{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:25:23Z","timestamp":1773311123092,"version":"3.50.1"},"reference-count":69,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.jinf.2020.01.010","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T20:36:01Z","timestamp":1579725361000},"page":"378-387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Complement related pattern recognition molecules as markers of short-term mortality in intensive care patients"],"prefix":"10.1016","volume":"80","author":[{"given":"Cecilie B.","family":"Hansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Bayarri-Olmos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus K.","family":"Kristensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine","family":"Pilely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorthe","family":"Hellemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Garred","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jinf.2020.01.010_bib0001","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S2213-2600(14)70061-X","article-title":"Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit","volume":"2","author":"Vincent","year":"2014","journal-title":"Lancet Respir Med"},{"issue":"3","key":"10.1016\/j.jinf.2020.01.010_bib0002","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis. current estimates and limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am J Respir Crit Care Med."},{"issue":"8","key":"10.1016\/j.jinf.2020.01.010_bib0003","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"14","key":"10.1016\/j.jinf.2020.01.010_bib0004","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM200104053441406","article-title":"Complement. First of two parts","volume":"344","author":"Walport","year":"2001","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.jinf.2020.01.010_bib0005","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJM200104123441506","article-title":"Complement. Second of two parts","volume":"344","author":"Walport","year":"2001","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"10.1016\/j.jinf.2020.01.010_bib0006","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.thromres.2014.03.014","article-title":"Crosstalk between the coagulation and complement systems in sepsis","volume":"133","author":"Lupu","year":"2014","journal-title":"Thromb Res"},{"issue":"6917","key":"10.1016\/j.jinf.2020.01.010_bib0007","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature01326","article-title":"The immunopathogenesis of sepsis","volume":"420","author":"Cohen","year":"2002","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0008","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4161\/viru.25436","article-title":"Host innate immune responses to sepsis","volume":"5","author":"Wiersinga","year":"2014","journal-title":"Virulence"},{"issue":"2","key":"10.1016\/j.jinf.2020.01.010_bib0009","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1152\/physrev.00016.2017","article-title":"PTX3, a humoral pattern recognition molecule, in innate immunity, tissue repair, and cancer","volume":"98","author":"Garlanda","year":"2018","journal-title":"Physiol Rev"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0010","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1146\/annurev.immunol.21.120601.140954","article-title":"Collectins and ficolins: humoral lectins of the innate immune defense","volume":"21","author":"Holmskov","year":"2003","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0011","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/imr.12468","article-title":"A journey through the lectin pathway of complement-MBL and beyond","volume":"274","author":"Garred","year":"2016","journal-title":"Immunol Rev"},{"issue":"5","key":"10.1016\/j.jinf.2020.01.010_bib0012","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nri800","article-title":"Evolution of the lectin\u2013complement pathway and its role in innate immunity","volume":"2","author":"Fujita","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0013","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-immunol-030409-101305","article-title":"An integrated view of humoral innate immunity: pentraxins as a paradigm","volume":"28","author":"Bottazzi","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jinf.2020.01.010_bib0014","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/493945","article-title":"Biological functions of the novel collectins CL-L1, CL-K1, and CL-P1","volume":"2012","author":"Ohtani","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.jinf.2020.01.010_bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3205072","article-title":"Ficolins and the recognition of pathogenic microorganisms: an overview of the innate immune response and contribution of single nucleotide polymorphisms","volume":"2019","author":"Bidula","year":"2019","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jinf.2020.01.010_bib0016","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/bs.ircmb.2015.01.003","article-title":"New insights into the role of ficolins in the lectin pathway of innate immunity","volume":"316","author":"Endo","year":"2015","journal-title":"Int Rev Cell Mol Biol"},{"issue":"3","key":"10.1016\/j.jinf.2020.01.010_bib0017","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000368778","article-title":"The long pentraxin PTX3 as a key component of humoral innate immunity and a candidate diagnostic for inflammatory