{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:45:28Z","timestamp":1777401928923,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":91,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004492","name":"National Youth Foundation of China","doi-asserted-by":"publisher","award":["81571781"],"award-info":[{"award-number":["81571781"]}],"id":[{"id":"10.13039\/501100004492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Interventional Medicine"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jimed.2019.07.006","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T11:48:21Z","timestamp":1564573701000},"page":"91-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Safety and efficacy of hepatic arterial infusion chemotherapy with raltitrexed and oxaliplatin post-transarterial chemoembolization for unresectable hepatocellular carcinoma"],"prefix":"10.1016","volume":"2","author":[{"given":"Baojiang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linzhong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoxing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuxin","family":"Kou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jimed.2019.07.006_bib1","first-page":"87","article-title":"Global cancer statistics","volume":"65","author":"Torre","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jimed.2019.07.006_bib2","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"The Lancet"},{"key":"10.1016\/j.jimed.2019.07.006_bib3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4240\/wjgs.v9.i12.233","article-title":"Advances and challenges in laparoscopic surgery in the management of hepatocellular carcinoma","volume":"9","author":"Ziogas","year":"2017","journal-title":"World J Gastrointest Surg"},{"key":"10.1016\/j.jimed.2019.07.006_bib4","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1590\/0102-6720201700040011","article-title":"Hepatocellular carcinoma: diagnosis and operative management","volume":"30","author":"Chedid","year":"2017","journal-title":"Arq Bras Cir Dig"},{"key":"10.1016\/j.jimed.2019.07.006_bib5","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","article-title":"Hepatocellular carcinoma","volume":"391","author":"Forner","year":"2018","journal-title":"The Lancet"},{"key":"10.1016\/j.jimed.2019.07.006_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12072-017-9799-9","article-title":"Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update","volume":"11","author":"Omata","year":"2017","journal-title":"Hepatol Int"},{"key":"10.1016\/j.jimed.2019.07.006_bib7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S1499-3872(17)60077-8","article-title":"Trends and outcomes of transarterial chemoembolization in hepatocellular carcinoma: a national survey","volume":"16","author":"Mumtaz","year":"2017","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"10.1016\/j.jimed.2019.07.006_bib8","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/CAD.0000000000000371","article-title":"Raltitrexed plus oxaliplatin-based transarterial chemoembolization in patients with unresectable hepatocellular carcinoma","volume":"27","author":"Zhao","year":"2016","journal-title":"Anti Cancer Drugs"},{"key":"10.1016\/j.jimed.2019.07.006_bib9","doi-asserted-by":"crossref","first-page":"79165","DOI":"10.18632\/oncotarget.16298","article-title":"Comparison of two transarterial chemoembolization regimens in patients with unresectable hepatocellular carcinoma: raltitrexed plus oxaliplatin versus 5-fluorouracil plus oxaliplatin","volume":"8","author":"Cui","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jimed.2019.07.006_bib10","first-page":"83","article-title":"Hepatic artery infusion chemotherapy using mFOLFOX versus transarterial chemoembolization for massive unresectable hepatocellular carcinoma: a prospective non-randomized study","volume":"36","author":"He","year":"2017","journal-title":"Chin J Canc"},{"key":"10.1016\/j.jimed.2019.07.006_bib11","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.3748\/wjg.v21.i13.3970","article-title":"Oxaliplatin and 5-fluorouracil hepatic infusion with lipiodolized chemoembolization in large hepatocellular carcinoma","volume":"21","author":"Li","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jimed.2019.07.006_bib12","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.3748\/wjg.v18.i16.1933","article-title":"Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?","volume":"18","author":"Kirikoshi","year":"2012","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jimed.2019.07.006_bib13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00280-009-1126-2","article-title":"A\u00a0randomized comparative study of high-dose and low-dose hepatic arterial infusion chemotherapy for intractable, advanced hepatocellular carcinoma","volume":"65","author":"Woo","year":"2010","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.jimed.2019.07.006_bib14","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1038\/bjc.2013.542","article-title":"Effect of hepatic arterial infusion chemotherapy of 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma in the Nationwide Survey of Primary Liver Cancer in Japan","volume":"109","author":"Nouso","year":"2013","journal-title":"Br J Canc"},{"key":"10.1016\/j.jimed.2019.07.006_bib15","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.3748\/wjg.v23.i8.1406","article-title":"Hepatic artery infusion with raltitrexed or 5-fluorouracil for colorectal cancer liver metastasis","volume":"23","author":"Guo","year":"2017","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jimed.2019.07.006_bib16","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/CAD.0b013e328337d469","article-title":"Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer: a retrospective study","volume":"21","author":"Khouri","year":"2010","journal-title":"Anti Cancer Drugs"},{"key":"10.1016\/j.jimed.2019.07.006_bib17","doi-asserted-by":"crossref","first-page":"10443","DOI":"10.3748\/wjg.v21.i36.10443","article-title":"Chemoembolization alone vs combined chemoembolization and hepatic arterial infusion chemotherapy in inoperable hepatocellular carcinoma patients","volume":"21","author":"Gao","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jimed.2019.07.006_bib18","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.3748\/wjg.v24.i23.2501","article-title":"Transarterial embolization and low-dose continuous hepatic arterial infusion chemotherapy with oxaliplatin and raltitrexed for hepatocellular carcinoma with major portal vein tumor thrombus","volume":"24","author":"Zhu","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jimed.2019.07.006_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.5507\/bp.2014.054","article-title":"Hepatic