{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:41:59Z","timestamp":1790041319019,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.jinf.2017.07.005","type":"journal-article","created":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T02:01:35Z","timestamp":1501293695000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Circulating levels of hydrogen sulfide and substance P in patients with sepsis"],"prefix":"10.1016","volume":"75","author":[{"given":"Ravinder Reddy","family":"Gaddam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Murdoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhav","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2017.07.005_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"Jama"},{"key":"10.1016\/j.jinf.2017.07.005_bib2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S2213-2600(14)70061-X","article-title":"Assessment of the worldwide burden of critical illness: the Intensive Care over Nations (ICON) audit","volume":"2","author":"Vincent","year":"2014","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jinf.2017.07.005_bib3","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jinf.2017.07.005_bib4","doi-asserted-by":"crossref","first-page":"L960","DOI":"10.1152\/ajplung.00388.2006","article-title":"Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-\u03baB","volume":"292","author":"Zhang","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jinf.2017.07.005_bib5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2119\/molmed.2009.00166","article-title":"Substance P in polymicrobial sepsis: molecular fingerprint of lung injury in preprotachykinin-A-\/-mice","volume":"16","author":"Hegde","year":"2010","journal-title":"Mol Med"},{"key":"10.1016\/j.jinf.2017.07.005_bib6","doi-asserted-by":"crossref","first-page":"L1193","DOI":"10.1152\/ajplung.00489.2005","article-title":"Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse","volume":"290","author":"Zhang","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jinf.2017.07.005_bib7","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1189\/jlb.0407237","article-title":"Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis","volume":"82","author":"Zhang","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jinf.2017.07.005_bib8","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.4049\/jimmunol.181.6.4320","article-title":"Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis","volume":"181","author":"Zhang","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jinf.2017.07.005_bib9","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1189\/jlb.0407217","article-title":"Neurokinin-1 receptor antagonist treatment protects mice against lung injury in polymicrobial sepsis","volume":"82","author":"Hegde","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jinf.2017.07.005_bib10","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"Li","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.jinf.2017.07.005_bib11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0024-3205(94)00927-9","article-title":"Changes in plasma concentrations of vasoactive neuropeptides in patients with sepsis and septic shock","volume":"56","author":"Arnalich","year":"1994","journal-title":"Life Sci"},{"key":"10.1016\/j.jinf.2017.07.005_bib12","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1097\/00003246-200208000-00020","article-title":"Systemic neuropeptide levels as predictive indicators for lethal outcome in patients with postoperative sepsis","volume":"30","author":"Beer","year":"2002","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jinf.2017.07.005_bib13","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jcrc.2015.05.012","article-title":"Association between serum substance P levels and mortality in patients with severe sepsis","volume":"30","author":"Lorente","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.jinf.2017.07.005_bib14","series-title":"2.5 Sepsis and septic shock. Textbook of adult emergency medicine","first-page":"57","author":"Holdgate","year":"2011"},{"key":"10.1016\/j.jinf.2017.07.005_bib15","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/bcpt.12210","article-title":"Simplified acute physiology score II\/acute physiology and chronic health evaluation II and prediction of the mortality and later development of complications in poisoned patients admitted to intensive care unit","volume":"115","author":"Alizadeh","year":"2014","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"2","key":"10.1016\/j.jinf.2017.07.005_bib16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/1756-185X.12472","article-title":"Hydrogen sulfide acts as a pro-inflammatory mediator in rheumatic disease","volume":"20","author":"Muniraj","year":"2014","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.jinf.2017.07.005_bib17","doi-asserted-by":"crossref","first-page":"L896","DOI":"10.1152\/ajplung.00053.2006","article-title":"Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice","volume":"291","author":"Bhatia","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"2","key":"10.1016\/j.jinf.2017.07.005_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2174\/1871528114666151201201719","article-title":"LPS up-regulates cystathionine \u03b3-lyase gene expression in primary human macrophages via NF-\u03baB\/ERK pathway","volume":"14","author":"Badiei","year":"2015","journal-title":"Inflamm Allergy Drug Targets"},{"key":"10.1016\/j.jinf.2017.07.005_bib19","doi-asserted-by":"crossref","DOI":"10.1097\/PCC.0000000000001223","article-title":"Hydrogen sulphide in exhaled gases from ventilated septic neonates and children: a preliminary report","author":"Bee","year":"2017","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.jinf.2017.07.005_bib20","article-title":"Expired hydrogen sulphide: a potential marker of