{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:46:38Z","timestamp":1791269198827,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Medicine"},{"name":"University Medical Center Hamburg-Eppendorf, Germany"},{"name":"Deutsche Forschungsgemeinschaft (DFG)","award":["LU1362\/2-1 581069"],"award-info":[{"award-number":["LU1362\/2-1 581069"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunological Methods"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.jim.2014.10.011","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T06:10:45Z","timestamp":1414649445000},"page":"82-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["CMV specific cytokine release assay in whole blood is optimized by combining synthetic CMV peptides and toll like receptor agonists"],"prefix":"10.1016","volume":"414","author":[{"given":"Werner","family":"Dammermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bochmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bentzien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Komorowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Steinhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Ullrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"van Lunzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"L\u00fcth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jim.2014.10.011_bb0010","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1128\/JCM.00563-13","article-title":"Comparison of cytomegalovirus (CMV) enzyme-linked immunosorbent spot and CMV quantifer on gamma interferon-releasing assays in assessing risk of CMV infection in kidney transplant recipients","volume":"51","author":"Abate","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jim.2014.10.011_bb0005","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jviromet.2013.10.036","article-title":"Optimization of interferon gamma ELISPOT assay to detect human cytomegalovirus specific T-cell responses in solid organ transplants","volume":"196","author":"Abate","year":"2013","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.jim.2014.10.011_bb0015","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/ejh.12187","article-title":"Rapid monitoring of immune reconstitution after allogeneic stem cell transplantation\u2014a comparison of different assays for the detection of cytomegalovirus-specific T cells","volume":"91","author":"Abu-Khader","year":"2013","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.jim.2014.10.011_bb0020","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/CMR.18.3.484-509.2005","article-title":"Diagnosis of lyme borreliosis","volume":"18","author":"Aguero-Rosenfeld","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jim.2014.10.011_bb0025","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1515\/jom-1991-910610","article-title":"Lyme borreliosis: detecting the great imitator","volume":"91","author":"Burdash","year":"1991","journal-title":"J. Am. Osteopath. Assoc."},{"key":"10.1016\/j.jim.2014.10.011_bb0030","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/1479-5876-9-143","article-title":"A whole blood monokine-based reporter assay provides a sensitive and robust measurement of the antigen-specific T cell response","volume":"9","author":"Chakera","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jim.2014.10.011_bb0035","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1128\/CVI.05633-11","article-title":"Performance of the QuantiFERON-cytomegalovirus (CMV) assay for detection and estimation of the magnitude and functionality of the CMV-specific gamma interferon-producing CD8(+) T-cell response in allogeneic stem cell transplant recipients","volume":"19","author":"Clari","year":"2012","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.jim.2014.10.011_bb0040","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jim.2013.08.004","article-title":"Toll like receptor 2 agonists lipoteichoic acid and peptidoglycan are able to enhance antigen specific IFNgamma release in whole blood during recall antigen responses","volume":"396","author":"Dammermann","year":"2013","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jim.2014.10.011_bb0045","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/jmv.21727","article-title":"Ex vivo monitoring of human cytomegalovirus-specific CD8(+) T-cell responses using the QuantiFERON-CMV assay in allogeneic hematopoietic stem cell transplant recipients attending an Irish hospital","volume":"82","author":"Fleming","year":"2010","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jim.2014.10.011_bb0050","doi-asserted-by":"crossref","first-page":"e48027","DOI":"10.1371\/journal.pone.0048027","article-title":"In vitro immunomodulation of a whole blood IFN-gamma release assay enhances T cell responses in subjects with latent tuberculosis infection","volume":"7","author":"Gaur","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jim.2014.10.011_bb0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000111505","article-title":"Immunoblot analysis of the seroreactivity to recombinant Borrelia burgdorferi sensu lato antigens, including VlsE, in the long-term course of treated patients with erythema