{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:42:06Z","timestamp":1792215726544,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidonline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Investigative Dermatology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jid.2026.09.858","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:12:00Z","timestamp":1792105920000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endothelial AHR-APLNR signaling preserves vascular glycocalyx integrity and limits neutrophil-driven skin injury during local MRSA infection"],"prefix":"10.1016","author":[{"given":"Kang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erle","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jid.2026.09.858_bib1","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jid.2019.10.017","article-title":"Staphylococcus aureus skin colonization is enhanced by the interaction of neutrophil extracellular traps with keratinocytes","volume":"140","author":"Bitschar","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.09.858_bib2","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.jid.2026.09.858_bib3","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20231425","article-title":"CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17","volume":"221","author":"Cavagnero","year":"2024","journal-title":"J Exp Med"},{"key":"10.1016\/j.jid.2026.09.858_bib4","doi-asserted-by":"crossref","first-page":"5894","DOI":"10.1038\/s41467-023-41484-3","article-title":"CREB1-driven CXCR4(hi) neutrophils promote skin inflammation in mouse models and human patients","volume":"14","author":"Chen","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2026.09.858_bib5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41423-025-01264-z","article-title":"The AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes epidermal and immune homeostasis in atopic dermatitis-like skin inflammation","volume":"22","author":"Chen","year":"2025","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jid.2026.09.858_bib6","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.jid.2020.07.028","article-title":"Neutrophils enhance cutaneous vascular dilation and permeability to aggravate psoriasis by releasing matrix metallopeptidase 9","volume":"141","author":"Chen","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.09.858_bib7","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3390\/ijms26041618","article-title":"The aryl hydrocarbon receptor (AHR): peacekeeper of the skin","volume":"26","author":"Dawe","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jid.2026.09.858_bib8","doi-asserted-by":"crossref","first-page":"15880","DOI":"10.1073\/pnas.1005743107","article-title":"Extracellular DNA traps promote thrombosis","volume":"107","author":"Fuchs","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jid.2026.09.858_bib9","doi-asserted-by":"crossref","first-page":"7729","DOI":"10.1038\/s41467-025-63003-2","article-title":"Apelin as a CNS-specific pathway for fenestrated capillary formation in the choroid plexus","volume":"16","author":"Herdt","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.jid.2026.09.858_bib10","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1038\/s41590-024-02006-5","article-title":"The diverse roles of neutrophils from protection to pathogenesis","volume":"25","author":"Herro","year":"2024","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2026.09.858_bib11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ni.3614","article-title":"The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin","volume":"18","author":"Hidaka","year":"2017","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jid.2026.09.858_bib12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1124\/mol.113.091165","article-title":"Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities","volume":"85","author":"Jin","year":"2014","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.jid.2026.09.858_bib13","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401947R","article-title":"Inhibition of proton sensor GPR68 suppresses endothelial dysfunction and acute lung injury caused by Staphylococcus aureus bacterial particles","volume":"39","author":"Karki","year":"2025","journal-title":"FASEB J"},{"key":"10.1016\/j.jid.2026.09.858_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110804","article-title":"Truncated oxidized phospholipids exacerbate endothelial dysfunction and lung injury caused by bacterial pathogens","volume":"109","author":"Karki","year":"2023","journal-title":"Cell Signal"},{"key":"10.1016\/j.jid.2026.09.858_bib15","doi-asserted-by":"crossref","DOI":"10.1172\/JCI160451","article-title":"An IGFBP7hi endothelial cell subset drives T cell extravasation in psoriasis via endothelial glycocalyx degradation","volume":"133","author":"Li","year":"2023","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jid.2026.09.858_bib16","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/j.jid.2024.02.013","article-title":"Endothelial dysfunction in psoriasis: an integrative review","volume":"144","author":"Li","year":"2024","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.09.858_bib17","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/s41586-023-06287-y","article-title":"Endothelial AHR activity prevents lung barrier disruption in viral infection","volume":"621","author":"Major","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jid.2026.09.858_bib18","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jid.2023.01.016","article-title":"IL-17 signaling in keratinocytes orchestrates the defense against Staphylococcus aureus skin