{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:46:41Z","timestamp":1792230401396,"version":"4.4.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.jinf.2015.04.014","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T21:46:38Z","timestamp":1429911998000},"page":"S10-S14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"S1","title":["What the pediatrician should know about non-typeable Haemophilus influenzae"],"prefix":"10.1016","volume":"71","author":[{"given":"Janet R.","family":"Gilsdorf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jinf.2015.04.014_bib1","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/cid\/cir735","article-title":"Current epidemiology and trends in invasive Haemophilus influenzae disease\u2013United States, 1989\u20132008","volume":"53","author":"MacNeil","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.1016\/j.jinf.2015.04.014_bib2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1473-3099(14)70027-1","article-title":"Hospital admission rates for meningitis and septicaemia caused by Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae in children in England over five decades: a population-based observational study","volume":"14","author":"Martin","year":"2014","journal-title":"Lancet Infect Dis"},{"issue":"Suppl: S22\u20137","key":"10.1016\/j.jinf.2015.04.014_bib3","article-title":"Capsules and virulence in the HAP group of bacteria","volume":"54","author":"Inzana","year":"1990","journal-title":"Can J Vet Res"},{"issue":"9","key":"10.1016\/j.jinf.2015.04.014_bib4","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3201\/eid1709.101991","article-title":"Increasing incidence of invasive Haemophilus influenzae disease in adults, Utah, USA","volume":"17","author":"Rubach","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jinf.2015.04.014_bib5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1086\/505499","article-title":"Genetic diversity of invasive strains of Haemophilus influenzae type b before and after introduction of the conjugate vaccine in Italy","volume":"43","author":"Cerquetti","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"Pt 4","key":"10.1016\/j.jinf.2015.04.014_bib6","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1099\/mic.0.024877-0","article-title":"Bacterial variation, virulence and vaccines","volume":"155","author":"Moxon","year":"2009","journal-title":"Microbiology"},{"issue":"1","key":"10.1016\/j.jinf.2015.04.014_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1128\/JCM.41.1.393-396.2003","article-title":"Identification of Haemophilus influenzae serotypes by standard slide agglutination serotyping and PCR-based capsule typing","volume":"41","author":"LaClaire","year":"2003","journal-title":"J Clin Microbiol"},{"issue":"7","key":"10.1016\/j.jinf.2015.04.014_bib8","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1128\/JCM.02509-10","article-title":"Use of bexB to detect the capsule locus in Haemophilus influenzae","volume":"49","author":"Davis","year":"2011","journal-title":"J Clin Microbiol"},{"issue":"10","key":"10.1016\/j.jinf.2015.04.014_bib9","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1128\/jcm.32.10.2382-2386.1994","article-title":"PCR for capsular typing of Haemophilus influenzae","volume":"32","author":"Falla","year":"1994","journal-title":"J Clin Microbiol"},{"issue":"6","key":"10.1016\/j.jinf.2015.04.014_bib10","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jinf.2012.08.005","article-title":"Invasive Haemophilus influenzae in the United States, 1999\u20132008: epidemiology and outcomes","volume":"65","author":"Livorsi","year":"2012","journal-title":"J Infect"},{"issue":"3","key":"10.1016\/j.jinf.2015.04.014_bib11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF02014895","article-title":"Relative proportions of Haemophilus species in the throat of healthy children and adults","volume":"3","author":"Kuklinska","year":"1984","journal-title":"Eur J Clin Microbiol"},{"issue":"6","key":"10.1016\/j.jinf.2015.04.014_bib12","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJM200102083440602","article-title":"Efficacy of a pneumococcal conjugate vaccine against acute otitis media","volume":"344","author":"Eskola","year":"2001","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.jinf.2015.04.014_bib13","doi-asserted-by":"crossref","first-page":"e44730","DOI":"10.1371\/journal.pone.0044730","article-title":"Nontypeable Haemophilus influenzae genetic islands associated with chronic pulmonary infection","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jinf.2015.04.014_bib14","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1128\/JCM.01331-06","article-title":"Identification