{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:40:46Z","timestamp":1788367246040,"version":"build-2803163510"},"reference-count":15,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.jinf.2013.06.007","type":"journal-article","created":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T01:02:23Z","timestamp":1371862943000},"page":"385-390","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Added value of PCR-testing for confirmation of invasive meningococcal disease in England"],"prefix":"10.1016","volume":"67","author":[{"given":"Ellen","family":"Heinsbroek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamez","family":"Ladhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Guiver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Kaczmarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Borrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2013.06.007_bib1","doi-asserted-by":"crossref","first-page":"B26","DOI":"10.1016\/j.vaccine.2011.12.032","article-title":"The changing and dynamic epidemiology of meningococcal disease","volume":"30","author":"Halperin","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.jinf.2013.06.007_bib2","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1016\/j.vaccine.2012.03.011","article-title":"Invasive meningococcal disease in England and Wales: implications for the introduction of new vaccines","volume":"30","author":"Ladhani","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.jinf.2013.06.007_bib3","series-title":"Meningococcal disease \u2013 epidemiological data","author":"Health Protection Agency","year":"2012"},{"key":"10.1016\/j.jinf.2013.06.007_bib4","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1099\/jmm.0.46288-0","article-title":"Epidemiology of meningococcal disease in England and Wales 1993\/94 to 2003\/04: contribution and experiences of the Meningococcal Reference Unit","volume":"55","author":"Gray","year":"2006","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jinf.2013.06.007_bib5","first-page":"54","article-title":"Creating a national service for the diagnosis of meningococcal disease by polymerase chain reaction","volume":"1","author":"Kaczmarski","year":"1998","journal-title":"Commun Dis Public Health"},{"key":"10.1016\/j.jinf.2013.06.007_bib6","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1128\/JCM.42.7.2919-2925.2004","article-title":"Prospective study of a real-time PCR that is highly sensitive, specific, and clinically useful for diagnosis of meningococcal disease in children","volume":"42","author":"Bryant","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jinf.2013.06.007_bib7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.diagmicrobio.2008.10.008","article-title":"Polymerase chain reaction for diagnosis and serogrouping of meningococcal disease in children","volume":"63","author":"Munoz-Almagro","year":"2009","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jinf.2013.06.007_bib8","series-title":"Bacterial meningitis and meningococcal septicaemia: management of bacterial meningitis and meningococcal septicaemia in children and young people younger than 16 years in primary and secondary care. NICE clinical guideline 102","author":"National Institute for Health and Clinical Excellence","year":"2010"},{"key":"10.1016\/j.jinf.2013.06.007_bib9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/bmj.320.7229.213","article-title":"Bacteraemia and antibiotic resistance of its pathogens reported in England and Wales between 1990 and 1998: trend analysis","volume":"320","author":"Reacher","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.jinf.2013.06.007_bib10","series-title":"Health protection (notification) regulations 2010","author":"The Stationery Office Limited (TSO)","year":"2010"},{"key":"10.1016\/j.jinf.2013.06.007_bib11","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/INF.0b013e318241f824","article-title":"The impact of meningococcal polymerase chain reaction testing on laboratory confirmation of invasive meningococcal disease","volume":"31","author":"Drew","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jinf.2013.06.007_bib12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1469-0691.2005.01327.x","article-title":"Dynamics of PCR-based diagnosis in patients with invasive meningococcal disease","volume":"12","author":"Bronska","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jinf.2013.06.007_bib13","doi-asserted-by":"crossref","first-page":"B73","DOI":"10.1016\/j.vaccine.2011.12.061","article-title":"The use of vaccine antigen characterization, for example by MATS, to guide the introduction of meningococcus B vaccines","volume":"30","author":"Vogel","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.jinf.2013.06.007_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1471-2458-9-95","article-title":"Pre-hospital antibiotic treatment and mortality caused by invasive meningococcal disease, adjusting for indication bias","volume":"9","author":"Perea-Milla","year":"2009","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jinf.2013.06.007_bib15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1086\/596707","article-title":"Severity of meningococcal disease associated with genomic bacterial load","volume":"48","author":"Darton","year":"2009","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445313001539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445313001539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:18:09Z","timestamp":1759007889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445313001539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0163445313001539"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2013.06.007","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Added value of PCR-testing for confirmation of invasive meningococcal disease in England","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2013.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}