{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:30:32Z","timestamp":1793413832767,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DE220101226"],"award-info":[{"award-number":["DE220101226"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["325640"],"award-info":[{"award-number":["325640"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002102","name":"King's Health Partners","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2017176"],"award-info":[{"award-number":["2017176"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012331","name":"LEO Fondet","doi-asserted-by":"publisher","award":["LF-OC-22-001033"],"award-info":[{"award-number":["LF-OC-22-001033"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jid.2026.05.010","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T23:09:59Z","timestamp":1779750599000},"page":"3025-3032.e21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dissecting the causal links between acne vulgaris and cardiometabolic health using Mendelian randomization"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-1679","authenticated-orcid":false,"given":"Caroline","family":"Brito Nunes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8539-8753","authenticated-orcid":false,"given":"Michael A.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8768-0904","authenticated-orcid":false,"given":"Gunn-Helen","family":"Moen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-1516","authenticated-orcid":false,"given":"Brittany L.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2026.05.010_bib1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40842-024-00202-8","article-title":"The impact of insulin resistance and glycaemic control on insulin-like growth factor-1 in patients with type 2 diabetes: a cross-sectional study","volume":"10","author":"AbdlWhab","year":"2024","journal-title":"Clin Diabetes Endocrinol"},{"key":"10.1016\/j.jid.2026.05.010_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2025.102189","article-title":"Sex hormone-binding globulin controls sex-specific lipolytic activity in human abdominal subcutaneous adipocytes","volume":"98","author":"Abildgaard","year":"2025","journal-title":"Mol Metab"},{"key":"10.1016\/j.jid.2026.05.010_bib3","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.21608\/ejhm.2020.116811","article-title":"Evaluation of the association between acne vulgaris and metabolic syndrome in adolescents at Zagazig University Hospitals","volume":"81","author":"Ahmed","year":"2020","journal-title":"Egypt J Hosp Med"},{"key":"10.1016\/j.jid.2026.05.010_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.20517\/mtod.2023.05","article-title":"Male hypogonadism in overweight and obesity","volume":"3","author":"Armeni","year":"2023","journal-title":"Metab Target Organ Damage"},{"key":"10.1016\/j.jid.2026.05.010_bib5","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000484168","article-title":"Suppressed adiponectin levels and increased adiponectin response to oral glucose load in lean women with severe acne normalizes after isotretinoin treatment","volume":"233","author":"Aydin","year":"2017","journal-title":"Dermatology"},{"key":"10.1016\/j.jid.2026.05.010_bib6","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/bjd.12149","article-title":"Epidemiology of acne vulgaris","volume":"168","author":"Bhate","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib7","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jsbmb.2007.09.001","article-title":"Androgens and body fat distribution","volume":"108","author":"Blouin","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jid.2026.05.010_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/tam.6.1.1.7","article-title":"Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency","volume":"6","author":"Boyanov","year":"2003","journal-title":"Aging Male"},{"key":"10.1016\/j.jid.2026.05.010_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002739","article-title":"Evidence of a causal relationship between body mass index and psoriasis: a Mendelian randomization study","volume":"16","author":"Budu-Aggrey","year":"2019","journal-title":"PLoS Med"},{"key":"10.1016\/j.jid.2026.05.010_bib10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD Score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2026.05.010_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115003","article-title":"Oxidative stress and metabolic syndrome in acne vulgaris: pathogenetic connections and potential role of dietary supplements and phytochemicals","volume":"164","author":"Bungau","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jid.2026.05.010_bib12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1089\/met.2022.0073","article-title":"Prevalence of metabolic syndrome and insulin resistance in adult patients with acne: association with traditional cardiovascular risk factors and acne severity","volume":"21","author":"Carneiro","year":"2023","journal-title":"Metab Syndr Relat Disord"},{"key":"10.1016\/j.jid.2026.05.010_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaad.2016.02.1220","article-title":"Dietary glycemic factors, insulin resistance, and adiponectin levels in acne vulgaris","volume":"75","author":"\u00c7erman","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib14","article-title":"Acne vulgaris and metabolic syndrome: a possible association","volume":"14","author":"Chandak","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.jid.2026.05.010_bib15","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00125-003-1074-z","article-title":"Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex","volume":"46","author":"Cnop","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.jid.2026.05.010_bib16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00403-019-01908-x","article-title":"From pathogenesis of acne vulgaris to anti-acne agents","volume":"311","author":"Cong","year":"2019","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2026.05.010_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1095-6433(03)00011-4","article-title":"Hyperinsulinemic