{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:43:59Z","timestamp":1792788239217,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022011","name":"CRUK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jid.2026.08.033","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:13:38Z","timestamp":1792718018000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathogenic Keratinocyte States and Fibroblast Niches Define the Tissue Microenvironment in Severe Hidradenitis Suppurativa"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5738-8734","authenticated-orcid":false,"given":"Xinyi","family":"Du-Harpur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1143-7905","authenticated-orcid":false,"given":"Clarisse","family":"Ganier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9268-3352","authenticated-orcid":false,"given":"Pavel","family":"Mazin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-2883","authenticated-orcid":false,"given":"Chris","family":"Cheshire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4492-5200","authenticated-orcid":false,"given":"Jeyrroy","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-5528","authenticated-orcid":false,"given":"Ellie","family":"Rashidghamat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5293-4778","authenticated-orcid":false,"given":"Nicholas M.","family":"Luscombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7586-4338","authenticated-orcid":false,"given":"Magnus D.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-5154","authenticated-orcid":false,"given":"Fiona M.","family":"Watt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jid.2026.08.033_bib1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s40265-021-01566-2","article-title":"Clinical Implementation of Biologics and Small Molecules in the Treatment of Hidradenitis Suppurativa","volume":"81","author":"Aarts","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.jid.2026.08.033_bib2","first-page":"1","article-title":"A skin colonizer disrupts inflammatory and humoral immune defenses in hidradenitis suppurativa","author":"Agbogan","year":"2026","journal-title":"EMBO Mol. Med. Springer Science and Business Media LLC"},{"key":"10.1016\/j.jid.2026.08.033_bib3","article-title":"The polygenic architecture of hidradenitis suppurativa reveals signaling mechanisms that implicate epithelial remodeling","author":"Atlas","year":"2025","journal-title":"medRxiv"},{"issue":"1","key":"10.1016\/j.jid.2026.08.033_bib4","article-title":"Activin-A signaling promotes epithelial-mesenchymal transition, invasion, and metastatic growth of breast cancer","volume":"1","author":"Bashir","year":"2015","journal-title":"NPJ Breast Cancer. Springer Science and Business Media LLC"},{"issue":"6","key":"10.1016\/j.jid.2026.08.033_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri.2016.48","article-title":"The influence of skin microorganisms on cutaneous immunity","volume":"16","author":"Belkaid","year":"2016","journal-title":"Nat. Rev. Immunol"},{"issue":"10","key":"10.1016\/j.jid.2026.08.033_bib6","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/s41556-023-01234-5","article-title":"Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation","volume":"25","author":"Bernab\u00e9-Rubio","year":"2023","journal-title":"Nat. Cell Biol. Nat Cell Biol"},{"issue":"7745","key":"10.1016\/j.jid.2026.08.033_bib7","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","article-title":"The single-cell transcriptional landscape of mammalian organogenesis","volume":"566","author":"Cao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jid.2026.08.033_bib8","article-title":"Tertiary lymphoid structures in autoimmune diseases","volume":"14","author":"Dong","year":"2023","journal-title":"Front. Immunol"},{"issue":"7479","key":"10.1016\/j.jid.2026.08.033_bib9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature12783","article-title":"Distinct fibroblast lineages determine dermal architecture in skin development and repair","volume":"504","author":"Driskell","year":"2013","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.jid.2026.08.033_bib10","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/exd.14273","article-title":"Histologic progression of acne inversa\/hidradenitis suppurativa: Implications for future investigations and therapeutic intervention","volume":"30","author":"Dunstan","year":"2021","journal-title":"Exp. Dermatol"},{"issue":"1","key":"10.1016\/j.jid.2026.08.033_bib11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jdin.2020.05.005","article-title":"Hidradenitis