{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:23:41Z","timestamp":1792481021348,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173819"],"award-info":[{"award-number":["82173819"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jid.2026.01.020","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:19:42Z","timestamp":1770164382000},"page":"2105-2127.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hydroxypinacolone 9-cis retinoate mitigates UV-induced photoaging by modulating extracellular matrix, fibroblasts, inflammation, and melanogenesis"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5227-7142","authenticated-orcid":false,"given":"Fan","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2096-0506","authenticated-orcid":false,"given":"Jianhong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruian","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongquan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1235-0537","authenticated-orcid":false,"given":"Daqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9879-8513","authenticated-orcid":false,"given":"Yicheng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2026.01.020_bib1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1194\/jlr.R030833","article-title":"Vitamin A and retinoid signaling: genomic and nongenomic effects","volume":"54","author":"Al Tanoury","year":"2013","journal-title":"J Lipid Res"},{"key":"10.1016\/j.jid.2026.01.020_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.838434","article-title":"Current insights into the role of neuropeptide Y in skin physiology and pathology","volume":"13","author":"Anderson","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jid.2026.01.020_bib3","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.3390\/ijms22083974","article-title":"Inflammatory molecules associated with ultraviolet radiation-mediated skin aging","volume":"22","author":"Ansary","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2026.01.020_bib4","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/CAD.0000000000000248","article-title":"MDI 301 suppresses myeloid leukemia cell growth in vitro and in vivo without the toxicity associated with all-trans retinoic acid therapy","volume":"26","author":"Aslam","year":"2015","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.jid.2026.01.020_bib5","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3390\/pharmaceutics15030731","article-title":"High stability and low irritation of retinol propionate and hydroxypinacolone retinoate supramolecular nanoparticles with effective anti-wrinkle efficacy","volume":"15","author":"Bai","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jid.2026.01.020_bib6","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/exd.14219","article-title":"The vitamin A ester retinyl propionate has a unique metabolic profile and higher retinoid-related bioactivity over retinol and retinyl palmitate in human skin models","volume":"30","author":"Bjerke","year":"2021","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.01.020_bib7","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1093\/emboj\/cdf331","article-title":"Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled","volume":"21","author":"Chapellier","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.jid.2026.01.020_bib8","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/1523-1747.ep12606988","article-title":"Retinoic acid receptor gamma mediates topical retinoid efficacy and irritation in animal models","volume":"104","author":"Chen","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.01.020_bib9","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1089\/wound.2019.1031","article-title":"Polydeoxyribonucleotide regulation of inflammation","volume":"9","author":"Colangelo","year":"2020","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.jid.2026.01.020_bib10","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1161\/CIRCRESAHA.118.314669","article-title":"Inflammation and its role in regeneration and repair","volume":"124","author":"Cooke","year":"2019","journal-title":"Circ Res"},{"key":"10.1016\/j.jid.2026.01.020_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/carcin\/bgi220","article-title":"Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor","volume":"27","author":"El-Abaseri","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jid.2026.01.020_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1468-2494.2007.00415.x","article-title":"Intrinsic and extrinsic factors in skin ageing: a review","volume":"30","author":"Farage","year":"2008","journal-title":"Int J Cosmet Sci"},{"key":"10.1016\/j.jid.2026.01.020_bib13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2147\/CCID.S44686","article-title":"Effect of the sun on visible clinical signs of aging in Caucasian skin","volume":"6","author":"Flament","year":"2013","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"10.1016\/j.jid.2026.01.020_bib14","first-page":"1421","article-title":"Roles of inflammation factors in melanogenesis","volume":"21","author":"Fu","year":"2020","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jid.2026.01.020_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062643","article-title":"Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists\/antagonists in mouse