{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:23:50Z","timestamp":1769153030877,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2020C03066"],"award-info":[{"award-number":["2020C03066"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunological Methods"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jim.2021.113179","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T19:17:14Z","timestamp":1635621434000},"page":"113179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Development of a time-resolved fluorescence immunoassay based on immunomagnetic beads for gastrin-17"],"prefix":"10.1016","volume":"499","author":[{"given":"Shaoxiong","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renjing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"BinrongWang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiumei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongming","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.jim.2021.113179_bb0005","first-page":"S49","article-title":"Limit of blank, limit of detection and limit of quantitation","volume":"29","author":"Armbruster","year":"2008","journal-title":"The Clinical biochemist Reviews"},{"issue":"9","key":"10.1016\/j.jim.2021.113179_bb0010","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1136\/gutjnl-2018-317556","article-title":"Development and validation of a prediction rule for estimating gastric cancer risk in the Chinese high-risk population: a nationwide multicentre study","volume":"68","author":"Cai","year":"2019","journal-title":"Gut."},{"issue":"5","key":"10.1016\/j.jim.2021.113179_bb0015","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12727","article-title":"A panel of stomach-specific biomarkers (GastroPanel\u00ae) for the diagnosis of atrophic gastritis: A prospective, multicenter study in a low gastric cancer incidence area","volume":"25","author":"Chapelle","year":"2020","journal-title":"Helicobacter"},{"key":"10.1016\/j.jim.2021.113179_bb0020","series-title":"EP7-a: Interference Testing in Clinical Chemistry; Approved Guideline","author":"CLSI","year":"2000"},{"issue":"8","key":"10.1016\/j.jim.2021.113179_bb0025","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1007\/s10620-010-1248-8","article-title":"Serum pepsinogens in gastric cancer screening","volume":"55","author":"Correa","year":"2010","journal-title":"Digestive Diseases and Sciences"},{"issue":"02","key":"10.1016\/j.jim.2021.113179_bb0030","first-page":"92","article-title":"Expert consensus on early gastric cancer screening process in China (draft) (Shanghai, 2017)","volume":"23","author":"Du","year":"2018","journal-title":"Gastroenterology."},{"issue":"1\u20132","key":"10.1016\/j.jim.2021.113179_bb0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000151616","article-title":"Stimulation of proliferation of U138-MG glioblastoma cells by gastrin-releasing peptide in combination with agents that enhance cAMP signaling","volume":"75","author":"Farias","year":"2008","journal-title":"Oncology."},{"key":"10.1016\/j.jim.2021.113179_bb0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.aca.2012.04.044","article-title":"Development of an immunomagnetic bead-based time-resolved fluorescence immunoassay for rapid determination of levels of carcinoembryonic antigen in human serum","volume":"734","author":"Hou","year":"2012","journal-title":"Analytica Chimica Acta"},{"issue":"12","key":"10.1016\/j.jim.2021.113179_bb0045","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.dld.2019.09.016","volume":"51","author":"Lahner","year":"2019","journal-title":"Digestive and Liver Disease"},{"issue":"12","key":"10.1016\/j.jim.2021.113179_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23518","article-title":"Analysis of serum gastrin-17 and Helicobacter pylori antibody in healthy Chinese population","volume":"34","author":"Liu","year":"2020","journal-title":"Journal of Clinical Laboratory Analysis"},{"issue":"9","key":"10.1016\/j.jim.2021.113179_bb0055","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1515\/CCLM.2010.256","article-title":"Prevalence of atrophic gastritis in dyspeptic patients in Piedmont. A survey using the GastroPanel test","volume":"48","author":"Lombardo","year":"2010","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"issue":"1","key":"10.1016\/j.jim.2021.113179_bb0060","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/gutjnl-2016-312288","article-title":"Management of Helicobacter pylori infection-the Maastricht V\/Florence consensus report","volume":"66","author":"Malfertheiner","year":"2017","journal-title":"Gut."},{"issue":"9","key":"10.1016\/j.jim.2021.113179_bb0065","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/MEG.0000000000000132","article-title":"Accuracy of GastroPanel for the diagnosis of atrophic gastritis","volume":"26","author":"McNicholl","year":"2014","journal-title":"European Journal of Gastroenterology & Hepatology"},{"issue":"7","key":"10.1016\/j.jim.2021.113179_bb0070","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0039-128X(93)90093-3","article-title":"Labeling of estradiol and testosterone alkyloxime derivatives with a europium chelate for time-resolved fluoroimmunoassays","volume":"58","author":"Mikola","year":"1993","journal-title":"Steroids."},{"issue":"1","key":"10.1016\/j.jim.2021.113179_bb0075","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbcan.2017.11.003","article-title":"Genetic host factors in Helicobacter pylori-induced carcinogenesis: emerging new paradigms","volume":"1869","author":"Mommersteeg","year":"2018","journal-title":"Biochimica et Biophysica Acta, Reviews on Cancer"},{"issue":"8","key":"10.1016\/j.jim.2021.113179_bb0080","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3889\/oamjms.2019.325","article-title":"The difference of serum Gastrin-17 level based on gastritis severity and Helicobacter pylori infection","volume":"7","author":"Parhusip","year":"2019","journal-title":"Open access Macedonian journal of medical sciences."},{"issue":"4","key":"10.1016\/j.jim.2021.113179_bb0085","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1055\/a-0859-1883","volume":"51","author":"Pimentel-Nunes","year":"2019","journal-title":"Endoscopy."