migrans","volume":"216","author":"Glatz","year":"2008","journal-title":"Dermatology"},{"key":"10.1016\/j.jim.2014.10.011_bb0060","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF02561539","article-title":"Epstein\u2013Barr virus and cytomegalovirus infections cause false-positive results in IgM two-test protocol for early Lyme borreliosis","volume":"27","author":"Goossens","year":"1999","journal-title":"Infection"},{"key":"10.1016\/j.jim.2014.10.011_bb0065","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/TP.0b013e31829df29d","article-title":"Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation","volume":"96","author":"Kotton","year":"2013","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.jim.2014.10.011_bb0070","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.eimc.2009.05.012","article-title":"Interferon gamma release assays: principles and practice","volume":"28","author":"Lalvani","year":"2010","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"10.1016\/j.jim.2014.10.011_bb0075","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/TP.0b013e31823c1cd4","article-title":"Clinical utility of cytomegalovirus cell-mediated immunity in transplant recipients with cytomegalovirus viremia","volume":"93","author":"Lisboa","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.jim.2014.10.011_bb0080","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1600-0625.2007.00592.x","article-title":"Enzyme-linked immunosorbent assay using multimers of the 16th non-collagenous domain of the BP180 antigen for sensitive and specific detection of pemphigoid autoantibodies","volume":"16","author":"Sitaru","year":"2007","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jim.2014.10.011_bb0085","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1086\/589242","article-title":"Prospective study of serologic tests for lyme disease","volume":"47","author":"Steere","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jim.2014.10.011_bb0090","first-page":"443","article-title":"Sensitivity and specificity of a gamma interferon blood test for tuberculosis infection","volume":"2","author":"Streeton","year":"1998","journal-title":"Int. J. Tuber. Lung Dis."},{"key":"10.1016\/j.jim.2014.10.011_bb0095","doi-asserted-by":"crossref","first-page":"e74744","DOI":"10.1371\/journal.pone.0074744","article-title":"Clinical assessment of anti-viral CD8+ T cell immune monitoring using QuantiFERON-CMV(R) assay to identify high risk allogeneic hematopoietic stem cell transplant patients with CMV infection complications","volume":"8","author":"Tey","year":"2013","journal-title":"PLoS One"},{"issue":"Suppl. 2","key":"10.1016\/j.jim.2014.10.011_bb0100","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1007\/s15010-013-0504-1","article-title":"Therapy and prophylaxis of opportunistic infections in HIV-infected patients: a guideline by the German and Austrian AIDS societies (DAIG\/OAG) (AWMF 055\/066)","volume":"41","author":"Thoden","year":"2013","journal-title":"Infection"},{"key":"10.1016\/j.jim.2014.10.011_bb0105","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1086\/590934","article-title":"Immunocompromised hosts: perspectives in the treatment and prophylaxis of cytomegalovirus disease in solid-organ transplant recipients","volume":"47","author":"Torres-Madriz","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jim.2014.10.011_bb0110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1399-3062.2006.00199.x","article-title":"Ex vivo monitoring of human cytomegalovirus-specific CD8+ T-cell responses using QuantiFERON-CMV","volume":"9","author":"Walker","year":"2007","journal-title":"Transpl. Infect. Dis."},{"key":"10.1016\/j.jim.2014.10.011_bb0115","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/cei.12123","article-title":"Association of human cytomegalovirus DNAaemia and specific granzyme B responses in lung transplant recipients","volume":"173","author":"Weseslindtner","year":"2013","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jim.2014.10.011_bb0120","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1111\/j.1600-6143.2008.02294.x","article-title":"Linking CMV serostatus to episodes of CMV reactivation following lung transplantation by measuring CMV-specific CD8+ T-cell immunity","volume":"8","author":"Westall","year":"2008","journal-title":"Am. J. Transplant."}],"container-title":["Journal of Immunological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002217591400297X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002217591400297X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T18:44:46Z","timestamp":1650480286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002217591400297X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":24,"alternative-id":["S002217591400297X"],"URL":"https:\/\/doi.org\/10.1016\/j.jim.2014.10.011","relation":{},"ISSN":["0022-1759"],"issn-type":[{"value":"0022-1759","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CMV specific cytokine release assay in whole blood is optimized by combining synthetic CMV peptides and toll like receptor agonists","name":"articletitle","label":"Article Title"},{"value":"Journal of Immunological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jim.2014.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}