diseases of civilization: more than just Syndrome X","volume":"136","author":"Cordain","year":"2003","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"10.1016\/j.jid.2026.05.010_bib18","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3389\/fimmu.2020.01582","article-title":"The effects of type 2 diabetes mellitus on organ metabolism and the immune system","volume":"11","author":"Daryabor","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2026.05.010_bib19","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jid.2026.05.010_bib20","doi-asserted-by":"crossref","DOI":"10.1080\/09546634.2023.2298878","article-title":"The cutaneous effects of androgens and androgen-mediated sebum production and their pathophysiologic and therapeutic importance in acne vulgaris","volume":"35","author":"Del Rosso","year":"2024","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.jid.2026.05.010_bib21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/jdv.15043","article-title":"Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates","volume":"32","author":"Dr\u00e9no","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2026.05.010_bib22","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1001\/jama.2021.17633","article-title":"Management of acne vulgaris: a review","volume":"326","author":"Eichenfield","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jid.2026.05.010_bib23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","article-title":"Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes","volume":"105","author":"Esser","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.jid.2026.05.010_bib24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mce.2009.08.018","article-title":"Adipose tissue as an endocrine organ","volume":"316","author":"Galic","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jid.2026.05.010_bib25","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2026.05.010_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s13555-016-0160-3","article-title":"Skin manifestations of insulin resistance: from a biochemical stance to a clinical diagnosis and management","volume":"7","author":"Gonz\u00e1lez-Saldivar","year":"2016","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.jid.2026.05.010_bib27","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.3390\/biomedicines11082294","article-title":"Insulin resistance in patients with acne vulgaris","volume":"11","author":"Gruszczy\u0144ska","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jid.2026.05.010_bib28","doi-asserted-by":"crossref","first-page":"808","DOI":"10.5114\/ada.2023.133468","article-title":"Relationship between body mass index z-score and acne severity in adolescents: a prospective analysis","volume":"40","author":"G\u00fcnd\u00fcz","year":"2023","journal-title":"Postepy Dermatol Alergol"},{"key":"10.1016\/j.jid.2026.05.010_bib29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12944-025-02436-6","article-title":"Negative association between 15 obesity- and lipid-related indices and testosterone in adult males: a population based cross-sectional study","volume":"24","author":"Guo","year":"2025","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.jid.2026.05.010_bib30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1001\/archderm.148.1.131","article-title":"A population-based study of acne and body mass index in adolescents","volume":"148","author":"Halvorsen","year":"2012","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib31","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.jid.2026.05.010_bib32","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"Kershaw","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jid.2026.05.010_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3390\/microorganisms13010161","article-title":"Skin microbiota: mediator of interactions between metabolic disorders and cutaneous health and disease","volume":"13","author":"Kreouzi","year":"2025","journal-title":"Microorganisms"},{"key":"10.1016\/j.jid.2026.05.010_bib34","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1600-0625.2009.00890.x","article-title":"New developments in our understanding of acne pathogenesis and treatment","volume":"18","author":"Kurokawa","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/srep35539","article-title":"Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis","volume":"6","author":"Laurent","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2026.05.010_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.124044","article-title":"Endocrine and metabolic drivers of sebum dysregulation: mechanisms and therapeutic strategies","volume":"383","author":"Li","year":"2025","journal-title":"Life Sci"},{"key":"10.1016\/j.jid.2026.05.010_bib37","article-title":"The causal relationship between acne vulgaris and BMI: a Mendelian randomization study","volume":"24","author":"Li","year":"2025","journal-title":"J Cosmet Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib38","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/skinhd\/vzae009","article-title":"The role of lipid metabolism in acne risk: integrating blood metabolite and genetic insights","volume":"5","author":"Liu","year":"2025","journal-title":"Skin Health Dis"},{"key":"10.1016\/j.jid.2026.05.010_bib39","doi-asserted-by":"crossref","first-page":"E353","DOI":"10.1152\/ajpendo.00339.2006","article-title":"Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study","volume":"292","author":"Maggio","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jid.2026.05.010_bib40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clindermatol.2017.09.006","article-title":"Acne vulgaris: the metabolic syndrome of the pilosebaceous follicle","volume":"36","author":"Melnik","year":"2018","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00403-024-03495-y","article-title":"Acne vulgaris: a warning sign for diagnosing metabolic