{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:31:06Z","timestamp":1769117466945,"version":"3.49.0"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nationalarchives.gov.uk\/doc\/open-government-licence\/version\/3\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunological Methods"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.jim.2017.03.007","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T09:33:52Z","timestamp":1489138432000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Establishment of the first WHO International Standard for etanercept, a TNF receptor II Fc fusion protein: Report of an international collaborative study"],"prefix":"10.1016","volume":"447","author":[{"given":"Meenu","family":"Wadhwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Bird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Dilger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Rigsby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Emmanuelle Behr","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jim.2017.03.007_bb0005","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cyto.2008.11.008","article-title":"Differences in binding and effector functions between classes of TNF antagonists","volume":"45","author":"Arora","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.jim.2017.03.007_bb0010","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00296-014-3080-5","article-title":"Etanercept biosimilars","volume":"35","author":"Azevedo","year":"2015","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.jim.2017.03.007_bb0015","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/1043-4666(94)90049-3","article-title":"TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells","volume":"6","author":"Butler","year":"1994","journal-title":"Cytokine"},{"key":"10.1016\/j.jim.2017.03.007_bb0025","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.1016\/mjd.2003.554","article-title":"Etanercept: an overview","volume":"49","author":"Goffe","year":"2003","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jim.2017.03.007_bb0030","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2307\/2529472","article-title":"Predicting the stability of biological standards and products","volume":"33","author":"Kirkwood","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.jim.2017.03.007_bb0035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jim.2011.08.022","article-title":"Reporter gene assay for the quantification of the activity and neutralizing antibody response to TNF\u03b1 antagonists","volume":"373","author":"Lallemand","year":"2011","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jim.2017.03.007_bb0040","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0022-1759(91)90239-C","article-title":"Acytotoxicity assay for tumor necrosis factor using a human rhabdomyosarcoma cell line","volume":"144","author":"Meager","year":"1991","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jim.2017.03.007_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-1759(94)90240-2","article-title":"International collaborative study of the candidate international standards for human tumour necrosis factors alpha (hTNF-\u03b1) and beta (hTNF-\u03b2) and for murine tumour necrosis factor alpha (mTNF-\u03b1)","volume":"170","author":"Meager","year":"1994","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jim.2017.03.007_bb0050","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.leukres.2010.07.040","article-title":"Proteomic differentiation pattern in the U937 cell line","volume":"35","author":"Minafra","year":"2011","journal-title":"Leuk. Res."},{"key":"10.1016\/j.jim.2017.03.007_bb0055","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.4049\/jimmunol.151.3.1548","article-title":"Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists","volume":"151","author":"Mohler","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.jim.2017.03.007_bb0060","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1056\/NEJM199707173370301","article-title":"Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein","volume":"337","author":"Moreland","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jim.2017.03.007_bb0065","doi-asserted-by":"crossref","first-page":"761","DOI":"10.4161\/mabs.22276","article-title":"Characterization and comparison of commercially available TNF receptor 2-Fc fusion protein products","volume":"4","author":"Tan","year":"2012","journal-title":"MAbs"},{"key":"10.1016\/j.jim.2017.03.007_bb0070","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","article-title":"Caspases: enemies within","volume":"281","author":"Thornberry","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jim.2017.03.007_bb0075","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.pharmthera.2007.10.001","article-title":"Tumor necrosis factor antagonist mechanisms of action: a comprehensive review","volume":"117","author":"Tracey","year":"2008","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jim.2017.03.007_bb0080","series-title":"Report on a Collaborative Study for Proposed 3rd International Standard for Tumor Necrosis Factor-alpha, TNF-\u03b1","author":"Wadhwa","year":"2013"}],"container-title":["Journal of Immunological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175916303891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175916303891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:37:51Z","timestamp":1692718671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022175916303891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":15,"alternative-id":["S0022175916303891"],"URL":"https:\/\/doi.org\/10.1016\/j.jim.2017.03.007","relation":{},"ISSN":["0022-1759"],"issn-type":[{"value":"0022-1759","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Establishment of the first WHO International Standard for etanercept, a TNF receptor II Fc fusion protein: Report of an international collaborative study","name":"articletitle","label":"Article Title"},{"value":"Journal of Immunological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jim.2017.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}