},{"issue":"8","key":"10.1016\/j.jim.2021.113179_bb0090","first-page":"4129","article-title":"Prevalence of H. pylori infection and atrophic gastritis in a population-based screening with serum biomarker panel (GastroPanel\u00ae) in St. Petersburg","volume":"36","author":"Roman","year":"2016","journal-title":"Anticancer Research"},{"issue":"7","key":"10.1016\/j.jim.2021.113179_bb0095","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1053\/j.gastro.2008.05.021","article-title":"Control of gastric acid secretion in health and disease","volume":"134","author":"Schubert","year":"2008","journal-title":"Gastroenterology."},{"key":"10.1016\/j.jim.2021.113179_bb0100","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2147\/CMAR.S149619","article-title":"Gastric cancer: epidemiology, prevention, classification, and treatment","volume":"10","author":"Sitarz","year":"2018","journal-title":"Cancer Management and Research"},{"issue":"9","key":"10.1016\/j.jim.2021.113179_bb0105","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1136\/gutjnl-2015-309252","article-title":"Kyoto global consensus report on Helicobacter pylori gastritis","volume":"64","author":"Sugano","year":"2015","journal-title":"Gut."},{"issue":"10","key":"10.1016\/j.jim.2021.113179_bb0110","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.3109\/00365521.2014.950693","article-title":"A comprehensive evaluation of fasting serum gastrin-17 as a predictor of diseased stomach in Chinese population","volume":"49","author":"Sun","year":"2014","journal-title":"Scandinavian Journal of Gastroenterology"},{"issue":"31","key":"10.1016\/j.jim.2021.113179_bb0115","doi-asserted-by":"crossref","first-page":"49322","DOI":"10.18632\/oncotarget.10337","article-title":"Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients","volume":"7","author":"Sz\u00e1sz","year":"2016","journal-title":"Oncotarget."},{"issue":"1","key":"10.1016\/j.jim.2021.113179_bb0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ab.2004.06.012","article-title":"Development and validation of a time-resolved fluorometric immunoassay for screening of antichlamydial activity using a genus-specific europium-conjugated antibody","volume":"333","author":"Tammela","year":"2004","journal-title":"Analytical Biochemistry"},{"issue":"5","key":"10.1016\/j.jim.2021.113179_bb0125","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/ajg.2017.55","article-title":"A serological biopsy using five stomach-specific circulating biomarkers for gastric Cancer risk assessment: a multi-phase study","volume":"112","author":"Tu","year":"2017","journal-title":"The American Journal of Gastroenterology"},{"issue":"Pt 5","key":"10.1016\/j.jim.2021.113179_bb0130","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1258\/000456303322326380","article-title":"Gastrin: an analytical review","volume":"40","author":"Varro","year":"2003","journal-title":"Annals of Clinical Biochemistry"},{"issue":"1","key":"10.1016\/j.jim.2021.113179_bb0135","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1038\/s41598-020-61472-7","article-title":"Prevalence of atrophic gastritis in Southwest China and predictive strength of serum gastrin-17: a cross-sectional study (SIGES)","volume":"10","author":"Wang","year":"2020","journal-title":"Scientific Reports"},{"issue":"3","key":"10.1016\/j.jim.2021.113179_bb0140","doi-asserted-by":"crossref","DOI":"10.1177\/0300060520914826","article-title":"Diagnostic value of serum pepsinogen I, pepsinogen II, and gastrin-17 levels for population-based screening for early-stage gastric cancer","volume":"48","author":"Wang","year":"2020","journal-title":"The Journal of international medical research."},{"issue":"2","key":"10.1016\/j.jim.2021.113179_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.22659","article-title":"Eu(3+) \/Sm(3+) dual-label time-resolved fluoroimmunoassay for measurement of hepatitis C virus antibodies","volume":"33","author":"Yang","year":"2019","journal-title":"Journal of Clinical Laboratory Analysis"},{"issue":"4","key":"10.1016\/j.jim.2021.113179_bb0150","doi-asserted-by":"crossref","first-page":"637","DOI":"10.4149\/neo_2018_180825N647","article-title":"The value of detecting pepsinogen and gastrin-17 levels in serum for pre-cancerous lesion screening in gastric cancer","volume":"66","author":"Yu","year":"2019","journal-title":"Neoplasma."},{"issue":"7","key":"10.1016\/j.jim.2021.113179_bb0155","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/apt.14248","article-title":"Systematic review with meta-analysis: diagnostic performance of the combination of pepsinogen, gastrin-17 and anti-Helicobacter pylori antibodies serum assays for the diagnosis of atrophic gastritis","volume":"46","author":"Zagari","year":"2017","journal-title":"Alimentary Pharmacology & Therapeutics"},{"issue":"2","key":"10.1016\/j.jim.2021.113179_bb0160","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1208\/s12248-020-0413-z","article-title":"Development and utility of an ELISA method for sensitive and specific detection of IgE antidrug antibodies","volume":"22","author":"Zhong","year":"2020","journal-title":"The AAPS Journal"}],"container-title":["Journal of Immunological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175921002246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175921002246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:27:58Z","timestamp":1762205278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022175921002246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":32,"alternative-id":["S0022175921002246"],"URL":"https:\/\/doi.org\/10.1016\/j.jim.2021.113179","relation":{},"ISSN":["0022-1759"],"issn-type":[{"value":"0022-1759","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a time-resolved fluorescence immunoassay based on immunomagnetic beads for gastrin-17","name":"articletitle","label":"Article Title"},{"value":"Journal of Immunological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jim.2021.113179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113179"}}