{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:50:30Z","timestamp":1791341430850,"version":"4.3.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Health and Medical Research Council (NHMRC)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunological Methods"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.jim.2012.02.012","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T06:01:31Z","timestamp":1329804091000},"page":"1-14","source":"Crossref","is-referenced-by-count":141,"title":["New and improved methods for measuring lymphocyte proliferation in vitro and in vivo using CFSE-like fluorescent dyes"],"prefix":"10.1016","volume":"379","author":[{"given":"Benjamin J.C.","family":"Quah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Parish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jim.2012.02.012_bb0005","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1440-1711.1998.00709.x","article-title":"Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements","volume":"76","author":"Barnden","year":"1998","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.jim.2012.02.012_bb0010","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1074-7613(00)80605-6","article-title":"Helper T cell differentiation is controlled by the cell cycle","volume":"9","author":"Bird","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.jim.2012.02.012_bb0015","doi-asserted-by":"crossref","first-page":"9488","DOI":"10.1073\/pnas.95.16.9488","article-title":"Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation","volume":"95","author":"Gett","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jim.2012.02.012_bb0020","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/334676a0","article-title":"Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice","volume":"334","author":"Goodnow","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.jim.2012.02.012_bb0025","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.184.1.277","article-title":"B cell differentiation and isotype switching is related to division cycle number","volume":"184","author":"Hodgkin","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jim.2012.02.012_bb0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(94)90169-4","article-title":"T cell receptor antagonist peptides induce positive selection","volume":"76","author":"Hogquist","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.jim.2012.02.012_bb0035","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1182\/blood-2003-06-2070","article-title":"New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population","volume":"103","author":"Jedema","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jim.2012.02.012_bb0040","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1084\/jem.186.2.239","article-title":"Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells","volume":"186","author":"Kurts","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jim.2012.02.012_bb0045","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cellimm.2009.01.007","article-title":"Assessment of lymphocyte proliferation: CFSE kills dividing cells and modulates expression of activation markers","volume":"256","author":"Last'ovicka","year":"2009","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jim.2012.02.012_bb0050","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0022-1759(94)90236-4","article-title":"Determination of lymphocyte division by flow cytometry","volume":"171","author":"Lyons","year":"1994","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jim.2012.02.012_bb0055","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1155\/1993\/98015","article-title":"Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen","volume":"3","author":"Mamalaki","year":"1993","journal-title":"Dev. Immunol."},{"key":"10.1016\/j.jim.2012.02.012_bb0060","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.4049\/jimmunol.165.11.6047","article-title":"Tumor-specific CD4+ T cells have a major \u201cpost-licensing\u201d role in CTL mediated anti-tumor immunity","volume":"165","author":"Marzo","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jim.2012.02.012_bb0065","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1046\/j.1440-1711.1999.00869.x","article-title":"Analysis of growth kinetics by division tracking","volume":"77","author":"Nordon","year":"1999","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.jim.2012.02.012_bb0070","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/cyto.990090617","article-title":"Modified histogram subtraction technique for analysis of flow cytometry data","volume":"9","author":"Overton","year":"1988","journal-title":"Cytometry"},{"key":"10.1016\/j.jim.2012.02.012_bb0075","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1440-1711.1999.00877.x","article-title":"Fluorescent dyes for lymphocyte migration and proliferation studies","volume":"77","author":"Parish","year":"1999","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.jim.2012.02.012_bb0115","doi-asserted-by":"crossref","first-page":"4.9.1","DOI":"10.1002\/0471142735.im0409s84","article-title":"Use of the intracellular fluorescent dye CFSE to monitor lymphocyte migration and proliferation","volume":"84","author":"Parish","year":"2009","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.jim.2012.02.012_bb0085","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/342559a0","article-title":"Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen","volume":"342","author":"Pircher","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.jim.2012.02.012_bb0120","doi-asserted-by":"crossref","unstructured":"Quah, B.J., Parish, C.R., 2010. The use of carboxyfluorescein diacetate succini- midyl ester (CFSE) to monitor lymphocyte proliferation. J. Vis. Exp. (44), e2259. DOI:10.3791\/2259.","DOI":"10.3791\/2259"},{"key":"10.1016\/j.jim.2012.02.012_bb0090","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/intimm\/dxh060","article-title":"In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity","volume":"16","author":"Quah","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jim.2012.02.012_bb0105","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1038\/nprot.2007.296","article-title":"Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester","volume":"2","author":"Quah","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jim.2012.02.012_bb0095","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1073\/pnas.0800259105","article-title":"Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer","volume":"105","author":"Quah","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jim.2012.02.012_bb0110","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.4049\/jimmunol.178.3.1285","article-title":"An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cells","volume":"178","author":"Stambas","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jim.2012.02.012_bb0125","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0022-1759(90)90322-M","article-title":"New fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopy","volume":"133","author":"Weston","year":"1990","journal-title":"J. Immunol. Methods"}],"container-title":["Journal of Immunological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175912000476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175912000476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T19:43:07Z","timestamp":1593718987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022175912000476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":23,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0022175912000476"],"URL":"https:\/\/doi.org\/10.1016\/j.jim.2012.02.012","relation":{},"ISSN":["0022-1759"],"issn-type":[{"value":"0022-1759","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}