{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:26:07Z","timestamp":1790335567972,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007509","name":"Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirug\u00eda Tor\u00e1cica (SEPAR)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007509","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Societat Catalana de Pneumologia (SOCAP)"},{"name":"Fundaci\u00f3 Catalana de Pneumologia (FUCAP)"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.jinf.2014.06.013","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T07:23:04Z","timestamp":1403853784000},"page":"590-599","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["IP-10 is an accurate biomarker for the diagnosis of tuberculosis in children"],"prefix":"10.1016","volume":"69","author":[{"given":"I.","family":"Latorre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Mialdea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Serra-Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Altet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Prat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"D\u00edez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Escribano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Casas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ausina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ruhwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2014.06.013_bib1","series-title":"Global tuberculosis report (WHO\/HTM\/TB\/2012.6)","author":"World Health Organization","year":"2012"},{"issue":"5","key":"10.1016\/j.jinf.2014.06.013_bib2","first-page":"636","article-title":"Global epidemiology of childhood tuberculosis","volume":"8","author":"Nelson","year":"2004","journal-title":"Int J Tuberc Lung Dis"},{"issue":"6","key":"10.1016\/j.jinf.2014.06.013_bib3","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1128\/JCM.42.6.2379-2387.2004","article-title":"Specific T-cell epitopes for immunoassay-based diagnosis of Mycobacterium tuberculosis infection","volume":"42","author":"Brock","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"3","key":"10.1016\/j.jinf.2014.06.013_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1086\/318081","article-title":"Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians","volume":"183","author":"Lalvani","year":"2001","journal-title":"J Infect Dis"},{"issue":"9519","key":"10.1016\/j.jinf.2014.06.013_bib5","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/S0140-6736(06)68579-6","article-title":"Use in routine clinical practice of two commercial blood tests for diagnosis of infection with Mycobacterium tuberculosis: a prospective study","volume":"367","author":"Ferrara","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jinf.2014.06.013_bib6","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1164\/rccm.200608-1099OC","article-title":"Comparison of two interferon-gamma assays and tuberculin skin test for tracing TB contacts","volume":"175","author":"Arend","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.jinf.2014.06.013_bib7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1183\/09031936.00115110","article-title":"Interferon-gamma release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis","volume":"37","author":"Diel","year":"2011","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.jinf.2014.06.013_bib8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1183\/09031936.00114810","article-title":"Interferon-gamma release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis","volume":"37","author":"Sester","year":"2011","journal-title":"Eur Respir J"},{"issue":"6","key":"10.1016\/j.jinf.2014.06.013_bib9","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1183\/09031936.00153408","article-title":"Interferon-gamma release assays do not identify more children with active tuberculosis than the tuberculin skin test","volume":"33","author":"Kampmann","year":"2009","journal-title":"Eur Respir J"},{"issue":"Suppl. 1","key":"10.1016\/j.jinf.2014.06.013_bib10","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1471-2334-14-S1-S6","article-title":"Systematic review and meta-analysis on the utility of Interferon-gamma release assays for the diagnosis of Mycobacterium tuberculosis infection in children: a 2013 update","volume":"14","author":"Sollai","year":"2014","journal-title":"BMC Infect Dis"},{"issue":"5","key":"10.1016\/j.jinf.2014.06.013_bib11","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1183\/09031936.00151413","article-title":"Beyond the IFN-gamma horizon: biomarkers for immunodiagnosis of infection with M. tuberculosis","volume":"43","author":"Chegou","year":"2013","journal-title":"Eur Respir J"},{"issue":"7","key":"10.1016\/j.jinf.2014.06.013_bib12","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.micinf.2007.02.021","article-title":"CXCL10\/IP-10 release is induced by incubation of whole blood