{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:21:59Z","timestamp":1789474919279,"version":"build-2803163510"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012331","name":"LEO Foundation","doi-asserted-by":"publisher","award":["LF-OC-23-001332"],"award-info":[{"award-number":["LF-OC-23-001332"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"FWF","doi-asserted-by":"publisher","award":["FWF-DOC32-B28"],"award-info":[{"award-number":["FWF-DOC32-B28"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022853","name":"Sch\u00fclke&Mayr GmbH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022853","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001704","name":"European Society of Clinical Microbiology and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jid.2026.06.1279","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:30:48Z","timestamp":1782516648000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-2127","authenticated-orcid":false,"given":"Saskia","family":"Seiser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7959-9027","authenticated-orcid":false,"given":"Helena","family":"Brezovec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7487-2918","authenticated-orcid":false,"given":"Philipp","family":"Penninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6399-0959","authenticated-orcid":false,"given":"Trinh","family":"Phan-Canh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5680-1737","authenticated-orcid":false,"given":"Doris","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3470-6119","authenticated-orcid":false,"given":"Frank P.","family":"Assen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6275-4607","authenticated-orcid":false,"given":"Tanya","family":"Ayub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2189-8783","authenticated-orcid":false,"given":"Franziska","family":"Rademacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5819-777X","authenticated-orcid":false,"given":"Regine","family":"Gl\u00e4ser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7977-8097","authenticated-orcid":false,"given":"Diana","family":"Cerbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0114-6904","authenticated-orcid":false,"given":"Philip","family":"Kienzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3144-7126","authenticated-orcid":false,"given":"Christian","family":"Freyst\u00e4tter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-4603","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Harder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-5955","authenticated-orcid":false,"given":"Karl","family":"Kuchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2461-0367","authenticated-orcid":false,"given":"Adelheid","family":"Elbe-B\u00fcrger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2026.06.1279_bib1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.tim.2023.10.008","article-title":"The adhesin Scf1 mediates Candida auris colonization","volume":"32","author":"Balakumar","year":"2024","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jid.2026.06.1279_bib2","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/sj.icb.7100078","article-title":"Interleukin-1alpha regulates antimicrobial peptide expression in human keratinocytes","volume":"85","author":"Bando","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jid.2026.06.1279_bib3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3390\/ijms17030423","article-title":"A review of ribonuclease 7\u2019s structure, regulation, and contributions to host defense","volume":"17","author":"Becknell","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2026.06.1279_bib4","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/exd.12759","article-title":"Bioinformatics approach for choosing the correct reference genes when studying gene expression in human keratinocytes","volume":"24","author":"Beer","year":"2015","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.06.1279_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/mi.2014.41","article-title":"The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide","volume":"8","author":"Bjerkan","year":"2015","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/ph9030041","article-title":"Multiple functions of the new cytokine-based antimicrobial peptide thymic stromal lymphopoietin (TSLP)","volume":"9","author":"Bjerkan","year":"2016","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.jid.2026.06.1279_bib7","doi-asserted-by":"crossref","first-page":"e13682","DOI":"10.1111\/myc.13682","article-title":"Skin innate immune response against fungal infections and the potential role of trained immunity","volume":"67","author":"Bombassaro","year":"2024","journal-title":"Mycoses"},{"key":"10.1016\/j.jid.2026.06.1279_bib8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/jof3040057","article-title":"Global and multi-national prevalence of fungal diseases-estimate precision","volume":"3","author":"Bongomin","year":"2017","journal-title":"J Fungi (Basel)"},{"key":"10.1016\/j.jid.2026.06.1279_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jid.2026.06.1279_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00371-20","article-title":"Candida auris phenotypic heterogeneity determines pathogenicity in vitro","volume":"5","author":"Brown","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.jid.2026.06.1279_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1588667","article-title":"The role of fibroblast-neutrophil crosstalk in the pathogenesis of inflammatory diseases: a multi-tissue perspective","volume":"16","author":"Cai","year":"2025","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib12","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1086\/322793","article-title":"Impaired antifungal effector activity but not inflammatory cell recruitment in interleukin-6-deficient