{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:07:57Z","timestamp":1758359277766,"version":"3.44.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2022C03118"],"award-info":[{"award-number":["2022C03118"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070730","82172336","82172336,82070730"],"award-info":[{"award-number":["82070730","82172336","82172336,82070730"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ23H050005"],"award-info":[{"award-number":["LQ23H050005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunological Methods"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jim.2023.113534","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T20:34:57Z","timestamp":1691440497000},"page":"113534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Establishment of growth stimulating gene 2 protein time-resolved fluorescence immunoassay and its application in sepsis"],"prefix":"10.1016","volume":"520","author":[{"given":"Lu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benqi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyi","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xindong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiming","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiumei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jim.2023.113534_bb0005","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jim.2023.113534_bb0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12929-018-0455-z","article-title":"IL-33 receptor (ST2) deficiency downregulates myeloid precursors, inflammatory NK and dendritic cells in early phase of sepsis","volume":"25","author":"Babic","year":"2018","journal-title":"J. Biomed. Sci."},{"issue":"3","key":"10.1016\/j.jim.2023.113534_bb0015","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s10875-011-9622-7","article-title":"Characterization of interleukin-33 and soluble ST2 in serum and their association with disease severity in patients with chronic kidney disease","volume":"32","author":"Bao","year":"2012","journal-title":"J. Clin. Immunol."},{"issue":"8","key":"10.1016\/j.jim.2023.113534_bb0020","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/ajh.22049","article-title":"Positive HIV ELISA test, autoimmune hemolytic anemia, and generalized lymphadenopathy: a unifying diagnosis","volume":"86","author":"Castillo","year":"2011","journal-title":"Am. J. Hematol."},{"issue":"3","key":"10.1016\/j.jim.2023.113534_bb0025","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s00216-018-1496-6","article-title":"Competitive light-initiated chemiluminescent assay: using 5-alpha-dihydrotestosterone-BSA as competitive antigen for quantitation of total testosterone in human sera","volume":"411","author":"Cui","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"issue":"6","key":"10.1016\/j.jim.2023.113534_bb0030","first-page":"1605","article-title":"Procalcitonin increase after endotoxin injection in normal subjects","volume":"79","author":"Dandona","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.jim.2023.113534_bb0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"S. Surviving Sepsis Campaign Guidelines Committee including The Pediatric, Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012","volume":"39","author":"Dellinger","year":"2013","journal-title":"Intensive Care Med."},{"issue":"3","key":"10.1016\/j.jim.2023.113534_bb0040","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/1071100720965136","article-title":"Species-specific immunoassay aids identification of pathogen and tracks infectivity in foot infection","volume":"42","author":"Hao","year":"2021","journal-title":"Foot Ankle Int."},{"issue":"5","key":"10.1016\/j.jim.2023.113534_bb0045","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/01.shk.0000142256.23382.5d","article-title":"Increased expression of toll-like receptor-2 and -4 on leukocytes from patients with sepsis","volume":"22","author":"Harter","year":"2004","journal-title":"Shock"},{"issue":"36","key":"10.1016\/j.jim.2023.113534_bb0050","doi-asserted-by":"crossref","first-page":"26369","DOI":"10.1074\/jbc.M704916200","article-title":"Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation","volume":"282","author":"Hayakawa","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jim.2023.113534_bb0055","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s00134-010-1773-0","article-title":"Soluble ST2 plasma concentrations predict mortality in severe sepsis","volume":"36","author":"Hoogerwerf","year":"2010","journal-title":"Intensive Care Med."},{"issue":"2","key":"10.1016\/j.jim.2023.113534_bb0060","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jim.2023.113534_bb0065","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3389\/fimmu.2020.00837","article-title":"Phospholipase A2 receptor autoantibodies as a novel serological biomarker for autoimmune thyroid disease associated nephropathy","volume":"11","author":"Huang","year":"2020","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.jim.2023.113534_bb0070","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/clinchem\/39.4.583","article-title":"Monoclonal antibodies specific for prothrombin fragment 1.2 and their use in a quantitative enzyme-linked immunosorbent assay","volume":"39","author":"Hursting","year":"1993","journal-title":"Clin. Chem."