{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:04:27Z","timestamp":1791309867803,"version":"4.3.1"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunological Methods"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.jim.2014.03.002","type":"journal-article","created":{"date-parts":[[2014,3,15]],"date-time":"2014-03-15T01:16:12Z","timestamp":1394846172000},"page":"39-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Mouse models of hepatitis B and delta virus infection"],"prefix":"10.1016","volume":"410","author":[{"given":"Maura","family":"Dandri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"L\u00fctgehetmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl.1","key":"10.1016\/j.jim.2014.03.002_bb0005","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1016\/S0168-8278(13)60129-4","article-title":"Proliferation of hepatitis B virus infected human hepatocytes induces suppression of viral replication and rapid cccDNA decrease in humanized mice. April 2013","volume":"58","author":"Allweiss","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jim.2014.03.002_bb0010","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jhep.2013.10.021","article-title":"Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration","volume":"60","author":"Allweiss","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jim.2014.03.002_bb0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1073\/pnas.86.1.207","article-title":"Expression and replication of hepatitis B virus genome in transgenic mice","volume":"86","author":"Araki","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jim.2014.03.002_bb0020","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nbt1326","article-title":"Robust expansion of human hepatocytes in Fah\u2212\/\u2212\/Rag2\u2212\/\u2212\/Il2rg\u2212\/\u2212 mice","volume":"25","author":"Azuma","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jim.2014.03.002_bb0025","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hep.20553","article-title":"Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary tupaia hepatocytes","volume":"41","author":"Baumert","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0030","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1172\/JCI58847","article-title":"IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome","volume":"122","author":"Belloni","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jim.2014.03.002_bb0035","doi-asserted-by":"crossref","first-page":"20507","DOI":"10.1073\/pnas.0710528105","article-title":"Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model","volume":"104","author":"Bissig","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jim.2014.03.002_bb0040","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1172\/JCI40094","article-title":"Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment","volume":"120","author":"Bissig","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jim.2014.03.002_bb0045","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/hep.510310231","article-title":"Reduced hepatitis B virus surface antigen-specific Th1 helper cell frequency of chronic HBV carriers is associated with a failure to produce antigen-specific antibodies in the trimera mouse [in process citation]","volume":"31","author":"Bocher","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0050","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI17704","article-title":"In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus","volume":"112","author":"Bordier","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jim.2014.03.002_bb0060","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3727\/096368908786516800","article-title":"Rescue of fertility in homozygous mice for the urokinase plasminogen activator transgene by the transplantation of mouse hepatocytes","volume":"17","author":"Brezillon","year":"2008","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jim.2014.03.002_bb0055","doi-asserted-by":"crossref","first-page":"e25096","DOI":"10.1371\/journal.pone.0025096","article-title":"Antiviral activity of Bay 41-4109 on hepatitis B virus in humanized Alb-uPA\/SCID mice","volume":"6","author":"Brezillon","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jim.2014.03.002_bb0065","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1128\/JVI.75.7.3469-3473.2001","article-title":"Replication of the human hepatitis delta virus genome Is initiated in mouse hepatocytes following intravenous injection of naked DNA or RNA sequences","volume":"75","author":"Chang","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0070","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.3865369","article-title":"A transgenic mouse model of the chronic hepatitis B surface antigen carrier state","volume":"230","author":"Chisari","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.jim.2014.03.002_bb0090","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jhep.2011.05.037","article-title":"Chimeric mouse model of hepatitis B virus infection","volume":"56","author":"Dandri","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jim.2014.03.002_bb0095","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1128\/JVI.70.8.5246-5254.1996","article-title":"Woodchuck hepatitis virus X protein is present in chronically infected woodchuck liver and woodchuck hepatocellular carcinomas which are permissive for viral replication","volume":"70","author":"Dandri","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0075","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1053\/jhep.2001.28189","article-title":"Woodchuck hepatocytes remain permissive for hepadnavirus infection and mouse liver repopulation after cryopreservation","volume":"34","author":"Dandri","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0080","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1053\/jhep.2001.23314","article-title":"Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus","volume":"33","author":"Dandri","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0085","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jhep.2004.09.021","article-title":"Chronic infection with hepatitis B viruses and antiviral drug evaluation in uPA mice after liver repopulation with tupaia hepatocytes","volume":"42","author":"Dandri","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jim.2014.03.002_bb0100","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1053\/j.gastro.2011.05.001","article-title":"5\u2032 Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice","volume":"141","author":"Ebert","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jim.2014.03.002_bb0105","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1053\/jhep.2000.9632","article-title":"Preclinical evaluation of two human anti-hepatitis B virus (HBV) monoclonal antibodies in the HBV-trimera mouse model and in HBV chronic carrier chimpanzees","volume":"32","author":"Eren","year":"2000","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jim.2014.03.002_bb0110","first-page":"538","article-title":"Persistent hepatitis D virus mono-infection in humanized mice is efficiently converted by hepatitis B virus to a productive co-infection","volume":"60","author":"Giersch","year":"2014","journal-title":"J Hepatol. 