{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:23:35Z","timestamp":1789773815822,"version":"4.0.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.jinf.2014.02.017","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T21:09:44Z","timestamp":1395522584000},"page":"69-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children"],"prefix":"10.1016","volume":"69","author":[{"given":"Heli","family":"Harvala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Simmonds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2014.02.017_bib1","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1073\/pnas.89.18.8847","article-title":"A distinct picornavirus group identified by sequence analysis","volume":"89","author":"Hyypia","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jinf.2014.02.017_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/INF.0b013e31815c1b07","article-title":"Severe neonatal parechovirus infection and similarity with enterovirus infection","volume":"27","author":"Verboon-Maciolek","year":"2008","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jinf.2014.02.017_bib3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/ana.21445","article-title":"Human parechovirus causes encephalitis with white matter injury in neonates","volume":"64","author":"Verboon-Maciolek","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jinf.2014.02.017_bib4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/QCO.0b013e32833890ca","article-title":"Parechoviruses in children: understanding a new infection","volume":"23","author":"Harvala","year":"2010","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.jinf.2014.02.017_bib5","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1086\/599094","article-title":"Aetiological role of human parechovirus type 3 in neonatal sepsis identified by direct typing assay on cerebrospinal fluid","volume":"199","author":"Harvala","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jinf.2014.02.017_bib6","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/jmv.22023","article-title":"Comparison of human parechovirus and enterovirus detection frequencies in cerebrospinal fluid samples collected over a 5-year period in Edinburgh \u2013 HPeV type 3 identified as the most common picornavirus type","volume":"83","author":"Harvala","year":"2011","journal-title":"J Med Virol"},{"key":"10.1016\/j.jinf.2014.02.017_bib7","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/01.inf.0000164810.60080.ad","article-title":"Diagnosis and outcomes of enterovirus infections in young infants","volume":"24","author":"Rittichier","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jinf.2014.02.017_bib8","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1542\/peds.103.3.e27","article-title":"A polymerase chain reaction-based epidemiological investigation of the incidence of nonpolio entoroviral infections in febrile and afebrile infants 90 days and younger","volume":"103","author":"Byington","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.jinf.2014.02.017_bib9","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1128\/JCM.01172-12","article-title":"Development and assay of RNA transcripts of enteroviruses species A-D, rhinovirus species A-C and human parechovirus: assessment of assay sensitivity and specificity of real-time screening and typing methods","volume":"50","author":"McLeish","year":"2012","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jinf.2014.02.017_bib10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1542\/peds.2009-1181","article-title":"Defining cerebrospinal fluid white blood cell count reference values in neonates and young infants","volume":"125","author":"Kestenbaum","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.jinf.2014.02.017_bib11","series-title":"Feverish illness in children: assessment and initial management in children younger than 5 years","author":"National Institute for Health and Care Excellence","year":"2013"},{"key":"10.1016\/j.jinf.2014.02.017_bib12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2337\/diacare.23.3.414","article-title":"Can enterovirus infections explain the increasing incidence of type 1 diabetes?","volume":"23","author":"Viskari","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jinf.2014.02.017_bib13","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S1473-3099(11)70090-1","article-title":"Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study","volume":"11","author":"Miller","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jinf.2014.02.017_bib14","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1086\/589752","article-title":"Human parechoviruses as an important viral cause of sepsislike illness and meningitis in young children","volume":"47","author":"Wolthers","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2014.02.017_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jcv.2012.04.016","article-title":"Human parechovirus infections, Lyon, France, 2008\u201310: evidence for severe cases","volume":"54","author":"Schuffenecker","year":"2012","journal-title":"J Clin Virol"},{"issue":"10","key":"10.1016\/j.jinf.2014.02.017_bib16","doi-asserted-by":"crossref","first-page":"e25957","DOI":"10.1371\/journal.pone.0025957","article-title":"Meningococcal disease in children in Merseyside, England: a 31 year descriptive study","volume":"6","author":"Stanton","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2014.02.017_bib17","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1056\/NEJM199102143240704","article-title":"Predictors of morbidity and mortality in neonates with herpes simplex virus infections","volume":"324","author":"Whitley","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jinf.2014.02.017_bib18","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/infdis\/jis446","article-title":"In enterovirus 71 encephalitis with cardio-respiratory compromise, elevated interleukin 1\u03b2, interleukin 1 receptor antagonist, and granulocyte colony-stimulating factor levels are markers of poor prognosis","volume":"206","author":"Griffiths","year":"2012","journal-title":"J Infect Dis"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445314000693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445314000693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:19:56Z","timestamp":1759007996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445314000693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0163445314000693"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2014.02.017","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2014.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}