diseases","volume":"165","author":"Jaillon","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0018","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/01.ATV.0000252126.48375.d5","article-title":"Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectoris","volume":"27","author":"Inoue","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"10.1016\/j.jinf.2020.01.010_bib0019","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/ijc.29822","article-title":"Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients","volume":"138","author":"Infante","year":"2016","journal-title":"Int J Cancer"},{"issue":"9","key":"10.1016\/j.jinf.2020.01.010_bib0020","doi-asserted-by":"crossref","first-page":"e73119","DOI":"10.1371\/journal.pone.0073119","article-title":"Pentraxin-3 serum levels are associated with disease severity and mortality in patients with systemic inflammatory response syndrome","volume":"8","author":"Bastrup-Birk","year":"2013","journal-title":"PLoS ONE"},{"issue":"7","key":"10.1016\/j.jinf.2020.01.010_bib0021","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1097\/00003246-200107000-00017","article-title":"Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients","volume":"29","author":"Muller","year":"2001","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.jinf.2020.01.010_bib0022","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00134-010-1752-5","article-title":"Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality","volume":"36","author":"Mauri","year":"2010","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0023","doi-asserted-by":"crossref","first-page":"e53661","DOI":"10.1371\/journal.pone.0053661","article-title":"Pentraxin 3 (PTX3) is associated with severe sepsis and fatal disease in emergency room patients with suspected infection: a prospective cohort study","volume":"8","author":"Uusitalo-Seppala","year":"2013","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.jinf.2020.01.010_bib0024","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/joim.12294","article-title":"Pentraxin-3 level at admission is a strong predictor of short-term mortality in a community-based hospital setting","volume":"277","author":"Bastrup-Birk","year":"2015","journal-title":"J Intern Med"},{"key":"10.1016\/j.jinf.2020.01.010_bib0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13054-016-1210-z","article-title":"Pentraxin-3 as a marker of disease severity and risk of death in patients with necrotizing soft tissue infections: a nationwide, prospective, observational study","volume":"20","author":"Hansen","year":"2016","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.jinf.2020.01.010_bib0026","doi-asserted-by":"crossref","first-page":"e17653","DOI":"10.1371\/journal.pone.0017653","article-title":"High plasma level of long pentraxin 3 (PTX3) is associated with fatal disease in bacteremic patients: a prospective cohort study","volume":"6","author":"Huttunen","year":"2011","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinf.2017.10.016","article-title":"Pentraxin-3 as a marker of sepsis severity and predictor of mortality outcomes: a systematic review and meta-analysis","volume":"76","author":"Lee","year":"2018","journal-title":"J Infect"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0028","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/eci.12704","article-title":"Pentraxin 3 in patients with severe sepsis or shock: the Albios trial","volume":"47","author":"Caironi","year":"2017","journal-title":"Eur J Clin Invest"},{"issue":"6","key":"10.1016\/j.jinf.2020.01.010_bib0029","first-page":"999","article-title":"Pentraxin-3 predicts Short- and Mid-term mortality in patients with sepsis and septic shock during intensive care treatment","volume":"64","author":"Hamed","year":"2018","journal-title":"Clin Lab"},{"issue":"2","key":"10.1016\/j.jinf.2020.01.010_bib0030","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/immu.200310022","article-title":"Biochemical and functional characterization of the interaction between pentraxin 3 and C1q","volume":"33","author":"Nauta","year":"2003","journal-title":"Eur J Immunol"},{"issue":"41","key":"10.1016\/j.jinf.2020.01.010_bib0031","doi-asserted-by":"crossref","first-page":"28263","DOI":"10.1074\/jbc.M109.009225","article-title":"Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition","volume":"284","author":"Ma","year":"2009","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.jinf.2020.01.010_bib0032","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1074\/jbc.M110.190637","article-title":"Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid p component trigger cross-activation of the complement system","volume":"286","author":"Ma","year":"2011","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0033","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ccc.2017.08.010","article-title":"Biomarkers in sepsis","volume":"34","author":"van Engelen","year":"2018","journal-title":"Crit Care Clin"},{"issue":"5","key":"10.1016\/j.jinf.2020.01.010_bib0034","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(15)70112-X","article-title":"Sepsis: a roadmap for future research","volume":"15","author":"Cohen","year":"2015","journal-title":"The Lancet Infectious Dis"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0035","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/CCM.0b013e318192fd9d","article-title":"A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis","volume":"37","author":"Shapiro","year":"2009","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0036","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/10408363.2013.764490","article-title":"Biomarkers