suppurativa is an autoinflammatory keratinization disease: A review of the clinical, histologic, and molecular evidence","volume":"1","author":"Frew","year":"2020","journal-title":"JAAD Int"},{"issue":"2","key":"10.1016\/j.jid.2026.08.033_bib12","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2313326120","article-title":"Multiscale spatial mapping of cell populations across anatomical sites in healthy human skin and basal cell carcinoma","volume":"121","author":"Ganier","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"2","key":"10.1016\/j.jid.2026.08.033_bib13","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jaad.2019.06.1301","article-title":"Evaluating patients\u2019 unmet needs in hidradenitis suppurativa: Results from the Global Survey Of Impact and Healthcare Needs (VOICE) Project","volume":"82","author":"Garg","year":"2020","journal-title":"J. Am. Acad. Dermatol"},{"issue":"10","key":"10.1016\/j.jid.2026.08.033_bib14","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1056\/NEJMoa2210140","article-title":"Nirogacestat, a \u03b3-secretase inhibitor for desmoid tumors","volume":"388","author":"Gounder","year":"2023","journal-title":"N. Engl. J. Med. Massachusetts Medical Society"},{"issue":"8052","key":"10.1016\/j.jid.2026.08.033_bib15","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/s41586-024-08376-y","article-title":"Skin autonomous antibody production regulates host-microbiota interactions","volume":"638","author":"Gribonika","year":"2025","journal-title":"Nature. Nature"},{"issue":"19","key":"10.1016\/j.jid.2026.08.033_bib16","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139930","article-title":"Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis","volume":"5","author":"Gudjonsson","year":"2020","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.jid.2026.08.033_bib17","first-page":"293","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol. Springer Science and Business Media LLC"},{"key":"10.1016\/j.jid.2026.08.033_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.immunol.20.090501.112049","article-title":"Molecular mechanism of class switch recombination: linkage with somatic hypermutation","volume":"20","author":"Honjo","year":"2002","journal-title":"Annu. Rev. Immunol"},{"issue":"3","key":"10.1016\/j.jid.2026.08.033_bib19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.celrep.2019.12.063","article-title":"Memory B Cell Activation, Broad Anti-influenza Antibodies, and Bystander Activation Revealed by Single-Cell Transcriptomics","volume":"30","author":"Horns","year":"2020","journal-title":"Cell Rep"},{"issue":"6","key":"10.1016\/j.jid.2026.08.033_bib20","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/bjd.19435","article-title":"The epidemiology of hidradenitis suppurativa","volume":"183","author":"Ingram","year":"2020","journal-title":"Br. J. Dermatol"},{"issue":"49","key":"10.1016\/j.jid.2026.08.033_bib21","article-title":"Epigenetic switch reshapes epithelial progenitor cell signatures and drives inflammatory pathogenesis in hidradenitis suppurativa","volume":"120","author":"Jin","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A. Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.jid.2026.08.033_bib22","first-page":"180","article-title":"CellChat for systematic analysis of cell-cell communication from single-cell transcriptomics","volume":"20","author":"Jin","year":"2025","journal-title":"Nat. Protoc. Springer Science and Business Media LLC"},{"issue":"10","key":"10.1016\/j.jid.2026.08.033_bib23","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1111\/exd.14451","article-title":"Hidradenitis suppurativa: A folliculotropic disease of innate immune barrier dysfunction?","volume":"30","author":"Johnston","year":"2021","journal-title":"Exp. Dermatol"},{"issue":"4","key":"10.1016\/j.jid.2026.08.033_bib24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jaad.2024.11.050","article-title":"A genome-wide association meta-analysis links hidradenitis suppurativa to common and rare sequence variants causing disruption of the Notch and Wnt\/\u03b2-catenin signaling pathways","volume":"92","author":"Kj\u00e6rsgaard Andersen","year":"2025","journal-title":"J. Am. Acad. Dermatol. Elsevier BV"},{"issue":"5","key":"10.1016\/j.jid.2026.08.033_bib25","first-page":"661","article-title":"Cell2location maps fine-grained cell types