{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:13:21Z","timestamp":1770437601964,"version":"3.49.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.jinf.2012.09.002","type":"journal-article","created":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T11:15:47Z","timestamp":1346930147000},"page":"320-329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Hearing loss in children treated for multidrug-resistant tuberculosis"],"prefix":"10.1016","volume":"66","author":[{"given":"James A.","family":"Seddon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Thee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayleen","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Ebrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneke C.","family":"Hesseling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Simon","family":"Schaaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2012.09.002_bib1","series-title":"Global tuberculosis control","author":"World Health Organization, Geneva, Switzerland","year":"2011"},{"key":"10.1016\/j.jinf.2012.09.002_bib2","series-title":"Guidlelines for the programmatic management of drug-resistant tuberculosis \u2013 emergency update","author":"World Health Organization, Geneva, Switzerland","year":"2008"},{"issue":"5","key":"10.1016\/j.jinf.2012.09.002_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/adc.80.5.433","article-title":"Childhood tuberculosis in an urban population in South Africa: burden and risk factor","volume":"80","author":"van Rie","year":"1999","journal-title":"Arch Dis Child"},{"issue":"3","key":"10.1016\/j.jinf.2012.09.002_bib4","first-page":"259","article-title":"The burden of childhood tuberculosis and the accuracy of community-based surveillance data","volume":"10","author":"Marais","year":"2006","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.jinf.2012.09.002_bib5","author":"World Health Organization, Geneva, Switzerland"},{"key":"10.1016\/j.jinf.2012.09.002_bib6","author":"World Health Organization, Geneva, Switzerland"},{"issue":"2","key":"10.1016\/j.jinf.2012.09.002_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/cid\/cir772","article-title":"Culture-confirmed multidrug-resistant tuberculosis in children: clinical features, treatment, and outcome","volume":"54","author":"Seddon","year":"2012","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.jinf.2012.09.002_bib8","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1542\/peds.2005-2235","article-title":"Community-based therapy for children with multidrug-resistant tuberculosis","volume":"117","author":"Drobac","year":"2006","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.jinf.2012.09.002_bib9","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1473-3099(12)70033-6","article-title":"Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis","volume":"12","author":"Ettehad","year":"2012","journal-title":"Lancet Infect Dis"},{"issue":"11","key":"10.1016\/j.jinf.2012.09.002_bib10","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1473-3099(11)70167-0","article-title":"Accuracy of the Xpert MTB\/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study","volume":"11","author":"Nicol","year":"2011","journal-title":"Lancet Infect Dis"},{"issue":"8","key":"10.1016\/j.jinf.2012.09.002_bib11","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1128\/AAC.00112-06","article-title":"Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis","volume":"50","author":"Hazbon","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.jinf.2012.09.002_bib12","first-page":"1","article-title":"Handbook of anti-tuberculosis agents","volume":"88","year":"2008","journal-title":"Tuberculosis (Edinb)"},{"issue":"6B","key":"10.1016\/j.jinf.2012.09.002_bib13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0002-9343(86)90497-3","article-title":"Aminoglycoside toxicity in infants and children","volume":"80","author":"McCracken","year":"1986","journal-title":"Am J Med"},{"issue":"5","key":"10.1016\/j.jinf.2012.09.002_bib14","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/AAC.43.5.1003","article-title":"Aminoglycosides: nephrotoxicity","volume":"43","author":"Mingeot-Leclercq","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"issue":"2\u20133","key":"10.1016\/j.jinf.2012.09.002_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tox.2008.04.015","article-title":"Aminoglycoside induced ototoxicity","volume":"249","author":"Guthrie","year":"2008","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.jinf.2012.09.002_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/138161207779313731","article-title":"Aminoglycoside-induced ototoxicity","volume":"13","author":"Selimoglu","year":"2007","journal-title":"Curr Pharm Des"},{"issue":"6","key":"10.1016\/j.jinf.2012.09.002_bib17","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/AUD.0b013e318157f033","article-title":"Current state of knowledge: psychosocial development in children with hearing impairment","volume":"28","author":"Moeller","year":"2007","journal-title":"Ear