mice with invasive pulmonary aspergillosis","volume":"184","author":"Cenci","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jid.2026.06.1279_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-11914-x","article-title":"Octenidine effectively reduces Candida auris colonisation on human skin","volume":"15","author":"Cerbu","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2026.06.1279_bib16","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.3201\/eid2509.190686","article-title":"Potential fifth clade of Candida auris, Iran, 2018","volume":"25","author":"Chow","year":"2019","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jid.2026.06.1279_bib17","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1146\/annurev-micro-032521-015858","article-title":"Candida auris genetics and emergence","volume":"77","author":"Chowdhary","year":"2023","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.jid.2026.06.1279_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02215-23","article-title":"Differential skin immune responses in mice intradermally infected with Candida auris and Candida albicans","volume":"11","author":"Datta","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jid.2026.06.1279_bib19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.it.2025.09.002","article-title":"Balancing IL-17-mediated protection and IFN-\u03b3-driven pathology at mucocutaneous barriers","volume":"47","author":"Dos Santos Dias","year":"2026","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0882-4010(03)00004-4","article-title":"Candida albicans triggers interleukin-8 secretion by oral epithelial cells","volume":"34","author":"Dongari-Bagtzoglou","year":"2003","journal-title":"Microb Pathog"},{"key":"10.1016\/j.jid.2026.06.1279_bib21","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1034\/j.1399-302X.1999.140606.x","article-title":"Candida albicans triggers interleukin-6 and interleukin-8 responses by oral fibroblasts in vitro","volume":"14","author":"Dongari-Bagtzoglou","year":"1999","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib22","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.mib.2011.07.001","article-title":"The role of Dectin-1 in the host defence against fungal infections","volume":"14","author":"Drummond","year":"2011","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.jid.2026.06.1279_bib23","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/infdis\/jiac094","article-title":"Ex vivo human and porcine skin effectively model Candida auris colonization, differentiating robust and poor fungal colonizers","volume":"225","author":"Eix","year":"2022","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jid.2026.06.1279_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010730","article-title":"Modeling Candida auris skin colonization: mice, swine, and humans","volume":"18","author":"Eix","year":"2022","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jid.2026.06.1279_bib25","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4049\/jimmunol.177.1.593","article-title":"Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10","volume":"177","author":"Eksteen","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib26","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1128\/iai.62.6.2195-2201.1994","article-title":"Differential priming effects of proinflammatory cytokines on human neutrophil oxidative burst in response to bacterial N-formyl peptides","volume":"62","author":"Elbim","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.jid.2026.06.1279_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4939-6515-1_2","article-title":"The changing epidemiology of invasive fungal infections","volume":"1508","author":"Enoch","year":"2017","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jid.2026.06.1279_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01056-17","article-title":"In vitro interactions of echinocandins with triazoles against multidrug-resistant Candida auris","volume":"61","author":"Fakhim","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jid.2026.06.1279_bib29","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00284-023-03416-8","article-title":"Intra-clade heterogeneity in Candida auris: risk of management","volume":"80","author":"Fayed","year":"2023","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.jid.2026.06.1279_bib30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11046-024-00868-9","article-title":"Transcriptome analysis of human dermal cells infected with Candida auris identified unique pathogenesis\/defensive mechanisms particularly ferroptosis","volume":"189","author":"Fayed","year":"2024","journal-title":"Mycopathologia"},{"key":"10.1016\/j.jid.2026.06.1279_bib31","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/154405910508400509","article-title":"Human beta-defensins: differential activity against candidal species and regulation by Candida albicans","volume":"84","author":"Feng","year":"2005","journal-title":"J Dent Res"},{"key":"10.1016\/j.jid.2026.06.1279_bib32","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1128\/iai.57.7.2115-2122.1989","article-title":"Tumor necrosis factor alpha potentiates neutrophil antimicrobial activity: increased fungicidal activity against Torulopsis glabrata and Candida albicans and associated increases in oxygen radical production and lysosomal enzyme release","volume":"57","author":"Ferrante","year":"1989","journal-title":"Infect Immun"},{"key":"10.1016\/j.jid.2026.06.1279_bib33","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00328721","article-title":"Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations","volume":"198","author":"Gillum","year":"1984","journal-title":"Mol Gen Genet"},{"key":"10.1016\/j.jid.2026.06.1279_bib34","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1086\/523110","article-title":"Immune