{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:29:51Z","timestamp":1790069391131,"version":"4.0.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour, and Welfare of Japan","doi-asserted-by":"publisher","award":["H22-kaken-001"],"award-info":[{"award-number":["H22-kaken-001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jinf.2015.09.038","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T05:28:41Z","timestamp":1445923721000},"page":"91-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones"],"prefix":"10.1016","volume":"72","author":[{"given":"Eisuke","family":"Murakami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7591-8287","authenticated-orcid":false,"given":"Masataka","family":"Tsuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Hiraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Miki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomokazu","family":"Kawaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Aikata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Nelson","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-3611","authenticated-orcid":false,"given":"Tomoyuki","family":"Akita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5530-5341","authenticated-orcid":false,"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2015.09.038_bib1","series-title":"Hepatitis B fact sheet","author":"WHO","year":"2014"},{"issue":"2","key":"10.1016\/j.jinf.2015.09.038_bib2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1172\/JCI58847","article-title":"IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome","volume":"122","author":"Belloni","year":"2012","journal-title":"J Clin Invest"},{"issue":"47","key":"10.1016\/j.jinf.2015.09.038_bib3","doi-asserted-by":"crossref","first-page":"19975","DOI":"10.1073\/pnas.0908365106","article-title":"Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function","volume":"106","author":"Belloni","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.jinf.2015.09.038_bib4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/scbi.2000.0321","article-title":"Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)","volume":"10","author":"Brechot","year":"2000","journal-title":"Semin Cancer Biol"},{"issue":"8","key":"10.1016\/j.jinf.2015.09.038_bib5","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1136\/gut.2004.054452","article-title":"Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas","volume":"54","author":"Murakami","year":"2005","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.jinf.2015.09.038_bib6","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1101\/gad.1.8.773","article-title":"The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma","volume":"1","author":"Nagaya","year":"1987","journal-title":"Genes Dev"},{"issue":"6","key":"10.1016\/j.jinf.2015.09.038_bib7","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1128\/jvi.61.6.1808-1813.1987","article-title":"Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children","volume":"61","author":"Yaginuma","year":"1987","journal-title":"J Virol"},{"issue":"Suppl. 1","key":"10.1016\/j.jinf.2015.09.038_bib8","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1016\/S0168-8278(02)00431-2","article-title":"Management of chronic hepatitis B","volume":"38","author":"Conjeevaram","year":"2003","journal-title":"J Hepatol"},{"issue":"6","key":"10.1016\/j.jinf.2015.09.038_bib9","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1002\/hep.21189","article-title":"Increased risk of adefovir resistance in patients with lamivudine-resistant chronic hepatitis B after 48 weeks of adefovir dipivoxil monotherapy","volume":"43","author":"Lee","year":"2006","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.jinf.2015.09.038_bib10","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0168-8278(99)80123-8","article-title":"Histological changes in liver biopsies after one year of lamivudine treatment in patients with chronic hepatitis B infection","volume":"30","author":"Suzuki","year":"1999","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.jinf.2015.09.038_bib11","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1053\/j.gastro.2007.02.039","article-title":"Drug targets and molecular mechanisms of drug resistance in chronic hepatitis B","volume":"132","author":"Ghany","year":"2007","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jinf.2015.09.038_bib12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/hep.21698","article-title":"Antiviral drug-resistant HBV: standardization of nomenclature and assays and recommendations for management","volume":"46","author":"Lok","year":"2007","journal-title":"Hepatology"},{"issue":"12","key":"10.1016\/j.jinf.2015.09.038_bib13","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1002\/jmv.20981","article-title":"Successful treatment of an entecavir-resistant hepatitis B virus variant","volume":"79","author":"Yatsuji","year":"2007","journal-title":"J Med Virol"},{"issue":"11","key":"10.1016\/j.jinf.2015.09.038_bib14","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1128\/AAC.00239-06","article-title":"Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif","volume":"50","author":"Yatsuji","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1016\/j.jinf.2015.09.038_bib15","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1053\/j.gastro.2009.08.063","article-title":"Hepatitis B virus resistance to nucleos(t)ide analogues","volume":"137","author":"Zoulim","year":"2009","journal-title":"Gastroenterology"},{"issue":"Suppl. 