Hear"},{"issue":"6","key":"10.1016\/j.jinf.2012.09.002_bib18","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/AUD.0b013e318157f07f","article-title":"Current state of knowledge: language and literacy of children with hearing impairment","volume":"28","author":"Moeller","year":"2007","journal-title":"Ear Hear"},{"issue":"9","key":"10.1016\/j.jinf.2012.09.002_bib19","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1469-8749.2011.04001.x","article-title":"Motor skill deficits in children with partial hearing","volume":"53","author":"Livingstone","year":"2011","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jinf.2012.09.002_bib20","author":"American Speech-Language-Hearing Association"},{"issue":"8","key":"10.1016\/j.jinf.2012.09.002_bib21","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.2105\/AJPH.2008.143271","article-title":"Surveillance of antituberculosis drug resistance among children from the Western Cape Province of South Africa\u2013an upward trend","volume":"99","author":"Schaaf","year":"2009","journal-title":"Am J Public Health"},{"key":"10.1016\/j.jinf.2012.09.002_bib22","author":"American Speech-Language-Hearing Association"},{"issue":"6","key":"10.1016\/j.jinf.2012.09.002_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/14992020600582117","article-title":"Distortion product otoacoustic emissions: an objective technique for the screening of hearing loss in children treated with platin derivatives","volume":"45","author":"Dhooge","year":"2006","journal-title":"Int J Audiol"},{"issue":"2","key":"10.1016\/j.jinf.2012.09.002_bib24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1375\/audi.28.2.90","article-title":"DPOAE changes in young children with confirmed hearing loss due to ototoxicity","volume":"28","author":"Beahan","year":"2006","journal-title":"Aust N Z J Audiol"},{"issue":"7","key":"10.1016\/j.jinf.2012.09.002_bib25","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1136\/thx.2009.131532","article-title":"Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis","volume":"65","author":"Prayle","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.jinf.2012.09.002_bib26","doi-asserted-by":"crossref","DOI":"10.1183\/09031936.00044812","article-title":"Hearing loss in patients on treatment for drug-resistant tuberculosis","author":"Seddon","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jinf.2012.09.002_bib27","unstructured":"South African health review 2010. Health and related indicators. Available at: http:\/\/www.hst.org.za\/sites\/default\/files\/sahr10_21.pdf [accessed 17.04.12]."},{"issue":"7","key":"10.1016\/j.jinf.2012.09.002_bib28","doi-asserted-by":"crossref","first-page":"928","DOI":"10.5588\/ijtld.11.0679","article-title":"The evolving epidemic of drug-resistant tuberculosis among children in Cape Town, South Africa","volume":"16","author":"Seddon","year":"2012","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.jinf.2012.09.002_bib29","first-page":"330","article-title":"Preferred methods for clinical determination of pure-tone thresholds","volume":"24","author":"Carhart","year":"1959","journal-title":"J Speech Hear Res"},{"key":"10.1016\/j.jinf.2012.09.002_bib30","first-page":"262","article-title":"Reference zero levels for pure tone audiometer","volume":"7","author":"Goodman","year":"1965","journal-title":"ASHA"},{"key":"10.1016\/j.jinf.2012.09.002_bib31","series-title":"Handbook of clinical audiology","author":"Katz","year":"2009"},{"key":"10.1016\/j.jinf.2012.09.002_bib32","unstructured":"American Speech-Language-Hearing Association. Audiologic screening (Technical report). 1994;Available at: http:\/\/www.asha.org\/docs\/pdf\/TR1994-00238.pdf [accessed August 2012]."},{"key":"10.1016\/j.jinf.2012.09.002_bib33","author":"American Speech-Language-Hearing Association"},{"issue":"7","key":"10.1016\/j.jinf.2012.09.002_bib34","first-page":"622","article-title":"Hearing loss and nephrotoxicity in long-term aminoglycoside treatment in patients with tuberculosis","volume":"6","author":"de Jager","year":"2002","journal-title":"Int J Tuberc Lung Dis"},{"issue":"11","key":"10.1016\/j.jinf.2012.09.002_bib35","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1086\/420742","article-title":"Aminoglycoside toxicity: daily versus thrice-weekly dosing for treatment of mycobacterial diseases","volume":"38","author":"Peloquin","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"8","key":"10.1016\/j.jinf.2012.09.002_bib36","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1093\/jac\/dkr221","article-title":"Multidrug-resistant tuberculosis (MDR-TB) treatment in the UK: a study of injectable use and toxicity in practice","volume":"66","author":"Sturdy","year":"2011","journal-title":"J Antimicrob Chemother"},{"issue":"5","key":"10.1016\/j.jinf.2012.09.002_bib37","doi-asserted-by":"crossref","first-page":"e37114","DOI":"10.1371\/journal.pone.0037114","article-title":"Outcomes of comprehensive care for children empirically treated for multidrug-resistant