skin","volume":"8","author":"Gericke","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2026.01.020_bib16","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1080\/09546630902763164","article-title":"Adapalene gel 0.1% is better tolerated than tretinoin gel 0.025% among healthy volunteers of various ethnic origins","volume":"20","author":"Goh","year":"2009","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.jid.2026.01.020_bib17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0092-8674(92)90479-V","article-title":"9-cis retinoic acid is a high affinity ligand for the retinoid X receptor","volume":"68","author":"Heyman","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.jid.2026.01.020_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjidi.2023.100222","article-title":"M1\/M2 macrophage skewing is related to reduction in types I, V, and VI collagens with aging in sun-exposed human skin","volume":"3","author":"Horiba","year":"2023","journal-title":"JID Innov"},{"key":"10.1016\/j.jid.2026.01.020_bib19","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1038\/sj.jid.5700856","article-title":"Radiation sources providing increased UVA\/UVB ratios attenuate the apoptotic effects of the UVB waveband UVA-dose-dependently in hairless mouse skin","volume":"127","author":"Ibuki","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.01.020_bib20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1755-148X.2012.00988.x","article-title":"Bimodal effect of retinoic acid on melanocyte differentiation identified by time-dependent analysis","volume":"25","author":"Inoue","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2026.01.020_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3390\/biomedicines8050101","article-title":"The role of IL-6 in skin fibrosis and cutaneous wound healing","volume":"8","author":"Johnson","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.jid.2026.01.020_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74179-6","article-title":"Dermal fibroblasts have different extracellular matrix profiles induced by TGF-\u03b2, PDGF and IL-6 in a model for skin fibrosis","volume":"10","author":"Juhl","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2026.01.020_bib23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.toxlet.2003.09.001","article-title":"The mechanism of retinol-induced irritation and its application to anti-irritant development","volume":"146","author":"Kim","year":"2003","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jid.2026.01.020_bib24","article-title":"Anti-photoaging properties of the phosphodiesterase 3 inhibitor cilostazol in ultraviolet b-irradiated hairless mice","volume":"6","author":"Kim","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2026.01.020_bib25","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.3390\/cells11162541","article-title":"Skin-aging pigmentation: who is the real enemy?","volume":"11","author":"Kim","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jid.2026.01.020_bib26","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0190-9622(89)70229-2","article-title":"The ultraviolet-irradiated hairless mouse: a model for photoaging","volume":"21","author":"Kligman","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jid.2026.01.020_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jdermsci.2010.02.004","article-title":"Decreased fibroblast contractile activity and reduced fibronectin expression are involved in skin photoaging","volume":"58","author":"Knott","year":"2010","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jid.2026.01.020_bib28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.5455\/medarh.2024.78.88-91","article-title":"Comparison of UVA vs UVB photoaging rat models in short-term exposure","volume":"78","author":"Mayangsari","year":"2024","journal-title":"Med Arch"},{"key":"10.1016\/j.jid.2026.01.020_bib29","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12964-024-01668-w","article-title":"IL-17 in wound repair: bridging acute and chronic responses","volume":"22","author":"Mu","year":"2024","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jid.2026.01.020_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2147\/ciia.2006.1.4.327","article-title":"Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety","volume":"1","author":"Mukherjee","year":"2006","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.jid.2026.01.020_bib31","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.3390\/ijms17091448","article-title":"Novel anti-melanogenesis properties of polydeoxyribonucleotide, a popular wound healing booster","volume":"17","author":"Noh","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2026.01.020_bib32","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.actbio.2017.12.006","article-title":"NF-\u03baB signaling is key in the wound healing processes of silk fibroin","volume":"67","author":"Park","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jid.2026.01.020_bib33","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jid.2020.11.006","article-title":"Inflammaging and the skin","volume":"141","author":"Pilkington","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.01.020_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222011088","article-title":"Role of PI3K-akt-mtor pathway as a pro-survival