syndrome","volume":"317","author":"Mohammed","year":"2024","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jid.2026.05.010_bib42","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jaad.2020.05.029","article-title":"The relationship of diagnosed acne and weight status in adolescent girls","volume":"84","author":"Mundluru","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib43","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1001\/jamadermatol.2015.4499","article-title":"Insulin resistance and metabolic syndrome in young men with acne","volume":"152","author":"Nagpal","year":"2016","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/479354","article-title":"Insulin resistance and skin diseases","volume":"2015","author":"Napolitano","year":"2015","journal-title":"Sci World J"},{"key":"10.1016\/j.jid.2026.05.010_bib45","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jaad.2021.12.033","article-title":"Acne and insulin resistance: a systematic review and meta-analysis","volume":"87","author":"Nickles","year":"2022","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1252972","article-title":"Insulin and the sebaceous gland function","volume":"14","author":"Okoro","year":"2023","journal-title":"Front Physiol"},{"key":"10.1016\/j.jid.2026.05.010_bib47","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jsbmb.2014.04.008","article-title":"Understanding androgen action in adipose tissue","volume":"143","author":"O\u2019Reilly","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jid.2026.05.010_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2017.07.675","article-title":"479 Sebocytes differentiation state affects their response to insulin stimulus. Possible implications in acne pathogenesis","volume":"137","author":"Ottaviani","year":"2017","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib49","doi-asserted-by":"crossref","first-page":"223","DOI":"10.4103\/ijd.IJD_321_20","article-title":"Metabolic status, obesity, and quality of life in patients with acne vulgaris: a cross-sectional case-control study","volume":"66","author":"Podder","year":"2021","journal-title":"Indian J Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib50","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41467-018-08000-4","article-title":"Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects","volume":"10","author":"Rask-Andersen","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2026.05.010_bib51","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a038984","article-title":"Multivariable Mendelian randomization and mediation","volume":"11","author":"Sanderson","year":"2021","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.jid.2026.05.010_bib52","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/exd.14803","article-title":"The possible role of yes-associated protein (YAP) on IGF-1-induced sebum production","volume":"32","author":"Shin","year":"2023","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib53","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.jaad.2019.04.009","article-title":"Acne and obesity: a nationwide study of 600,404 adolescents","volume":"81","author":"Snast","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib54","doi-asserted-by":"crossref","first-page":"723","DOI":"10.4103\/jfmpc.jfmpc_1232_23","article-title":"Correlation between acne and insulin resistance; experience from central India","volume":"13","author":"Srivastava","year":"2024","journal-title":"J Family Med Prim Care"},{"key":"10.1016\/j.jid.2026.05.010_bib55","series-title":"Metabolic syndrome","author":"Swarup","year":"2025"},{"key":"10.1016\/j.jid.2026.05.010_bib56","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.3390\/ijms25042397","article-title":"Changes in cells associated with insulin resistance","volume":"25","author":"Szablewski","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2026.05.010_bib57","first-page":"27","article-title":"The role of inflammation in the pathology of acne","volume":"6","author":"Tanghetti","year":"2013","journal-title":"J Clin Aesthet Dermatol"},{"key":"10.1016\/j.jid.2026.05.010_bib58","doi-asserted-by":"crossref","first-page":"616","DOI":"10.4239\/wjd.v12.i5.616","article-title":"Role of insulin and insulin resistance in androgen excess disorders","volume":"12","author":"Unluhizarci","year":"2021","journal-title":"World J Diabetes"},{"key":"10.1016\/j.jid.2026.05.010_bib59","article-title":"Acne vulgaris: a review of the pathophysiology, treatment, and recent nanotechnology based advances","volume":"36","author":"Vasam","year":"2023","journal-title":"Biochem Biophys Rep"},{"key":"10.1016\/j.jid.2026.05.010_bib60","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases [published correction appears in Nat Genet 2018;50:1196]","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"10.1016\/j.jid.2026.05.010_bib61","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.18632\/aging.202160","article-title":"Impact of metabolic syndrome on sex hormones and reproductive function: a meta-analysis of 2923 cases and 14062 controls","volume":"13","author":"Zhou","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jid.2026.05.010_bib62","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.clindermatol.2004.03.004","article-title":"Acne and sebaceous gland function","volume":"22","author":"Zouboulis","year":"2004","journal-title":"Clin Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26012224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26012224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:53:08Z","timestamp":1793411588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X26012224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0022202X26012224"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2026.05.010","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dissecting the causal links between acne vulgaris and cardiometabolic health using Mendelian randomization","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2026.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}