2014 Mar"},{"key":"10.1016\/j.jim.2014.03.002_bb0115","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1101\/gad.7.12a.2298","article-title":"Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice","volume":"7","author":"Grompe","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/j.jim.2014.03.002_bb0120","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.pathol.1.110304.100230","article-title":"Immunobiology and pathogenesis of viral hepatitis","volume":"1","author":"Guidotti","year":"2006","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jim.2014.03.002_bb0125","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1128\/JVI.68.3.1265-1270.1994","article-title":"Interleukin-2 and alpha\/beta interferon down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor-dependent and -independent pathways","volume":"68","author":"Guidotti","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0140","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1128\/JVI.69.10.6158-6169.1995","article-title":"High-level hepatitis B virus replication in transgenic mice","volume":"69","author":"Guidotti","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1074-7613(00)80295-2","article-title":"Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes","volume":"4","author":"Guidotti","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.jim.2014.03.002_bb0135","doi-asserted-by":"crossref","first-page":"7056","DOI":"10.1128\/JVI.70.10.7056-7061.1996","article-title":"The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice","volume":"70","author":"Guidotti","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0145","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1126\/science.284.5415.825","article-title":"Viral clearance without destruction of infected cells during acute HBV infection","volume":"284","author":"Guidotti","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jim.2014.03.002_bb0150","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ajpath.2013.09.008","article-title":"Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice","volume":"184","author":"Gutti","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jim.2014.03.002_bb0155","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.bbrc.2011.01.042","article-title":"The reconstituted \u2018humanized liver\u2019 in TK-NOG mice is mature and functional","volume":"405","author":"Hasegawa","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jim.2014.03.002_bb0160","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1128\/JVI.73.1.474-481.1999","article-title":"Hepatitis B virus RNA-binding proteins associated with cytokine-induced clearance of viral RNA from the liver of transgenic mice","volume":"73","author":"Heise","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0165","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jhep.2009.09.002","article-title":"Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice","volume":"51","author":"Hiraga","year":"2009","journal-title":"J. Hepatol."},{"issue":"9785","key":"10.1016\/j.jim.2014.03.002_bb0170","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0140-6736(10)61931-9","article-title":"Hepatitis delta virus","volume":"378","author":"Hughes","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jim.2014.03.002_bb0175","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/hep.510290228","article-title":"The hepatitis B virus-trimera mouse: a model for human HBV infection and evaluation of anti-HBV therapeutic agents","volume":"29","author":"Ilan","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0180","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.virol.2005.01.004","article-title":"Differential dynamics of the peripheral and intrahepatic cytotoxic T lymphocyte response to hepatitis B surface antigen","volume":"333","author":"Isogawa","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.jim.2014.03.002_bb0190","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0166-3542(01)00223-6","article-title":"Characterizing antiviral activity of adefovir dipivoxil in transgenic mice expressing hepatitis B virus","volume":"55","author":"Julander","year":"2002","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jim.2014.03.002_bb0185","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0166-3542(03)00109-8","article-title":"Characterization of antiviral activity of entecavir in transgenic mice expressing hepatitis B virus","volume":"59","author":"Julander","year":"2003","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jim.2014.03.002_bb0195","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/jps.20783","article-title":"In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver","volume":"96","author":"Katoh","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jim.2014.03.002_bb0200","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/351317a0","article-title":"HBx gene of hepatitis B virus induces liver cancer in transgenic mice","volume":"351","author":"Kim","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.jim.2014.03.002_bb0205","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0016-5085(03)00720-0","article-title":"Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA","volume":"125","author":"Klein","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jim.2014.03.002_bb0210","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbrc.2013.10.040","article-title":"A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections","volume":"441","author":"Kosaka","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jim.2014.03.002_bb0215","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nm1698","article-title":"Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge","volume":"14","author":"Law","year":"2008","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.jim.2014.03.002_bb0220","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/cmi.2013.66","article-title":"HBV life cycle is restricted in mouse hepatocytes expressing human NTCP","volume":"11","author":"Li","year":"2014","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.jim.2014.03.002_bb0225","doi-asserted-by":"crossref","first-page":"9340","DOI":"10.1073\/pnas.1004762107","article-title":"Hepatitis B virus core antigen determines viral persistence in a C57BL\/6 mouse model","volume":"107","author":"Lin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jim.2014.03.002_bb0240","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/hep.23611","article-title":"In vivo proliferation of hepadnavirus-infected hepatocytes induces loss of covalently closed circular DNA in mice","volume":"52","author":"Lutgehetmann","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0230","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1053\/j.gastro.2011.02.057","article-title":"Hepatitis