recognition of Candida albicans beta-glucan by Dectin-1","volume":"196","author":"Gow","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jid.2026.06.1279_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/exd.12046","article-title":"The skin surface as antimicrobial barrier: present concepts and future outlooks","volume":"22","author":"Harder","year":"2013","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.06.1279_bib36","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1126\/science.abo0693","article-title":"Microbiota and maintenance of skin barrier function","volume":"376","author":"Harris-Tryon","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jid.2026.06.1279_bib37","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.4049\/jimmunol.170.3.1452","article-title":"CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity","volume":"170","author":"Hieshima","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib38","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1038\/s41467-019-09915-2","article-title":"Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor","volume":"10","author":"Ho","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2026.06.1279_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2024.102510","article-title":"Innate immune response to Candida auris","volume":"80","author":"Holt","year":"2024","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.jid.2026.06.1279_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011843","article-title":"Mechanisms of pathogenicity for the emerging fungus Candida auris","volume":"19","author":"Horton","year":"2023","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jid.2026.06.1279_bib41","doi-asserted-by":"crossref","first-page":"e00910","DOI":"10.1128\/mSphere.00910-19","article-title":"Candida auris forms high-burden biofilms in skin niche conditions and on porcine skin","volume":"5","author":"Horton","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.jid.2026.06.1279_bib42","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00406-21","article-title":"Candida auris Cell Wall mannosylation Contributes to neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata","volume":"6","author":"Horton","year":"2021","journal-title":"mSphere"},{"key":"10.1016\/j.jid.2026.06.1279_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1329438","article-title":"Use of a Candida albicans SC5314 PacBio HiFi reads dataset to close gaps in the reference genome assembly, reveal a subtelomeric gene family, and produce accurate phased allelic sequences","volume":"14","author":"Hoyer","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jid.2026.06.1279_bib44","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.chom.2020.12.002","article-title":"Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies","volume":"29","author":"Huang","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jid.2026.06.1279_bib45","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1074\/jbc.M607321200","article-title":"The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity","volume":"282","author":"Huang","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jid.2026.06.1279_bib46","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/ar3893","article-title":"Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy","volume":"14","author":"Huppler","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jid.2026.06.1279_bib47","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.3390\/ijms22084233","article-title":"Detection of antimicrobial peptides in Stratum corneum by mass spectrometry","volume":"22","author":"Jenei","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2026.06.1279_bib48","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00799-22","article-title":"Transcriptomics and phenotyping define genetic signatures associated with echinocandin resistance in Candida auris","volume":"13","author":"Jenull","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.jid.2026.06.1279_bib49","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.142067","article-title":"Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin","volume":"5","author":"Jiang","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2026.06.1279_bib50","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01403-18","article-title":"Emerging fungal pathogen Candida auris evades neutrophil attack","volume":"9","author":"Johnson","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.jid.2026.06.1279_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113569","article-title":"Human \u03b2 defensins-1, an antimicrobial peptide, kills Candida glabrata by generating oxidative stress and arresting the cell cycle in G0\/G1 phase","volume":"154","author":"Kamli","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.jid.2026.06.1279_bib52","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0923-1811(03)00043-4","article-title":"Candida albicans induced interleukin 8 production by human keratinocytes","volume":"31","author":"Kano","year":"2003","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jid.2026.06.1279_bib53","doi-asserted-by":"crossref","DOI":"10.1093\/mmy\/myae042","article-title":"Candida auris-a systematic review to inform the world health organization fungal priority pathogens list","volume":"62","author":"Kim","year":"2024","journal-title":"Med Mycol"},{"key":"10.1016\/j.jid.2026.06.1279_bib54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11046-025-01000-1","article-title":"Genome sequences and antifungal susceptibility of Candida auris from a patient with atopic dermatitis","volume":"190","author":"Kim","year":"2025","journal-title":"Mycopathologia"},{"key":"10.1016\/j.jid.2026.06.1279_bib55","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.immuni.2019.02.023","article-title":"Choreographing