{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:57:06Z","timestamp":1786114626097,"version":"build-2736575974"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["350193106\/FOR2690\/TP01"],"award-info":[{"award-number":["350193106\/FOR2690\/TP01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["397846571"],"award-info":[{"award-number":["397846571"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["255156212 \/CRC1158\/Z02-INF"],"award-info":[{"award-number":["255156212 \/CRC1158\/Z02-INF"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["255156212\/CRC1158\/A01"],"award-info":[{"award-number":["255156212\/CRC1158\/A01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["350193106\/FOR2690\/TP03"],"award-info":[{"award-number":["350193106\/FOR2690\/TP03"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jid.2026.06.1266","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:12:05Z","timestamp":1781651525000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Direct sensitizing and activating effects of IL-31 are restricted to a single, functionally, and transcriptionally classified porcine dorsal root ganglion neuron subtype"],"prefix":"10.1016","author":[{"given":"Zeinab","family":"Abbasi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8360-4349","authenticated-orcid":false,"given":"Marc","family":"Behrendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-0362","authenticated-orcid":false,"given":"Sabrina","family":"da Silva Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-497X","authenticated-orcid":false,"given":"Roman","family":"Rukwied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9736-7241","authenticated-orcid":false,"given":"Martin","family":"Schmelz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6606-3731","authenticated-orcid":false,"given":"Hans J\u00fcrgen","family":"Solinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2026.06.1266_bib1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.pain.2012.02.022","article-title":"Pain sensitivity and opioid analgesia: a pharmacogenomic twin study","volume":"153","author":"Angst","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.jid.2026.06.1266_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.843225","article-title":"Bradykinin-induced sensitization of transient receptor potential channel melastatin 3 calcium responses in mouse nociceptive neurons","volume":"16","author":"Behrendt","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jid.2026.06.1266_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj9173","article-title":"Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia","volume":"10","author":"Bhuiyan","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.jid.2026.06.1266_bib4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.exphem.2007.01.028","article-title":"Regulation of myeloid progenitor cell proliferation\/survival by IL-31 receptor and IL-31","volume":"35","author":"Broxmeyer","year":"2007","journal-title":"Exp Hematol"},{"key":"10.1016\/j.jid.2026.06.1266_bib5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: involvement of TRPV1 and TRPA1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2026.06.1266_bib6","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ejcb.2011.07.006","article-title":"Signaling by IL-31 and functional consequences","volume":"91","author":"Cornelissen","year":"2012","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.jid.2026.06.1266_bib7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.anai.2025.09.014","article-title":"Basic mechanisms of itch and advances in clinical management","volume":"136","author":"Coscarella","year":"2025","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jid.2026.06.1266_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.569361","article-title":"Cell calcium imaging as a reliable method to study neuron-glial circuits","volume":"14","author":"de Melo Reis","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jid.2026.06.1266_bib9","article-title":"Optimum electrical sinusoidal frequency stimulation to activate C-nociceptors","volume":"11","author":"Dileep","year":"2026","journal-title":"PAIN Rep"},{"key":"10.1016\/j.jid.2026.06.1266_bib10","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1113\/jphysiol.2003.042127","article-title":"The TTX-resistant sodium channel Nav1.8 (SNS\/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons","volume":"550","author":"Djouhri","year":"2003","journal-title":"J Physiol"},{"key":"10.1016\/j.jid.2026.06.1266_bib11","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jaci.2016.02.020","article-title":"The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves","volume":"138","author":"Feld","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2026.06.1266_bib12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.it.2024.03.008","article-title":"Sensory neuronal control of skin barrier immunity","volume":"45","author":"Feng","year":"2024","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jid.2026.06.1266_bib13","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1186\/s12967-023-04698-z","article-title":"Peripheral signaling pathways contributing to non-histaminergic itch in humans [published correction appears in J Transl Med 2025;23:58]","volume":"21","author":"Fiebig","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.jid.2026.06.1266_bib14","doi-asserted-by":"crossref","DOI":"10.1177\/1744806917745179","article-title":"Characterisation of Nav1.7 functional expression in rat dorsal root ganglia neurons by using an electrical field stimulation assay","volume":"13","author":"Fouillet","year":"2017","journal-title":"Mol Pain"},{"key":"10.1016\/j.jid.2026.06.1266_bib15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jid.2026.06.1266_bib16","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/exd.14279","article-title":"Itch intensity in prurigo nodularis is closely related to dermal interleukin-31, oncostatin M, IL-31 receptor alpha and oncostatin M receptor