{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:16:50Z","timestamp":1790324210111,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"PRO-IMPLANT Foundation"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.jinf.2019.05.015","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T02:34:38Z","timestamp":1558406078000},"page":"123-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Performance of synovial fluid D-lactate for the diagnosis of periprosthetic joint infection: A prospective observational study"],"prefix":"10.1016","volume":"79","author":[{"given":"Katsiaryna","family":"Yermak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Karbysheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Perka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Trampuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Renz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jinf.2019.05.015_bib0001","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1302\/0301-620X.99B3.BJJ-2016-0684.R1","article-title":"Improving the accuracy of synovial fluid analysis in the diagnosis of prosthetic joint infection with simple and inexpensive biomarkers","volume":"99","author":"Sousa","year":"2017","journal-title":"Bone Joint J"},{"issue":"1","key":"10.1016\/j.jinf.2019.05.015_bib0002","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1302\/0301-620X.89B1.17485","article-title":"Interleukin-6, procalcitonin and TNF-\u03b1: markers of peri-prosthetic infection following total joint replacement","volume":"89","author":"Bottner","year":"2007","journal-title":"J Bone Joint Surg Br Vol"},{"issue":"8","key":"10.1016\/j.jinf.2019.05.015_bib0003","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s11999-010-1298-4","article-title":"Synovial fluid biomarkers for periprosthetic infection","volume":"468","author":"Deirmengian","year":"2010","journal-title":"Clin Orthop Rel Res"},{"issue":"10","key":"10.1016\/j.jinf.2019.05.015_bib0004","doi-asserted-by":"crossref","first-page":"923","DOI":"10.5301\/ijao.5000168","article-title":"Epidemiology and new developments in the diagnosis of prosthetic joint infection","volume":"35","author":"Corvec","year":"2012","journal-title":"Int J Artif Organs"},{"issue":"8","key":"10.1016\/j.jinf.2019.05.015_bib0005","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1097\/CORR.0000000000000336","article-title":"Is the enzyme-linked immunosorbent assay more accurate than the lateral flow alpha defensin test for diagnosing periprosthetic joint infection?","volume":"476","author":"Sigmund","year":"2018","journal-title":"Clin Orthop Rel Res"},{"issue":"9","key":"10.1016\/j.jinf.2019.05.015_bib0006","doi-asserted-by":"crossref","first-page":"742","DOI":"10.2106\/JBJS.17.01005","article-title":"Alpha defensin lateral flow test for diagnosis of periprosthetic joint infection: not a screening but a confirmatory test","volume":"100","author":"Renz","year":"2018","journal-title":"JBJS"},{"issue":"16","key":"10.1016\/j.jinf.2019.05.015_bib0007","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1056\/NEJMra040181","article-title":"Prosthetic-joint infections","volume":"351","author":"Zimmerli","year":"2004","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jinf.2019.05.015_bib0008","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.diagmicrobio.2017.10.016","article-title":"Synovial fluid multiplex PCR is superior to culture for detection of low-virulent pathogens causing periprosthetic joint infection","volume":"90","author":"Morgenstern","year":"2018","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"8","key":"10.1016\/j.jinf.2019.05.015_bib0009","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1056\/NEJMcp0905029","article-title":"Infection associated with prosthetic joints","volume":"361","author":"Del Pozo","year":"2009","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jinf.2019.05.015_bib0010","doi-asserted-by":"crossref","first-page":"e9358","DOI":"10.1371\/journal.pone.0009358","article-title":"C-reactive protein, erythrocyte sedimentation rate and orthopedic implant infection","volume":"5","author":"Piper","year":"2010","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.jinf.2019.05.015_bib0011","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00264-017-3430-5","article-title":"C-reactive protein may misdiagnose prosthetic joint infections, particularly chronic and low-grade infections","volume":"41","author":"P\u00e9rez-Prieto","year":"2017","journal-title":"Int Orthop"},{"issue":"7","key":"10.1016\/j.jinf.2019.05.015_bib0012","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1093\/jn\/135.7.1619","article-title":"D-lactate in human and ruminant metabolism","volume":"135","author":"Ewaschuk","year":"2005","journal-title":"J Nutr"},{"issue":"1\u20132","key":"10.1016\/j.jinf.2019.05.015_bib0013","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1570-0232(02)00500-7","article-title":"Metabolic acidosis: separation methods and biological relevance of organic acids and lactic acid enantiomers","volume":"781","author":"Ewaschuk","year":"2002","journal-title":"J Chromatogr B"},{"issue":"12","key":"10.1016\/j.jinf.2019.05.015_bib0014","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1042\/CS20140683","article-title":"The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases","volume":"128","author":"Maessen","year":"2015","journal-title":"Clin Sci"},{"issue":"3","key":"10.1016\/j.jinf.2019.05.015_bib0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1128\/jcm.27.3.385-388.1989","article-title":"D-lactate acid measurements in the diagnosis of bacterial infections","volume":"27","author":"Smith","year":"1989","journal-title":"J Clin Microbiol"},{"issue":"11","key":"10.1016\/j.jinf.2019.05.015_bib0016","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1007\/BF02005455","article-title":"Determination of D-lactate concentration for rapid diagnosis of bacterial infections of body