from tuberculosis patients with ESAT-6, CFP10 and TB7.7","volume":"9","author":"Ruhwald","year":"2007","journal-title":"Microbes Infect"},{"issue":"2","key":"10.1016\/j.jinf.2014.06.013_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1586\/erm.11.97","article-title":"IP-10 release assays in the diagnosis of tuberculosis infection: current status and future directions","volume":"12","author":"Ruhwald","year":"2012","journal-title":"Expert Rev Mol Diagn"},{"issue":"1","key":"10.1016\/j.jinf.2014.06.013_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2249.2011.04488.x","article-title":"Discrimination of agonist and antagonist forms of CXCL10 in biological samples","volume":"167","author":"Casrouge","year":"2012","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"10.1016\/j.jinf.2014.06.013_bib15","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1172\/JCI40594","article-title":"Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV","volume":"121","author":"Casrouge","year":"2011","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.jinf.2014.06.013_bib16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jinf.2014.02.008","article-title":"High urine IP-10 levels associate with chronic HCV infection","volume":"68","author":"Petrone","year":"2014","journal-title":"J Infect"},{"issue":"7","key":"10.1016\/j.jinf.2014.06.013_bib17","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/jmv.23932","article-title":"Circulating pro- and anti-angiogenic mediators in patients infected with hepatitis C at different stages of hepatocellular carcinoma","volume":"86","author":"Talaat","year":"2014","journal-title":"J Med Virol"},{"issue":"6","key":"10.1016\/j.jinf.2014.06.013_bib18","first-page":"731","article-title":"Chemokine IP-10: an adjunct marker for latent tuberculosis infection in children","volume":"13","author":"Lighter","year":"2009","journal-title":"Int J Tuberc Lung Dis"},{"issue":"6","key":"10.1016\/j.jinf.2014.06.013_bib19","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1183\/09031936.00039010","article-title":"Potential of interferon-gamma-inducible protein 10 in improving tuberculosis diagnosis in HIV-infected patients","volume":"36","author":"Aabye","year":"2010","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.jinf.2014.06.013_bib20","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3109\/00365548.2011.632644","article-title":"Interferon-gamma inducible protein 10 as a biomarker for active tuberculosis and latent tuberculosis infection in children: a case-control study","volume":"44","author":"Alsleben","year":"2012","journal-title":"Scand J Infect Dis"},{"issue":"6","key":"10.1016\/j.jinf.2014.06.013_bib21","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jinf.2012.02.013","article-title":"Interferon gamma and interferon gamma inducible protein-10 in detecting tuberculosis infection","volume":"64","author":"Syed Ahamed Kabeer","year":"2012","journal-title":"J Infect"},{"issue":"1","key":"10.1016\/j.jinf.2014.06.013_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jinf.2012.03.017","article-title":"IP-10 is an additional marker for tuberculosis (TB) detection in HIV-infected persons in a low-TB endemic country","volume":"65","author":"Vanini","year":"2012","journal-title":"J Infect"},{"issue":"6","key":"10.1016\/j.jinf.2014.06.013_bib23","doi-asserted-by":"crossref","first-page":"e39228","DOI":"10.1371\/journal.pone.0039228","article-title":"A simple method to quantitate IP-10 in dried blood and plasma spots","volume":"7","author":"Aabye","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jinf.2014.06.013_bib24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1183\/09031936.00129412","article-title":"Dried plasma spots in the diagnosis of tuberculosis: IP-10 release assay on filter paper","volume":"42","author":"Aabye","year":"2013","journal-title":"Eur Respir J"},{"issue":"8","key":"10.1016\/j.jinf.2014.06.013_bib25","doi-asserted-by":"crossref","first-page":"e2858","DOI":"10.1371\/journal.pone.0002858","article-title":"Improving T-cell assays for the diagnosis of latent TB infection: potential of a diagnostic test based on IP-10","volume":"3","author":"Ruhwald","year":"2008","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jinf.2014.06.013_bib26","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1097\/INF.0b013e31817d05a3","article-title":"Interferon gamma, interferon-gamma-induced-protein 10, and tuberculin responses of children at high risk of tuberculosis infection","volume":"27","author":"Petrucci","year":"2008","journal-title":"Pediatr Infect Dis J"},{"issue":"12","key":"10.1016\/j.jinf.2014.06.013_bib27","doi-asserted-by":"crossref","first-page":"e3901","DOI":"10.1371\/journal.pone.0003901","article-title":"Is IP-10 a better biomarker for active and latent tuberculosis in children than