beta","volume":"30","author":"Hashimoto","year":"2021","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.06.1266_bib17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/all.12316","article-title":"Interleukin-31 does not induce immediate itch in atopic dermatitis patients and healthy controls after skin challenge","volume":"69","author":"Hawro","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jid.2026.06.1266_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1593141","article-title":"Natriuretic peptides modulate monocyte-derived Langerhans cell differentiation and promote a migratory phenotype","volume":"16","author":"Horv\u00e1th","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2026.06.1266_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0006-8993(82)90899-X","article-title":"Responses of mechanoreceptive afferent units in the glabrous skin of the human hand to sinusoidal skin displacements","volume":"244","author":"Johansson","year":"1982","journal-title":"Brain Res"},{"key":"10.1016\/j.jid.2026.06.1266_bib20","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/ana.25231","article-title":"Tuning in C-nociceptors to reveal mechanisms in chronic neuropathic pain","volume":"83","author":"Jonas","year":"2018","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jid.2026.06.1266_bib21","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41467-023-36014-0","article-title":"Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function","volume":"14","author":"Jung","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2026.06.1266_bib22","doi-asserted-by":"crossref","first-page":"468","DOI":"10.5021\/ad.2011.23.4.468","article-title":"IL-31 serum protein and tissue mRNA levels in patients with atopic dermatitis","volume":"23","author":"Kim","year":"2011","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.jid.2026.06.1266_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2478\/jvetres-2021-0045","article-title":"A pilot study to establish an ovalbumin-induced atopic dermatitis minipig model","volume":"65","author":"Kim","year":"2021","journal-title":"J Vet Res"},{"key":"10.1016\/j.jid.2026.06.1266_bib24","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.pain.2012.05.017","article-title":"High spontaneous activity of C-nociceptors in painful polyneuropathy","volume":"153","author":"Kleggetveit","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.jid.2026.06.1266_bib25","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.cell.2025.12.048","article-title":"Molecular architecture of human dermal sleeping nociceptors","volume":"189","author":"K\u00f6rner","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.jid.2026.06.1266_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/HEP.0000000000000728","article-title":"Seladelpar treatment reduces IL-31 and pruritus in patients with primary biliary cholangitis","volume":"80","author":"Kremer","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.jid.2026.06.1266_bib27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1152\/jn.1992.68.2.581","article-title":"Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro","volume":"68","author":"Kress","year":"1992","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jid.2026.06.1266_bib28","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1056\/NEJMoa2301333","article-title":"Phase 3 trial of nemolizumab in patients with prurigo nodularis","volume":"389","author":"Kwatra","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jid.2026.06.1266_bib29","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1152\/jn.1991.66.1.190","article-title":"Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms","volume":"66","author":"LaMotte","year":"1991","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jid.2026.06.1266_bib30","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/jdv.13794","article-title":"Interleukin (IL) 31 induces in cynomolgus monkeys a rapid and intense itch response that can be inhibited by an IL-31 neutralizing antibody","volume":"31","author":"Lewis","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2026.06.1266_bib31","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1289\/ehp.7199","article-title":"Epidemiologic evaluation of measurement data in the presence of detection limits","volume":"112","author":"Lubin","year":"2004","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jid.2026.06.1266_bib32","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1113\/jphysiol.1996.sp021516","article-title":"The vasodilator component of neurogenic inflammation is caused by a special subclass of heat-sensitive nociceptors in the skin of the pig","volume":"494","author":"Lynn","year":"1996","journal-title":"J Physiol"},{"key":"10.1016\/j.jid.2026.06.1266_bib33","author":"Marsh"},{"key":"10.1016\/j.jid.2026.06.1266_bib34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41684-021-00862-4","article-title":"A systematic review of porcine models in translational pain research","volume":"50","author":"Meijs","year":"2021","journal-title":"Lab Anim (NY)"},{"key":"10.1016\/j.jid.2026.06.1266_bib35","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.jaci.2017.12.1002","article-title":"New mechanism underlying IL-31-induced atopic dermatitis","volume":"141","author":"Meng","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2026.06.1266_bib36","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.1233765","article-title":"The cells and circuitry for itch responses in mice","volume":"340","author":"Mishra","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jid.2026.06.1266_bib37","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1152\/jn.90482.2008","article-title":"Separate peripheral pathways for pruritus in man","volume":"100","author":"Namer","year":"2008","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jid.2026.06.1266_bib38","article-title":"Interleukin-31 signaling bridges the gap between immune cells, the nervous system and epithelial