{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:49:50Z","timestamp":1792183790582,"version":"4.4.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.jinf.2005.11.010","type":"journal-article","created":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T09:36:36Z","timestamp":1136972196000},"page":"248-254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease"],"prefix":"10.1016","volume":"53","author":[{"given":"Richard A.","family":"Martinello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Esper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Weibel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie L.","family":"Landry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jinf.2005.11.010_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1056\/NEJM200007273430407","article-title":"Chronic obstructive pulmonary disease","volume":"343","author":"Barnes","year":"2000","journal-title":"N Engl J Med"},{"issue":"Suppl. 5","key":"10.1016\/j.jinf.2005.11.010_bib2","doi-asserted-by":"crossref","first-page":"121S","DOI":"10.1378\/chest.121.5_suppl.121S","article-title":"COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity","volume":"121","author":"Mannino","year":"2002","journal-title":"Chest"},{"issue":"9","key":"10.1016\/j.jinf.2005.11.010_bib3","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1053\/rmed.2002.1334","article-title":"The costs of exacerbations in chronic obstructive pulmonary disease (COPD)","volume":"96","author":"Andersson","year":"2002","journal-title":"Respir Med"},{"issue":"Suppl. 5","key":"10.1016\/j.jinf.2005.11.010_bib4","doi-asserted-by":"crossref","first-page":"136S","DOI":"10.1378\/chest.121.5_suppl.136S","article-title":"Exacerbations: etiology and pathophysiologic mechanisms","volume":"121","author":"Wedzicha","year":"2002","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.jinf.2005.11.010_bib5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1034\/j.1399-3003.2000.16d19.x","article-title":"Detection of rhinovirus in induced sputum at exacerbation of chronic obstructive pulmonary disease","volume":"16","author":"Seemungal","year":"2000","journal-title":"Eur Respir J"},{"issue":"9","key":"10.1016\/j.jinf.2005.11.010_bib6","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1164\/ajrccm.164.9.2105011","article-title":"Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease","volume":"164","author":"Seemungal","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.jinf.2005.11.010_bib7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/89098","article-title":"A newly discovered human pneumovirus isolated from young children with respiratory tract disease","volume":"7","author":"van den Hoogen","year":"2001","journal-title":"Nat Med"},{"issue":"10","key":"10.1016\/j.jinf.2005.11.010_bib8","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/01.inf.0000091347.27554.ff","article-title":"Human metapneumovirus, a newly emerging respiratory virus","volume":"22","author":"Kahn","year":"2003","journal-title":"Pediatr Infect Dis J"},{"issue":"5","key":"10.1016\/j.jinf.2005.11.010_bib9","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1086\/367901","article-title":"Human metapneumovirus infections in young and elderly adults","volume":"187","author":"Falsey","year":"2003","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.jinf.2005.11.010_bib10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa025472","article-title":"Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children","volume":"350","author":"Williams","year":"2004","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.jinf.2005.11.010_bib11","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1086\/382482","article-title":"A 1-year experience with human metapneumovirus in children aged <5 years","volume":"189","author":"Esper","year":"2004","journal-title":"J Infect Dis"},{"issue":"9343","key":"10.1016\/j.jinf.2005.11.010_bib12","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0140-6736(02)11391-2","article-title":"Metapneumovirus and acute wheezing in children","volume":"360","author":"Jartti","year":"2002","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jinf.2005.11.010_bib13","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1128\/JCM.38.2.708-711.2000","article-title":"SimulFluor respiratory screen for rapid detection of multiple respiratory viruses in clinical specimens by immunofluorescence staining","volume":"38","author":"Landry","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jinf.2005.11.010_bib14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/biomet\/26.4.404","article-title":"The use of confidence or fiducial limits illustrated in the case of the binomial","volume":"26","author":"Clopper","year":"1934","journal-title":"Biometrika"},{"issue":"2","key":"10.1016\/j.jinf.2005.11.010_bib15","doi-asserted-by":"crossref","first-page":"196","DOI":"10.7326\/0003-4819-106-2-196","article-title":"Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease","volume":"106","author":"Anthonisen","year":"1987","journal-title":"Ann Intern Med"},{"issue":"4","key":"10.1016\/j.jinf.2005.11.010_bib16","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3201\/eid1004.030393","article-title":"Antigenic