{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:05:37Z","timestamp":1790406337102,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.jinf.2016.01.004","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T12:46:16Z","timestamp":1453725976000},"page":"478-485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Altered interferon-\u03b3 response in patients with Q-fever fatigue syndrome"],"prefix":"10.1016","volume":"72","author":[{"given":"Stephan P.","family":"Keijmel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud P.H.","family":"Raijmakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal P.","family":"Bleeker-Rovers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos W.M.","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teske","family":"Schoffelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"van Deuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2016.01.004_bib1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/978-94-007-4315-1_17","article-title":"Epidemic Q fever in humans in the Netherlands","volume":"984","author":"van der Hoek","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jinf.2016.01.004_bib2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1017\/S0950268812001203","article-title":"Screening for Coxiella burnetii seroprevalence in chronic Q fever high-risk groups reveals the magnitude of the Dutch Q fever outbreak","volume":"141","author":"Kampschreur","year":"2013","journal-title":"Epidemiol Infect"},{"issue":"3","key":"10.1016\/j.jinf.2016.01.004_bib3","doi-asserted-by":"crossref","first-page":"20058","DOI":"10.2807\/ese.17.03.20058-en","article-title":"Relation between Q fever notifications and Coxiella burnetii infections during the 2009 outbreak in The Netherlands","volume":"17","author":"van der Hoek","year":"2012","journal-title":"Euro Surveill"},{"issue":"5","key":"10.1016\/j.jinf.2016.01.004_bib4","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1128\/JCM.03221-13","article-title":"Chronic Q fever in the Netherlands five years after the start of the Q fever epidemic: results from the Dutch Chronic Q Fever Database","volume":"52","author":"Kampschreur","year":"2014","journal-title":"J Clin Microbiol"},{"issue":"Suppl. 1","key":"10.1016\/j.jinf.2016.01.004_bib5","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jinf.2015.04.024","article-title":"Recent advances in the study of Q fever epidemiology, diagnosis and management","volume":"71","author":"Million","year":"2015","journal-title":"J Infect"},{"key":"10.1016\/j.jinf.2016.01.004_bib6","series-title":"The post Q fever fatigue syndrome: an epidemiological study (dissertation)","author":"Shannon","year":"1992"},{"key":"10.1016\/j.jinf.2016.01.004_bib7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0140-6736(96)91469-5","article-title":"Protracted debility and fatigue after acute Q fever","volume":"347","author":"Marmion","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.jinf.2016.01.004_bib8","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0140-6736(96)91470-1","article-title":"Protracted fatigue and debility after acute Q fever","volume":"347","author":"Ayres","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.jinf.2016.01.004_bib9","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s15010-010-0052-x","article-title":"One-year follow-up of patients of the ongoing Dutch Q fever outbreak: clinical, serological and echocardiographic findings","volume":"38","author":"Limonard","year":"2010","journal-title":"Infection"},{"key":"10.1016\/j.jinf.2016.01.004_bib10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1471-2334-11-97","article-title":"The health status of Q-fever patients after long-term follow-up","volume":"11","author":"Morroy","year":"2011","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jinf.2016.01.004_bib11","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/qjmed\/95.8.527","article-title":"Chronic fatigue following infection by Coxiella burnetii (Q fever): ten-year follow-up of the, 1989 UK outbreak cohort","volume":"95","author":"Wildman","year":"2002","journal-title":"QJM \u2013 Int J Med"},{"key":"10.1016\/j.jinf.2016.01.004_bib12","series-title":"Economical consequences of the Q fever outbreak [in Dutch]","first-page":"2011","author":"Tempelmann","year":"2011"},{"issue":"8","key":"10.1016\/j.jinf.2016.01.004_bib13","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/qjmed\/91.8.549","article-title":"Cytokine dysregulation in the post-Q-fever fatigue syndrome","volume":"91","author":"Penttila","year":"1998","journal-title":"QJM"},{"issue":"3","key":"10.1016\/j.jinf.2016.01.004_bib14","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1017\/S0950268899003763","article-title":"Long-term persistence of Coxiella burnetii in the host after primary Q fever","volume":"124","author":"Harris","year":"2000","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.jinf.2016.01.004_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2169\/internalmedicine.43.49","article-title":"Improvement of chronic nonspecific symptoms by long-term minocycline treatment in Japanese patients with Coxiella burnetii infection considered to have post-Q fever fatigue syndrome","volume":"43","author":"Arashima","year":"2004","journal-title":"Intern Med"},{"issue":"11","key":"10.1016\/j.jinf.2016.01.004_bib16","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/qjmed\/hcq113","article-title":"Long-term persistence after acute Q fever of non-infective Coxiella burnetii cell components, including antigens","volume":"103","author":"Sukocheva","year":"2010","journal-title":"QJM"},{"issue":"1","key":"10.1016\/j.jinf.2016.01.004_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/qjmed\/hci009","article-title":"Long-term persistence of Coxiella burnetii after acute primary Q