{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:25:44Z","timestamp":1790972744125,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,4,21]],"date-time":"2027-04-21T00:00:00Z","timestamp":1808265600000},"content-version":"am","delay-in-days":355,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012331","name":"LEO Fondet","doi-asserted-by":"publisher","award":["LF-OC-25-002031"],"award-info":[{"award-number":["LF-OC-25-002031"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK118134"],"award-info":[{"award-number":["R01DK118134"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY033709"],"award-info":[{"award-number":["R01EY033709"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK121178"],"award-info":[{"award-number":["R01DK121178"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AG063377"],"award-info":[{"award-number":["R21AG063377"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY033360"],"award-info":[{"award-number":["R01EY033360"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jid.2025.09.371","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T04:35:38Z","timestamp":1760070938000},"page":"1271-1283.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["KCTD1\/KCTD15-Mediated Repression of AP-2\u03b1\/AP-2\u03b2 Is Required for Proper Skin Appendage Development and Epidermal Homeostasis"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5199-2299","authenticated-orcid":false,"given":"Bill","family":"Senapati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2725-0715","authenticated-orcid":false,"given":"Jackelyn R.","family":"Raymundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7643-170X","authenticated-orcid":false,"given":"Jasson","family":"Makkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7673-2564","authenticated-orcid":false,"given":"Ryan R.","family":"Driskell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3866-020X","authenticated-orcid":false,"given":"Alexander G.","family":"Marneros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2025.09.371_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.semcdb.2014.01.007","article-title":"Early inductive events in ectodermal appendage morphogenesis","volume":"25\u201326","author":"Biggs","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.jid.2025.09.371_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ydbio.2003.10.039","article-title":"Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects","volume":"267","author":"Brewer","year":"2004","journal-title":"Dev Biol"},{"key":"10.1016\/j.jid.2025.09.371_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2023.100926","article-title":"KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors","volume":"43","author":"Di Fiore","year":"2023","journal-title":"Neoplasia"},{"key":"10.1016\/j.jid.2025.09.371_bib4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jcb.22002","article-title":"The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation","volume":"106","author":"Ding","year":"2009","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jid.2025.09.371_bib5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/bdrc.20158","article-title":"Epidermal patterning and induction of different hair types during mouse embryonic development","volume":"87","author":"Duverger","year":"2009","journal-title":"Birth Defects Res C Embryo Today"},{"key":"10.1016\/j.jid.2025.09.371_bib6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/dbio.2002.0597","article-title":"Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation\/inactivation in the mouse","volume":"244","author":"Hayashi","year":"2002","journal-title":"Dev Biol"},{"key":"10.1016\/j.jid.2025.09.371_bib7","first-page":"3895","article-title":"KCTD1 mutants in scalp-ear-nipple syndrome and AP-2\u03b1 P59A in Char syndrome reciprocally abrogate their interactions, but can regulate Wnt\/\u03b2-catenin signaling","volume":"22","author":"Hu","year":"2020","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jid.2025.09.371_bib27","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.devcel.2023.07.015","article-title":"Molecular and spatial landmarks of early mouse skin development","volume":"58","author":"Jacob","year":"2023","journal-title":"Dev Cell"},{"key":"10.1016\/j.jid.2025.09.371_bib28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.stem.2020.01.012","article-title":"The molecular anatomy of mouse skin during hair growth and rest","volume":"26","author":"Joost","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jid.2025.09.371_bib8","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1038\/s41467-022-29644-3","article-title":"Transcription factors AP-2\u03b1 and AP-2\u03b2 regulate distinct segments of the distal nephron in the mammalian kidney","volume":"13","author":"Lamontagne","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2025.09.371_bib9","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jid.2024.08.014","article-title":"Deep hair phenomics: implications in endocrinology, development, and aging","volume":"145","author":"Makkar","year":"2025","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.09.371_bib10","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.devcel.2020.05.026","article-title":"AP-2\u03b2\/KCTD1 control distal nephron differentiation and protect against renal fibrosis","volume":"54","author":"Marneros","year":"2020","journal-title":"Dev Cell"},{"key":"10.1016\/j.jid.2025.09.371_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108616","article-title":"Magnesium and calcium homeostasis depend on KCTD1 function in the distal nephron","volume":"34","author":"Marneros","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2025.09.371_bib12","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1016\/j.jid.2024.05.014","article-title":"Aplasia cutis congenita pathomechanisms reveal key regulators of skin and skin appendage morphogenesis","volume":"144","author":"Marneros","year":"2024","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.09.371_bib13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.ajhg.2013.03.002","article-title":"Mutations in KCTD1 cause scalp-ear-nipple syndrome","volume":"92","author":"Marneros","year":"2013","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jid.2025.09.371_bib14","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/jmg-2023-109531","article-title":"BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome","volume":"61","author":"Miller","year":"2024","journal-title":"J Med Genet"},{"key":"10.1016\/j.jid.2025.09.371_bib15","article-title":"KCTD1\/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis","volume":"134","author":"Raymundo","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jid.2025.09.371_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46911-4","article-title":"Molecular basis of the scalp-ear-nipple syndrome unraveled by the characterization of disease-causing KCTD1 mutants","volume":"9","author":"Smaldone","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2025.09.371_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41389-019-0175-6","article-title":"KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2","volume":"8","author":"Spiombi","year":"2019","journal-title":"Oncogenesis"},{"key":"10.1016\/j.jid.2025.09.371_bib18","doi-asserted-by":"crossref","first-page":"dev157438","DOI":"10.1242\/dev.157438","article-title":"AP-2\u03b1 and AP-2\u03b2 cooperatively orchestrate homeobox gene expression during branchial arch patterning","volume":"145","author":"Van Otterloo","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.jid.2025.09.371_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/13816810.2022.2144900","article-title":"KCTD1 and Scalp-Ear-Nipple ('Finlay-Marks') syndrome may be associated with myopia and Thin basement membrane nephropathy through an effect on the collagen IV \u03b13 and \u03b14 chains","volume":"44","author":"Wang","year":"2023","journal-title":"Ophthal Genet"},{"key":"10.1016\/j.jid.2025.09.371_bib20","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.200510002","article-title":"AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis","volume":"172","author":"Wang","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jid.2025.09.371_bib21","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1101\/gad.5.4.670","article-title":"Analysis of the DNA-binding and activation properties of the human transcription factor AP-2","volume":"5","author":"Williams","year":"1991","journal-title":"Genes Dev"},{"key":"10.1016\/j.jid.2025.09.371_bib22","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1126\/science.1998122","article-title":"Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins","volume":"251","author":"Williams","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.jid.2025.09.371_bib23","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1073\/pnas.1300203110","article-title":"Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2","volume":"110","author":"Zarelli","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2025.09.371_bib24","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.jid.2023.12.017","article-title":"AP-2\u03b1\/AP-2\u03b2 transcription factors are key regulators of epidermal homeostasis","volume":"144","author":"Zhang","year":"2024","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.09.371_bib25","article-title":"KCTD1\/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis","volume":"134","author":"Raymundo","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jid.2025.09.371_bib26","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.jid.2023.12.017","article-title":"AP-2\u03b1\/AP-2\u03b2 transcription factors are key regulators of epidermal homeostasis","volume":"144","author":"Zhang","year":"2024","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25028325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25028325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:22:13Z","timestamp":1781857333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X25028325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0022202X25028325"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2025.09.371","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KCTD1\/KCTD15-Mediated Repression of AP-2\u03b1\/AP-2\u03b2 Is Required for Proper Skin Appendage Development and Epidermal Homeostasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2025.09.371","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}