{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:24:59Z","timestamp":1789557899763,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24-AI093969"],"award-info":[{"award-number":["K24-AI093969"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AI068804"],"award-info":[{"award-number":["R01-AI068804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.jinf.2015.11.002","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T21:46:17Z","timestamp":1452289577000},"page":"302-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Increased in\u00a0vitro phenol-soluble modulin production is associated with soft tissue infection source in clinical isolates of methicillin-susceptible Staphylococcus aureus"],"prefix":"10.1016","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6445-7331","authenticated-orcid":false,"given":"Robert","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwang-Soo","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batu","family":"Sharma-Kuinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R.","family":"Berlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-lung","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua T.","family":"Thaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Ruffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Maskarinec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian H.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Q.","family":"Fortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthymia","family":"Giannitsioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Durante-Mangoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeina A.","family":"Kanafani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Vance G.","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2015.11.002_bib1","doi-asserted-by":"crossref","first-page":"S350","DOI":"10.1086\/533591","article-title":"Pathogenesis of methicillin-resistant Staphylococcus aureus infection","volume":"46","author":"Gordon","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2015.11.002_bib2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1203\/PDR.0b013e31819dc44d","article-title":"Molecular pathogenesis of Staphylococcus aureus infection","volume":"65","author":"Liu","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.jinf.2015.11.002_bib3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ijmm.2013.11.019","article-title":"Phenol-soluble modulins","volume":"304","author":"Otto","year":"2014","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.jinf.2015.11.002_bib4","doi-asserted-by":"crossref","first-page":"e1000533","DOI":"10.1371\/journal.ppat.1000533","article-title":"Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA","volume":"5","author":"Queck","year":"2009","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jinf.2015.11.002_bib5","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/nm1656","article-title":"Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA","volume":"13","author":"Wang","year":"2007","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.jinf.2015.11.002_bib6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jinf.2015.06.005","article-title":"Clinical MRSA isolates from skin and soft tissue infections show increased in\u00a0vitro production of phenol soluble modulins","volume":"71","author":"Berlon","year":"2015","journal-title":"J Infect"},{"key":"10.1016\/j.jinf.2015.11.002_bib7","doi-asserted-by":"crossref","first-page":"e1003269","DOI":"10.1371\/journal.ppat.1003269","article-title":"Mobile genetic element SCCmec-encoded psm-mec RNA suppresses translation of agrA and attenuates MRSA virulence","volume":"9","author":"Kaito","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jinf.2015.11.002_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1099\/00222615-30-4-245","article-title":"Production of \u201cvirulence factors\u201d by \u201cepidemic\u201d methicillin-resistant Staphylococcus aureus in\u00a0vitro","volume":"30","author":"Jordens","year":"1989","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jinf.2015.11.002_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jaci.2009.10.039","article-title":"Secreted virulence factor comparison between methicillin resistant and methicillin-sensitive Staphylococcus aureus, and its relevance to atopic dermatitis","volume":"125","author":"Schlievert","year":"2010","journal-title":"J Allergy Clin Immun"},{"key":"10.1016\/j.jinf.2015.11.002_bib10","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1086\/587896","article-title":"Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organisms","volume":"46","author":"Stryjewski","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2015.11.002_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/cid\/ciq031","article-title":"Telavancin versus vancomycin for hospital-acquired pneumonia due to gram-positive pathogens","volume":"52","author":"Rubinstein","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2015.11.002_bib12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1086\/313753","article-title":"Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis","volume":"30","author":"Li","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2015.11.002_bib13","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1128\/JCM.01643-09","volume":"47","author":"Bae","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jinf.2015.11.002_bib14","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1001\/jama.293.24.3012","article-title":"Staphylococcus aureus endocarditis: a consequence of medical