{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:13:44Z","timestamp":1791112424202,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.jinf.2008.03.007","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T12:50:34Z","timestamp":1209127834000},"page":"33-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Identifying HIV patients with an unfavorable cardiovascular risk profile in the clinical practice: Results from the SIMONE study"],"prefix":"10.1016","volume":"57","author":[{"given":"Giuseppe Vittorio L.","family":"De Socio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giustino","family":"Parruti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Quirino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Schillaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Adriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Marconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Franzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canio","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Vichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Penco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Sfara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giordano","family":"Madeddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bonfanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2008.03.007_bib1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0735-1097(85)80397-1","article-title":"Cardiac lesions in acquired immune deficiency syndrome (AIDS)","volume":"5","author":"Cammarosano","year":"1985","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jinf.2008.03.007_bib2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199803263381301","article-title":"Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators","volume":"338","author":"Palella","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jinf.2008.03.007_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1056\/NEJMra041811","article-title":"Cardiovascular risk and body-fat abnormalities in HIV-infected adults","volume":"352","author":"Grinspoon","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jinf.2008.03.007_bib4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0002-8703(91)90861-B","article-title":"Cardiovascular disease risk profiles","volume":"121","author":"Anderson","year":"1991","journal-title":"Am Heart J"},{"key":"10.1016\/j.jinf.2008.03.007_bib5","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"Wilson","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jinf.2008.03.007_bib6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.0000133317.49796.0E","article-title":"National Heart, Lung, and Blood Institute; American College of Cardiology Foundation; American Heart Association. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines","volume":"110","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jinf.2008.03.007_bib7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.qai.0000147525.26746.07","article-title":"Managing cardiovascular risk in patients with HIV infection","volume":"38","author":"Stein","year":"2005","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.jinf.2008.03.007_bib8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2337\/diacare.28.1.132","article-title":"Metabolic syndrome among HIV-infected patients: prevalence, characteristics, and related factors","volume":"28","author":"Jeric\u00f3","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jinf.2008.03.007_bib9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/00126334-200211010-00015","article-title":"High prevalence of metabolic syndrome among HIV-infected patients: link with the cardiovascular risk","volume":"31","author":"Bruno","year":"2002","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.jinf.2008.03.007_bib10","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/QAI.0b013e318074ef83","article-title":"HIV and metabolic syndrome: a comparison with the general population","volume":"45","author":"Bonfanti","year":"2007","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.jinf.2008.03.007_bib11","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jinf.2008.03.007_bib12","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.2337\/diacare.28.7.1769","article-title":"Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence","volume":"28","author":"Ford","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jinf.2008.03.007_bib13","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2337\/diacare.24.4.683","article-title":"Cardiovascular morbidity and mortality associated with the metabolic syndrome","volume":"24","author":"Isomaa","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jinf.2008.03.007_bib14","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive Summary of the Third Report of the National Cholesterol Educational Programme (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","volume":"285","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.jinf.2008.03.007_bib15","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMoa062744","article-title":"Class of antiretroviral drugs and the risk of myocardial infarction","volume":"356","author":"Friis-Moller","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jinf.2008.03.007_bib16","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1097\/00002030-200311210-00010","article-title":"Clinical Epidemiology Group from the French Hospital Database. Increased risk of myocardial infarction with duration of protease inhibitor therapy in HIV-infected