{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T12:14:02Z","timestamp":1780143242052,"version":"3.54.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,5,26]],"date-time":"2027-05-26T00:00:00Z","timestamp":1811289600000},"content-version":"am","delay-in-days":359,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008374","name":"Center for AIDS Research, Emory University","doi-asserted-by":"publisher","award":["AI027767"],"award-info":[{"award-number":["AI027767"]}],"id":[{"id":"10.13039\/100008374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI154842"],"award-info":[{"award-number":["R01AI154842"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR072213"],"award-info":[{"award-number":["R01AR072213"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR073004"],"award-info":[{"award-number":["R01AR073004"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR071157"],"award-info":[{"award-number":["R01AR071157"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jid.2025.10.602","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:26:21Z","timestamp":1762561581000},"page":"1649-1660.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of UVB-induced TREM-1\u2013positive tolerogenic dendritic cells and TREM-1 signaling as a target in the prevention of UVB-induced immune suppression and skin carcinogenesis"],"prefix":"10.1016","volume":"146","author":[{"given":"Carlos Alberto","family":"Mier-Aguilar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Asif","family":"Sherwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Tsuruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha","family":"Abdelsamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Crossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sejong","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej T.","family":"Slominski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig A.","family":"Elmets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5730-0037","authenticated-orcid":false,"given":"Nabiha","family":"Yusuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7989-6932","authenticated-orcid":false,"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2025.10.602_bib1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI167951","article-title":"Targeting TREM1 augments antitumor T cell immunity by inhibiting myeloid-derived suppressor cells and restraining anti-PD-1 resistance","volume":"133","author":"Ajith","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jid.2025.10.602_bib2","first-page":"1","article-title":"Dendritic cell subsets and locations","volume":"348","author":"Balan","year":"2019","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.jid.2025.10.602_bib3","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.4049\/jimmunol.164.10.4991","article-title":"Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes","volume":"164","author":"Bouchon","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib4","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/35074114","article-title":"TREM-1 amplifies inflammation and is a crucial mediator of septic shock","volume":"410","author":"Bouchon","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jid.2025.10.602_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nri1106","article-title":"TREMs in the immune system and beyond","volume":"3","author":"Colonna","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib6","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/s41577-023-00837-1","article-title":"The biology of TREM receptors","volume":"23","author":"Colonna","year":"2023","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093338","article-title":"Genome-wide transcriptional profiling of skin and dorsal root ganglia after ultraviolet-B-induced inflammation","volume":"9","author":"Dawes","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2025.10.602_bib8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jdermsci.2017.05.016","article-title":"Increased TREM-1 expression in inflamed skin has no functional impact on the pathogenesis of cutaneous disorders","volume":"88","author":"Dr\u00e4ger","year":"2017","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jid.2025.10.602_bib9","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.1038\/skinbio.2013.179","article-title":"Milestones in photocarcinogenesis","volume":"133","author":"Elmets","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.10.602_bib10","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.158.3.781","article-title":"Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation","volume":"158","author":"Elmets","year":"1983","journal-title":"J Exp Med"},{"key":"10.1016\/j.jid.2025.10.602_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.det.2014.03.005","article-title":"Photoimmunology","volume":"32","author":"Elmets","year":"2014","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.jid.2025.10.602_bib12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/cyto.a.24501","article-title":"PeacoQC: peak-based selection of high quality cytometry data","volume":"101","author":"Emmaneel","year":"2022","journal-title":"Cytometry A"},{"key":"10.1016\/j.jid.2025.10.602_bib13","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1189\/jlb.0304193","article-title":"The intensity of neutrophil infiltration controls the number of antigen-primed CD8 T cells recruited into cutaneous antigen challenge sites","volume":"76","author":"Engeman","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jid.2025.10.602_bib14","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1084\/jem.20040708","article-title":"A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis","volume":"200","author":"Gibot","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.jid.2025.10.602_bib15","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.4049\/jimmunol.144.11.4121","article-title":"Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion","volume":"144","author":"Gocinski","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib16","first-page":"4","article-title":"UV