{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:09:36Z","timestamp":1793660976708,"version":"4.5.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006692","name":"University of Turin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunological Methods"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jim.2025.113918","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T19:47:05Z","timestamp":1754423225000},"page":"113918","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Peripheral blood and nasal swabs Type I and III IFNs signature in RSV positive infant with bronchiolitis"],"prefix":"10.1016","volume":"543","author":[{"given":"Francesco","family":"Savino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Montanari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Dini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Ferroglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Burdisso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Calvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Clemente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gambarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Galliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Bergallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jim.2025.113918_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1332772","article-title":"Development and comparison of immunologic assays to detect primary RSV infections in infants","volume":"14","author":"Anderson","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jim.2025.113918_bb0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/vaccines5030016","article-title":"The central conserved region (CCR) of respiratory syncytial virus (RSV) G protein modulates host miRNA expression and alters the cellular response to infection","volume":"5","author":"Bakre","year":"2017","journal-title":"Vaccines"},{"key":"10.1016\/j.jim.2025.113918_bb0015","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fped.2020.00244","article-title":"Human endogenous retroviruses are preferentially expressed in mononuclear cells from cord blood than from maternal blood and in the fetal part of placenta","volume":"8","author":"Bergallo","year":"2020","journal-title":"Front. Pediatr."},{"issue":"28","key":"10.1016\/j.jim.2025.113918_bb0020","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2202370119","article-title":"Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction","volume":"119","author":"Beucher","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.jim.2025.113918_bb0025","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41591-020-01202-8","article-title":"Immune determinants of COVID-19 disease presentation and severity","volume":"27","author":"Brodin","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.jim.2025.113918_bb0030","series-title":"Bronchiolitis in Children: Diagnosis and Management","year":"2021"},{"issue":"5","key":"10.1016\/j.jim.2025.113918_bb0035","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/ppul.24676","article-title":"Association between respiratory syncytial virus hospitalization in infancy and childhood asthma","volume":"55","author":"Coutts","year":"2020","journal-title":"Pediatr. Pulmonol."},{"issue":"10349","key":"10.1016\/j.jim.2025.113918_bb0040","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0140-6736(22)01016-9","article-title":"Bronchiolitis","volume":"400","author":"Dalziel","year":"2022","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jim.2025.113918_bb0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s40121-017-0151-4","article-title":"The burden and Long-term respiratory morbidity associated with respiratory syncytial virus infection in early childhood","volume":"6","author":"Fauroux","year":"2017","journal-title":"Infect. Dis. Ther."},{"issue":"7053","key":"10.1016\/j.jim.2025.113918_bb0050","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature04082","article-title":"Mechanism of action of interferon and ribavirin in treatment of hepatitis C","volume":"436","author":"Feld","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jim.2025.113918_bb0055","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41590-020-00840-x","article-title":"Untuned antiviral immunity in COVID-19 revealed by temporal Type I\/III interferon patterns and flu comparison","volume":"22","author":"Galani","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jim.2025.113918_bb0060","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3390\/diagnostics14100971","article-title":"Characteristics of RNA stabilizer RNApro for peripheral blood collection","volume":"14","author":"Gambarino","year":"2024","journal-title":"Diagnostics"},{"issue":"5","key":"10.1016\/j.jim.2025.113918_bb0065","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1056\/NEJMoa1913556","article-title":"Single-dose nirsevimab for prevention of RSV in preterm infants","volume":"383","author":"Griffin","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"6504","key":"10.1016\/j.jim.2025.113918_bb0070","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.abc6027","article-title":"Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients","volume":"369","author":"Hadjadj","year":"2020","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.jim.2025.113918_bb0075","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1056\/NEJMoa2110275","article-title":"Nirsevimab for prevention of RSV in healthy late-preterm and term infants","volume":"386","author":"Hammitt","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jim.2025.113918_bb0080","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3389\/fimmu.2019.00566","article-title":"Role of type I interferon (IFN) in the respiratory Syn-cytial virus (RSV) immune response and disease severity","volume":"10","author":"Hijano","year":"2019","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.jim.2025.113918_bb0085","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.micinf.2004.03.010","article-title":"Mechanisms of illness during respiratory syncytial virus infection: the lungs, the virus and the immune response","volume":"6","author":"Hoffman","year":"2004","journal-title":"Microbes Infect."