men","volume":"17","author":"Mary-Krause","year":"2003","journal-title":"AIDS"},{"key":"10.1016\/j.jinf.2008.03.007_bib17","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1080\/00365540701230884","article-title":"Is estimated cardiovascular risk higher in HIV-infected patients than in the general population?","volume":"39","author":"De Socio","year":"2007","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.jinf.2008.03.007_bib18","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1089\/apc.2006.0165","article-title":"Global cardiovascular risk in patients with HIV infection: concordance and differences in estimates according to three risk equations (Framingham, SCORE, and PROCAM)","volume":"21","author":"Knobel","year":"2007","journal-title":"AIDS Patient Care STDS"},{"key":"10.1016\/j.jinf.2008.03.007_bib19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/hc0302.102575","article-title":"Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study","volume":"105","author":"Assmann","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jinf.2008.03.007_bib20","first-page":"94S","article-title":"[No authors listed]; Gruppo di Ricerca del Progetto CUORE. [The Italian Heart Project-longitudinal studies]","volume":"5","year":"2004","journal-title":"Ital Heart J"},{"key":"10.1016\/j.jinf.2008.03.007_bib21","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0195-668X(03)00114-3","article-title":"Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project","volume":"24","author":"Conroy","year":"2003","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jinf.2008.03.007_bib22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/01.qai.0000219775.20174.2d","article-title":"CISAI Study Group. Metabolic syndrome: a real threat for HIV-positive patients?: results from the SIMONE study","volume":"42","author":"Bonfanti","year":"2006","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.jinf.2008.03.007_bib23","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1097\/00002030-200107270-00008","article-title":"HIV Outpatient Study Investigators. Clinical assessment of HIV-associated lipodystrophy in an ambulatory population","volume":"15","author":"Lichtenstein","year":"2001","journal-title":"AIDS"},{"key":"10.1016\/j.jinf.2008.03.007_bib24","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1001\/archinte.162.22.2621","article-title":"LipoICoNa Study. Incidence of adipose tissue alterations in first-line antiretroviral therapy: the LipoICoNa Study","volume":"162","author":"Galli","year":"2002","journal-title":"Arch Intern Med"},{"issue":"21","key":"10.1016\/j.jinf.2008.03.007_bib25","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1001\/archinte.1997.00440420033005","article-title":"[No authors listed] The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure","volume":"157","year":"1997","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jinf.2008.03.007_bib26","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.2337\/diacare.26.11.3160","article-title":"The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Follow-up report on the diagnosis of diabetes mellitus","volume":"26","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jinf.2008.03.007_bib27","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/ije\/dyh405","article-title":"CUORE Project Research Group. Prediction of coronary events in a low incidence population. Assessing accuracy of the CUORE Cohort Study prediction equation","volume":"34","author":"Ferrario","year":"2005","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jinf.2008.03.007_bib28","unstructured":"http:\/\/www.cuore.iss.it\/eng\/distribuzione\/colesterolemia.asp."},{"key":"10.1016\/j.jinf.2008.03.007_bib29","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1086\/375844","article-title":"French WHO MONICA Project and the APROCO (ANRS EP11) Study Group. Risk factors for coronary heart disease in patients treated for human immunodeficiency virus infection compared with the general population","volume":"37","author":"Saves","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2008.03.007_bib30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.numecd.2005.12.008","article-title":"Comparison of methods to identify individuals at increased risk of cardiovascular disease in Italian cohorts","volume":"17","author":"Giavarina","year":"2007","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.jinf.2008.03.007_bib31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1053\/euhj.1999.1864","article-title":"Comparison of the Framingham risk function-based coronary chart with risk function from an Italian population study","volume":"21","author":"Menotti","year":"2000","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jinf.2008.03.007_bib32","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1258\/095646205774357398","article-title":"Atherogenic lipid profile and cardiovascular risk factors in HIV-infected patients (Netar Study)","volume":"16","author":"Santos","year":"2005","journal-title":"Int J STD AIDS"},{"issue":"8","key":"10.1016\/j.jinf.2008.03.007_bib33","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10096-004-1177-6","article-title":"Elevated Framingham risk score in HIV-positive patients on highly active antiretroviral therapy: results from a Norwegian study of 721 subjects","volume":"23","author":"Bergersen","year":"2004","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jinf.2008.03.007_bib34","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1086\/521935","article-title":"Ten-year predicted coronary heart disease risk in HIV-infected