tuberculosis in a setting of high HIV prevalence","volume":"7","author":"Satti","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jinf.2012.09.002_bib38","first-page":"CD005091","article-title":"One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates","author":"Rao","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1016\/j.jinf.2012.09.002_bib39","first-page":"CD002009","article-title":"Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis","author":"Smyth","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"10.1016\/j.jinf.2012.09.002_bib40","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/archotol.124.5.529","article-title":"Sensorineural hearing loss in children after liver transplantation","volume":"124","author":"Deutsch","year":"1998","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.jinf.2012.09.002_bib41","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00003446-199810000-00001","article-title":"Children with minimal sensorineural hearing loss: prevalence, educational performance, and functional status","volume":"19","author":"Bess","year":"1998","journal-title":"Ear Hear"},{"issue":"6","key":"10.1016\/j.jinf.2012.09.002_bib42","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/AUD.0b013e318157f01f","article-title":"Current state of knowledge: speech recognition and production in children with hearing impairment","volume":"28","author":"Eisenberg","year":"2007","journal-title":"Ear Hear"},{"issue":"6","key":"10.1016\/j.jinf.2012.09.002_bib43","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/AUD.0b013e318157f049","article-title":"Current state of knowledge: perceptual processing by children with hearing impairment","volume":"28","author":"Jerger","year":"2007","journal-title":"Ear Hear"},{"issue":"5","key":"10.1016\/j.jinf.2012.09.002_bib44","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1001\/archotol.130.5.556","article-title":"The importance of high-frequency audibility in the speech and language development of children with hearing loss","volume":"130","author":"Stelmachowicz","year":"2004","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.jinf.2012.09.002_bib45","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1542\/peds.102.5.1161","article-title":"Language of early- and later-identified children with hearing loss","volume":"102","author":"Yoshinaga-Itano","year":"1998","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.jinf.2012.09.002_bib46","doi-asserted-by":"crossref","first-page":"E43","DOI":"10.1542\/peds.106.3.e43","article-title":"Early intervention and language development in children who are deaf and hard of hearing","volume":"106","author":"Moeller","year":"2000","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.jinf.2012.09.002_bib47","first-page":"440","article-title":"Aminoglycoside-induced hearing loss: South Africans at risk","volume":"99","author":"Bardien","year":"2009","journal-title":"S Afr Med J"},{"key":"10.1016\/j.jinf.2012.09.002_bib48","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2350-10-2","article-title":"A rapid method for detection of five known mutations associated with aminoglycoside-induced deafness","volume":"10","author":"Bardien","year":"2009","journal-title":"BMC Med Genet"},{"issue":"1","key":"10.1016\/j.jinf.2012.09.002_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0378-5955(94)90040-X","article-title":"A molecular and cellular hypothesis for aminoglycoside-induced deafness","volume":"78","author":"Cortopassi","year":"1994","journal-title":"Hear Res"},{"issue":"18","key":"10.1016\/j.jinf.2012.09.002_bib50","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1093\/nar\/21.18.4174","article-title":"A molecular basis for human hypersensitivity to aminoglycoside antibiotics","volume":"21","author":"Hutchin","year":"1993","journal-title":"Nucleic Acids Res"},{"issue":"17","key":"10.1016\/j.jinf.2012.09.002_bib51","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMc053428","article-title":"Aspirin to prevent gentamicin-induced hearing loss","volume":"354","author":"Sha","year":"2006","journal-title":"N Engl J Med"},{"issue":"44","key":"10.1016\/j.jinf.2012.09.002_bib52","doi-asserted-by":"crossref","first-page":"16019","DOI":"10.1073\/pnas.0508053102","article-title":"Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss","volume":"102","author":"Kalinec","year":"2005","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445312002538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445312002538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:17:22Z","timestamp":1759007842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445312002538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0163445312002538"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2012.09.002","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hearing loss in children treated for multidrug-resistant tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2012.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}