arterial infusion in hepatocellular carcinoma: a single center experience","volume":"159","author":"Melichar","year":"2015","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.jimed.2019.07.006_bib20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00535-014-0978-3","article-title":"A\u00a0comparative study between sorafenib and hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis","volume":"50","author":"Song","year":"2015","journal-title":"J\u00a0Gastroenterol"},{"key":"10.1016\/j.jimed.2019.07.006_bib21","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/jjco\/hyx038","article-title":"A\u00a0Phase I\/II trial of continuous hepatic intra-arterial infusion of 5-fluorouracil, mitoxantrone and cisplatin for advanced hepatocellular carcinoma","volume":"47","author":"Ikeda","year":"2017","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.jimed.2019.07.006_bib22","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.2147\/OTT.S136806","article-title":"Hepatic artery-infusion chemotherapy improved survival of hepatocellular carcinoma after radical hepatectomy","volume":"10","author":"Feng","year":"2017","journal-title":"OncoTargets Ther"},{"key":"10.1016\/j.jimed.2019.07.006_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000334439","article-title":"Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellular carcinoma","volume":"81","author":"Yamashita","year":"2011","journal-title":"Oncology"},{"key":"10.1016\/j.jimed.2019.07.006_bib24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/liv.12112","article-title":"Effects of antiviral therapy on hepatitis B virus reactivation and liver function after resection or chemoembolization for hepatocellular carcinoma","volume":"33","author":"Lao","year":"2013","journal-title":"Liver Int"},{"key":"10.1016\/j.jimed.2019.07.006_bib25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/SLA.0b013e318262b218","article-title":"Posthepatectomy HBV reactivation in hepatitis B-related hepatocellular carcinoma influences postoperative survival in patients with preoperative low HBV-DNA levels","volume":"257","author":"Huang","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.jimed.2019.07.006_bib26","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1148\/radiol.13121498","article-title":"Hepatocellular carcinoma: high hepatitis B viral load and mortality in patients treated with transarterial chemoembolization","volume":"267","author":"Yu","year":"2013","journal-title":"Radiology"},{"key":"10.1016\/j.jimed.2019.07.006_bib27","doi-asserted-by":"crossref","first-page":"412","DOI":"10.5604\/01.3001.0009.8596","article-title":"Risk factors for prognosis of hepatocellular carcinoma after curative resection in patients with low hepatitis B viral load","volume":"16","author":"Qu","year":"2017","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.jimed.2019.07.006_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/bjc.2013.346","article-title":"A\u00a0derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients","volume":"109","author":"Absenger","year":"2013","journal-title":"Br J Canc"},{"key":"10.1016\/j.jimed.2019.07.006_bib29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/jamaoncol.2017.4771","article-title":"Association of the lung immune prognostic index with immune checkpoint inhibitor outcomes in patients with advanced non-small cell lung cancer","volume":"4","author":"Mezquita","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jimed.2019.07.006_bib30","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/annonc\/mdw016","article-title":"Baseline neutrophils and derived neutrophil-to-lymphocyte ratio: prognostic relevance in metastatic melanoma patients receiving ipilimumab","volume":"27","author":"Ferrucci","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jimed.2019.07.006_bib31","article-title":"Neutrophil-to-lymphocyte and aspartate-to-alanine aminotransferase ratios predict hepatocellular carcinoma prognosis after transarterial embolization","volume":"96","author":"Liu","year":"2017","journal-title":"Medicine (Baltim)"},{"key":"10.1016\/j.jimed.2019.07.006_bib32","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.3892\/ol.2016.4359","article-title":"Derived neutrophil to lymphocyte ratio predicts prognosis for patients with HBV-associated hepatocellular carcinoma following transarterial chemoembolization","volume":"11","author":"Zhou","year":"2016","journal-title":"Oncol Lett"},{"key":"10.1016\/j.jimed.2019.07.006_bib33","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/hepr.12436","article-title":"Blood neutrophil to lymphocyte ratio as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy","volume":"45","author":"Terashima","year":"2015","journal-title":"Hepatol Res"},{"key":"10.1016\/j.jimed.2019.07.006_bib34","doi-asserted-by":"crossref","first-page":"110","DOI":"10.5604\/01.3001.0010.7542","article-title":"Prognostic ability of BCLC-B subclassification in patients with hepatocellular carcinoma undergoing transarterial chemoembolization","volume":"17","author":"Biolato","year":"2018","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.jimed.2019.07.006_bib35","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000006745","article-title":"Barcelona clinic liver cancer-stage C hepatocellular carcinoma: a novel approach to subclassification and treatment","volume":"96","author":"Jun","year":"2017","journal-title":"Medicine (Baltim)"}],"updated-by":[{"DOI":"10.1016\/j.jimed.2020.10.011","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000}},{"DOI":"10.1016\/j.jimed.2021.01.002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000}}],"container-title":["Journal of Interventional Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2096360219300882?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2096360219300882?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:07:13Z","timestamp":1761869233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2096360219300882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S2096360219300882"],"URL":"https:\/\/doi.org\/10.1016\/j.jimed.2019.07.006","relation":{},"ISSN":["2096-3602"],"issn-type":[{"value":"2096-3602","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and efficacy of hepatic arterial infusion chemotherapy with raltitrexed and oxaliplatin post-transarterial chemoembolization for unresectable hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Interventional Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jimed.2019.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Shanghai Journal of Interventional Medicine Press. Production and hosting by Elsevier B.V. on behalf of KeAi.","name":"copyright","label":"Copyright"}]}}