of new genetic regions more prevalent in nontypeable Haemophilus influenze otitis media than in throat strains","volume":"44","author":"Xie","year":"2006","journal-title":"J Clin Micro"},{"key":"10.1016\/j.jinf.2015.04.014_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.meegid.2012.11.023","article-title":"Population structure in nontypeable Haemophilus influenzae","volume":"14","author":"LaCross","year":"2013","journal-title":"Infect Genet Evol"},{"issue":"2","key":"10.1016\/j.jinf.2015.04.014_bib16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1128\/JCM.01832-07","article-title":"Relationships of nontypeable Haemophilus influenzae strains to hemolytic and nonhemolytic Haemophilus haemolyticus strains","volume":"46","author":"McCrea","year":"2008","journal-title":"J Clin Microbiol"},{"issue":"1","key":"10.1016\/j.jinf.2015.04.014_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1086\/509824","article-title":"Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae","volume":"195","author":"Murphy","year":"2007","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.jinf.2015.04.014_bib18","doi-asserted-by":"crossref","first-page":"e34083","DOI":"10.1371\/journal.pone.0034083","article-title":"Molecular surveillance of true nontypeable Haemophilus influenzae: an evaluation of PCR screening assays","volume":"7","author":"Binks","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jinf.2015.04.014_bib19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1128\/CMR.00103-13","article-title":"Classification, identification, and clinical significance of haemophilus and aggregatibacter species with host specificity for humans","volume":"27","author":"Norskov-Lauritsen","year":"2014","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"10.1016\/j.jinf.2015.04.014_bib20","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1128\/JB.00782-08","article-title":"Delineation of the species Haemophilus influenzae by phenotype, multilocus sequence phylogeny, and detection of marker genes","volume":"191","author":"Norskov-Lauritsen","year":"2009","journal-title":"J Bacteriol"},{"issue":"3","key":"10.1016\/j.jinf.2015.04.014_bib21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/CMR.00072-12","article-title":"Matrix-assisted laser desorption ionization-time of flight mass spectrometry: a fundamental shift in the routine practice of clinical microbiology","volume":"26","author":"Clark","year":"2013","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"10.1016\/j.jinf.2015.04.014_bib22","doi-asserted-by":"crossref","first-page":"e63222","DOI":"10.1371\/journal.pone.0063222","article-title":"Rapid discrimination of Haemophilus influenzae, H. parainfluenzae, and H. haemolyticus by fluorescence in situ hybridization (FISH) and two matrix-assisted laser-desorption-ionization time-of-flight mass spectrometry (MALDI-TOF-MS) platforms","volume":"8","author":"Frickmann","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2015.04.014_bib23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1741-7007-3-6","article-title":"Fuzzy species among recombinogenic bacteria","volume":"3","author":"Hanage","year":"2005","journal-title":"BMC Biol"},{"issue":"7","key":"10.1016\/j.jinf.2015.04.014_bib24","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1128\/JCM.06575-11","article-title":"Haemophilus haemolyticus isolates causing clinical disease","volume":"50","author":"Anderson","year":"2012","journal-title":"J Clin Microbiol"},{"issue":"4","key":"10.1016\/j.jinf.2015.04.014_bib25","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1128\/JCM.06688-11","article-title":"An invasive Haemophilus haemolyticus isolate","volume":"50","author":"Morton","year":"2012","journal-title":"J Clin Microbiol"},{"issue":"5","key":"10.1016\/j.jinf.2015.04.014_bib26","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/jac\/dks532","article-title":"Prevalence and mechanisms of beta-lactam resistance in Haemophilus haemolyticus","volume":"68","author":"Witherden","year":"2013","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl.S1","key":"10.1016\/j.jinf.2015.04.014_bib27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/jac\/dkf810","article-title":"The PROTEKT surveillance study: antimicrobial susceptinility of Haemophilus influenzae and Moraxella catarrhalis from community-acquired respiratory tract infections","volume":"50","author":"Hoban","year":"2002","journal-title":"J Antimicrob Chemother"},{"issue":"8","key":"10.1016\/j.jinf.2015.04.014_bib28","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1128\/AAC.00415-12","article-title":"Increase of beta-lactam-resistant