{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:52:04Z","timestamp":1791327124879,"version":"4.3.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RU 5211"],"award-info":[{"award-number":["RU 5211"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR 2690"],"award-info":[{"award-number":["FOR 2690"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019944","name":"Sanofi Aventis GmbH","doi-asserted-by":"publisher","award":["SGZ-2018-12395"],"award-info":[{"award-number":["SGZ-2018-12395"]}],"id":[{"id":"10.13039\/100019944","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jid.2026.04.005","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T23:03:57Z","timestamp":1776726237000},"page":"2812-2818.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of itch intensity scales in atopic dermatitis: Differential measurement properties and associations with relevant cytokines"],"prefix":"10.1016","volume":"146","author":[{"given":"Felix","family":"Witte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Wiegmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Teitge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Westmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena K.","family":"Raker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Royeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Zeidler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Agelopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-7786","authenticated-orcid":false,"given":"Sonja","family":"St\u00e4nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2026.04.005_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4103\/0019-5154.152565","article-title":"Role of interleukin-2 in uremic pruritus among attendants of AL-Zahraa hospital dialysis unit","volume":"60","author":"Azim","year":"2015","journal-title":"Indian J Dermatol"},{"key":"10.1016\/j.jid.2026.04.005_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1604883","article-title":"Evaluation of the levels of interleukins IL-4, IL-13, IL-5, IL-10 and IL-33 in atopic dermatitis patients with and without dupilumab therapy","volume":"16","author":"\u010celakovsk\u00e1","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2026.04.005_bib3","article-title":"The expression of BAFF, APRIL and TWEAK is altered in eczema skin but not in the circulation of atopic and seborrheic eczema patients","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2026.04.005_bib4","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaci.2012.07.012","article-title":"Progressive activation of T(H)2\/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis","volume":"130","author":"Gittler","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2026.04.005_bib5","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.jaci.2014.10.013","article-title":"Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis","volume":"134","author":"Hamilton","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2026.04.005_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00403-021-02214-1","article-title":"A real-world study of the longitudinal course of itch severity and frequency in adults with atopic dermatitis","volume":"314","author":"Hong","year":"2022","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2026.04.005_bib7","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1398-9995.2005.00774.x","article-title":"Serum thymus and activation-regulated chemokine, macrophage-derived chemokine and eotaxin as markers of severity of atopic dermatitis","volume":"60","author":"Jahnz-Rozyk","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.jid.2026.04.005_bib8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jaad.2019.06.043","article-title":"Validity and reliability of itch assessment scales for chronic pruritus in adults: a prospective multicenter study","volume":"82","author":"Jang","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jid.2026.04.005_bib9","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.3390\/ijms21144883","article-title":"Advances in understanding the initial steps of pruritoceptive itch: how the itch hits the switch","volume":"21","author":"Kahremany","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2026.04.005_bib10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1046\/j.1365-2249.2002.01727.x","article-title":"Serum macrophage-derived chemokine (MDC) levels are closely related with the disease activity of atopic dermatitis","volume":"127","author":"Kakinuma","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jid.2026.04.005_bib11","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1398-9995.2011.02545.x","article-title":"Functional effects of interleukin 31 in human primary keratinocytes","volume":"66","author":"Kasraie","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jid.2026.04.005_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.691279","article-title":"HDAC6 and CXCL13 mediate atopic dermatitis by regulating cellular interactions and expression levels of miR-9 and SIRT1","volume":"12","author":"Kwon","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jid.2026.04.005_bib13","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1034\/j.1399-3038.2003.00052.x","article-title":"Serum concentration of macrophage-derived chemokine may be a useful inflammatory marker for assessing severity of atopic dermatitis in infants and young children","volume":"14","author":"Leung","year":"2003","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jid.2026.04.005_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/cea.14267","article-title":"Exploring biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab (B-PAD study)","volume":"53","author":"Nakahara","year":"2023","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jid.2026.04.005_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17307-z","article-title":"IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration","volume":"7","author":"Ovsiy","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2026.04.005_bib16","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/bjd.17243","article-title":"Measurement properties of three assessments of burden used in atopic dermatitis in adults","volume":"180","author":"Patel","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2026.04.005_bib17","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1111\/jdv.19911","article-title":"Proteomic, miRNA and bacterial biomarker patterns in atopic dermatitis patients and their course upon anti-IL-4R\u03b1 therapy","volume":"38","author":"Pa\u017eur","year":"2024","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2026.04.005_bib18","doi-asserted-by":"crossref","first-page":"502","DOI":"10.2340\/00015555-1246","article-title":"Assessment of pruritus intensity: prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus","volume":"92","author":"Phan","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2026.04.005_bib19","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.jaci.2021.01.013","article-title":"Biomarkers in atopic dermatitis-a review on behalf of the International Eczema Council","volume":"147","author":"Renert-Yuval","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2026.04.005_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54559-6","article-title":"Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases","volume":"15","author":"Seremet","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2026.04.005_bib21","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1016\/j.jid.2018.03.1517","article-title":"Patients with atopic dermatitis colonized with Staphylococcus aureus Have a distinct phenotype and endotype","volume":"138","author":"Simpson","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.04.005_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107598","article-title":"MCP-1: function, regulation, and involvement in disease","volume":"101","author":"Singh","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jid.2026.04.005_bib23","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2340\/00015555-1620","article-title":"Pruritus assessment in clinical trials: consensus recommendations from the International Forum for the Study of Itch (IFSI) Special Interest Group Scoring Itch in Clinical Trials","volume":"93","author":"St\u00e4nder","year":"2013","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2026.04.005_bib24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2340\/00015555-2494","article-title":"Dynamic pruritus score: evaluation of the validity and reliability of a new instrument to assess the course of pruritus","volume":"97","author":"St\u00e4nder","year":"2017","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2026.04.005_bib25","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/jdv.17111","article-title":"Pruritus Intensity Scales across Europe: a prospective validation study","volume":"35","author":"Storck","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2026.04.005_bib26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jid.2021.06.032","article-title":"Measurement properties of patient-reported outcome measures for pruritus: an updated systematic review","volume":"142","author":"Topp","year":"2022","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.04.005_bib27","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/00015550410034444","article-title":"Expression of CCR2 on monocytes and macrophages in chronically inflamed skin in atopic dermatitis and psoriasis","volume":"84","author":"Vestergaard","year":"2004","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jid.2026.04.005_bib28","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jid.2025.08.012","article-title":"Cutaneous neuroanatomical and cellular response to dupilumab treatment in atopic dermatitis","volume":"146","author":"Wiegmann","year":"2025","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.04.005_bib29","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/j.jaci.2022.03.017","article-title":"The HOME Core outcome set for clinical trials of atopic dermatitis","volume":"149","author":"Williams","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2026.04.005_bib30","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-036562","article-title":"Assessing the relevance and uptake of core outcome sets (an agreed minimum collection of outcomes to measure in research studies) in Cochrane systematic reviews: a review","volume":"10","author":"Williamson","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.jid.2026.04.005_bib31","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/bjd.17744","article-title":"Peak pruritus Numerical Rating Scale: psychometric validation and responder definition for assessing itch in moderate-to-severe atopic dermatitis","volume":"181","author":"Yosipovitch","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2026.04.005_bib32","article-title":"Potential biomarkers of atopic dermatitis","volume":"9","author":"Yu","year":"2022","journal-title":"Front Med (Lausanne)"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26010468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26010468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:25:19Z","timestamp":1791325519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X26010468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0022202X26010468"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2026.04.005","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of itch intensity scales in atopic dermatitis: Differential measurement properties and associations with relevant cytokines","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2026.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}