5","key":"10.1016\/j.jinf.2015.09.038_bib16","doi-asserted-by":"crossref","first-page":"S174","DOI":"10.1002\/hep.22900","article-title":"Antiviral resistance and hepatitis B therapy","volume":"49","author":"Ghany","year":"2009","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jinf.2015.09.038_bib17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12072-008-9048-3","article-title":"Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure","volume":"2","author":"Locarnini","year":"2008","journal-title":"Hepatol Int"},{"issue":"1","key":"10.1016\/j.jinf.2015.09.038_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1128\/MMBR.64.1.51-68.2000","article-title":"Hepatitis B virus biology","volume":"64","author":"Seeger","year":"2000","journal-title":"Microbiol Mol Biol Rev"},{"issue":"2\u20133","key":"10.1016\/j.jinf.2015.09.038_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0166-3542(96)00938-2","article-title":"DNA polymerase activity of hepatitis B virus particles: differential inhibition by L-enantiomers of nucleotide analogs","volume":"30","author":"Davis","year":"1996","journal-title":"Antiviral Res"},{"issue":"13","key":"10.1016\/j.jinf.2015.09.038_bib20","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1073\/pnas.90.13.6320","article-title":"Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA","volume":"90","author":"Jacobo-Molina","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.jinf.2015.09.038_bib21","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1002\/j.1460-2075.1989.tb08565.x","article-title":"Identification of four conserved motifs among the RNA-dependent polymerase encoding elements","volume":"8","author":"Poch","year":"1989","journal-title":"Embo J"},{"issue":"16","key":"10.1016\/j.jinf.2015.09.038_bib22","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/jnci\/djn243","article-title":"Associations between hepatitis B virus genotype and mutants and the risk of hepatocellular carcinoma","volume":"100","author":"Yang","year":"2008","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"10.1016\/j.jinf.2015.09.038_bib23","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.jhep.2008.02.019","article-title":"Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up","volume":"48","author":"Yatsuji","year":"2008","journal-title":"J Hepatol"},{"issue":"8","key":"10.1016\/j.jinf.2015.09.038_bib24","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3851\/IMP1679","article-title":"Evolution and suppression of HBV strains with multidrug resistance to lamivudine, adefovir dipivoxil and entecavir in a patient with chronic hepatitis B","volume":"15","author":"Liu","year":"2010","journal-title":"Antivir Ther"},{"issue":"2","key":"10.1016\/j.jinf.2015.09.038_bib25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/hep.26277","article-title":"Efficacy of tenofovir disoproxil fumarate at 240 weeks in patients with chronic hepatitis B with high baseline viral\u00a0load","volume":"58","author":"Gordon","year":"2013","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.jinf.2015.09.038_bib26","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/hep.26686","article-title":"No detectable resistance to tenofovir disoproxil fumarate after 6 years of therapy in patients with chronic hepatitis B","volume":"59","author":"Kitrinos","year":"2014","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jinf.2015.09.038_bib27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/hep.24078","article-title":"No resistance to tenofovir disoproxil fumarate detected after up to 144 weeks of therapy in patients monoinfected with chronic hepatitis B virus","volume":"53","author":"Snow-Lampart","year":"2011","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.jinf.2015.09.038_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.23246","article-title":"Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside\/nucleotide analogues","volume":"51","author":"van Bommel","year":"2010","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.jinf.2015.09.038_bib29","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1053\/jhep.2003.50458","article-title":"Determinants for sustained HBeAg response to lamivudine therapy","volume":"38","author":"Chien","year":"2003","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.jinf.2015.09.038_bib30","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/jmv.21902","article-title":"Mutation pattern of lamivudine resistance in relation to hepatitis B genotypes: hepatitis B genotypes differ in their lamivudine resistance associated mutation pattern","volume":"82","author":"Damerow","year":"2010","journal-title":"J Med Virol"},{"issue":"4","key":"10.1016\/j.jinf.2015.09.038_bib31","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/hep.21345","article-title":"Influence of hepatitis B virus genotypes on the intra- and extracellular expression of viral DNA and antigens","volume":"44","author":"Sugiyama","year":"2006","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jinf.2015.09.038_bib32","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/01.pap.0000249927.67907.eb","article-title":"Hepatitis B genotypes and response to antiviral therapy: a review","volume":"14","author":"Palumbo","year":"2007","journal-title":"Am J Ther"},{"issue":"1","key":"10.1016\/j.jinf.2015.09.038_bib33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/jmv.20320","article-title":"Persistence of acute infection with hepatitis B virus genotype A and treatment in Japan","volume":"76","author":"Suzuki","year":"2005","journal-title":"J Med Virol"},{"issue":"8","key":"10.1016\/j.jinf.2015.09.038_bib34","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/90968","article-title":"Hepatitis C virus replication in mice with chimeric human