invasive Haemophilus influenzae in Sweden, 1997 to 2010","volume":"56","author":"Resman","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jinf.2015.04.014_bib29","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1128\/CMR.00040-06","article-title":"Antimicrobial resistance in Haemophilus influenzae","volume":"20","author":"Tristam","year":"2007","journal-title":"Clin Microbiol Rev"},{"issue":"8","key":"10.1016\/j.jinf.2015.04.014_bib30","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1128\/AAC.01772-10","article-title":"Moraxella catarrhalis outer membrane vesicles carry beta-lactamase and promote survival of Streptococcus pneumoniae and Haemophilus influenzae by inactivating amoxicillin","volume":"55","author":"Schaar","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"10.1016\/j.jinf.2015.04.014_bib31","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1093\/jac\/dkt189","article-title":"PCR screening for the N526K substitution in isolates of Haemophilus influenzae and Haemophilus haemolyticus","volume":"68","author":"Witherden","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jinf.2015.04.014_bib32","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1128\/AAC.01545-06","article-title":"Horizontal gene transfer of ftsI, encoding penicillin-binding protein 3, in Haemophilus influenzae","volume":"51","author":"Takahata","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"issue":"9512","key":"10.1016\/j.jinf.2015.04.014_bib33","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0140-6736(06)68304-9","article-title":"Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study","volume":"367","author":"Prymula","year":"2006","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jinf.2015.04.014_bib34","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1473-3099(13)70338-4","article-title":"Effect of pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) on outpatient antimicrobial purchases: a double-blind, cluster randomised phase 3-4 trial","volume":"14","author":"Palmu","year":"2014","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"10.1016\/j.jinf.2015.04.014_bib35","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1016\/j.ijid.2010.10.005","article-title":"Invasive Haemophilus influenzae in British Columbia: non-Hib and non-typeable strains causing disease in children and adults","volume":"15","author":"Shuel","year":"2011","journal-title":"Int J Infect Dis"},{"issue":"10","key":"10.1016\/j.jinf.2015.04.014_bib36","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1007\/s10096-012-1623-9","article-title":"Epidemiology and evolution of antibiotic resistance of Haemophilus influenzae in children 5 years of age or less in France, 2001-2008: a retrospective database analysis","volume":"31","author":"Dabernat","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"4","key":"10.1016\/j.jinf.2015.04.014_bib37","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/jac\/dkq533","article-title":"Polymorphism in ftsI gene and {beta}-lactam susceptibility in Portuguese Haemophilus influenzae strains: clonal dissemination of beta-lactamase-positive isolates with decreased susceptibility to amoxicillin\/clavulanic acid","volume":"66","author":"Barbosa","year":"2011","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"10.1016\/j.jinf.2015.04.014_bib38","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1017\/S0950268812001082","article-title":"High prevalence of nasal carriage of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae in healthy children in Korea","volume":"141","author":"Bae","year":"2013","journal-title":"Epidemiol Infect"},{"issue":"5","key":"10.1016\/j.jinf.2015.04.014_bib39","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1089\/mdr.2013.0186","article-title":"Oropharyngeal colonization by nontypeable Haemophilus influenzae among healthy children attending day care centers","volume":"20","author":"Puig","year":"2014","journal-title":"Microb Drug Resist"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445315001073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445315001073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:20:37Z","timestamp":1759008037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445315001073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":39,"alternative-id":["S0163445315001073"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2015.04.014","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What the pediatrician should know about non-typeable Haemophilus influenzae","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2015.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}