{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:20:50Z","timestamp":1791141650439,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.jinf.2012.03.017","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T12:47:29Z","timestamp":1333025249000},"page":"49-59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["IP-10 is an additional marker for tuberculosis (TB) detection in HIV-infected persons in a low-TB endemic country"],"prefix":"10.1016","volume":"65","author":[{"given":"Valentina","family":"Vanini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Petruccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Gioia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilda","family":"Cuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Orchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Rianda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Alba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Giancola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristide","family":"Conte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Schinin\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Busi Rizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Girardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Goletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2012.03.017_bib1","first-page":"CD000171","article-title":"Treatment of latent tuberculosis infection in HIV infected persons","volume":"20","author":"Akolo","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jinf.2012.03.017_bib2","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/00002030-200209270-00021","article-title":"High incidence of tuberculin skin test conversion among HIV-infected individuals who have a favourable immunological response to highly active antiretroviral therapy","volume":"16","author":"Girardi","year":"2002","journal-title":"AIDS"},{"key":"10.1016\/j.jinf.2012.03.017_bib3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1473-3099(11)70146-3","article-title":"Fact and fiction in tuberculosis vaccine research: 10 years later","volume":"11","author":"Kaufmann","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib4","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1001\/jama.293.22.2719","article-title":"Effect of routine isoniazid preventive therapy on tuberculosis incidence among HIV-infected men in South Africa: a novel randomized incremental recruitment study","volume":"293","author":"Grant","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.jinf.2012.03.017_bib5","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0140-6736(00)02742-2","article-title":"Specific immune-based diagnosis of tuberculosis","volume":"356","author":"Andersen","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jinf.2012.03.017_bib6","doi-asserted-by":"crossref","first-page":"e12577","DOI":"10.1371\/journal.pone.0012577","article-title":"Is IP-10 an accurate marker for detecting M. tuberculosis-specific response in HIV-infected persons?","volume":"5","author":"Goletti","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2012.03.017_bib7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1183\/09031936.00115110","article-title":"Interferon-gamma release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis","volume":"37","author":"Diel","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jinf.2012.03.017_bib8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/QAD.0b013e328334895e","article-title":"Comparison of interferon gamma and interferon gamma-inducible protein-10 secretion in HIV-tuberculosis patients","volume":"24","author":"Kabeer","year":"2010","journal-title":"AIDS"},{"key":"10.1016\/j.jinf.2012.03.017_bib9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/bmb\/ldp039","article-title":"A 100 year update on diagnosis of tuberculosis infection","volume":"93","author":"Lalvani","year":"2010","journal-title":"Br Med Bull"},{"key":"10.1016\/j.jinf.2012.03.017_bib10","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.5588\/ijtld.10.0631","article-title":"Interferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis","volume":"15","author":"Mandalakas","year":"2011","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1183\/09031936.00114810","article-title":"Interferon-gamma release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis","volume":"37","author":"Sester","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jinf.2012.03.017_bib12","series-title":"Guidelines for intensified tuberculosis case-finding and isoniazid preventive therapy for people living with HIV in resource-constrained settings. WHO guidelines 2011","author":"WHO","year":"2011"},{"key":"10.1016\/j.jinf.2012.03.017_bib13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0140-6736(10)62173-3","article-title":"Tuberculosis","volume":"378","author":"Lawn","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jinf.2012.03.017_bib14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.diagmicrobio.2011.09.024","article-title":"Detection of immune cell response to M. tuberculosis-specific antigens by quantitative polymerase chain reaction","volume":"72","author":"Bibova","year":"2012","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1586\/eri.11.23","article-title":"Tuberculosis assays: past, present and future","volume":"9","author":"Chegou","year":"2011","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.jinf.2012.03.017_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1183\/09031936.00140009","article-title":"Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection","volume":"36","author":"Goletti","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jinf.2012.03.017_bib17","doi-asserted-by":"crossref","first-page":"e18315","DOI":"10.1371\/journal.pone.0018315","article-title":"Methylated