of sepsis","volume":"50","author":"Faix","year":"2013","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"24","key":"10.1016\/j.jinf.2020.01.010_bib0037","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1093\/hmg\/ddm265","article-title":"Heterozygosity of mannose-binding lectin (MBL2) genotypes predicts advantage (heterosis) in relation to fatal outcome in intensive care patients","volume":"16","author":"Hellemann","year":"2007","journal-title":"Hum Mol Genet"},{"issue":"10","key":"10.1016\/j.jinf.2020.01.010_bib0038","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.imbio.2013.04.010","article-title":"Plasma YKL-40 and CHI3L1 in systemic inflammation and sepsis-experience from two prospective cohorts","volume":"218","author":"Kornblit","year":"2013","journal-title":"Immunobiology"},{"issue":"24","key":"10.1016\/j.jinf.2020.01.010_bib0039","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","article-title":"A new simplified acute physiology score (SAPS II) based on a european\/north american multicenter study","volume":"270","author":"Le Gall","year":"1993","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.jinf.2020.01.010_bib0040","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1365-3083.2007.01915.x","article-title":"The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels","volume":"65","author":"Munthe-Fog","year":"2007","journal-title":"Scand J Immunol"},{"issue":"9","key":"10.1016\/j.jinf.2020.01.010_bib0041","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1016\/j.molimm.2007.12.012","article-title":"Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state","volume":"45","author":"Munthe-Fog","year":"2008","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jinf.2020.01.010_bib0042","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.3389\/fimmu.2018.02238","article-title":"Development of a quantitative assay for the characterization of human collectin-11 (CL-11, CL-K1)","volume":"9","author":"Bayarri-Olmos","year":"2018","journal-title":"Front Immunol."},{"issue":"6","key":"10.1016\/j.jinf.2020.01.010_bib0043","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1378\/chest.101.6.1481","article-title":"The accp-sccm consensus conference on sepsis and organ failure","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"issue":"12","key":"10.1016\/j.jinf.2020.01.010_bib0044","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: a critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.jinf.2020.01.010_bib0045","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1515\/CCLM.2009.110","article-title":"Determination of physiological plasma pentraxin 3 (PTX3) levels in healthy populations","volume":"47","author":"Yamasaki","year":"2009","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0046","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0009-8981(81)90005-X","article-title":"Solid phase radioimmunoassays for human C-reactive protein","volume":"117","author":"Shine","year":"1981","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jinf.2020.01.010_bib0047","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev.immunol.23.021704.115756","article-title":"Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility","volume":"23","author":"Garlanda","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jinf.2020.01.010_bib0048","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/978-1-4419-0901-5_7","article-title":"Pattern recognition by pentraxins","volume":"653","author":"Agrawal","year":"2009","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"10.1016\/j.jinf.2020.01.010_bib0049","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.4049\/jimmunol.161.6.3169","article-title":"Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast africa and South America","volume":"161","author":"Madsen","year":"1998","journal-title":"J Immunol (Baltimore, Md: 1950)"},{"issue":"6","key":"10.1016\/j.jinf.2020.01.010_bib0050","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.4049\/jimmunol.155.6.3013","article-title":"Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein","volume":"155","author":"Madsen","year":"1995","journal-title":"J Immunol (Baltimore, Md: 1950)"},{"issue":"2","key":"10.1016\/j.jinf.2020.01.010_bib0051","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/sj.gene.6364283","article-title":"Mannose-binding lectin and its genetic variants","volume":"7","author":"Garred","year":"2006","journal-title":"Genes Immun"},{"issue":"1\u20132","key":"10.1016\/j.jinf.2020.01.010_bib0052","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0022-1759(00)00198-8","article-title":"Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers","volume":"241","author":"Steffensen","year":"2000","journal-title":"J Immunol Methods"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0053","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s10753-014-0037-5","article-title":"Relationship of serum mannose-binding lectin levels with the development of sepsis: a