{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:59:57Z","timestamp":1789178397667,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jinf.2020.03.065","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T01:36:17Z","timestamp":1587519377000},"page":"131-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis"],"prefix":"10.1016","volume":"81","author":[{"given":"M.","family":"Bassetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Giacobbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Grecchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rebuffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Zuccaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Scudeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Akova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alastruey-Izquierdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Arikan-Akdagli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Azoulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Blot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.A.","family":"Cornely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lass-Fl\u00f6rl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Koehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cuenca-Estrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.W.","family":"de Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.G.","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"De Waele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Garnacho-Montero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hoenigl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.S.","family":"Kanj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Lamoth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Maertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Martin-Loeches","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.J.","family":"Kullberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Agvald-Ohman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Poulakou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Righi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sanguinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.S.","family":"Taccone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-F.","family":"Timsit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Vazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wauters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Calandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Asperges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tejada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lebihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Karaiskos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Peghin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.L.","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cortegiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2020.03.065_bib0001","doi-asserted-by":"crossref","first-page":"i39","DOI":"10.1093\/jac\/dkx032","article-title":"Invasive mould infections in the ICU setting: complexities and solutions","volume":"72","author":"Bassetti","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jinf.2020.03.065_bib0002","doi-asserted-by":"crossref","first-page":"i19","DOI":"10.1093\/jac\/dkx030","article-title":"Early diagnosis of invasive mould infections and disease","volume":"72","author":"Lamoth","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jinf.2020.03.065_bib0003","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.2165\/00003495-200767110-00004","article-title":"Invasive aspergillosis: epidemiology, diagnosis and management in immunocompromised patients","volume":"67","author":"Maschmeyer","year":"2007","journal-title":"Drugs"},{"key":"10.1016\/j.jinf.2020.03.065_bib0004","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13054-014-0722-7","article-title":"Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes","volume":"19","author":"Taccone","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.jinf.2020.03.065_bib0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1086\/323335","article-title":"Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus","volume":"34","author":"Ascioglu","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2020.03.065_bib0006","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","volume":"46","author":"De Pauw","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2020.03.065_bib0007","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.healun.2011.01.701","article-title":"A 2010 working formulation for the standardization of definitions of infections in cardiothoracic transplant recipients","volume":"30","author":"Husain","year":"2011","journal-title":"J Heart Lung Transpl"},{"key":"10.1016\/j.jinf.2020.03.065_bib0008","article-title":"Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium","author":"Donnelly","year":"2019","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2020.03.065_bib0009","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1164\/rccm.201111-1978OC","article-title":"A clinical algorithm to diagnose invasive pulmonary aspergillosis in critically ill patients","volume":"186","author":"Blot","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jinf.2020.03.065_bib0010","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1183\/09031936.00062206","article-title":"Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease","volume":"30","author":"Bulpa","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jinf.2020.03.065_bib0011","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/cc4823","article-title":"Clinical relevance of Aspergillus isolation from respiratory tract samples in critically ill patients","volume":"10","author":"Vandewoude","year":"2006","journal-title":"Crit