{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:45:53Z","timestamp":1792525553000,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3601800"],"award-info":[{"award-number":["2022YFC3601800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82322057"],"award-info":[{"award-number":["82322057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273518"],"award-info":[{"award-number":["82273518"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jid.2025.09.374","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T03:22:19Z","timestamp":1760498539000},"page":"1256-1264.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrative Mendelian Randomization and Transcriptomic Analysis Reveal the Causal Association between Psoriatic Arthritis and Uveitis"],"prefix":"10.1016","volume":"146","author":[{"given":"Junfeng","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangquan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erle","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongbin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongrui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2025.09.374_bib1","article-title":"Identification of the novel allele, HLA-DQB1\u221703:517, in a Saudi individual","volume":"104","author":"AlAbduladheem","year":"2024","journal-title":"HLA"},{"key":"10.1016\/j.jid.2025.09.374_bib2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08460","article-title":"Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1","volume":"462","author":"Barbie","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jid.2025.09.374_bib3","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/rheumatology\/keaa692","article-title":"Incidence of extra-articular manifestations in ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis: results from a national register-based cohort study","volume":"60","author":"Bengtsson","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.jid.2025.09.374_bib4","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.178499","article-title":"Single-cell RNA-Seq analysis reveals cell subsets and gene signatures associated with rheumatoid arthritis disease activity","volume":"9","author":"Binvignat","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2025.09.374_bib5","article-title":"Uveitis for the non-ophthalmologist","volume":"372","author":"Burkholder","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jid.2025.09.374_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/annrheumdis-2017-212328","article-title":"Risk of uveitis and inflammatory bowel disease in people with psoriatic arthritis: a population-based cohort study","volume":"77","author":"Charlton","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jid.2025.09.374_bib7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1001\/jamaophthalmol.2017.0569","article-title":"Risk of uveitis among people with psoriasis: a nationwide cohort study","volume":"135","author":"Chi","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.jid.2025.09.374_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1151837","article-title":"Two-sample Mendelian randomization analysis evaluates causal associations between inflammatory bowel disease and osteoporosis","volume":"11","author":"Dai","year":"2023","journal-title":"Front Public Health"},{"key":"10.1016\/j.jid.2025.09.374_bib9","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2022-002781","article-title":"Uveitis in psoriatic arthritis: study of 406 patients in a single university center and literature review","volume":"9","author":"De Vicente Delm\u00e1s","year":"2023","journal-title":"RMD Open"},{"key":"10.1016\/j.jid.2025.09.374_bib10","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/jamadermatol.2015.1986","article-title":"Association of psoriatic disease with uveitis: a Danish nationwide cohort study","volume":"151","author":"Egeberg","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2025.09.374_bib11","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jid.2025.09.374_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh4655","article-title":"Global lactylome reveals lactylation-dependent mechanisms underlying TH17 differentiation in experimental autoimmune uveitis","volume":"9","author":"Fan","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.jid.2025.09.374_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41572-021-00293-y","article-title":"Psoriatic arthritis","volume":"7","author":"FitzGerald","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jid.2025.09.374_bib14","first-page":"91","article-title":"Psoriasis and uveitis: links and risks","volume":"9","author":"Fotiadou","year":"2019","journal-title":"Psoriasis (Auckl)"},{"key":"10.1016\/j.jid.2025.09.374_bib15","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/s41401-020-00523-1","article-title":"Anti-inflammatory signaling through G protein-coupled receptors","volume":"41","author":"Ge","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jid.2025.09.374_bib16","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1093\/bioinformatics\/btac409","article-title":"ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2","volume":"38","author":"Gustavsson","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jid.2025.09.374_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.134821","article-title":"Understanding and manipulating the recognition of necrosis-inducing secreted protein 1 (NIS1) by BRI1-associated receptor kinase 1 (BAK1)","volume":"278","author":"Han","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jid.2025.09.374_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.jid.2025.09.374_bib19","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s10067-023-06834-y","article-title":"The risk factors for uveitis among psoriatic arthritis patients: a population-based cohort study","volume":"43","author":"Hijazi","year":"2024","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.jid.2025.09.374_bib20","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1038\/s41467-024-48313-1","article-title":"Receptor-like cytoplasmic kinases of different subfamilies differentially regulate SOBIR1\/BAK1-mediated immune responses in Nicotiana benthamiana","volume":"15","author":"Huang","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2025.09.374_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2021.101692","article-title":"The epidemiology of psoriatic arthritis: a literature review","volume":"35","author":"Karmacharya","year":"2021","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.jid.2025.09.374_bib22","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X21998279","article-title":"Psoriatic arthritis and the association with cardiometabolic disease: a narrative review","volume":"13","author":"Karmacharya","year":"2021","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.jid.2025.09.374_bib23","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/jdv.19060","article-title":"Risk of uveitis in patients with psoriasis in Korea: a nationwide population-based cohort study","volume":"37","author":"Kim","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2025.09.374_bib24","doi-asserted-by":"crossref","first-page":"7886","DOI":"10.1038\/s41467-024-52188-7","article-title":"Cytosolic