immunity in the skin epithelial barrier","volume":"50","author":"Kobayashi","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jid.2026.06.1279_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006424","article-title":"RNase 7 contributes to the cutaneous defense against Enterococcus faecium","volume":"4","author":"K\u00f6ten","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jid.2026.06.1279_bib57","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1093\/infdis\/jix153","article-title":"Central role for dermal fibroblasts in skin model protection against Candida albicans","volume":"215","author":"K\u00fchbacher","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jid.2026.06.1279_bib58","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1016\/j.jid.2025.02.002","article-title":"Role of formyl peptide receptor 2 and toll-like receptor 2 in skin barrier function and atopic dermatitis","volume":"145","author":"Lebtig","year":"2025","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.06.1279_bib59","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1600-0625.2008.00832.x","article-title":"Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through toll-like receptor 2","volume":"18","author":"Li","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.06.1279_bib60","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/odi.15092","article-title":"Antifungal recombinant psoriasin of human origin effectively inhibits fungal growth on denture base","volume":"31","author":"Lifshits","year":"2025","journal-title":"Oral Dis"},{"key":"10.1016\/j.jid.2026.06.1279_bib61","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1056\/NEJMra2402635","article-title":"Candida auris infections","volume":"391","author":"Lionakis","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jid.2026.06.1279_bib62","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses","volume":"64","author":"Lockhart","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jid.2026.06.1279_bib63","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/21505594.2021.2019950","article-title":"Pathogenesis and virulence of Candida albicans","volume":"13","author":"Lopes","year":"2022","journal-title":"Virulence"},{"key":"10.1016\/j.jid.2026.06.1279_bib64","doi-asserted-by":"crossref","first-page":"e523","DOI":"10.1093\/cid\/ciaf365","article-title":"Improved consistency of Candida auris colonization screening with an anterior nares and hands composite sample","volume":"81","author":"L\u00f3pez","year":"2026","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jid.2026.06.1279_bib65","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1128\/iai.62.7.2761-2772.1994","article-title":"Tumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis","volume":"62","author":"Louie","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.jid.2026.06.1279_bib66","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1189\/jlb.3HI0716-293RR","article-title":"Frontline Science: tumor necrosis factor-\u03b1 stimulation and priming of human neutrophil granule exocytosis","volume":"102","author":"McLeish","year":"2017","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jid.2026.06.1279_bib67","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/jof3040052","article-title":"The role of IL-17 in protection against mucosal candida infections","volume":"3","author":"Mengesha","year":"2017","journal-title":"J Fungi (Basel)"},{"key":"10.1016\/j.jid.2026.06.1279_bib68","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41423-020-0412-0","article-title":"Neutrophil chemoattractant receptors in health and disease: double-edged swords","volume":"17","author":"Metzemaekers","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib69","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.intimp.2017.08.012","article-title":"CCL28 chemokine: an anchoring point bridging innate and adaptive immunity","volume":"51","author":"Mohan","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jid.2026.06.1279_bib70","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature17625","article-title":"Candidalysin is a fungal peptide toxin critical for mucosal infection","volume":"532","author":"Moyes","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jid.2026.06.1279_bib71","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1038\/s41467-018-07779-6","article-title":"Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species","volume":"9","author":"Mu\u00f1oz","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2026.06.1279_bib72","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2025.2532815","article-title":"Comprehensive analysis of human keratinocyte interactions with Candida albicans and Candida parapsilosis","volume":"16","author":"Nov\u00e1k","year":"2025","journal-title":"Virulence"},{"key":"10.1016\/j.jid.2026.06.1279_bib73","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/gb-2004-5-7-230","article-title":"Candida albicans genome sequence: a platform for genomics in the absence of genetics","volume":"5","author":"Odds","year":"2004","journal-title":"Genome Biol"},{"key":"10.1016\/j.jid.2026.06.1279_bib74","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1038\/jid.2010.37","article-title":"Staphylococcus aureus stimulates neutrophil targeting chemokine expression in keratinocytes through an autocrine IL-1\u03b1 signaling loop","volume":"130","author":"Olaru","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.06.1279_bib75","article-title":"Skin and hard surface disinfection against Candida auris \u2013 what we know today","volume":"11","author":"Omardien","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jid.2026.06.1279_bib76","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.4049\/jimmunol.165.6.2943","article-title":"A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues","volume":"165","author":"Pan","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib77","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41564-025-02189-z","article-title":"Candida