infection?","author":"Bee","year":"2017","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jinf.2017.07.005_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12038-016-9598-9","article-title":"Cystathionine-\u03b3-lyase gene silencing with siRNA in monocytes\/macrophages attenuates inflammation in cecal ligation and puncture-induced sepsis in the mouse","volume":"41","author":"Badiei","year":"2016","journal-title":"J Biosci"},{"key":"10.1016\/j.jinf.2017.07.005_bib22","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1089\/ars.2009.2927","article-title":"Hydrogen sulfide and substance P in inflammation","volume":"12","author":"Bhatia","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jinf.2017.07.005_bib23","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.4049\/jimmunol.176.6.3813","article-title":"Preprotachykinin-A gene products are key mediators of lung injury in polymicrobial sepsis","volume":"176","author":"Puneet","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jinf.2017.07.005_bib24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1189\/jlb.0807575","article-title":"Role of preprotachykinin-A gene products on multiple organ injury in LPS-induced endotoxemia","volume":"83","author":"Ng","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jinf.2017.07.005_bib25","doi-asserted-by":"crossref","first-page":"e0160521","DOI":"10.1371\/journal.pone.0160521","article-title":"Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis","volume":"11","author":"Gaddam","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2017.07.005_bib26","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.4049\/jimmunol.179.6.4153","article-title":"Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury","volume":"179","author":"Zhang","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.jinf.2017.07.005_bib27","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/BF01700168","article-title":"C-reactive protein as an indicator of resolution of sepsis in the intensive care unit","volume":"21","author":"Yentis","year":"1995","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.jinf.2017.07.005_bib28","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1177\/0310057X9101900204","article-title":"C-reactive protein as a diagnostic test of sepsis in the critically ill","volume":"19","author":"Matson","year":"1991","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.jinf.2017.07.005_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/cc2877","article-title":"Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction","volume":"8","author":"Castelli","year":"2004","journal-title":"Crit Care"},{"key":"10.1016\/j.jinf.2017.07.005_bib30","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S1473-3099(07)70052-X","article-title":"Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review and meta-analysis","volume":"7","author":"Tang","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jinf.2017.07.005_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0009-8981(02)00101-8","article-title":"Pathobiochemistry and clinical use of procalcitonin","volume":"323","author":"Meisner","year":"2002","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jinf.2017.07.005_bib32","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/00003246-199704000-00009","article-title":"Cytokines, nitrite\/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia","volume":"25","author":"De Werra","year":"1997","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jinf.2017.07.005_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/cc306","article-title":"Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS","volume":"3","author":"Meisner","year":"1999","journal-title":"Crit Care"},{"key":"10.1016\/j.jinf.2017.07.005_bib34","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1097\/00003246-200004000-00007","article-title":"Relationship between procalcitonin plasma levels and severity of injury, sepsis, organ failure, and mortality in injured patients","volume":"28","author":"Wanner","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jinf.2017.07.005_bib35","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.diagmicrobio.2012.12.011","article-title":"Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis","volume":"75","author":"Jekarl","year":"2013","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jinf.2017.07.005_bib36","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1542\/peds.108.4.e61","article-title":"Reactive hyperemia and interleukin 6, interleukin 8, and tumor necrosis factor-\u03b1 in the diagnosis of early-onset neonatal sepsis","volume":"108","author":"Martin","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.jinf.2017.07.005_bib37","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1182\/blood.V74.5.1704.1704","article-title":"Increased plasma levels of interleukin-6 in sepsis","volume":"74","author":"Hack","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.jinf.2017.07.005_bib38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0002-9343(91)90069-A","article-title":"High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. The Swiss-Dutch J5 Immunoglobulin Study Group","volume":"91","author":"Calandra","year":"1991","journal-title":"Am J Med"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445317302499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445317302499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:25:18Z","timestamp":1759008318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445317302499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0163445317302499"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2017.07.005","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating levels of hydrogen sulfide and substance P in patients with sepsis","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2017.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}