infection","volume":"143","author":"Moos","year":"2023","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.09.858_bib19","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.immuni.2023.11.007","article-title":"Trans-endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing","volume":"57","author":"Mukhopadhyay","year":"2024","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.jid.2026.09.858_bib20","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1038\/s12276-026-01760-w","article-title":"Apelin\u2013APLNR pathway across development, inflammation, and vascular remodeling: an endothelial perspective","volume":"58","author":"Park","year":"2026","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jid.2026.09.858_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/falgy.2024.1323405","article-title":"Aryl hydrocarbon receptor and IL-13 signaling crosstalk in human keratinocytes and atopic dermatitis","volume":"5","author":"Proper","year":"2024","journal-title":"Front Allergy"},{"key":"10.1016\/j.jid.2026.09.858_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52041-8","article-title":"Neutrophils promote venular thrombosis by shaping the rheological environment for platelet aggregation","volume":"9","author":"Puhr-Westerheide","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jid.2026.09.858_bib23","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1159\/000524033","article-title":"Staphylococcus aureus activates the aryl hydrocarbon receptor in human keratinocytes","volume":"14","author":"Stange","year":"2022","journal-title":"J Innate Immun"},{"key":"10.1016\/j.jid.2026.09.858_bib24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00281-011-0295-3","article-title":"Neutrophils in innate host defense against Staphylococcus aureus infections","volume":"34","author":"Rigby","year":"2012","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.jid.2026.09.858_bib25","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.jid.2024.01.030","article-title":"The aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2A","volume":"144","author":"Smits","year":"2024","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.09.858_bib26","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.jvs.2025.01.005","article-title":"Peripheral vascular emboli in patients with infective endocarditis are common","volume":"81","author":"Sung","year":"2025","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jid.2026.09.858_bib27","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/dvg.20654","article-title":"The contribution of the Tie2+ lineage to primitive and definitive hematopoietic cells","volume":"48","author":"Tang","year":"2010","journal-title":"Genesis"},{"key":"10.1016\/j.jid.2026.09.858_bib28","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.jid.2023.01.013","article-title":"Skin colonization with S. aureus can lead to increased NLRP1 inflammasome activation in patients with atopic dermatitis","volume":"143","author":"Vaher","year":"2023","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jid.2026.09.858_bib29","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/s41586-023-06508-4","article-title":"Endothelial sensing of AHR ligands regulates intestinal homeostasis","volume":"621","author":"Wiggins","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jid.2026.09.858_bib30","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/all.15998","article-title":"Propionate alleviates itch in murine models of atopic dermatitis by modulating sensory TRP channels of dorsal root ganglion","volume":"79","author":"Xu","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.jid.2026.09.858_bib31","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1111\/exd.14768","article-title":"Pathophysiology of generalized pustular psoriasis","volume":"32","author":"Young","year":"2023","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jid.2026.09.858_bib32","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.jaci.2018.11.036","article-title":"A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor","volume":"143","author":"Yu","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jid.2026.09.858_bib33","article-title":"Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis","volume":"13","author":"Zhang","year":"2023","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.jid.2026.09.858_bib34","article-title":"Commensal Cutibacterium acnes-derived indolelactic acid safeguards skin barrier function through the aryl hydrocarbon receptor","volume":"7","author":"Zhang","year":"2026","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.jid.2026.09.858_bib35","article-title":"Neutrophils in generalized pustular psoriasis: key players in disease progression","author":"Zhang","year":"2025","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.jid.2026.09.858_bib36","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.jid.2019.11.022","article-title":"Aryl hydrocarbon receptor in cutaneous vascular endothelial cells restricts psoriasis development by negatively regulating neutrophil recruitment","volume":"140","author":"Zhu","year":"2020","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Investigative Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26037784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X26037784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:09:18Z","timestamp":1792213758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X26037784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":36,"alternative-id":["S0022202X26037784"],"URL":"https:\/\/doi.org\/10.1016\/j.jid.2026.09.858","relation":{},"ISSN":["0022-202X"],"issn-type":[{"value":"0022-202X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial AHR-APLNR signaling preserves vascular glycocalyx integrity and limits neutrophil-driven skin injury during local MRSA infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Investigative Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jid.2026.09.858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Society for Investigative Dermatology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}