radiation-induced immunosuppression and skin cancer","volume":"74","author":"Granstein","year":"2004","journal-title":"Cutis"},{"key":"10.1016\/j.jid.2025.10.602_bib17","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.4049\/jimmunol.153.11.4915","article-title":"Active induction of unresponsiveness (tolerance) to DNFB by in vivo ultraviolet-exposed epidermal cells is dependent upon infiltrating class II MHC+ CD11bbright monocytic\/macrophagic cells","volume":"153","author":"Hammerberg","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib18","doi-asserted-by":"crossref","first-page":"5254","DOI":"10.4049\/jimmunol.157.12.5254","article-title":"Reversal of immunosuppression inducible through ultraviolet-exposed skin by in vivo anti-CD11b treatment","volume":"157","author":"Hammerberg","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib19","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1084\/jem.187.7.1133","article-title":"Activated complement component 3 (C3) is required for ultraviolet induction of immunosuppression and antigenic tolerance","volume":"187","author":"Hammerberg","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jid.2025.10.602_bib20","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.4049\/jimmunol.177.10.6852","article-title":"CD8+ IL-17-producing T cells are important in effector functions for the elicitation of contact hypersensitivity responses","volume":"177","author":"He","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib21","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.4049\/jimmunol.0804108","article-title":"IL-17 and IFN-{gamma} mediate the elicitation of contact hypersensitivity responses by different mechanisms and both are required for optimal responses","volume":"183","author":"He","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.add9990","article-title":"TREM1 activation of myeloid cells promotes antitumor immunity","volume":"15","author":"Juric","year":"2023","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2025.10.602_bib23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nri3150","article-title":"Early immune events in the induction of allergic contact dermatitis","volume":"12","author":"Kaplan","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/jnci\/57.1.211","article-title":"Immunologic parameters of ultraviolet carcinogenesis","volume":"57","author":"Kripke","year":"1976","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jid.2025.10.602_bib25","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.4049\/jimmunol.145.9.2833","article-title":"Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization","volume":"145","author":"Kripke","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib26","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1038\/jid.2015.207","article-title":"Langerhans cells facilitate UVB-induced epidermal carcinogenesis","volume":"135","author":"Lewis","year":"2015","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.10.602_bib27","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.3324\/haematol.2021.280404","article-title":"Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice","volume":"107","author":"Li","year":"2022","journal-title":"Haematologica"},{"key":"10.1016\/j.jid.2025.10.602_bib28","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/boc.201200013","article-title":"Signalling mechanisms of the leukocyte integrin \u03b1M\u03b22: current and future perspectives","volume":"104","author":"Lim","year":"2012","journal-title":"Biol Cell"},{"key":"10.1016\/j.jid.2025.10.602_bib29","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2025.10.602_bib30","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/1523-1747.ep12326032","article-title":"In human dermis, ultraviolet radiation induces expansion of a CD36+ CD11b+ CD1- macrophage subset by infiltration and proliferation; CD1+ Langerhans-like dendritic antigen-presenting cells are concomitantly depleted","volume":"105","author":"Meunier","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.10.602_bib31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-immunol-032713-120204","article-title":"Transcriptional control of dendritic cell development","volume":"34","author":"Murphy","year":"2016","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib32","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1751-1097.2010.00859.x","article-title":"Differential roles of T-cell subsets in regulation of ultraviolet radiation induced cutaneous photocarcinogenesis","volume":"87","author":"Nasti","year":"2011","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.jid.2025.10.602_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/1523-1747.ep12275379","article-title":"Alteration in murine epidermal langerhans cell population by various UV irradiations: quantitative and morphologic studies on the effects of various wavelengths of monochromatic radiation on Ia-bearing cells","volume":"84","author":"Obata","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.10.602_bib34","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/ni.3200","article-title":"Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow","volume":"16","author":"Schlitzer","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib35","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.4049\/jimmunol.172.2.1036","article-title":"Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivity","volume":"172","author":"Schwarz","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib36","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/jid.2009.429","article-title":"Langerhans cells are required for UVR-induced immunosuppression","volume":"130","author":"Schwarz","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.10.602_bib37","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ejcb.2010.09.011","article-title":"Molecular mechanisms of ultraviolet radiation-induced immunosuppression","volume":"90","author":"Schwarz","year":"2011","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jid.2025.10.602_bib38","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4049\/jimmunol.146.2.485","article-title":"Ultraviolet