B virus limits response of human hepatocytes to interferon-alpha in chimeric mice","volume":"140","author":"Lutgehetmann","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jim.2014.03.002_bb0235","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/hep.24758","article-title":"Humanized chimeric uPA mouse model for the study of hepatitis B and D virus interactions and preclinical drug evaluation","volume":"55","author":"Lutgehetmann","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0255","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1128\/JVI.36.3.829-836.1980","article-title":"Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus","volume":"36","author":"Mason","year":"1980","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0245","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1073\/pnas.79.13.3997","article-title":"Asymmetric replication of duck hepatitis B virus DNA in liver cells: free minus-strand DNA","volume":"79","author":"Mason","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jim.2014.03.002_bb0250","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1073\/pnas.0409332102","article-title":"Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection","volume":"102","author":"Mason","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jim.2014.03.002_bb0260","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nbt824","article-title":"Inhibition of hepatitis B virus in mice by RNA interference","volume":"21","author":"McCaffrey","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jim.2014.03.002_bb0265","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jhep.2011.06.016","article-title":"Rapid early HDV RNA decline in the peripheral blood but prolonged intrahepatic hepatitis delta antigen persistence after liver transplantation","volume":"56","author":"Mederacke","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jim.2014.03.002_bb0270","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/90968","article-title":"Hepatitis C virus replication in mice with chimeric human livers","volume":"7","author":"Mercer","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.jim.2014.03.002_bb0280","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.antiviral.2008.07.006","article-title":"The human liver-uPA-SCID mouse: a model for the evaluation of antiviral compounds against HBV and HCV","volume":"80","author":"Meuleman","year":"2008","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jim.2014.03.002_bb0275","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/hep.24692","article-title":"A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo","volume":"55","author":"Meuleman","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0285","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1126\/science.1691527","article-title":"Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice","volume":"248","author":"Moriyama","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.jim.2014.03.002_bb0290","doi-asserted-by":"crossref","first-page":"e59611","DOI":"10.1371\/journal.pone.0059611","article-title":"Targeted induction of interferon-lambda in humanized chimeric mouse liver abrogates hepatotropic virus infection","volume":"8","author":"Nakagawa","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jim.2014.03.002_bb0295","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.virusres.2007.12.024","article-title":"Hepatitis B viruses: reverse transcription a different way","volume":"134","author":"Nassal","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.jim.2014.03.002_bb0300","article-title":"Cyclosporin A inhibits hepatitis B and hepatitis D virus entry by cyclophilin-independent interference with the NTCP receptor","author":"Nkongolo","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jim.2014.03.002_bb0305","first-page":"3226","article-title":"Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice","volume":"119","author":"Ohira","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jim.2014.03.002_bb0310","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1053\/j.gastro.2013.10.056","article-title":"Hepatitis virus infection affects DNA methylation in mice with humanized livers","volume":"146","author":"Okamoto","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jim.2014.03.002_bb0315","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/hep.25651","article-title":"Severe necroinflammatory reaction caused by natural killer cell-mediated Fas\/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse","volume":"56","author":"Okazaki","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0320","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1073\/pnas.95.1.310","article-title":"Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma","volume":"95","author":"Petersen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jim.2014.03.002_bb0325","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nbt1389","article-title":"Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein","volume":"26","author":"Petersen","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jim.2014.03.002_bb0330","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1128\/JVI.75.6.2900-2911.2001","article-title":"Nuclear covalently closed circular viral genomic DNA in the liver of hepatocyte nuclear factor 1 alpha-null hepatitis B virus transgenic mice","volume":"75","author":"Raney","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0335","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1126\/science.8108734","article-title":"Replacement of diseased mouse liver by hepatic cell transplantation","volume":"263","author":"Rhim","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jim.2014.03.002_bb0340","doi-asserted-by":"crossref","first-page":"4942","DOI":"10.1073\/pnas.92.11.4942","article-title":"Complete reconstitution of mouse liver with xenogeneic hepatocytes","volume":"92","author":"Rhim","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jim.2014.03.002_bb0345","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jhep.2009.01.004","article-title":"Hepatitis D: thirty years after","volume":"50","author":"Rizzetto","year":"2009","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jim.2014.03.002_bb0350","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000150418","article-title":"The woodchuck: an animal model for hepatitis B virus infection in man","volume":"38","author":"Roggendorf","year":"1995","journal-title":"Intervirology"},{"key":"10.1016\/j.jim.2014.03.002_bb0355","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/hep.1840210211","article-title":"Long-term clinical and virological outcome after liver transplantation for cirrhosis caused by chronic delta