HBHA produced in M. smegmatis discriminates between active and non-active tuberculosis disease among RD1-responders","volume":"6","author":"Delogu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2012.03.017_bib18","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.tube.2011.02.006","article-title":"Discriminating between latent and active tuberculosis with multiple biomarker responses","volume":"91","author":"Frahm","year":"2011","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.jinf.2012.03.017_bib19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/1471-2334-9-182","article-title":"New tools for detecting latent tuberculosis infection: evaluation of RD1-specific long-term response","volume":"9","author":"Butera","year":"2009","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1365-3083.2011.02642.x","article-title":"M. tuberculosis sonicate induced IFNgamma, CXCL10 and IL10 can differentiate severity in tuberculosis","volume":"75","author":"Hasan","year":"2011","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jinf.2012.03.017_bib21","first-page":"1548","article-title":"Cytokine responses to QuantiFERON(R) peptides, purified protein derivative and recombinant ESAT-6 in children with tuberculosis","volume":"14","author":"Lighter-Fisher","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1465-9921-8-5","article-title":"Isoniazid prophylaxis differently modulates T-cell responses to RD1-epitopes in contacts recently exposed to Mycobacterium tuberculosis: a pilot study","volume":"8","author":"Goletti","year":"2007","journal-title":"Respir Res"},{"issue":"10","key":"10.1016\/j.jinf.2012.03.017_bib23","doi-asserted-by":"crossref","first-page":"e3417","DOI":"10.1371\/journal.pone.0003417","article-title":"Accuracy of immunodiagnostic tests for active tuberculosis using single and combined results: a multicenter TBNET-study","volume":"3","author":"Goletti","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2012.03.017_bib24","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1164\/rccm.200904-0557OC","article-title":"Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trials group study","volume":"180","author":"Jafari","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jinf.2012.03.017_bib25","doi-asserted-by":"crossref","first-page":"e27539","DOI":"10.1371\/journal.pone.0027539","article-title":"Higher frequency of T-cell response to M. tuberculosis latency antigen Rv2628 at the site of active tuberculosis disease than in peripheral blood","volume":"6","author":"Chiacchio","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2012.03.017_bib26","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/j.1469-0691.2009.03104.x","article-title":"Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients, latently infected individuals, and controls","volume":"16","author":"Biselli","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jinf.2012.03.017_bib27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1471-2334-9-99","article-title":"Cytometric detection of antigen-specific IFN-gamma\/IL-2 secreting cells in the diagnosis of tuberculosis","volume":"9","author":"Sargentini","year":"2009","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1586\/ers.09.31","article-title":"Biomarkers of latent TB infection","volume":"3","author":"Ruhwald","year":"2009","journal-title":"Expert Rev Respir Med"},{"key":"10.1016\/j.jinf.2012.03.017_bib29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.tube.2011.01.001","article-title":"A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis","volume":"91","author":"Ruhwald","year":"2011","journal-title":"Tuberculosis (Edinb)"},{"key":"10.1016\/j.jinf.2012.03.017_bib30","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1183\/09031936.00148308","article-title":"T-cell interferon-gamma release assays: can we do better?","volume":"32","author":"Lalvani","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jinf.2012.03.017_bib31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jinf.2010.05.002","article-title":"IFN-gamma, but not IP-10, MCP-2 or IL-2 response to RD1 selected peptides associates to active tuberculosis","volume":"61","author":"Goletti","year":"2010","journal-title":"J Infect"},{"key":"10.1016\/j.jinf.2012.03.017_bib32","doi-asserted-by":"crossref","first-page":"e3901","DOI":"10.1371\/journal.pone.0003901","article-title":"Is IP-10 a better biomarker for active and latent tuberculosis in children than IFNgamma?","volume":"3","author":"Whittaker","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2012.03.017_bib33","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.4049\/jimmunol.179.5.2722","article-title":"PDGF synergistically enhances IFN-gamma-induced expression of CXCL10 in blood-derived macrophages: implications for HIV dementia","volume":"179","author":"Dhillon","year":"2007","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.jinf.2012.03.017_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.micinf.2004.09.004","article-title":"IFN-gamma-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection","volume":"7","author":"Azzurri","year":"2005","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jinf.2012.03.017_bib35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/1471-2334-10-333","article-title":"IP-10 detection in urine is associated with lung diseases","volume":"10","author":"Cannas","year":"2010","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib36","article-title":"Discordance