fever","volume":"98","author":"Marmion","year":"2005","journal-title":"QJM"},{"issue":"10","key":"10.1016\/j.jinf.2016.01.004_bib18","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/qjmed\/hcp077","article-title":"Q fever: persistence of antigenic non-viable cell residues of Coxiella burnetii in the host\u2013implications for post Q fever infection fatigue syndrome and other chronic sequelae","volume":"102","author":"Marmion","year":"2009","journal-title":"QJM"},{"issue":"7","key":"10.1016\/j.jinf.2016.01.004_bib19","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/1469-0691.12423","article-title":"A combination of interferon-gamma and interleukin-2 production by Coxiella burnetii-stimulated circulating cells discriminates between chronic Q fever and past Q fever","volume":"20","author":"Schoffelen","year":"2014","journal-title":"Clin Microbiol Infect"},{"issue":"7","key":"10.1016\/j.jinf.2016.01.004_bib20","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1086\/529049","article-title":"T cells and tuberculosis: beyond interferon-gamma","volume":"197","author":"Lalvani","year":"2008","journal-title":"J Infect Dis"},{"issue":"7","key":"10.1016\/j.jinf.2016.01.004_bib21","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1128\/IAI.00101-10","article-title":"Role of CD4+ and CD8+ T cells in clearance of primary pulmonary infection with Coxiella burnetii","volume":"78","author":"Read","year":"2010","journal-title":"Infect Immun"},{"key":"10.1016\/j.jinf.2016.01.004_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1749-6632.2009.04515.x","article-title":"Intracellular life of Coxiella burnetii in macrophages","volume":"1166","author":"Ghigo","year":"2009","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"10.1016\/j.jinf.2016.01.004_bib23","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1128\/IAI.01767-06","article-title":"T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice","volume":"75","author":"Andoh","year":"2007","journal-title":"Infect Immun"},{"issue":"8","key":"10.1016\/j.jinf.2016.01.004_bib24","doi-asserted-by":"crossref","first-page":"e103749","DOI":"10.1371\/journal.pone.0103749","article-title":"Diagnosis of Coxiella burnetii infection: comparison of a whole blood interferon-gamma production assay and a Coxiella ELISPOT","volume":"9","author":"Schoffelen","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.jinf.2016.01.004_bib25","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1093\/cid\/cit129","article-title":"Specific interferon gamma detection for the diagnosis of previous Q fever","volume":"56","author":"Schoffelen","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2016.01.004_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fmicb.2015.00093","article-title":"Specific in\u00a0vitro interferon-gamma and IL-2 production as biomarkers during treatment of chronic Q fever","volume":"6","author":"Schoffelen","year":"2015","journal-title":"Front Microbiol"},{"issue":"4","key":"10.1016\/j.jinf.2016.01.004_bib27","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.diagmicrobio.2014.12.008","article-title":"Early cytokine and antibody responses against Coxiella burnetii in aerosol infection of BALB\/c mice","volume":"81","author":"Schoffelen","year":"2015","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jinf.2016.01.004_bib28","series-title":"Dutch guideline Q fever fatigue syndrome [in Dutch]","author":"National Institute for Public Health and the Environment","year":"2012"},{"issue":"23","key":"10.1016\/j.jinf.2016.01.004_bib29","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/j.vaccine.2013.03.062","article-title":"Implementation of a Q fever vaccination program for high-risk patients in the Netherlands","volume":"31","author":"Isken","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.jinf.2016.01.004_bib30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jinf.2011.12.014","article-title":"Chronic Q fever: review of the literature and a proposal of new diagnostic criteria","volume":"64","author":"Wegdam-Blans","year":"2012","journal-title":"J Infect"},{"issue":"9","key":"10.1016\/j.jinf.2016.01.004_bib31","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1073\/pnas.0931379100","article-title":"Complete genome sequence of the Q-fever pathogen Coxiella burnetii","volume":"100","author":"Seshadri","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6754","key":"10.1016\/j.jinf.2016.01.004_bib32","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jinf.2016.01.004_bib33","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-2249.1993.tb08226.x","article-title":"Variation in interferon-gamma responses to Coxiella burnetii antigens with lymphocytes from vaccinated or naturally infected subjects","volume":"94","author":"Izzo","year":"1993","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"10.1016\/j.jinf.2016.01.004_bib34","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3109\/00048679809062727","article-title":"The relationship between fatigue, psychological and immunological variables in acute infectious illness","volume":"32","author":"Bennett","year":"1998","journal-title":"Aust N Z J Psychiatry"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445316000219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445316000219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:22:39Z","timestamp":1759008159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445316000219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S0163445316000219"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2016.01.004","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered interferon-\u03b3 response in patients with Q-fever fatigue syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2016.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}