{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:29:13Z","timestamp":1762205353998,"version":"build-2065373602"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T00:00:00Z","timestamp":1566691200000},"content-version":"am","delay-in-days":328,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunological Methods"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.jim.2018.06.007","type":"journal-article","created":{"date-parts":[[2018,6,9]],"date-time":"2018-06-09T10:41:56Z","timestamp":1528540916000},"page":"63-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Measuring type I interferon using reporter gene assays based on readily available cell lines"],"prefix":"10.1016","volume":"461","author":[{"given":"Phyllis A.","family":"Rees","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Joel","family":"Lowy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jim.2018.06.007_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105385","article-title":"Early activation of MAP kinases by influenza a virus X-31 in murine macrophage cell lines","volume":"9","author":"Cannon","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jim.2018.06.007_bb0010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0022-1759(96)00168-8","article-title":"A highly precise reporter gene bioassay for type I interferon","volume":"199","author":"Canosi","year":"1996","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"10.1016\/j.jim.2018.06.007_bb0015","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1128\/jcm.9.4.471-475.1979","article-title":"Assay of human interferon in Vero cells by several methods","volume":"9","author":"Ferreira","year":"1979","journal-title":"J. Clin. Microbiol."},{"author":"InvivoGen","key":"10.1016\/j.jim.2018.06.007_bb0020"},{"issue":"927","key":"10.1016\/j.jim.2018.06.007_bb0025","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1098\/rspb.1957.0048","article-title":"Virus interference. I. The interferon","volume":"147","author":"Isaacs","year":"1957","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"issue":"1","key":"10.1016\/j.jim.2018.06.007_bb0030","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jim.2018.06.007_bb0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.imlet.2012.08.006","article-title":"Cationic influenza virosomes as an adjuvanted delivery system for CTL induction by DNA vaccination","volume":"148","author":"Jamali","year":"2012","journal-title":"Immunol. Lett."},{"issue":"2\u20133","key":"10.1016\/j.jim.2018.06.007_bb0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1359-6101(00)00026-5","article-title":"Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression","volume":"12","author":"Julkunen","year":"2001","journal-title":"Cytokine Growth Factor Rev."},{"issue":"9","key":"10.1016\/j.jim.2018.06.007_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073840","article-title":"Toll-like receptor 4-mediated nuclear factor kappa B activation is essential for sensing exogenous oxidants to propagate and maintain oxidative\/nitrosative cellular stress","volume":"8","author":"Karki","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jim.2018.06.007_bb0050","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.freeradbiomed.2014.03.005","article-title":"Activation of c-Src: a hub for exogenous pro-oxidant-mediated activation of Toll-like receptor 4 signaling","volume":"71","author":"Karki","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.jim.2018.06.007_bb0055","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.molimm.2014.11.017","article-title":"Z-100, extracted from Mycobacterium tuberculosis strain Aoyama B, promotes TNF-alpha production via nucleotide-binding oligomerization domain containing 2 (Nod2)-dependent NF-kappaB activation in RAW264.7 cells","volume":"64","author":"Katsunuma","year":"2015","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.jim.2018.06.007_bb0060","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0166-0934(01)00316-0","article-title":"Improvements in methods for calculating virus titer estimates from TCID50 and plaque assays","volume":"96","author":"Labarre","year":"2001","journal-title":"J. Virol. Methods"},{"issue":"1","key":"10.1016\/j.jim.2018.06.007_bb0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0022-1759(95)00100-O","article-title":"A sensitive biological assay for interferons","volume":"185","author":"Lewis","year":"1995","journal-title":"J. Immunol. Methods"},{"issue":"1\u20132","key":"10.1016\/j.jim.2018.06.007_bb0070","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jim.2011.09.015","article-title":"Development and validation of a cell-based SEAP reporter assay for the detection of neutralizing antibodies against an anti-IL-13 therapeutic antibody","volume":"375","author":"Liao","year":"2012","journal-title":"J. Immunol. Methods"},{"issue":"11","key":"10.1016\/j.jim.2018.06.007_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049049","article-title":"Identification of small molecules with type I interferon inducing properties by high-throughput screening","volume":"7","author":"Martinez-Gil","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jim.2018.06.007_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JVI.01417-16","article-title":"Influenza virus overcomes cellular blocks to productively replicate, impacting macrophage function","volume":"91","author":"Marvin","year":"2017","journal-title":"J. Virol."},{"issue":"1\u20132","key":"10.1016\/j.jim.2018.06.007_bb0085","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0022-1759(01)00570-1","article-title":"Biological assays for interferons","volume":"261","author":"Meager","year":"2002","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"10.1016\/j.jim.2018.06.007_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002668","article-title":"A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon","volume":"8","author":"Ortigoza","year":"2012","journal-title":"PLoS Pathog."},{"issue":"5","key":"10.1016\/j.jim.2018.06.007_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036594","article-title":"High throughput screening for small molecule enhancers of the interferon signaling pathway to drive next-generation antiviral drug discovery","volume":"7","author":"Patel","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jim.2018.06.007_bb0100","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/1087057113496848","article-title":"High-throughput screening normalized to biological response: application to antiviral drug discovery","volume":"19","author":"Patel","year":"2014","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.jim.2018.06.007_bb0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2004.00204.x","article-title":"Interferons, interferon-like cytokines, and their receptors","volume":"202","author":"Pestka","year":"2004","journal-title":"Immunol. Rev."},{"issue":"1\u20132","key":"10.1016\/j.jim.2018.06.007_bb0110","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jim.2008.01.011","article-title":"A novel reporter gene assay for interferons based on CHO-K1 cells","volume":"333","author":"Smilovic","year":"2008","journal-title":"J. Immunol. Methods"},{"issue":"6","key":"10.1016\/j.jim.2018.06.007_bb0115","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1462-5822.2006.00716.x","article-title":"Interferon signalling network in innate defence","volume":"8","author":"Takaoka","year":"2006","journal-title":"Cell. Microbiol."},{"issue":"10","key":"10.1016\/j.jim.2018.06.007_bb0120","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1084\/jem.20101664","article-title":"Type I interferon: friend or foe?","volume":"207","author":"Trinchieri","year":"2010","journal-title":"J. Exp. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.jim.2018.06.007_bb0125","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1093\/infdis\/jiv070","article-title":"Cancer immunity: lessons from infectious diseases","volume":"212","author":"Trinchieri","year":"2015","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.jim.2018.06.007_bb0130","article-title":"Innate immune response of human alveolar macrophages during influenza A infection","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jim.2018.06.007_bb0135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1600-065X.2008.00698.x","article-title":"Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha\/beta, IFN-gamma, and IFN-lambda in host defense","volume":"226","author":"Zhang","year":"2008","journal-title":"Immunol. Rev."}],"container-title":["Journal of Immunological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175918300358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175918300358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:26:32Z","timestamp":1762205192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022175918300358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":27,"alternative-id":["S0022175918300358"],"URL":"https:\/\/doi.org\/10.1016\/j.jim.2018.06.007","relation":{},"ISSN":["0022-1759"],"issn-type":[{"type":"print","value":"0022-1759"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Measuring type I interferon using reporter gene assays based on readily available cell lines","name":"articletitle","label":"Article Title"},{"value":"Journal of Immunological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jim.2018.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}