auris skin tropism and antifungal resistance are mediated by carbonic anhydrase Nce103","volume":"11","author":"Phan-Canh","year":"2026","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jid.2026.06.1279_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115976","article-title":"White-Brown switching controls phenotypic plasticity and virulence of Candida auris","volume":"44","author":"Phan-Canh","year":"2025","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2026.06.1279_bib79","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012559","article-title":"Do morphogenetic switching and intraspecies variation enhance virulence of Candida auris?","volume":"20","author":"Phan-Canh","year":"2024","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jid.2026.06.1279_bib80","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00977-24","article-title":"Rapid in vitro evolution of flucytosine resistance in Candida auris","volume":"10","author":"Phan-Canh","year":"2025","journal-title":"mSphere"},{"key":"10.1016\/j.jid.2026.06.1279_bib81","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/s41591-021-01383-w","article-title":"Integrated genomic, epidemiologic investigation of Candida auris skin colonization in a skilled nursing facility","volume":"27","author":"Proctor","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.jid.2026.06.1279_bib82","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/s41586-025-08608-9","article-title":"Clonal Candida auris and ESKAPE pathogens on the skin of residents of nursing homes","volume":"639","author":"Proctor","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jid.2026.06.1279_bib83","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.3389\/fimmu.2019.02553","article-title":"The antimicrobial and immunomodulatory function of RNase 7 in skin","volume":"10","author":"Rademacher","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib84","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1111\/exd.14433","article-title":"Antimicrobial peptides and proteins: interaction with the skin microbiota","volume":"30","author":"Rademacher","year":"2021","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.06.1279_bib85","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3390\/ijms17040560","article-title":"RNase 7 in cutaneous defense","volume":"17","author":"Rademacher","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2026.06.1279_bib86","series-title":"Methods in yeast genetics: a laboratory course manual","author":"Rose","year":"1990"},{"key":"10.1016\/j.jid.2026.06.1279_bib87","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.3389\/fmicb.2018.03081","article-title":"Candida auris: what have we learned about its mechanisms of pathogenicity?","volume":"9","author":"Rossato","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jid.2026.06.1279_bib88","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/mbo3.373","article-title":"Exploring the mechanisms of action of human secretory RNase 3 and RNase 7 against Candida albicans","volume":"5","author":"Salazar","year":"2016","journal-title":"MicrobiologyOpen"},{"key":"10.1016\/j.jid.2026.06.1279_bib89","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.adf8972","article-title":"A Candida auris-specific adhesin, SCF1, governs surface association, colonization, and virulence","volume":"381","author":"Santana","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.jid.2026.06.1279_bib90","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012011","article-title":"The many faces of Candida auris: phenotypic and strain variation in an emerging pathogen","volume":"20","author":"Santana","year":"2024","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jid.2026.06.1279_bib91","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1348-0421.2008.00083.x","article-title":"Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital","volume":"53","author":"Satoh","year":"2009","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib92","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1128\/IAI.73.5.2758-2765.2005","article-title":"Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis","volume":"73","author":"Schaller","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.jid.2026.06.1279_bib93","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jaci.2008.03.027","article-title":"Antimicrobial peptides and the skin immune defense system","volume":"122","author":"Schauber","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib94","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2026.06.1279_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2023.105234","article-title":"Native human and mouse skin infection models to study Candida auris-host interactions","volume":"26","author":"Seiser","year":"2024","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jid.2026.06.1279_bib96","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/cid\/ciab327","article-title":"Positive correlation between Candida auris skin-colonization burden and environmental contamination at a Ventilator-Capable Skilled Nursing Facility in Chicago","volume":"73","author":"Sexton","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jid.2026.06.1279_bib97","doi-asserted-by":"crossref","first-page":"001835","DOI":"10.1099\/jmm.0.001835","article-title":"Antifungal activity of human antimicrobial peptides targeting apoptosis in Candida auris","volume":"73","author":"Shaban","year":"2024","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jid.2026.06.1279_bib98","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.jid.2024.06.1280","article-title":"The central roles of keratinocytes in