tissues","volume":"8","author":"Nemmer","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jid.2026.06.1266_bib39","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71752","article-title":"Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons","volume":"10","author":"Nguyen","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.jid.2026.06.1266_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pain.2009.10.006","article-title":"Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human","volume":"148","author":"Obreja","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.jid.2026.06.1266_bib41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cell.2017.08.006","article-title":"Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch","volume":"171","author":"Oetjen","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jid.2026.06.1266_bib42","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/exd.13236","article-title":"Cynomolgus monkey model of interleukin-31-induced scratching depicts blockade of human interleukin-31 receptor A by a humanized monoclonal antibody","volume":"27","author":"Oyama","year":"2018","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.06.1266_bib43","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/vetsci10050329","article-title":"Establishment of an intradermal canine IL-31-induced pruritus model to evaluate therapeutic candidates in atopic dermatitis","volume":"10","author":"Pearson","year":"2023","journal-title":"Vet Sci"},{"key":"10.1016\/j.jid.2026.06.1266_bib44","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1016\/j.celrep.2017.11.066","article-title":"Functional and molecular characterization of mechanoinsensitive \"silent\" nociceptors","volume":"21","author":"Prato","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2026.06.1266_bib45","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.cell.2024.02.006","article-title":"A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes","volume":"187","author":"Qi","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.jid.2026.06.1266_bib46","series-title":"R: a language and environment for statistical computing","year":"2022"},{"key":"10.1016\/j.jid.2026.06.1266_bib47","doi-asserted-by":"crossref","first-page":"14841","DOI":"10.1523\/JNEUROSCI.3005-11.2011","article-title":"A role for nociceptive, myelinated nerve fibers in itch sensation","volume":"31","author":"Ringkamp","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.jid.2026.06.1266_bib48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuroscience.2017.11.047","article-title":"Human vs. Mouse nociceptors - Similarities and Differences","volume":"387","author":"Rostock","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.jid.2026.06.1266_bib49","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/jnr.22351","article-title":"Nerve growth factor-evoked nociceptor sensitization in pig skin in vivo","volume":"88","author":"Rukwied","year":"2010","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.jid.2026.06.1266_bib50","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1097\/j.pain.0000000000001912","article-title":"Slow depolarizing stimuli differentially activate mechanosensitive and silent C nociceptors in human and pig skin","volume":"161","author":"Rukwied","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.jid.2026.06.1266_bib51","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.it.2024.03.005","article-title":"Modulation of host immunity by sensory neurons","volume":"45","author":"Saraiva-Santos","year":"2024","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jid.2026.06.1266_bib52","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2026.06.1266_bib53","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1212\/01.WNL.0000078193.64949.08","article-title":"Active \"itch fibers\" in chronic pruritus","volume":"61","author":"Schmelz","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.jid.2026.06.1266_bib54","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/00001756-200002280-00041","article-title":"Which nerve fibers mediate the axon reflex flare in human skin?","volume":"11","author":"Schmelz","year":"2000","journal-title":"NeuroReport"},{"key":"10.1016\/j.jid.2026.06.1266_bib55","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/brain\/123.3.560","article-title":"Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres","volume":"123","author":"Schmelz","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.jid.2026.06.1266_bib56","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1523\/JNEUROSCI.17-20-08003.1997","article-title":"Specific C-receptors for itch in human skin","volume":"17","author":"Schmelz","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.jid.2026.06.1266_bib57","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1152\/jn.2002.88.4.1859","article-title":"Innervation territories of mechano-insensitive C nociceptors in human skin","volume":"88","author":"Schmidt","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.jid.2026.06.1266_bib58","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jpain.2023.01.009","article-title":"Optimized electrical stimulation of C-Nociceptors in humans based on the chronaxie of porcine C-fibers","volume":"24","author":"Schneider","year":"2023","journal-title":"J Pain"},{"key":"10.1016\/j.jid.2026.06.1266_bib59","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pain.2011.08.015","article-title":"Microneurographic identification of spontaneous activity in C-nociceptors in neuropathic pain states in humans and rats","volume":"153","author":"Serra","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.jid.2026.06.1266_bib60","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1097\/j.pain.0000000000001973","article-title":"Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization","volume":"161","author":"Shiers","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.jid.2026.06.1266_bib61","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1016\/j.pain.2011.06.001","article-title":"Sensory responses to injection and punctate application of capsaicin