fluids","volume":"10","author":"Marcos","year":"1991","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"4","key":"10.1016\/j.jinf.2019.05.015_bib0017","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/03009749409103061","article-title":"Synovial-fluid D-lactic acid in bacterial and other acute joint effusions","volume":"23","author":"Kortekangas","year":"1994","journal-title":"Scand J Rheumatol"},{"issue":"19","key":"10.1016\/j.jinf.2019.05.015_bib0018","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.cca.2012.06.018","article-title":"The clinical diagnostic significance of cerebrospinal fluid d\u2010lactate for bacterial meningitis","volume":"413","author":"Chen","year":"2012","journal-title":"Clin Chim Acta"},{"issue":"2","key":"10.1016\/j.jinf.2019.05.015_bib0019","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/joim.12233","article-title":"Clinical presentation and treatment of orthopaedic implant\u2010associated infection","volume":"276","author":"Zimmerli","year":"2014","journal-title":"J Intern Med"},{"issue":"2","key":"10.1016\/j.jinf.2019.05.015_bib0020","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/CMR.00111-13","article-title":"Prosthetic joint infection","volume":"27","author":"Tande","year":"2014","journal-title":"Clin Microbiol Rev"},{"issue":"7","key":"10.1016\/j.jinf.2019.05.015_bib0021","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1056\/NEJMoa061588","article-title":"Sonication of removed hip and knee prostheses for diagnosis of infection","volume":"357","author":"Trampuz","year":"2007","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jinf.2019.05.015_bib0022","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1128\/JCM.02482-12","article-title":"Sonication versus vortexing of implants for diagnosis of prosthetic joint infection","volume":"51","author":"Portillo","year":"2013","journal-title":"J Clin Microbiol"},{"issue":"1","key":"10.1016\/j.jinf.2019.05.015_bib0023","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0003-2697(05)80004-1","article-title":"Fluorimetric assay of D-lactate","volume":"206","author":"McLellan","year":"1992","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jinf.2019.05.015_bib0024","unstructured":"R Core Team (2018). R:A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL http:\/\/www.R-project.org\/."},{"issue":"1","key":"10.1016\/j.jinf.2019.05.015_bib0025","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11999-014-3722-7","article-title":"The alpha-defensin test for periprosthetic joint infection outperforms the leukocyte esterase test strip","volume":"473","author":"Deirmengian","year":"2015","journal-title":"Clin Orthop Rel Res"},{"key":"10.1016\/j.jinf.2019.05.015_bib0026","doi-asserted-by":"crossref","unstructured":"Parvizi J, Gehrke T. International consensus group on periprosthetic joint I (2014) definition of periprosthetic joint infection. J Arthrop. 29(7):1331.","DOI":"10.1016\/j.arth.2014.03.009"},{"key":"10.1016\/j.jinf.2019.05.015_bib0027","doi-asserted-by":"crossref","first-page":"16","DOI":"10.22203\/eCM.v037a02","article-title":"Influence of retrieved hip-and knee-prosthesis biomaterials on microbial detection by sonication","volume":"37","author":"Karbysheva","year":"2019","journal-title":"Eur Cells Mater"},{"issue":"1","key":"10.1016\/j.jinf.2019.05.015_bib0028","doi-asserted-by":"crossref","first-page":"e54335","DOI":"10.1371\/journal.pone.0054335","article-title":"Faecal D\/L lactate ratio is a metabolic signature of microbiota imbalance in patients with short bowel syndrome","volume":"8","author":"Mayeur","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jinf.2019.05.015_bib0029","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/15376516.2017.1285971","article-title":"Evaluation of methylglyoxal toxicity in human erythrocytes, leukocytes and platelets","volume":"27","author":"Prestes","year":"2017","journal-title":"Toxicol Mech Methods"},{"issue":"6","key":"10.1016\/j.jinf.2019.05.015_bib0030","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1093\/clinchem\/43.6.1010","article-title":"Determination of D-lactate by enzymatic methods in biological fluids: study of interferences","volume":"43","author":"Mart\u00ed","year":"1997","journal-title":"Clin Chem"},{"key":"10.1016\/j.jinf.2019.05.015_bib0031","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jpba.2015.06.014","article-title":"Elevated urinary D-lactate levels in patients with diabetes and microalbuminuria","volume":"116","author":"Chou","year":"2015","journal-title":"J Pharm Biomed Anal"},{"issue":"2","key":"10.1016\/j.jinf.2019.05.015_bib0032","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.aca.2004.11.033","article-title":"Fluorimetric determination of D-lactate in urine of normal and diabetic rats by column-switching high-performance liquid chromatography","volume":"534","author":"Lee","year":"2005","journal-title":"Anal Chim Acta"},{"issue":"12","key":"10.1016\/j.jinf.2019.05.015_bib0033","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.prp.2014.09.017","article-title":"Revised histopathological consensus classification of joint implant related pahtology","volume":"210","author":"Krenn","year":"2014","journal-title":"Pathol. Res. Pract"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445319301598?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445319301598?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:27:36Z","timestamp":1759008456000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445319301598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0163445319301598"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2019.05.015","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Performance of synovial fluid D-lactate for the diagnosis of periprosthetic joint infection: A prospective observational study","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2019.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}