{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:51:07Z","timestamp":1786992667881,"version":"build-2736575974"},"reference-count":17,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001009","name":"Bristol Myers Squibb Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jid.2026.01.045","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:11:53Z","timestamp":1775074313000},"page":"1469-1472.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hidradenitis suppurativa: Intentional efforts to unravel precise mechanisms"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2621-1207","authenticated-orcid":false,"given":"Arsema K.","family":"Zadu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4183-9383","authenticated-orcid":false,"given":"Beita","family":"Badiei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7706-1464","authenticated-orcid":false,"given":"Carmelo","family":"Carmona-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2760-3904","authenticated-orcid":false,"given":"Haley B.","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-8706","authenticated-orcid":false,"given":"Amanda M.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1573-1653","authenticated-orcid":false,"given":"Lynn","family":"Petukhova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-2608","authenticated-orcid":false,"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5358-4247","authenticated-orcid":false,"given":"Angel S.","family":"Byrd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2026.01.045_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav5908","article-title":"Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa","volume":"11","author":"Byrd","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2026.01.045_bib2","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jid.2021.07.187","article-title":"Autoantibodies present in hidradenitis suppurativa correlate with disease severity and promote the release of proinflammatory cytokines in macrophages","volume":"142","author":"Carmona-Rivera","year":"2022","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.01.045_bib3","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s00403-024-02947-9","article-title":"Positive correlation of hidradenitis suppurativa and ultra-processed foods consumption","volume":"316","author":"Haddad","year":"2024","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2026.01.045_bib4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s13555-023-01085-w","article-title":"Burden of hidradenitis suppurativa: a systematic literature review of patient reported outcomes","volume":"14","author":"Kimball","year":"2024","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.jid.2026.01.045_bib5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jaci.2024.09.001","article-title":"Neutrophil extracellular traps activate Notch-\u03b3-secretase signaling in hidradenitis suppurativa","volume":"155","author":"Oliveira","year":"2025","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2026.01.045_bib6","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1016\/j.jid.2025.07.019","article-title":"A conceptual framework for the clinical translation of human genetic studies","volume":"145","author":"Simmonds","year":"2025","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.01.045_bib7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s13555-020-00354-2","article-title":"Review of comorbidities of hidradenitis suppurativa: implications for daily clinical practice","volume":"10","author":"Tzellos","year":"2020","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.jid.2026.01.045_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/exd.15087","article-title":"Gram-negative anaerobes elicit a robust keratinocytes immune response with potential insights into HS pathogenesis","volume":"33","author":"Williams","year":"2024","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.01.045_bib9","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jid.2025.01.026","article-title":"Decoding tertiary lymphoid structures in hidradenitis suppurativa: new mechanistic insights","volume":"145","author":"Yu","year":"2025","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.01.045_bib10","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/bjd.15748","article-title":"Development and validation of the International Hidradenitis suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity","volume":"177","author":"Zouboulis","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2026.01.045_bib11","doi-asserted-by":"crossref","first-page":"12207","DOI":"10.1038\/s41598-019-48226-w","article-title":"Specimen collection for translational studies in hidradenitis suppurativa","volume":"9","author":"Byrd","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2026.01.045_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/exd.14340","article-title":"Hidradenitis suppurativa in South-East Asia and East Asia","volume":"30","author":"Chandran","year":"2021","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.01.045_bib17","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/s10875-023-01518-3","article-title":"Inborn errors of immunity in hidradenitis suppurativa pathogenesis and disease burden","volume":"43","author":"Colvin","year":"2023","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jid.2026.01.045_bib13","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.169870","article-title":"Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa","volume":"9","author":"Lowe","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2026.01.045_bib14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000516467","article-title":"Clinical trials and skin of color: the example of hidradenitis suppurativa","volume":"238","author":"Okeke","year":"2021","journal-title":"Dermatology"},{"key":"10.1016\/j.jid.2026.01.045_bib15","doi-asserted-by":"crossref","first-page":"i22","DOI":"10.1093\/bjd\/ljae399","article-title":"Leveraging genotypes and phenotypes to implement precision medicine in hidradenitis suppurativa management","volume":"192","author":"Petukhova","year":"2025","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2026.01.045_bib16","doi-asserted-by":"crossref","first-page":"10755","DOI":"10.1038\/s41467-025-65789-7","article-title":"Plastic associated endocrine disruptors reduce nicastrin protein and potentiate inflammation in hidradenitis suppurativa skin disease","volume":"16","author":"Williams","year":"2025","journal-title":"Nat Commun"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26001405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26001405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:49:55Z","timestamp":1779756595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X26001405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0022202X26001405"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2026.01.045","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hidradenitis suppurativa: Intentional efforts to unravel precise mechanisms","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2026.01.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc. on behalf of Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}