in spatial transcriptomics","volume":"40","author":"Kleshchevnikov","year":"2022","journal-title":"Nat. Biotechnol. Springer Science and Business Media LLC"},{"issue":"12","key":"10.1016\/j.jid.2026.08.033_bib26","first-page":"1289","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods. Springer Science and Business Media LLC"},{"issue":"2","key":"10.1016\/j.jid.2026.08.033_bib27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bjd\/ljad345","article-title":"Hidradenitis suppurativa: new insights into disease mechanisms and an evolving treatment landscape","volume":"190","author":"Krueger","year":"2024","journal-title":"Br. J. Dermatol. Oxford University Press (OUP)"},{"issue":"0","key":"10.1016\/j.jid.2026.08.033_bib28","article-title":"Spatial transcriptomics maps early B-cell and T-cell activation in hidradenitis suppurativa","volume":"0","author":"Lee","year":"2026","journal-title":"J. Invest. Dermatol. Elsevier BV"},{"issue":"10","key":"10.1016\/j.jid.2026.08.033_bib29","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1016\/j.jid.2025.03.010","article-title":"Expression of glandular genes in the tunnel epithelium of hidradenitis suppurativa","volume":"145","author":"Lin","year":"2025","journal-title":"J. Invest. Dermatol. Elsevier BV"},{"issue":"1","key":"10.1016\/j.jid.2026.08.033_bib30","first-page":"3","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct. Target. Ther. Springer Science and Business Media LLC"},{"issue":"3","key":"10.1016\/j.jid.2026.08.033_bib31","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.169870","article-title":"Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa","volume":"9","author":"Lowe","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.jid.2026.08.033_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.665873","article-title":"Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa","volume":"8","author":"Mariottoni","year":"2021","journal-title":"Front. Med"},{"issue":"4","key":"10.1016\/j.jid.2026.08.033_bib33","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/bjd\/ljad184","article-title":"Targeting the NLRP3 inflammasome reduces inflammation in hidradenitis suppurativa skin","volume":"189","author":"Moran","year":"2023","journal-title":"Br. J. Dermatol. Br J Dermatol"},{"issue":"6","key":"10.1016\/j.jid.2026.08.033_bib34","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.jaci.2020.12.651","article-title":"Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa","volume":"147","author":"Navrazhina","year":"2021","journal-title":"J. Allergy Clin. Immunol"},{"issue":"1","key":"10.1016\/j.jid.2026.08.033_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/jdv.16677","article-title":"Hidradenitis suppurativa: an update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life","volume":"35","author":"Nguyen","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol"},{"issue":"4","key":"10.1016\/j.jid.2026.08.033_bib36","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jid.2017.09.051","article-title":"Hidradenitis suppurativa-like lesions associated with pharmacologic inhibition of gamma-secretase","volume":"138","author":"O\u2019Sullivan Coyne","year":"2018","journal-title":"J. Invest. Dermatol. Elsevier BV"},{"issue":"5","key":"10.1016\/j.jid.2026.08.033_bib37","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.devcel.2004.09.014","article-title":"gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis","volume":"7","author":"Pan","year":"2004","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.jid.2026.08.033_bib38","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jid.2018.01.016","article-title":"Spatial and single-cell transcriptional profiling identifies functionally distinct human dermal fibroblast subpopulations","volume":"138","author":"Philippeos","year":"2018","journal-title":"J. Invest. Dermatol"},{"issue":"3","key":"10.1016\/j.jid.2026.08.033_bib39","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/jid.2012.372","article-title":"\u03b3-Secretase mutations in hidradenitis suppurativa: new insights into disease pathogenesis","volume":"133","author":"Pink","year":"2013","journal-title":"J. Invest. Dermatol"},{"issue":"6527","key":"10.1016\/j.jid.2026.08.033_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba6500","article-title":"Developmental cell programs are co-opted in inflammatory skin