livers","volume":"7","author":"Mercer","year":"2001","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.jinf.2015.09.038_bib35","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0002-9440(10)63352-4","article-title":"Near completely humanized liver in mice shows human-type metabolic responses to drugs","volume":"165","author":"Tateno","year":"2004","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.jinf.2015.09.038_bib36","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/hep.20892","article-title":"Infection of human hepatocyte chimeric mouse with genetically engineered hepatitis B virus","volume":"42","author":"Tsuge","year":"2005","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.jinf.2015.09.038_bib37","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/hep.20580","article-title":"G to A hypermutation of hepatitis B virus","volume":"41","author":"Noguchi","year":"2005","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.jinf.2015.09.038_bib38","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/hep.21581","article-title":"Serum HBV RNA is a predictor of early emergence of the YMDD mutant in patients treated with lamivudine","volume":"45","author":"Hatakeyama","year":"2007","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.jinf.2015.09.038_bib39","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1007\/s00535-012-0737-2","article-title":"Serum HBV RNA and HBeAg are useful markers for the safe discontinuation of nucleotide analogue treatments in chronic hepatitis B patients","volume":"48","author":"Tsuge","year":"2013","journal-title":"J Gastroenterol"},{"issue":"2","key":"10.1016\/j.jinf.2015.09.038_bib40","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0016-5085(03)00939-9","article-title":"Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase","volume":"125","author":"Angus","year":"2003","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.jinf.2015.09.038_bib41","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/jmv.20701","article-title":"Response to long-term lamivudine treatment in patients infected with hepatitis B virus genotypes A, B, and C","volume":"78","author":"Kobayashi","year":"2006","journal-title":"J Med Virol"},{"issue":"7","key":"10.1016\/j.jinf.2015.09.038_bib42","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1128\/AAC.00138-06","article-title":"Intracellular metabolism and in\u00a0vitro activity of tenofovir against hepatitis B virus","volume":"50","author":"WEt","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"10.1016\/j.jinf.2015.09.038_bib43","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1177\/135965350501000612","article-title":"Selection of hepatitis B virus polymerase mutations in HIV-coinfected patients treated with tenofovir","volume":"10","author":"Sheldon","year":"2005","journal-title":"Antivir Ther"},{"issue":"2","key":"10.1016\/j.jinf.2015.09.038_bib44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.antiviral.2012.12.007","article-title":"The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir","volume":"97","author":"Qin","year":"2013","journal-title":"Antiviral Res"},{"issue":"9","key":"10.1016\/j.jinf.2015.09.038_bib45","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1002\/jmv.24201","article-title":"Tenofovir-based rescue therapy in chronic hepatitis B patients with suboptimal responses to adefovir with prior lamivudine resistance","volume":"87","author":"Cho","year":"2015","journal-title":"J Med Virol"},{"issue":"6","key":"10.1016\/j.jinf.2015.09.038_bib46","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1053\/j.gastro.2009.08.061","article-title":"Factors that predict response of patients with hepatitis B e antigen-positive chronic hepatitis B to peginterferon-alfa","volume":"137","author":"Buster","year":"2009","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.jinf.2015.09.038_bib47","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/apt.12207","article-title":"Meta-analysis: the association of hepatitis B virus genotypes and hepatocellular carcinoma","volume":"37","author":"Wong","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.jinf.2015.09.038_bib48","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jhep.2012.04.037","article-title":"Long-term continuous entecavir therapy in nucleos(t)ide-naive chronic hepatitis B patients","volume":"57","author":"Ono","year":"2012","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.jinf.2015.09.038_bib49","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000071460","article-title":"Efficacy of lamivudine therapy and factors associated with emergence of resistance in chronic hepatitis B virus infection in Japan","volume":"46","author":"Suzuki","year":"2003","journal-title":"Intervirology"},{"issue":"2","key":"10.1016\/j.jinf.2015.09.038_bib50","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1537-2995.2007.01522.x","article-title":"Minimum infectious dose of hepatitis B virus in chimpanzees and difference in the dynamics of viremia between genotype A and genotype C","volume":"48","author":"Komiya","year":"2008","journal-title":"Transfusion"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445315003394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445315003394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:22:36Z","timestamp":1759008156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445315003394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0163445315003394"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2015.09.038","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of tenofovir disoproxil fumarate on drug-resistant HBV clones","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2015.09.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}