signaling and resistance-mediating mechanism to therapy of prostate cancer","volume":"22","author":"Pungsrinont","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2026.01.020_bib35","author":"Purcell"},{"key":"10.1016\/j.jid.2026.01.020_bib36","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jdermsci.2023.08.006","article-title":"Molecular insights of human skin epidermal and dermal aging","volume":"112","author":"Quan","year":"2023","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jid.2026.01.020_bib37","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1159\/000371708","article-title":"Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging: a mini-review","volume":"61","author":"Quan","year":"2015","journal-title":"Gerontology"},{"key":"10.1016\/j.jid.2026.01.020_bib38","first-page":"292","article-title":"Role of retinoic acid receptor gamma in the rhino mouse and rabbit irritation models of retinoid activity","volume":"8","author":"Reczek","year":"1995","journal-title":"Skin Pharmacol"},{"key":"10.1016\/j.jid.2026.01.020_bib39","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/1523-1747.ep12284435","article-title":"Expression of the alpha and beta retinoic acid receptors in skin","volume":"93","author":"Rees","year":"1989","journal-title":"J Invest Dermatol"},{"issue":"5 Suppl","key":"10.1016\/j.jid.2026.01.020_bib69","doi-asserted-by":"crossref","first-page":"S223","DOI":"10.1016\/j.jid.2018.03.1327","article-title":"Anti-aging effects of retinoid hydroxypinacolone retinoate on skin models","volume":"138","author":"Ruth","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.01.020_bib40","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00011-022-01598-8","article-title":"Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin","volume":"71","author":"Salminen","year":"2022","journal-title":"Inflamm Res"},{"key":"10.1016\/j.jid.2026.01.020_bib41","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/php.13872","article-title":"Comparison of five retinoids for anti-photoaging therapy: evaluation of anti-inflammatory and anti-oxidative activities in vitro and therapeutic efficacy in vivo","volume":"100","author":"Shu","year":"2024","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.jid.2026.01.020_bib42","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3390\/nu12020300","article-title":"Wheat extract oil (WEO) attenuates uvb-induced photoaging via collagen synthesis in human keratinocytes and hairless mice","volume":"12","author":"Son","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.jid.2026.01.020_bib43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0378-4274(97)00065-9","article-title":"Lack of involvement of retinoic acid receptor alpha in retinoid-induced skin irritation in hairless mice","volume":"92","author":"Standeven","year":"1997","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.jid.2026.01.020_bib44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/cosmetics3040035","article-title":"Topical retinol restores type I collagen production in photoaged forearm skin within four weeks","volume":"3","author":"Sun","year":"2016","journal-title":"Cosmetics"},{"key":"10.1016\/j.jid.2026.01.020_bib45","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.3390\/cells9122660","article-title":"Retinoic acid and its derivatives in skin","volume":"9","author":"Szyma\u0144ski","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jid.2026.01.020_bib46","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.3390\/cells10051219","article-title":"The PI3K\/Akt pathway: emerging roles in skin homeostasis and a group of non-malignant skin disorders","volume":"10","author":"Teng","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jid.2026.01.020_bib47","first-page":"49","article-title":"Mechanisms for hyperpigmentation in postinflammatory pigmentation, urticaria pigmentosa and sunburn","volume":"179","author":"Tomita","year":"1989","journal-title":"Dermatologica"},{"key":"10.1016\/j.jid.2026.01.020_bib48","article-title":"Exposure to solar ultraviolet radiation establishes a novel immune suppressive lipidome in skin-draining lymph nodes","volume":"13","author":"Tse","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2026.01.020_bib49","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/pcmr.12985","article-title":"Participation of keratinocyte- and fibroblast-derived factors in melanocyte homeostasis, the response to UV, and pigmentary disorders","volume":"34","author":"Upadhyay","year":"2021","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jid.2026.01.020_bib50","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00403-006-0720-y","article-title":"MDI 301, a non-irritating retinoid, induces changes in human skin that underlie repair","volume":"298","author":"Varani","year":"2007","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2026.01.020_bib51","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00403-003-0416-5","article-title":"Separation of retinoid-induced epidermal and dermal thickening from skin irritation","volume":"295","author":"Varani","year":"2003","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2026.01.020_bib52","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0002-9440(10)64040-0","article-title":"Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro","volume":"158","author":"Varani","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jid.2026.01.020_bib53","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0378-5122(96)01066-3","article-title":"Changes