hepatitis","volume":"21","author":"Samuel","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0360","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(91)90615-6","article-title":"Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene","volume":"66","author":"Sandgren","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jim.2014.03.002_bb0365","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1172\/JCI200421087","article-title":"MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs","volume":"113","author":"Sitia","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jim.2014.03.002_bb0370","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1098-2744(199604)15:4<261::AID-MC3>3.0.CO;2-J","article-title":"Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene","volume":"15","author":"Slagle","year":"1996","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.jim.2014.03.002_bb0375","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.2353\/ajpath.2009.090349","article-title":"A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation","volume":"175","author":"Song","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jim.2014.03.002_bb0380","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1128\/JVI.75.11.5108-5118.2001","article-title":"Transfer of hepatitis B virus genome by adenovirus vectors into cultured cells and mice: crossing the species barrier","volume":"75","author":"Sprinzl","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0385","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1073\/pnas.0307422100","article-title":"Residual integrated viral DNA after hepadnavirus clearance by nucleoside analog therapy","volume":"101","author":"Summers","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jim.2014.03.002_bb0390","first-page":"113","article-title":"The role of the HBV envelope proteins in the HDV replication cycle","volume":"307","author":"Sureau","year":"2006","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.jim.2014.03.002_bb0395","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0002-9440(10)63352-4","article-title":"Near completely humanized liver in mice shows human-type metabolic responses to drugs","volume":"165","author":"Tateno","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jim.2014.03.002_bb0400","doi-asserted-by":"crossref","first-page":"e77298","DOI":"10.1371\/journal.pone.0077298","article-title":"Chimeric mouse model for the infection of hepatitis B and C viruses","volume":"8","author":"Tesfaye","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jim.2014.03.002_bb0410","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/hep.20892","article-title":"Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis B virus","volume":"42","author":"Tsuge","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0405","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1099\/vir.0.019224-0","article-title":"HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice","volume":"91","author":"Tsuge","year":"2010","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0420","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3851\/IMP2075","article-title":"Strong antiviral activity of the new l-hydroxycytidine derivative, l-Hyd4FC, in HBV-infected human chimeric uPA\/SCID mice","volume":"17","author":"Volz","year":"2012","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.jim.2014.03.002_bb0415","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jhep.2012.12.008","article-title":"The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus","volume":"58","author":"Volz","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jim.2014.03.002_bb0425","first-page":"153","article-title":"The tupaia model for the study of hepatitis B virus: direct infection and HBV genome transduction of primary tupaia hepatocytes","volume":"96","author":"von Weizsacker","year":"2004","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.jim.2014.03.002_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.510240101","article-title":"Hepatitis B virus infection of tupaia hepatocytes in vitro and in vivo","volume":"24","author":"Walter","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.jim.2014.03.002_bb0435","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1053\/j.gastro.2011.01.001","article-title":"A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease","volume":"140","author":"Washburn","year":"2011","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jim.2014.03.002_bb0440","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/gutjnl-2013-304713","article-title":"Anti-tumour necrosis factor agents reduce non-steroidal anti-inflammatory drug-induced small bowel injury in rheumatoid arthritis patients","volume":"63","author":"Watanabe","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.jim.2014.03.002_bb0445","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0166-3542(01)00216-9","article-title":"Inhibition of human hepatitis B virus (HBV) by a novel non-nucleosidic compound in a transgenic mouse model","volume":"54","author":"Weber","year":"2002","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jim.2014.03.002_bb0450","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1128\/JVI.77.2.1227-1236.2003","article-title":"Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes","volume":"77","author":"Wieland","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0460","doi-asserted-by":"crossref","first-page":"e00049","DOI":"10.7554\/eLife.00049","article-title":"Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus","volume":"1","author":"Yan","year":"2012","journal-title":"eLife"},{"key":"10.1016\/j.jim.2014.03.002_bb0455","doi-asserted-by":"crossref","first-page":"7977","DOI":"10.1128\/JVI.03540-12","article-title":"Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholate cotransporting polypeptide","volume":"87","author":"Yan","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2014.03.002_bb0465","doi-asserted-by":"crossref","first-page":"13825","DOI":"10.1073\/pnas.202398599","article-title":"Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection","volume":"99","author":"Yang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jim.2014.03.002_bb0470","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1128\/JVI.68.3.2026-2030.1994","article-title":"Woodchuck hepatitis virus X protein is required for viral infection in vivo","volume":"68","author":"Zoulim","year":"1994","journal-title":"J. Virol."}],"container-title":["Journal of Immunological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175914000763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175914000763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T02:12:03Z","timestamp":1746151923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022175914000763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":94,"alternative-id":["S0022175914000763"],"URL":"https:\/\/doi.org\/10.1016\/j.jim.2014.03.002","relation":{},"ISSN":["0022-1759"],"issn-type":[{"value":"0022-1759","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mouse models of hepatitis B and delta virus infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Immunological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jim.2014.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}