disease","volume":"371","author":"Reynolds","year":"2021","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.jid.2026.08.033_bib41","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jamadermatol.2017.0904","article-title":"The Follicular Skin Microbiome in Patients With Hidradenitis Suppurativa and Healthy Controls","volume":"153","author":"Ring","year":"2017","journal-title":"JAMA Dermatol"},{"issue":"9","key":"10.1016\/j.jid.2026.08.033_bib42","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.jid.2020.02.046","article-title":"The Surface Microbiome of Clinically Unaffected Skinfolds in Hidradenitis Suppurativa: A Cross-Sectional Culture-Based and 16S rRNA Gene Amplicon Sequencing Study in 60 Patients","volume":"140","author":"Riverain-Gillet","year":"2020","journal-title":"J. Invest. Dermatol"},{"issue":"1","key":"10.1016\/j.jid.2026.08.033_bib43","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-020-0149-1","article-title":"Hidradenitis suppurativa","volume":"6","author":"Sabat","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"10.1016\/j.jid.2026.08.033_bib44","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S0022-202X(26)00543-9","article-title":"Hair-raising effects of WNT10A in hidradenitis suppurativa","volume":"146","author":"Spindler","year":"2026","journal-title":"J. Invest. Dermatol. Elsevier BV"},{"issue":"3","key":"10.1016\/j.jid.2026.08.033_bib45","article-title":"Single-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa","volume":"134","author":"van Straalen","year":"2024","journal-title":"J. Clin. Invest. American Society for Clinical Investigation"},{"issue":"9","key":"10.1016\/j.jid.2026.08.033_bib46","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1001\/jamadermatol.2023.2217","article-title":"Genetic variants associated with hidradenitis suppurativa","volume":"159","author":"Sun","year":"2023","journal-title":"JAMA Dermatol. JAMA Dermatol"},{"issue":"6","key":"10.1016\/j.jid.2026.08.033_bib47","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/bjd.17578","article-title":"Substantially reduced life expectancy in patients with hidradenitis suppurativa: a Finnish nationwide registry study","volume":"180","author":"Tiri","year":"2019","journal-title":"Br. J. Dermatol"},{"issue":"1","key":"10.1016\/j.jid.2026.08.033_bib48","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/wdev.86","article-title":"The TGFbeta superfamily signaling pathway: TGFbeta superfamily signaling pathway","volume":"2","author":"Weiss","year":"2013","journal-title":"Wiley Interdiscip. Rev. Dev. Biol. Wiley"},{"issue":"5","key":"10.1016\/j.jid.2026.08.033_bib49","doi-asserted-by":"crossref","DOI":"10.1111\/exd.15087","article-title":"Gram-negative anaerobes elicit a robust keratinocytes immune response with potential insights into HS pathogenesis","volume":"33","author":"Williams","year":"2024","journal-title":"Exp. Dermatol"},{"issue":"8","key":"10.1016\/j.jid.2026.08.033_bib50","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/s41556-023-01184-y","article-title":"The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates","volume":"25","author":"Yang","year":"2023","journal-title":"Nat. Cell Biol. Nature Publishing Group"},{"key":"10.1016\/j.jid.2026.08.033_bib51","doi-asserted-by":"crossref","unstructured":"Yu W-W, Barrett JNP, Tong J, Lin M-J, Marohn M, Devlin JC, et al. Skin immune-mesenchymal interplay within tertiary lymphoid structures promotes autoimmune pathogenesis in hidradenitis suppurativa. Immunity. Elsevier BV; 2024;57(12):2827-2842.e5","DOI":"10.1016\/j.immuni.2024.11.010"},{"issue":"12","key":"10.1016\/j.jid.2026.08.033_bib52","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/exd.14214","article-title":"What causes hidradenitis suppurativa ?-15 years after","volume":"29","author":"Zouboulis","year":"2020","journal-title":"Exp. Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26037851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26037851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:10:09Z","timestamp":1792786209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X26037851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":52,"alternative-id":["S0022202X26037851"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2026.08.033","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathogenic Keratinocyte States and Fibroblast Niches Define the Tissue Microenvironment in Severe Hidradenitis Suppurativa","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2026.08.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}]}}