B radiation converts Langerhans cells from immunogenic to tolerogenic antigen-presenting cells. Induction of specific clonal anergy in CD4+ T helper 1 cells","volume":"146","author":"Simon","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib39","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2308374121","article-title":"Photo-neuro-immuno-endocrinology: how the ultraviolet radiation regulates the body, brain, and immune system","volume":"121","author":"Slominski","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jid.2025.10.602_bib40","doi-asserted-by":"crossref","first-page":"107S","DOI":"10.1038\/jid.1994.19","article-title":"Relationship between ultraviolet radiation-induced immunosuppression and carcinogenesis","volume":"103","author":"Streilein","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.10.602_bib41","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/s41590-023-01545-7","article-title":"Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses","volume":"24","author":"Sulczewski","year":"2023","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib42","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/cbin.10693","article-title":"Lipopolysaccharide induces TREM-1-dependent HIF-1\u03b1 expression in human keratinocyte cell line","volume":"40","author":"Tu","year":"2016","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.jid.2025.10.602_bib43","first-page":"185","article-title":"Mechanisms underlying UV-induced immune suppression","volume":"571","author":"Ullrich","year":"2005","journal-title":"Mutat Res"},{"key":"10.1016\/j.jid.2025.10.602_bib44","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.4049\/jimmunol.160.5.2080","article-title":"IL-12 reverses established antigen-specific tolerance of contact sensitivity by affecting costimulatory molecules B7-1 (CD80) and B7-2 (CD86)","volume":"160","author":"Ushio","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib45","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.4049\/jimmunol.165.12.6783","article-title":"CD4+ Th1 and CD8+ Type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity","volume":"165","author":"Wang","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib46","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.4049\/jimmunol.0900235","article-title":"Epidermal Langerhans cells are not required for UV-induced immunosuppression","volume":"183","author":"Wang","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003900","article-title":"TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance","volume":"10","author":"Weber","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jid.2025.10.602_bib48","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.4049\/jimmunol.158.10.4721","article-title":"Development of effector CD8+ T cells in contact hypersensitivity occurs independently of CD4+ T cells","volume":"158","author":"Xu","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib49","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1053\/ajcd.2000.8009","article-title":"Sensitization versus elicitation in allergic contact dermatitis: potential differences at cellular and molecular levels","volume":"11","author":"Xu","year":"2000","journal-title":"Am J Contact Dermat"},{"key":"10.1016\/j.jid.2025.10.602_bib50","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.183.3.1001","volume":"183","author":"Xu","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.jid.2025.10.602_bib51","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.4049\/jimmunol.159.9.4217","article-title":"Distinct roles for B7-1 and B7-2 determinants during priming of effector CD8+ Tc1 and regulatory CD4+ Th2 cells for contact hypersensitivity","volume":"159","author":"Xu","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib52","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4049\/jimmunol.1701056","article-title":"Ultraviolet B-induced maturation of CD11b-type langerin-dendritic cells controls the expansion of Foxp3+ regulatory T cells in the skin","volume":"200","author":"Yamazaki","year":"2018","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2025.10.602_bib53","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/1523-1747.ep12504877","article-title":"Susceptibility to effects of UVB radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans","volume":"95","author":"Yoshikawa","year":"1990","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.10.602_bib54","doi-asserted-by":"crossref","first-page":"15118","DOI":"10.1074\/jbc.M113.536490","article-title":"Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival","volume":"289","author":"Yuan","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jid.2025.10.602_bib55","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1038\/sj.jid.5701251","article-title":"UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system","volume":"128","author":"Zhang","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2025.10.602_bib56","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1093\/bioinformatics\/bty895","article-title":"Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences","volume":"35","author":"Zhu","year":"2019","journal-title":"Bioinformatics"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25035262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X25035262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:47:22Z","timestamp":1779756442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X25035262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0022202X25035262"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2025.10.602","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of UVB-induced TREM-1\u2013positive tolerogenic dendritic cells and TREM-1 signaling as a target in the prevention of UVB-induced immune suppression and skin carcinogenesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2025.10.602","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}