},{"key":"10.1016\/j.jim.2025.113918_bb0090","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1128\/JVI.06757-11","article-title":"Plasticity and virus specificity of the airway epithelial cell immune response during respiratory virus infection","volume":"86","author":"Ioannidis","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2025.113918_bb0095","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41392-023-01340-8","article-title":"Increased type III interferons and NK cell functions in SARS-CoV-2-infected children","volume":"8","author":"Jeong","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.jim.2025.113918_bb0100","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa2031994","article-title":"Baricitinib plus Remdesivir for hospitalized adults with Covid-19","volume":"384","author":"Kalil","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jim.2025.113918_bb0105","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/mi.2017.120","article-title":"Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium","volume":"11","author":"Kalinowski","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jim.2025.113918_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.101303","article-title":"Type III IFNs: beyond antiviral protection","volume":"43","author":"Kotenko","year":"2019","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jim.2025.113918_bb0120","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1128\/JVI.01740-06","article-title":"Retinoic acid-inducible gene I mediates early antiviral response and toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells","volume":"81","author":"Liu","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.jim.2025.113918_bb0125","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"10","key":"10.1016\/j.jim.2025.113918_bb0130","article-title":"Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs","volume":"218","author":"Lopez","year":"2021","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.jim.2025.113918_bb0135","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13052-022-01392-6","article-title":"UPDATE \u2013 2022. Italian guidelines on the management of bronchiolitis in infants","volume":"49","author":"Manti","year":"2023","journal-title":"Ital. J. Pediatr."},{"issue":"49","key":"10.1016\/j.jim.2025.113918_bb0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13052-022-01392-6","article-title":"UPDATE \u2013 2022. Italian guidelines on the management of bronchiolitis in infants","volume":"2023","author":"Manti","year":"2023","journal-title":"Ital. J. Pediatr."},{"issue":"4","key":"10.1016\/j.jim.2025.113918_bb0145","doi-asserted-by":"crossref","first-page":"265","DOI":"10.4049\/immunohorizons.2200010","article-title":"Current landscape of IFN-\u03bb: induction, inhibition, and potential clinical applications to treat respiratory viral infections","volume":"7","author":"Mart\u00ednez-Espinoza","year":"2023","journal-title":"ImmunoHorizons"},{"issue":"5","key":"10.1016\/j.jim.2025.113918_bb0150","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/14712598.2023.2211709","article-title":"Interferon lambda as a potential treatment for COVID-19","volume":"23","author":"McCarthy","year":"2023","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.jim.2025.113918_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.coviro.2023.101337","article-title":"Structural basis for respiratory syncytial virus and human metapneumovirus neutralization","volume":"61","author":"Miller","year":"2023","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.jim.2025.113918_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105450","article-title":"Advancing respir-atory virus diagnostics: integrating the nasal IFN-I score for improved viral detection","volume":"110","author":"Mommert-Tripon","year":"2024","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.jim.2025.113918_bb0165","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1126\/sciadv.abe5984","article-title":"A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood","volume":"7","author":"Ng","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jim.2025.113918_bb0170","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/infdis\/jiw191","article-title":"Robust cytokine and chemokine response in nasopharyngeal secretions: asso-ciation with decreased severity in children with physician diagnosed bronchiolitis","volume":"214","author":"Nicholson","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jim.2025.113918_bb0175","series-title":"NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (NIH Guidelines)","year":"2025"},{"key":"10.1016\/j.jim.2025.113918_bb0180","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.virusres.2011.07.011","article-title":"Type-III interferon, not Type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells","volume":"160","author":"Okabayashi","year":"2011","journal-title":"Virus Res."},{"issue":"4","key":"10.1016\/j.jim.2025.113918_bb0185","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1164\/rccm.201309-1616OC","article-title":"Mucosal immune responses predict clinical outcomes during influenza infection independently of age and vi-ral load","volume":"189","author":"Oshansky","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jim.2025.113918_bb0190","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.0105-2896.2004.00204.x","article-title":"Interferons, interferon-like cytokines, and their receptors","volume":"202","author":"Pestka","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jim.2025.113918_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172953","article-title":"The interdepen dencies of viral load, the innate immune response, and clinical out-come in children presenting to the emergency department with respiratory syncytial virus-associated bronchiolitis","volume":"12","author":"Piedra","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jim.2025.113918_bb0200","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1128\/CMR.14.4.778-809.2001","article-title":"Antiviral actions of interferons","volume":"14","author":"Samuel","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"issue":"19","key":"10.1016\/j.jim.2025.113918_bb0205","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1073\/pnas.0707882105","article-title":"Interferon signaling and treatment outcome in chronic hepatitis C","volume":"105","author":"Sarasin-Filipowicz","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.jim.2025.113918_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105310","article-title":"Host transcriptional responses in nasal swabs identify potential SARS-CoV-2 infection in PCR negative patients","volume":"25","author":"Saravia-Butler","year":"2022","journal-title":"iScience"},{"issue":"5","key":"10.1016\/j.jim.2025.113918_bb0215","first-page":"467","article-title":"Interfe-Ron lambda 1\u20133 expression in infants hospitalized for RSV or HRV associated bronchiolitis","volume":"68","author":"Selvaggi","year":"2014","journal-title":"J. Inf. Secur."