: emerging role in the cardiovascular system, ovarian development, immunology and cancer","volume":"168","author":"Ling","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jid.2025.07.030_bib6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jaci.2023.07.005","article-title":"Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab","volume":"153","author":"Ma","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2025.07.030_bib7","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/sj.bjp.0707216","article-title":"Endothelin-1 activates ETA receptors to cause reflex scratching in BALB\/c mice","volume":"151","author":"McQueen","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jid.2025.07.030_bib8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jaci.2023.05.004","article-title":"Basic mechanisms of itch","volume":"152","author":"Misery","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2025.07.030_bib9","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2500\/aap.2015.36.3846","article-title":"Plasma endothelin-1 levels during exacerbation of atopic dermatitis","volume":"36","author":"Tsybikov","year":"2015","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jid.2025.07.030_bib10","article-title":"DIRECT-NET: an efficient method to discover cis-regulatory elements and construct regulatory networks from single-cell multiomics data","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.jid.2025.07.030_bib11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2025.07.030_bib12","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1128\/MCB.20.4.1436-1447.2000","article-title":"Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics","volume":"20","author":"Dickson","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jid.2025.07.030_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2025.07.030_bib14","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jaci.2023.07.005","article-title":"Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab","volume":"153","author":"Ma","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2025.07.030_bib15","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.jaci.2021.10.004","article-title":"Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab","volume":"149","author":"Tsoi","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2025.07.030_bib16","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.jaci.2019.11.047","article-title":"Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses","volume":"145","author":"Tsoi","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2025.07.030_bib17","article-title":"DIRECT-NET: an efficient method to discover cis-regulatory elements and construct regulatory networks from single-cell multiomics data","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci Adv"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25023541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25023541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:33:48Z","timestamp":1779942828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X25023541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0022202X25023541"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2025.07.030","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelin-2 from Keratinocytes and its Association with Itch in Skin Diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2025.07.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}