and genetic variability of human metapneumoviruses","volume":"10","author":"van den Hoogen","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jinf.2005.11.010_bib17","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3201\/eid1007.030633","article-title":"Human metapneumovirus and chronic obstructive pulmonary disease","volume":"10","author":"Vicente","year":"2004","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"10.1016\/j.jinf.2005.11.010_bib18","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jinf.2004.07.011","article-title":"Respiratory viral infections in patients with chronic, obstructive pulmonary disease","volume":"50","author":"Beckham","year":"2005","journal-title":"J Infect"},{"issue":"1","key":"10.1016\/j.jinf.2005.11.010_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/thorax.58.1.37","article-title":"Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study","volume":"58","author":"Rohde","year":"2003","journal-title":"Thorax"},{"issue":"3","key":"10.1016\/j.jinf.2005.11.010_bib20","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1128\/JCM.42.3.981-986.2004","article-title":"Real-time reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages","volume":"42","author":"Maertzdorf","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"Suppl. 11","key":"10.1016\/j.jinf.2005.11.010_bib21","doi-asserted-by":"crossref","first-page":"S215","DOI":"10.1097\/01.inf.0000144668.81573.6d","article-title":"Human metapneumovirus as a major cause of human respiratory tract disease","volume":"23","author":"Crowe","year":"2004","journal-title":"Pediatr Infect Dis J"},{"issue":"8","key":"10.1016\/j.jinf.2005.11.010_bib22","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1128\/JCM.41.8.3597-3601.2003","article-title":"Comparison of SmartCycler real-time reverse transcription-PCR assay in a public health laboratory with direct immunofluorescence and cell culture assays in a medical center for detection of influenza A virus","volume":"41","author":"Habib-Bein","year":"2003","journal-title":"J Clin Microbiol"},{"issue":"2","key":"10.1016\/j.jinf.2005.11.010_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/jmv.10391","article-title":"Seroprevalence of human metapneumovirus in Japan","volume":"70","author":"Ebihara","year":"2003","journal-title":"J Med Virol"},{"issue":"13","key":"10.1016\/j.jinf.2005.11.010_bib24","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1128\/JVI.78.13.6927-6937.2004","article-title":"The two major human metapneumovirus genetic lineages are highly related antigenically, and the fusion (F) protein is a major contributor to this antigenic relatedness","volume":"78","author":"Skiadopoulos","year":"2004","journal-title":"J Virol"},{"issue":"11","key":"10.1016\/j.jinf.2005.11.010_bib25","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1086\/340518","article-title":"Characterization of human metapneumoviruses isolated from patients in North America","volume":"185","author":"Peret","year":"2002","journal-title":"J Infect Dis"},{"issue":"9","key":"10.1016\/j.jinf.2005.11.010_bib26","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3201\/eid0809.020238","article-title":"Respiratory tract reinfections by the new human Metapneumovirus in an immunocompromised child","volume":"8","author":"Pelletier","year":"2002","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"10.1016\/j.jinf.2005.11.010_bib27","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3201\/eid0903.020289","article-title":"Human metapneumovirus in severe respiratory syncytial virus bronchiolitis","volume":"9","author":"Greensill","year":"2003","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"10.1016\/j.jinf.2005.11.010_bib28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1086\/426457","article-title":"Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis","volume":"191","author":"Semple","year":"2005","journal-title":"J Infect Dis"},{"issue":"20","key":"10.1016\/j.jinf.2005.11.010_bib29","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa030634","article-title":"Identification of severe acute respiratory syndrome in Canada","volume":"348","author":"Poutanen","year":"2003","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.jinf.2005.11.010_bib30","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1164\/ajrccm.164.9.2108099c","article-title":"Viral infection and exacerbations of chronic obstructive pulmonary disease","volume":"164","author":"Hogg","year":"2001","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445305003725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445305003725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:30:15Z","timestamp":1758987015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445305003725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0163445305003725"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2005.11.010","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2005.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 The British Infection Society. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}