Care"},{"key":"10.1016\/j.jinf.2020.03.065_bib0012","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/myc.12869","article-title":"Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project","volume":"62","author":"Bassetti","year":"2019","journal-title":"Mycoses"},{"key":"10.1016\/j.jinf.2020.03.065_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.jinf.2020.03.065_bib0014","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1164\/rccm.200704-606OC","article-title":"Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients","volume":"177","author":"Meersseman","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jinf.2020.03.065_bib0015","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1469-0691.2010.03357.x","volume":"17","author":"Acosta","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jinf.2020.03.065_bib0016","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jinf.2016.02.019","article-title":"Galactomannan in bronchoalveolar lavage fluid for diagnosis of invasive aspergillosis in non-hematological patients","volume":"72","author":"Fortun","year":"2016","journal-title":"J Infect"},{"key":"10.1016\/j.jinf.2020.03.065_bib0017","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/13693780801978968","article-title":"Value of a single galactomannan determination (Platelia) for the diagnosis of invasive aspergillosis in non-hematological patients with clinical isolation of Aspergillus spp","volume":"46","author":"Guinea","year":"2008","journal-title":"Med Mycol"},{"key":"10.1016\/j.jinf.2020.03.065_bib0018","doi-asserted-by":"crossref","first-page":"R138","DOI":"10.1186\/cc11443","article-title":"Role of galactomannan determinations in bronchoalveolar lavage fluid samples from critically ill patients with chronic obstructive pulmonary disease for the diagnosis of invasive pulmonary aspergillosis: a prospective study","volume":"16","author":"He","year":"2012","journal-title":"Crit Care"},{"key":"10.1016\/j.jinf.2020.03.065_bib0019","doi-asserted-by":"crossref","first-page":"e561","DOI":"10.1016\/j.cmi.2016.01.027","article-title":"Aspergillus PCR in serum for the diagnosis, follow-up and prognosis of invasive aspergillosis in neutropenic and nonneutropenic patients","volume":"22","author":"Imbert","year":"2016","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jinf.2020.03.065_bib0020","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3109\/00365548.2012.657672","article-title":"Diagnostic value of the serum galactomannan assay for invasive aspergillosis: it is less useful in non-haematological patients","volume":"44","author":"Ku","year":"2012","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.jinf.2020.03.065_bib0021","first-page":"148","article-title":"Assessment of Platelia Aspergillus enzyme immunoassay for the diagnosis of invasive aspergillosis","volume":"40","author":"Lai","year":"2007","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jinf.2020.03.065_bib0022","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jinf.2010.08.014","article-title":"Aspergillus galactomannan antigen assay in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis","volume":"61","author":"Park","year":"2010","journal-title":"J Infect"},{"key":"10.1016\/j.jinf.2020.03.065_bib0023","article-title":"The diagnosis of invasive and noninvasive pulmonary aspergillosis by serum and bronchoalveolar lavage fluid galactomannan assay","volume":"2015","author":"Zhang","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jinf.2020.03.065_bib0024","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s12223-018-0618-z","article-title":"Local retrospective analysis of galactomannan cut-off values in bronchoalveolar lavage fluids for diagnosis of invasive aspergillosis","volume":"63","author":"Bellanger","year":"2018","journal-title":"Folia Microbiol"},{"key":"10.1016\/j.jinf.2020.03.065_bib0025","doi-asserted-by":"crossref","first-page":"12","DOI":"10.18869\/acadpub.cmm.1.1.12","article-title":"Detection of galactomannan in bronchoalveolar lavage of the intensive care unit patients at risk for invasive aspergillosis","volume":"1","author":"Khodavaisy","year":"2015","journal-title":"Curr Med Mycol"},{"key":"10.1016\/j.jinf.2020.03.065_bib0026","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1164\/rccm.201407-1275OC","article-title":"Novel tests for diagnosis of invasive aspergillosis in patients with underlying respiratory diseases","volume":"190","author":"Prattes","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jinf.2020.03.065_bib0027","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1128\/JCM.05026-11","article-title":"Diagnosis of invasive aspergillosis by a commercial real-time PCR assay for Aspergillus DNA in bronchoalveolar lavage fluid samples from high-risk patients compared to a galactomannan enzyme immunoassay","volume":"49","author":"Torelli","year":"2011","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jinf.2020.03.065_bib0028","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13054-015-0905-x","article-title":"Multicenter evaluation of a lateral-flow device test for diagnosing invasive pulmonary aspergillosis in ICU patients","volume":"19","author":"Eigl","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.jinf.2020.03.065_bib0029","first-page":"75","article-title":"Detection of Pneumocystis jirovecii and Aspergillus spp. DNa in bronchoalveolar lavage fluids by commercial real-time PCr assays: comparison with conventional diagnostic tests","volume":"38","author":"Orsi","year":"2015","journal-title":"New Microbiol"},{"key":"10.1016\/j.jinf.2020.03.065_bib0030","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/crj.12551","article-title":"Values of radiological examinations for the diagnosis and prognosis of invasive bronchial-pulmonary aspergillosis in critically ill patients with chronic obstructive pulmonary diseases","volume":"12","author":"Huang","year":"2018","journal-title":"Clin Respir J"},{"key":"10.1016\/j.jinf.2020.03.065_bib0031","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1086\/503427","article-title":"Diagnosis of invasive aspergillosis using a galactomannan assay: a meta-analysis","volume":"42","author":"Pfeiffer","year":"2006","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445320302206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445320302206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:28:10Z","timestamp":1759008490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445320302206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0163445320302206"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2020.03.065","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2020.03.065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}