IFNgamma?","volume":"3","author":"Whittaker","year":"2008","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jinf.2014.06.013_bib28","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1183\/09031936.00012212","article-title":"Use of tuberculin skin test, IFN-gamma release assays and IFN-gamma-induced protein-10 to identify children with TB infection","volume":"41","author":"Yassin","year":"2013","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.jinf.2014.06.013_bib29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.tube.2011.01.001","article-title":"A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis","volume":"91","author":"Ruhwald","year":"2011","journal-title":"Tuberculosis (Edinb)"},{"issue":"3","key":"10.1016\/j.jinf.2014.06.013_bib30","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.diagmicrobio.2009.07.015","article-title":"Quantitative evaluation of T-cell response after specific antigen stimulation in active and latent tuberculosis infection in adults and children","volume":"65","author":"Latorre","year":"2009","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"5","key":"10.1016\/j.jinf.2014.06.013_bib31","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1183\/09031936.00022710","article-title":"Diagnosing TB infection in children: analysis of discordances using in\u00a0vitro tests and the tuberculin skin test","volume":"37","author":"Altet-Gomez","year":"2011","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.jinf.2014.06.013_bib32","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1128\/CVI.00364-07","article-title":"Comparison of two commercially available gamma interferon blood tests for immunodiagnosis of tuberculosis","volume":"15","author":"Dominguez","year":"2008","journal-title":"Clin Vaccine Immunol"},{"issue":"9","key":"10.1016\/j.jinf.2014.06.013_bib33","doi-asserted-by":"crossref","first-page":"e44728","DOI":"10.1371\/journal.pone.0044728","article-title":"Foxp3+ regulatory T cells among tuberculosis patients: impact on prognosis and restoration of antigen specific IFN-gamma producing T cells","volume":"7","author":"Singh","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jinf.2014.06.013_bib34","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2012-001751","article-title":"Evaluation of the filter paper IP-10 tests in school children after exposure to tuberculosis: a prospective cohort study with a 4-year follow-up","volume":"2","author":"Tuuminen","year":"2012","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.jinf.2014.06.013_bib35","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nm.2299","article-title":"Dominant TNF-alpha+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease","volume":"17","author":"Harari","year":"2011","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.jinf.2014.06.013_bib36","doi-asserted-by":"crossref","first-page":"e17813","DOI":"10.1371\/journal.pone.0017813","article-title":"Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states","volume":"6","author":"Sester","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2014.06.013_bib37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2334-11-135","article-title":"IP-10 response to RD1 antigens might be a useful biomarker for monitoring tuberculosis therapy","volume":"11","author":"Kabeer","year":"2011","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jinf.2014.06.013_bib38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2334-12-10","article-title":"Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting","volume":"12","author":"Chegou","year":"2012","journal-title":"BMC Infect Dis"},{"issue":"6","key":"10.1016\/j.jinf.2014.06.013_bib39","doi-asserted-by":"crossref","first-page":"e38501","DOI":"10.1371\/journal.pone.0038501","article-title":"Potential of host markers produced by infection phase-dependent antigen-stimulated cells for the diagnosis of tuberculosis in a highly endemic area","volume":"7","author":"Chegou","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jinf.2014.06.013_bib40","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/00365548.2011.611167","article-title":"Specific Mycobacterium tuberculosis T cell responses to RD1-selected peptides for the monitoring of anti-tuberculosis therapy","volume":"44","author":"Latorre","year":"2012","journal-title":"Scand J Infect Dis"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445314001911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445314001911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:20:48Z","timestamp":1759008048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445314001911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0163445314001911"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2014.06.013","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IP-10 is an accurate biomarker for the diagnosis of tuberculosis in children","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2014.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}