},{"issue":"8","key":"10.1016\/j.jim.2025.113918_bb0220","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1086\/512162","article-title":"Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever","volume":"195","author":"Simmons","year":"2007","journal-title":"J. Infect. Dis."},{"issue":"4","key":"10.1016\/j.jim.2025.113918_bb0225","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3390\/pathogens12040577","article-title":"NRF2 antioxidant response and inter-feron-stimulated genes are differentially expressed in respiratory-syncytial-virus- and rhinovirus-infected hospitalized children","volume":"12","author":"Sorrentino","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/j.jim.2025.113918_bb0230","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1128\/JVI.78.8.4363-4369.2004","article-title":"Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages","volume":"78","author":"Spann","year":"2004","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.jim.2025.113918_bb0235","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005189.pub3","article-title":"Antibiotics for bronchiolitis in children","volume":"15","author":"Spurling","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jim.2025.113918_bb0240","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.biochem.67.1.227","article-title":"How cells respond to interferons","volume":"67","author":"Stark","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jim.2025.113918_bb0245","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fimmu.2017.00119","article-title":"Interferon lambda: modulating immunity in infectious diseases","volume":"8","author":"Syedbasha","year":"2017","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jim.2025.113918_bb0250","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/infdis\/jiac404","article-title":"Type III interferons, viral loads, age, and disease severity in young children with respiratory syncytial virus infection","volume":"227","author":"Taveras","year":"2022","journal-title":"J. Infect. Dis."},{"issue":"12","key":"10.1016\/j.jim.2025.113918_bb0255","doi-asserted-by":"crossref","first-page":"e747","DOI":"10.1016\/S1473-3099(24)00455-9","article-title":"The respiratory syncytial virus vaccine and monoclonal antibody landscape: the road to global access","volume":"24","author":"Terstappen","year":"2024","journal-title":"Lancet Infect. Dis."},{"issue":"5","key":"10.1016\/j.jim.2025.113918_bb0260","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/08916934.2020.1777281","article-title":"Enhanced expression of human endogenous retroviruses in new-onset type 1 diabetes: potential pathogenetic and therapeutic implications","volume":"53","author":"Tovo","year":"2020","journal-title":"Autoimmunity"},{"issue":"11","key":"10.1016\/j.jim.2025.113918_bb0265","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.3390\/ijms21113980","article-title":"Chronic HCV infection is associated with Overex-pression of human endogenous retroviruses that persists after drug-induced viral clearance","volume":"21","author":"Tovo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.jim.2025.113918_bb0270","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.3390\/ijms22147481","article-title":"COVID-19 in children: expressions of type I\/II\/III interferons, TRIM28, SETDB1, and endogenous retroviruses in mild and severe cases","volume":"22","author":"Tovo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jim.2025.113918_bb0275","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3390\/cimb45020079","article-title":"Expressions of type I and III interferons, endogenous retroviruses, TRIM28, and SETDB1 in children with respiratory syncytial virus bronchiolitis Curr","volume":"45","author":"Tovo","year":"2023","journal-title":"Issues Mol. Biol."},{"key":"10.1016\/j.jim.2025.113918_bb0280","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao0052","article-title":"PGD2\/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-\u03bb production","volume":"10","author":"Werder","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jim.2025.113918_bb0285","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/738547","article-title":"Respiratory syncytial virus nonstructural proteins upregulate SOCS1 and SOCS3 in the different manner from endogenous IFN signaling","volume":"2015","author":"Zheng","year":"2015","journal-title":"J Immunol Res"},{"issue":"6","key":"10.1016\/j.jim.2025.113918_bb0290","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.chom.2020.04.017","article-title":"Heightened innate immune responses in the respiratory tract of COVID-19 patients","volume":"27","author":"Zhou","year":"2020","journal-title":"Cell Host Microbe"}],"container-title":["Journal of Immunological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175925001188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022175925001188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T05:17:00Z","timestamp":1779859020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022175925001188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":57,"alternative-id":["S0022175925001188"],"URL":"https:\/\/doi.org\/10.1016\/j.jim.2025.113918","relation":{},"ISSN":["0022-1759"],"issn-type":[{"value":"0022-1759","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peripheral blood and nasal swabs Type I and III IFNs signature in RSV positive infant with bronchiolitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Immunological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jim.2025.113918","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113918"}}