FKBPL and ER-resident CKAP4 co-regulates ER-phagy and protein secretion","volume":"15","author":"Li","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2025.09.374_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jare.2023.07.010","article-title":"Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy","volume":"60","author":"Lin","year":"2024","journal-title":"J Adv Res"},{"key":"10.1016\/j.jid.2025.09.374_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3023127","article-title":"Potential molecular mechanisms of plantain in the treatment of gout and hyperuricemia based on network pharmacology","volume":"2020","author":"Liu","year":"2020","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jid.2025.09.374_bib27","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12933-023-01974-6","article-title":"Causal associations between type 1 diabetes mellitus and cardiovascular diseases: a Mendelian randomization study","volume":"22","author":"Liu","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.jid.2025.09.374_bib28","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1016\/S2665-9913(22)00334-4","article-title":"Role of neutrophil interleukin-23 in spondyloarthropathy spectrum disorders","volume":"5","author":"Macleod","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.jid.2025.09.374_bib29","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1080\/15548627.2024.2350270","article-title":"Picornavirus VP3 protein induces autophagy through the TP53-BAD-BAX axis to promote viral replication","volume":"20","author":"Mao","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.jid.2025.09.374_bib30","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/12034754251322764","article-title":"The bidirectional association between psoriatic disease and uveitis: an updated meta-analysis","volume":"29","author":"Miao","year":"2025","journal-title":"J Cutan Med Surg"},{"key":"10.1016\/j.jid.2025.09.374_bib31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/gepi.22522","article-title":"Bias correction for inverse variance weighting Mendelian randomization","volume":"47","author":"Mounier","year":"2023","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.jid.2025.09.374_bib32","first-page":"135","article-title":"Translation and adaptation of the adult developmental coordination disorder\/dyspraxia checklist (ADC) into Asian Uzbekistan","volume":"11","author":"Orifjon","year":"2023","journal-title":"Sports (Basel)"},{"key":"10.1016\/j.jid.2025.09.374_bib33","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.ophtha.2018.05.014","article-title":"Targeting interleukin-23 in the treatment of noninfectious uveitis","volume":"125","author":"Pepple","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jid.2025.09.374_bib34","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1093\/rheumatology\/keaa062","article-title":"Prevalence of extra-articular manifestations in psoriatic arthritis: a systematic review and meta-analysis","volume":"59","author":"Pittam","year":"2020","journal-title":"Rheumatology"},{"key":"10.1016\/j.jid.2025.09.374_bib35","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s40265-023-01857-w","article-title":"Managing psoriatic arthritis patients presenting with axial symptoms","volume":"83","author":"Poddubnyy","year":"2023","journal-title":"Drugs"},{"key":"10.1016\/j.jid.2025.09.374_bib36","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jid.2025.09.374_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.18637\/jss.v079.c02","article-title":"plotROC: a tool for plotting ROC curves","volume":"79","author":"Sachs","year":"2017","journal-title":"J Stat Softw"},{"key":"10.1016\/j.jid.2025.09.374_bib38","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41576-019-0150-2","article-title":"RNA sequencing: the teenage years","volume":"20","author":"Stark","year":"2019","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jid.2025.09.374_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009440","article-title":"A more accurate method for colocalisation analysis allowing for multiple causal variants","volume":"17","author":"Wallace","year":"2021","journal-title":"PLoS Genet"},{"key":"10.1016\/j.jid.2025.09.374_bib40","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/08923973.2018.1434792","article-title":"The essential role of G protein-coupled receptor (GPCR) signaling in regulating T cell immunity","volume":"40","author":"Wang","year":"2018","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"10.1016\/j.jid.2025.09.374_bib41","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1161\/CIRCRESAHA.121.319296","article-title":"Endothelial Yin Yang 1 phosphorylation at S118 induces atherosclerosis under flow","volume":"129","author":"Wei","year":"2021","journal-title":"Circ Res"},{"key":"10.1016\/j.jid.2025.09.374_bib42","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1093\/rheumatology\/keaf110","article-title":"Incidence of uveitis and inflammatory bowel disease in psoriatic disease, and psoriatic disease in uveitis and inflammatory bowel disease","volume":"64","author":"Williams","year":"2025","journal-title":"Rheumatology"},{"key":"10.1016\/j.jid.2025.09.374_bib43","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1210\/clinem\/dgac683","article-title":"Graves disease and inflammatory bowel disease: a bidirectional Mendelian randomization","volume":"108","author":"Xian","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jid.2025.09.374_bib44","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.3390\/nu14183683","article-title":"Genetic causal association between iron status and osteoarthritis: a two-sample Mendelian randomization","volume":"14","author":"Xu","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jid.2025.09.374_bib45","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1093\/brain\/awae048","article-title":"HLA-DQB1\u221705 subtypes and not DRB1\u221710:01 mediates risk in anti-IgLON5 disease","volume":"147","author":"Yogeshwar","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.jid.2025.09.374_bib46","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.jid.2025.09.374_bib47","article-title":"Analysis of differentially expressed genes in individuals with noninfectious uveitis based on data in the gene expression omnibus database","volume":"101","author":"Zhang","year":"2022","journal-title":"Medicine (Baltimore)"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25034050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25034050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:20:18Z","timestamp":1781857218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X25034050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0022202X25034050"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2025.09.374","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative Mendelian Randomization and Transcriptomic Analysis Reveal the Causal Association between Psoriatic Arthritis and Uveitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2025.09.374","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}