of the basement membrane and type IV collagen in human skin during aging","volume":"25","author":"V\u00e1zquez","year":"1996","journal-title":"Maturitas"},{"key":"10.1016\/j.jid.2026.01.020_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0328647","article-title":"Assessing changes in ultraviolet radiation-exposed mouse skin using optical coherence tomography","volume":"20","author":"Vejlsby","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2026.01.020_bib55","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1097\/CM9.0000000000002488","article-title":"Targeting senescent dermal fibroblasts responsible for hyperactive melanocytes in melasma","volume":"136","author":"Wan","year":"2023","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.jid.2026.01.020_bib56","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1111\/jocd.15662","article-title":"The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging","volume":"22","author":"Wang","year":"2023","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.jid.2026.01.020_bib57","doi-asserted-by":"crossref","DOI":"10.1111\/srt.13539","article-title":"Combination of dimethylmethoxy chromanol and turmeric root extract synergically attenuates ultraviolet-induced oxidative damage by increasing endogenous antioxidants in hacat cells","volume":"29","author":"Wang","year":"2023","journal-title":"Skin Res Technol"},{"key":"10.1016\/j.jid.2026.01.020_bib58","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1524-475X.2007.00338.x","article-title":"MDI 301, a nonirritating retinoid, improves abrasion wound healing in damaged\/atrophic skin","volume":"16","author":"Warner","year":"2008","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jid.2026.01.020_bib59","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1034\/j.1600-0749.2003.00055.x","article-title":"The role of kit-ligand in melanocyte development and epidermal homeostasis","volume":"16","author":"Wehrle-Haller","year":"2003","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jid.2026.01.020_bib60","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/ics.12372","article-title":"Elastin structure and its involvement in skin photoageing","volume":"39","author":"Weihermann","year":"2017","journal-title":"Int J Cosmet Sci"},{"key":"10.1016\/j.jid.2026.01.020_bib61","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1523-1747.1999.00510.x","article-title":"Topical all-trans retinoic acid augments ultraviolet radiation-induced increases in activated melanocyte numbers in mice","volume":"112","author":"Welsh","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.01.020_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155679","article-title":"Lapagyl mitigates UV-induced inflammation and immunosuppression via foxp3+ Tregs and ccl pathway: a single-cell transcriptomics study","volume":"129","author":"Xie","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jid.2026.01.020_bib63","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3390\/biom15020296","article-title":"Improvement of skin condition through RXR alpha-activating materials","volume":"15","author":"Ye","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.jid.2026.01.020_bib64","doi-asserted-by":"crossref","first-page":"392","DOI":"10.5114\/ada.2019.87443","article-title":"Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments","volume":"36","author":"Zasada","year":"2019","journal-title":"Postepy Dermatol Alergol"},{"key":"10.1016\/j.jid.2026.01.020_bib65","doi-asserted-by":"crossref","first-page":"43889","DOI":"10.18632\/oncotarget.16803","article-title":"MDI 301, a synthetic retinoid, depressed levels of matrix metalloproteinases and oxidative stress in diabetic dermal fibroblasts","volume":"8","author":"Zhai","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jid.2026.01.020_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70112","article-title":"Single-cell analysis reveals fibroblast-derived migrasomes as cxcl12 carriers promoting skin wound repair","volume":"14","author":"Zhou","year":"2025","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.jid.2026.01.020_bib67","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.devcel.2020.11.002","article-title":"A single-cell transcriptomic atlas of human skin aging","volume":"56","author":"Zou","year":"2021","journal-title":"Dev Cell"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26000692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26000692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T19:17:57Z","timestamp":1786303077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X26000692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":68,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0022202X26000692"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2026.01.020","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydroxypinacolone 9-cis retinoate mitigates UV-induced photoaging by modulating extracellular matrix, fibroblasts, inflammation, and melanogenesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2026.01.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}