coordinating skin immunity","volume":"144","author":"Simmons","year":"2024","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.06.1279_bib99","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/j.1600-0625.2011.01391.x","article-title":"Thymic stromal lymphopoietin exerts antimicrobial activities","volume":"20","author":"Sonesson","year":"2011","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.06.1279_bib100","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/ki.2012.410","article-title":"Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract","volume":"83","author":"Spencer","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.jid.2026.06.1279_bib101","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41592-025-02595-5","article-title":"Cellpose3: one-click image restoration for improved cellular segmentation","volume":"22","author":"Stringer","year":"2025","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2026.06.1279_bib102","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat Methods"},{"key":"10.1016\/j.jid.2026.06.1279_bib117","doi-asserted-by":"crossref","first-page":"100878","DOI":"10.1016\/S2666-5247(24)00101-0","article-title":"Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study","volume":"5","author":"Suphavilai","year":"2024","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.jid.2026.06.1279_bib103","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/pr.2013.60","article-title":"Association of high levels of \u03b1-defensins and S100A proteins with Candida mannan detection in bronchoalveolar lavage fluid of preterm neonates","volume":"74","author":"Vento","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jid.2026.06.1279_bib104","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41586-025-08741-5","article-title":"Matrix-producing neutrophils populate and shield the skin [published correction appears in Nature 2025;641:E10]","volume":"641","author":"Vicanolo","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jid.2026.06.1279_bib105","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1086\/503363","article-title":"Endogenous interleukin (IL)-1 alpha and IL-1 beta are crucial for host defense against disseminated candidiasis","volume":"193","author":"Vonk","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jid.2026.06.1279_bib106","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fimmu.2013.00177","article-title":"Unique versus redundant functions of IL-1\u03b1 and IL-1\u03b2 in the tumor microenvironment","volume":"4","author":"Voronov","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.jid.2026.06.1279_bib107","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/exd.14858","article-title":"The immune function of dermal fibroblasts in skin defence against pathogens","volume":"32","author":"Wang","year":"2023","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.06.1279_bib108","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1038\/s41467-022-31201-x","article-title":"Innate immune responses against the fungal pathogen Candida auris","volume":"13","author":"Wang","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2026.06.1279_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112522","article-title":"Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response","volume":"42","author":"Weerasinghe","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.jid.2026.06.1279_bib110","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1084\/jem.20041069","article-title":"CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate [published correction appears in J Exp Med 2004;200:following 108]","volume":"200","author":"Wilson","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.jid.2026.06.1279_bib112","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/rheumatology\/keu035","article-title":"Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo","volume":"53","author":"Wright","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jid.2026.06.1279_bib113","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.intimp.2017.09.008","article-title":"Dectin-1 is essential for IL-1\u03b2 production through JNK activation and apoptosis in Aspergillus fumigatus keratitis","volume":"52","author":"Yuan","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jid.2026.06.1279_bib114","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41426-018-0187-x","article-title":"Filamentation in Candida auris, an emerging fungal pathogen of humans: passage through the mammalian body induces a heritable phenotypic switch","volume":"7","author":"Yue","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.jid.2026.06.1279_bib115","doi-asserted-by":"crossref","DOI":"10.1017\/S0950268819001638","article-title":"Epidemiology, risk factors and outcomes of Candida albicans vs. non-albicans candidaemia in adult patients in Northeast China","volume":"147","author":"Zhang","year":"2019","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.jid.2026.06.1279_bib116","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1038\/s41467-025-60876-1","article-title":"Adhesin Als4112 promotes Candida auris skin colonization through interactions with keratinocytes and extracellular matrix proteins","volume":"16","author":"Zhao","year":"2025","journal-title":"Nat Commun"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X2602659X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X2602659X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:02:40Z","timestamp":1786482160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X2602659X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":114,"alternative-id":["S0022202X2602659X"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2026.06.1279","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2026.06.1279","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}