meta-analysis","volume":"38","author":"Gao","year":"2015","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.jinf.2020.01.010_bib0054","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1210\/jc.2002-021478","article-title":"Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels","volume":"88","author":"Hansen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0055","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/01.shk.0000186928.57109.8d","article-title":"Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome","volume":"25","author":"Gordon","year":"2006","journal-title":"Shock"},{"issue":"9","key":"10.1016\/j.jinf.2020.01.010_bib0056","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1086\/379044","article-title":"Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome","volume":"188","author":"Garred","year":"2003","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.jinf.2020.01.010_bib0057","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s10875-005-4702-1","article-title":"Mannose binding lectin acute phase activity in patients with severe infection","volume":"25","author":"Dean","year":"2005","journal-title":"J Clin Immunol"},{"issue":"6","key":"10.1016\/j.jinf.2020.01.010_bib0058","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1055\/s-0039-1685140","article-title":"Reduced mannose-binding lectin-associated serine protease (MASP)-1 is associated with disturbed coagulation in septic shock","volume":"119","author":"Larsen","year":"2019","journal-title":"Thromb Haemost"},{"issue":"3","key":"10.1016\/j.jinf.2020.01.010_bib0059","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1086\/422397","article-title":"Role of mannose-binding lectin in the innate defense against Candida albicans: enhancement of complement activation, but lack of opsonic function, in phagocytosis by human dendritic cells","volume":"190","author":"Ip","year":"2004","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jinf.2020.01.010_bib0060","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.3389\/fimmu.2018.02664","article-title":"Age and sex-associated changes of complement activity and complement levels in a healthy caucasian population","volume":"9","author":"Gaya da Costa","year":"2018","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.jinf.2020.01.010_bib0061","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1093\/hmg\/ddi173","article-title":"Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2","volume":"14","author":"Hummelshoj","year":"2005","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.jinf.2020.01.010_bib0062","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1074\/jbc.M608627200","article-title":"Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain","volume":"282","author":"Tanio","year":"2007","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0063","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000233475","article-title":"Structural insights into the recognition properties of human ficolins","volume":"2","author":"Garlatti","year":"2010","journal-title":"J Innate Immun"},{"issue":"5","key":"10.1016\/j.jinf.2020.01.010_bib0064","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1159\/000447327","article-title":"The Lectin complement pathway in patients with necrotizing soft tissue infection","volume":"8","author":"Hansen","year":"2016","journal-title":"J Innate Immun"},{"issue":"4","key":"10.1016\/j.jinf.2020.01.010_bib0065","doi-asserted-by":"crossref","first-page":"e320","DOI":"10.1038\/emm.2017.51","article-title":"An overview of the synergy and crosstalk between pentraxins and collectins\/ficolins: their functional relevance in complement activation","volume":"49","author":"Ma","year":"2017","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.jinf.2020.01.010_bib0066","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/117693510500100110","article-title":"Impact of freeze-thaw cycles and storage time on plasma samples used in mass spectrometry based biomarker discovery projects","volume":"1","author":"Mitchell","year":"2005","journal-title":"Cancer Inform"},{"issue":"1","key":"10.1016\/j.jinf.2020.01.010_bib0067","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12967-017-1154-3","article-title":"Stability of pro- and anti-inflammatory immune biomarkers for human cohort studies","volume":"15","author":"Graham","year":"2017","journal-title":"J Transl Med"},{"issue":"2","key":"10.1016\/j.jinf.2020.01.010_bib0068","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3349\/ymj.2017.58.2.370","article-title":"Long pentraxin 3 as a predictive marker of mortality in severe septic patients who received successful early goal-directed therapy","volume":"58","author":"Kim","year":"2017","journal-title":"Yonsei Med J"},{"issue":"3","key":"10.1016\/j.jinf.2020.01.010_bib0069","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017653","article-title":"High plasma level of long pentraxin 3 (PTX3) is associated with fatal disease in bacteremic patients: a prospective cohort study","volume":"6","author":"Huttunen","year":"2011","journal-title":"PLoS ONE"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445320300347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445320300347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:28:17Z","timestamp":1759008497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445320300347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0163445320300347"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2020.01.010","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complement related pattern recognition molecules as markers of short-term mortality in intensive care patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2020.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}