progress","volume":"293","author":"Fowler","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.jinf.2015.11.002_bib15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/archinternmed.2008.603","article-title":"Clinical presentation, etiology and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study","volume":"169","author":"Murdoch","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jinf.2015.11.002_bib16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.22203\/eCM.v004a04","article-title":"An introduction to Staphylococcus aureus, and techniques for identifying and quantifying S. aureus adhesins in relation to adhesion to biomaterials: review","volume":"4","author":"Harris","year":"2002","journal-title":"Eur Cells Mater"},{"key":"10.1016\/j.jinf.2015.11.002_bib17","first-page":"285","article-title":"Sequence analysis of the variable number tandem repeat in Staphylococcus aureus protein A gene: spa typing","volume":"431","author":"Mathema","year":"2008","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jinf.2015.11.002_bib18","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/infdis\/jir441","article-title":"Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection","volume":"204","author":"Kobayashi","year":"2011","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jinf.2015.11.002_bib19","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1128\/AEM.03157-12","article-title":"Distinct roles of phenol-soluble modulins in spreading of Staphylococcus aureus on wet surfaces","volume":"79","author":"Tsompanidou","year":"2013","journal-title":"Appl Environ Microb"},{"key":"10.1016\/j.jinf.2015.11.002_bib20","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.micinf.2011.11.013","article-title":"Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins: implications for diagnosis and pathogenesis","volume":"14","author":"Cheung","year":"2012","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jinf.2015.11.002_bib21","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.4049\/jimmunol.1202563","article-title":"Staphylococcus aureus phenol-soluble modulin peptides modulate dendritic cell functions and increase in\u00a0vitro priming of regulatory T cells","volume":"190","author":"Schreiner","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.jinf.2015.11.002_bib22","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.molcel.2008.08.005","article-title":"RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus","volume":"32","author":"Queck","year":"2008","journal-title":"Mol Cell"},{"key":"10.1016\/j.jinf.2015.11.002_bib23","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1172\/JCI117530","article-title":"Diminished virulence of a sar-\/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis","volume":"94","author":"Cheung","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jinf.2015.11.002_bib24","doi-asserted-by":"crossref","first-page":"e1004298","DOI":"10.1371\/journal.ppat.1004298","article-title":"Production of an attenuated phenol-soluble modulin variant unique to the MRSA clonal complex 30 increases severity of bloodstream infection","volume":"10","author":"Cheung","year":"2014","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jinf.2015.11.002_bib25","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/infdis\/jir389","article-title":"Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins","volume":"204","author":"Nienaber","year":"2011","journal-title":"J Infec Dis"},{"key":"10.1016\/j.jinf.2015.11.002_bib26","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.chom.2008.10.001","article-title":"Apolipoprotein B is an innate barrier against invasive Staphylococcus aureus infection","volume":"4","author":"Peterson","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jinf.2015.11.002_bib27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nrmicro3110","article-title":"Phenol-soluble modulins and staphylococcal infection","volume":"11","author":"Peschel","year":"2013","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jinf.2015.11.002_bib28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1146\/annurev-micro-092412-155746","article-title":"Neutrophils versus Staphylococcus aureus: a biological tug of war","volume":"67","author":"Spaan","year":"2013","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.jinf.2015.11.002_bib29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/cmi.12233","article-title":"Cytoplasmic replication of Staphylococcus aureus upon phagosomal escape triggered by phenol-soluble modulin \u03b1","volume":"16","author":"Grosz","year":"2014","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.jinf.2015.11.002_bib30","doi-asserted-by":"crossref","first-page":"e100260","DOI":"10.1371\/journal.pone.0100260","article-title":"Inhibition of exotoxin production by mobile genetic element SCCmec-encoded psm-mec RNA is conserved in staphylococcal species","volume":"9","author":"Ikuo","year":"2014","journal-title":"PLoS One"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016344531500362X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016344531500362X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:22:32Z","timestamp":1759008152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016344531500362X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S016344531500362X"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2015.11.002","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased in\u00a0vitro phenol-soluble modulin production is associated with soft tissue infection source in clinical isolates of methicillin-susceptible Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2015.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}