and histamine to the skin","volume":"152","author":"Sikand","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.jid.2026.06.1266_bib62","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0140-6736(24)01203-0","article-title":"Nemolizumab with concomitant topical therapy in adolescents and adults with moderate-to-severe atopic dermatitis (ARCADIA 1 and ARCADIA 2): results from two replicate, double-blind, randomised controlled phase 3 trials","volume":"404","author":"Silverberg","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jid.2026.06.1266_bib63","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1038\/jid.2013.227","article-title":"IL-31 is produced by the malignant T-cell population in cutaneous T-cell lymphoma and correlates with CTCL pruritus","volume":"133","author":"Singer","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.06.1266_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.101826","article-title":"Efficacy and safety of vixarelimab, a human monoclonal oncostatin M receptor \u03b2 antibody, in moderate-to-severe prurigo nodularis: a randomised, double-blind, placebo-controlled, phase 2a study","volume":"57","author":"Sofen","year":"2023","journal-title":"EClinicalmedicine"},{"key":"10.1016\/j.jid.2026.06.1266_bib65","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav5464","article-title":"Inhibition of natriuretic peptide receptor 1 reduces itch in mice","volume":"11","author":"Solinski","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2026.06.1266_bib66","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1016\/j.celrep.2019.02.089","article-title":"Nppb neurons are sensors of mast cell-induced itch","volume":"26","author":"Solinski","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2026.06.1266_bib67","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/jdv.20851","article-title":"A multidisciplinary Delphi consensus on the modern definition of pruritus: sensation and disease","volume":"40","author":"St\u00e4nder","year":"2025","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jid.2026.06.1266_bib68","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.molimm.2014.10.023","article-title":"The immunology of the porcine skin and its value as a model for human skin","volume":"66","author":"Summerfield","year":"2015","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jid.2026.06.1266_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113433","article-title":"Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch","volume":"42","author":"Takahashi","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2026.06.1266_bib70","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/978-3-662-44605-8_15","article-title":"Antihistamines and itch","volume":"226","author":"Thurmond","year":"2015","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.jid.2026.06.1266_bib71","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe3037","article-title":"Oncostatin M can sensitize sensory neurons in inflammatory pruritus","volume":"13","author":"Tseng","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2026.06.1266_bib72","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1097\/j.pain.0000000000003742","article-title":"Upregulated natriuretic peptide B expression as a hallmark of chronic itch","volume":"166","author":"Tseng","year":"2025","journal-title":"Pain"},{"key":"10.1016\/j.jid.2026.06.1266_bib73","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s43188-023-00185-1","article-title":"Comparison of structural characteristics and molecular markers of rabbit skin, pig skin, and reconstructed human epidermis for an ex vivo human skin model","volume":"39","author":"Uhm","year":"2023","journal-title":"Toxicol Res"},{"key":"10.1016\/j.jid.2026.06.1266_bib74","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jid.2026.06.1266_bib75","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1354\/vp.37-6-565","article-title":"Morphologic and immunohistochemical features of experimentally induced allergic contact dermatitis in Gottingen minipigs","volume":"37","author":"Vana","year":"2000","journal-title":"Vet Pathol"},{"key":"10.1016\/j.jid.2026.06.1266_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252211943","article-title":"Direct effects of the Janus Kinase inhibitor baricitinib on sensory neurons","volume":"25","author":"Vazquez","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2026.06.1266_bib77","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1113\/JP280269","article-title":"Maximum axonal following frequency separates classes of cutaneous unmyelinated nociceptors in the pig","volume":"599","author":"Werland","year":"2021","journal-title":"J Physiol"},{"key":"10.1016\/j.jid.2026.06.1266_bib78","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jid.2023.09.273","article-title":"Brain natriuretic peptide exerts inflammation and peripheral itch in a mouse model of atopic dermatitis","volume":"144","author":"Wheeler","year":"2024","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.06.1266_bib79","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1038\/s41593-024-01794-1","article-title":"Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation","volume":"27","author":"Yu","year":"2024","journal-title":"Nat Neurosci"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26026047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26026047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T21:19:31Z","timestamp":1785964771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X26026047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":79,"alternative-id":["S0022202X26026047"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2026.06.1266","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct sensitizing and activating effects of IL-31 are restricted to a single, functionally, and transcriptionally classified porcine dorsal root ganglion neuron subtype","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2026.06.1266","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}