men and women","volume":"45","author":"Kaplan","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2008.03.007_bib35","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1056\/NEJMoa030218","article-title":"The Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group. Combination antiretroviral therapy and the risk of myocardial infarction","volume":"349","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jinf.2008.03.007_bib36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1468-1293.2006.00362.x","article-title":"DAD Study Group. The use of\u00a0the Framingham equation to predict myocardial infarctions in HIV-infected patients: comparison with observed events in the D:A:D Study","volume":"7","author":"Law","year":"2006","journal-title":"HIV Med"},{"key":"10.1016\/j.jinf.2008.03.007_bib37","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/01.hjr.0000230107.78524.da","article-title":"[No authors listed] DECODE Study Group. Does diagnosis of the metabolic syndrome detect further men at high risk of cardiovascular death beyond those identified by a conventional cardiovascular risk score? The DECODE Study","volume":"14","year":"2007","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"10.1016\/j.jinf.2008.03.007_bib38","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1097\/QAD.0b013e3282efad32","article-title":"on behalf of the INITIO Trial International Coordinating Committee. Metabolic syndrome, cardiovascular disease and type 2 diabetes mellitus after initiation of antiretroviral therapy in HIV infection","volume":"21","author":"Wand","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.jinf.2008.03.007_bib39","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1086\/516616","article-title":"Metabolic syndrome and subclinical atherosclerosis in patients infected with HIV","volume":"44","author":"Mangili","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2008.03.007_bib40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1086\/317541","article-title":"Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy","volume":"32","author":"Hadigan","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2008.03.007_bib41","unstructured":"Freitas P, Carvalho D, Correia F, Marques R, Serr\u00e3o R, Mota-Miranda A, et\u00a0al. Patients with HIV associated lipodystrophy have an increased risk of cardiovascular disease [Abstract P121] Eighth International Congress on Drug Therapy in HIV Infection Glasgow UK 12\u201316 November 2006."},{"key":"10.1016\/j.jinf.2008.03.007_bib42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2337\/dc06-1075","volume":"30","author":"Samaras","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jinf.2008.03.007_bib43","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1161\/01.ATV.0000157784.25920.a7","article-title":"Hypoadiponectinemia is associated with ischemic cerebrovascular disease","volume":"25","author":"Chen","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jinf.2008.03.007_bib44","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1097\/QAD.0b013e3280adc91e","article-title":"The role of adipokines in relation to HIV lipodystrophy","volume":"21","author":"Sweeney","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.jinf.2008.03.007_bib45","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1097\/00002030-200404300-00010","article-title":"on behalf of the PREVALEAT Group. Colour-Doppler ultrasonography of carotid vessels in patients treated with antiretroviral therapy: a comparative study","volume":"18","author":"Maggi","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.jinf.2008.03.007_bib46","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1468-1293.2006.00401.x","article-title":"Increased serum lipids are associated with higher CD4 lymphocyte count in HIV-infected women","volume":"7","author":"Floris-Moore","year":"2006","journal-title":"HIV Med"},{"key":"10.1016\/j.jinf.2008.03.007_bib47","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/01.qai.0000159323.59250.83","article-title":"Increased cardiovascular disease risk indices in HIV-infected women","volume":"39","author":"Dolan","year":"2005","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.jinf.2008.03.007_bib48","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/j.jacc.2003.12.049","article-title":"Prognostic value of the metabolic syndrome in essential hypertension","volume":"43","author":"Schillaci","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jinf.2008.03.007_bib49","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1161\/01.ATV.0000183744.38509.de","article-title":"Impact of treatment with protease inhibitors on aortic stiffness in adult patients with human immunodeficiency virus infection","volume":"25","author":"Schillaci","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445308001278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445308001278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T15:33:22Z","timestamp":1758987202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445308001278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0163445308001278"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2008.03.007","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identifying HIV patients with an unfavorable cardiovascular risk profile in the clinical practice: Results from the SIMONE study","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2008.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 The British Infection Society. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}