},{"issue":"1\u20132","key":"10.1016\/j.jim.2023.113534_bb0075","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0731-7085(99)00010-2","article-title":"Simultaneous determination of alpha-fetoprotein, human chorionic gonadotropin and estriol in serum of pregnant women by time-resolved fluoroimmunoassay","volume":"20","author":"Ito","year":"1999","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"22","key":"10.1016\/j.jim.2023.113534_bb0080","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1039\/D2AY00120A","article-title":"A rapid and quantitative detection method for plasma soluble growth stimulating gene protein 2 based on time resolved fluorescence immunochromatography","volume":"14","author":"Jing","year":"2022","journal-title":"Anal. Methods"},{"issue":"10","key":"10.1016\/j.jim.2023.113534_bb0085","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nrd2660","article-title":"The IL-33\/ST2 pathway: therapeutic target and novel biomarker","volume":"7","author":"Kakkar","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.jim.2023.113534_bb0090","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1007\/s00268-020-05589-w","article-title":"Expression of pancreatic stone protein is unaffected by trauma and subsequent surgery in burn patients","volume":"44","author":"Klein","year":"2020","journal-title":"World J. Surg."},{"issue":"1","key":"10.1016\/j.jim.2023.113534_bb0095","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0952-7915(99)80003-X","article-title":"The Toll-receptor family and control of innate immunity","volume":"11","author":"Kopp","year":"1999","journal-title":"Curr. Opin. Immunol."},{"issue":"4","key":"10.1016\/j.jim.2023.113534_bb0100","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/clc.23799","article-title":"Soluble ST2 in the prediction of heart failure and death in patients with atrial fibrillation","volume":"45","author":"Krittayaphong","year":"2022","journal-title":"Clin. Cardiol."},{"issue":"8","key":"10.1016\/j.jim.2023.113534_bb0105","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00011-016-0937-y","article-title":"Sepsis: in search of cure","volume":"65","author":"Lakshmikanth","year":"2016","journal-title":"Inflamm. Res."},{"issue":"9","key":"10.1016\/j.jim.2023.113534_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138940","article-title":"Elevated plasma soluble ST2 is associated with heart failure symptoms and outcome in aortic stenosis","volume":"10","author":"Lancellotti","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jim.2023.113534_bb0115","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/124021","article-title":"Interpretation of C-reactive protein concentrations in critically ill patients","volume":"2013","author":"Lelubre","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jim.2023.113534_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155390","article-title":"The IL-33\/ST2 pathway is not essential to Th2 stimulation but is key for modulation and survival during chronic infection with Schistosoma mansoni in mice","volume":"138","author":"Maggi","year":"2021","journal-title":"Cytokine"},{"issue":"10","key":"10.1016\/j.jim.2023.113534_bb0125","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1097\/QAD.0000000000001105","article-title":"The plasma levels of soluble ST2 as a marker of gut mucosal damage in early HIV infection","volume":"30","author":"Mehraj","year":"2016","journal-title":"AIDS"},{"issue":"6","key":"10.1016\/j.jim.2023.113534_bb0130","first-page":"1005","article-title":"Interleukin-33 in Tissue Homeostasis","volume":"42","author":"Molofsky","year":"2015","journal-title":"Injury Inflamm. Immun."},{"issue":"3","key":"10.1016\/j.jim.2023.113534_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/s17030480","article-title":"Rapid and Sensitive Lateral Flow Immunoassay Method for Procalcitonin (PCT) Based on Time-Resolved Immunochromatography","volume":"17","author":"Shao","year":"2017","journal-title":"Sensors (Basel)"},{"issue":"11","key":"10.1016\/j.jim.2023.113534_bb0140","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.4049\/jimmunol.166.11.6633","article-title":"A novel pathway regulating lipopolysaccharide-induced shock by ST2\/T1 via inhibition of Toll-like receptor 4 expression","volume":"166","author":"Sweet","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.jim.2023.113534_bb0145","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.3389\/fimmu.2018.02004","article-title":"Regulatory mechanisms of IL-33-ST2-mediated allergic inflammation","volume":"9","author":"Takatori","year":"2018","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.jim.2023.113534_bb0150","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0014-5793(89)81679-5","article-title":"A putative protein of a growth specific cDNA from BALB\/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor","volume":"258","author":"Tominaga","year":"1989","journal-title":"FEBS Lett."},{"issue":"11","key":"10.1016\/j.jim.2023.113534_bb0155","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1002\/eji.201141629","article-title":"IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells","volume":"41","author":"Yang","year":"2011","journal-title":"Eur. J. Immunol."}],"container-title":["Journal of Immunological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175923001163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175923001163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T16:39:32Z","timestamp":1758299972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022175923001163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":31,"alternative-id":["S0022175923001163"],"URL":"https:\/\/doi.org\/10.1016\/j.jim.2023.113534","relation":{},"ISSN":["0022-1759"],"issn-type":[{"type":"print","value":"0022-1759"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Establishment of growth stimulating gene 2 protein time-resolved fluorescence immunoassay and its application in sepsis","name":"articletitle","label":"Article Title"},{"value":"Journal of Immunological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jim.2023.113534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113534"}}