among commercially-available diagnostics for latent tuberculosis infection","author":"Mancuso","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jinf.2012.03.017_bib37","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1164\/ajrccm.161.4.16141","article-title":"Diagnostic standards and classification of tuberculosis in adults and children","volume":"161","author":"American Thoracic Society\/Centers for Disease Control and Prevention","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jinf.2012.03.017_bib38","series-title":"Tuberculosis Handbook","author":"World Health Organization","year":"1998"},{"key":"10.1016\/j.jinf.2012.03.017_bib39","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1136\/thx.2010.136242","article-title":"A simple, valid, numerical score for grading chest x-ray severity in adult smear-positive pulmonary tuberculosis","volume":"65","author":"Ralph","year":"2010","journal-title":"Thorax"},{"issue":"7","key":"10.1016\/j.jinf.2012.03.017_bib40","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1086\/507427","article-title":"Region of difference 1 antigen-specific CD4+ memory T cells correlate with a favorable outcome of tuberculosis","volume":"194","author":"Goletti","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib41","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1183\/09031936.00039010","article-title":"Potential of interferon-gamma-inducible protein 10 in improving tuberculosis diagnosis in HIV-infected patients","volume":"36","author":"Aabye","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jinf.2012.03.017_bib42","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.diagmicrobio.2011.07.012","article-title":"Comparison of interferon gamma-inducible protein-10 and interferon gamma-based QuantiFERON TB Gold assays with tuberculin skin test in HIV-infected subjects","volume":"71","author":"Kabeer","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib43","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/QAI.0b013e31820b07ab","article-title":"Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis","volume":"56","author":"Cattamanchi","year":"2011","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.jinf.2012.03.017_bib44","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1086\/523012","article-title":"T cell responses to commercial Mycobacterium tuberculosis-specific antigens in HIV-infected patients","volume":"45","author":"Goletti","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2334-8-11","article-title":"Response to M. tuberculosis selected RD1 peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study","volume":"8","author":"Goletti","year":"2008","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib46","doi-asserted-by":"crossref","first-page":"e9051","DOI":"10.1371\/journal.pone.0009051","article-title":"Role of QuantiFERON-TB gold, interferon gamma inducible protein-10 and tuberculin skin test in active tuberculosis diagnosis","volume":"5","author":"Syed Ahamed Kabeer","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2012.03.017_bib47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF03402042","article-title":"Identification of early secretory antigen target-6 epitopes for the immunodiagnosis of active tuberculosis","volume":"9","author":"Vincenti","year":"2003","journal-title":"Mol Med"},{"key":"10.1016\/j.jinf.2012.03.017_bib48","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1365-2249.2007.03462.x","article-title":"Response to region of difference 1 (RD1) epitopes in human immunodeficiency virus (HIV)-infected individuals enrolled with suspected active tuberculosis: a pilot study","volume":"150","author":"Vincenti","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jinf.2012.03.017_bib49","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1183\/09031936.00045509","article-title":"Relationship of immunodiagnostic assays for tuberculosis and numbers of circulating CD4+ T-cells in HIV infection","volume":"35","author":"Leidl","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jinf.2012.03.017_bib50","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/1471-2334-10-348","article-title":"IFN-gamma response on T-cell based assays in HIV-infected patients for detection of tuberculosis infection","volume":"10","author":"Latorre","year":"2010","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jinf.2012.03.017_bib51","doi-asserted-by":"crossref","first-page":"e5718","DOI":"10.1371\/journal.pone.0005718","article-title":"Role of interferon gamma release assay in active TB diagnosis among HIV infected individuals","volume":"4","author":"Syed Ahamed Kabeer","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2012.03.017_bib52","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1183\/09031936.00055508","article-title":"Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis","volume":"32","author":"Ruhwald","year":"2008","journal-title":"Eur Respir J"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445312000928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445312000928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:16:40Z","timestamp":1759007800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445312000928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0163445312000928"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2012.03.017","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IP-10 is an additional marker for tuberculosis (TB) detection in HIV-infected persons in a low-TB endemic country","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2012.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}