{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T20:26:16Z","timestamp":1771359976550,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.jinf.2015.04.005","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T21:30:54Z","timestamp":1429306254000},"page":"258-265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["High negative predictive value diagnostic strategies for the reevaluation of early antifungal treatment: A multicenter prospective trial in patients at risk for invasive fungal infections"],"prefix":"10.1016","volume":"71","author":[{"given":"Lilia","family":"Hasseine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Cassaing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Robert-Gangneux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Fillaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Marty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Gangneux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Sirvent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Mondain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Hyvernat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Cointault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Lavayssi\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Georges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"de Guibert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislas","family":"Nimubona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Revest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Tattevin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2015.04.005_bib1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/MCP.0b013e32835f1ad1","article-title":"Frequency, diagnosis and management of fungal respiratory infections","volume":"19","author":"Hayes","year":"2013","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.jinf.2015.04.005_bib2","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1086\/378745","article-title":"Attributable mortality of nosocomial candidemia, revisited","volume":"37","author":"Gudlaugsson","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2015.04.005_bib3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s11908-005-0044-7","article-title":"Global trends in candidemia: review of reports from 1995\u20132005","volume":"7","author":"Morgan","year":"2005","journal-title":"Curr Infect Dis Rep"},{"key":"10.1016\/j.jinf.2015.04.005_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/CMR.00029-06","article-title":"Epidemiology of invasive candidiasis: a persistent public health problem","volume":"20","author":"Pfaller","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jinf.2015.04.005_bib5","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1097\/CCM.0b013e31819efac0","article-title":"Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005\u20132006)","volume":"37","author":"Leroy","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jinf.2015.04.005_bib6","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.2165\/00003495-200767110-00004","article-title":"Invasive aspergillosis: epidemiology, diagnosis and management in immunocompromised patients","volume":"67","author":"Maschmeyer","year":"2007","journal-title":"Drugs"},{"key":"10.1016\/j.jinf.2015.04.005_bib7","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1111\/j.1469-0691.2011.03548.x","article-title":"Epidemiological trends in invasive aspergillosis in France: the SAIF network (2005\u20132007)","volume":"17","author":"Lortholary","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jinf.2015.04.005_bib8","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/jac\/dks266","article-title":"Indications and outcomes of antifungal therapy in French patients with haematological conditions or recipients of haematopoietic stem cell transplantation","volume":"67","author":"Herbrecht","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jinf.2015.04.005_bib9","first-page":"341","article-title":"Pulmonary aspergillosis: early diagnosis improves survival","volume":"62","author":"Von Eiff","year":"1995","journal-title":"Respir Int Rev Thorac Dis"},{"key":"10.1016\/j.jinf.2015.04.005_bib10","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1128\/AAC.49.9.3640-3645.2005","article-title":"Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality","volume":"49","author":"Morrell","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jinf.2015.04.005_bib11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2217\/17460913.2.3.231","article-title":"Posaconazole: a next-generation triazole antifungal","volume":"2","author":"Farowski","year":"2007","journal-title":"Future Microbiol"},{"key":"10.1016\/j.jinf.2015.04.005_bib12","article-title":"Antifungal pre-emptive strategy for high-risk neutropenic patients: Why the story is still ongoing","author":"Cordonnier","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jinf.2015.04.005_bib13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1086\/510592","article-title":"Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortality","volume":"44","author":"Upton","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2015.04.005_bib14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/bmt.2010.175","article-title":"European guidelines for antifungal management in leukemia and hematopoietic stem cell transplant recipients: summary of the ECIL 3\u20132009 update","volume":"46","author":"Maertens","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jinf.2015.04.005_bib15","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1093\/jac\/dks256","article-title":"Adherence to recommendations for the use of antifungal agents in a tertiary care hospital","volume":"67","author":"Nivoix","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jinf.2015.04.005_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1086\/323335","article-title":"Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus","volume":"34","author":"Ascioglu","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2015.04.005_bib17","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","volume":"46","author":"De Pauw","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2015.04.005_bib18","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1473-3099(13)70076-8","article-title":"Galactomannan and PCR versus culture and histology for directing use of antifungal treatment for invasive aspergillosis in high-risk haematology patients: a randomised controlled trial","volume":"13","author":"Morrissey","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jinf.2015.04.005_bib19","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/sj.bmt.1704768","article-title":"A prospective study of real-time panfungal PCR for the early diagnosis of invasive fungal infection in haemato-oncology patients","volume":"35","author":"Jordanides","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jinf.2015.04.005_bib20","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1128\/JCM.05316-11","article-title":"Evaluation of Aspergillus PCR protocols for testing serum specimens","volume":"49","author":"White","year":"2011","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jinf.2015.04.005_bib21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1086\/499949","article-title":"The evolution and evaluation of a whole blood polymerase chain reaction assay for the detection of invasive aspergillosis in hematology patients in a routine clinical setting","volume":"42","author":"White","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2015.04.005_bib22","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1086\/512812","article-title":"Comparison of histopathological analysis, culture, and polymerase chain reaction assays to detect invasive mold infections from biopsy specimens","volume":"44","author":"Rickerts","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2015.04.005_bib23","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1086\/521245","article-title":"The value of computed tomography-guided percutaneous lung biopsy for diagnosis of invasive fungal infection in immunocompromised patients","volume":"45","author":"Lass-Fl\u00f6rl","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2015.04.005_bib24","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1128\/JCM.03322-12","article-title":"Multicenter comparison of serum and whole-blood specimens for detection of Aspergillus DNA in high-risk haematological patients","volume":"51","author":"Springer","year":"2013","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jinf.2015.04.005_bib25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1473-3099(09)70019-2","article-title":"Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis","volume":"9","author":"Mengoli","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jinf.2015.04.005_bib26","series-title":"Molecular detection of human fungal pathogens","first-page":"673","author":"Cassaing","year":"2011"},{"key":"10.1016\/j.jinf.2015.04.005_bib27","first-page":"141","article-title":"Azole-resistance in Aspergillus: proposed nomenclature and breakpoints","volume":"12","author":"Verweij","year":"2009","journal-title":"Drug Resist Updat Rev Comment Antimicrob Anticancer Chemother"},{"key":"10.1016\/j.jinf.2015.04.005_bib28","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1128\/JCM.05316-11","article-title":"European Aspergillus PCR Initiative (EAPCRI). Evaluation of Aspergillus PCR protocols for testing serum specimens","volume":"49","author":"White","year":"2011","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jinf.2015.04.005_bib29","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1128\/JCM.36.5.1169-1175.1998","article-title":"Panfungal PCR assay for detection of fungal infection in human blood specimens","volume":"36","author":"Van Burik","year":"1998","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jinf.2015.04.005_bib30","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jinf.2013.04.020","article-title":"Prevention and diagnosis of invasive fungal disease in high-risk patients within an integrative care pathway","volume":"67","author":"Barnes","year":"2013","journal-title":"J Infect"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445315000985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445315000985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:21:54Z","timestamp":1759008114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445315000985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0163445315000985"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2015.04.005","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High negative predictive value diagnostic strategies for the reevaluation of early antifungal treatment: A multicenter prospective trial in patients at risk for invasive fungal infections","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2015.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}