{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:36:27Z","timestamp":1792784187358,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["439968\/2016-0"],"award-info":[{"award-number":["439968\/2016-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Inova Fiocruz\/VPPCB","award":["VPPCB-007-FIO-18-2-19"],"award-info":[{"award-number":["VPPCB-007-FIO-18-2-19"]}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.124207\/2016-00"],"award-info":[{"award-number":["88887.124207\/2016-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.jinf.2020.09.028","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T02:34:17Z","timestamp":1601087657000},"page":"766-775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Downregulation of IGF2 expression in third trimester placental tissues from Zika virus infected women in Brazil"],"prefix":"10.1016","volume":"81","author":[{"given":"Andr\u00e9ia A.","family":"Suzukawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Zanluca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha A.N.","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"de Noronha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Koishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline B.V.","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Z.","family":"Rebutini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seigo","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruana F.F.","family":"Hansel-Frose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius S.C.","family":"Parreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano","family":"Bordignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R.","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Passetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Nunes","family":"Duarte dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.jinf.2020.09.028_bib0001","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"et al. Zika virus outbreak on Yap Island, Federated states of micronesia","volume":"360","author":"Duffy","year":"2009","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jinf.2020.09.028_bib0002","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1590\/0074-02760150192","article-title":"First report of autochthonous transmission of Zika virus in Brazil","volume":"110","author":"Zanluca","year":"2015","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"24","key":"10.1016\/j.jinf.2020.09.028_bib0003","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1056\/NEJMoa1602412","article-title":"Zika virus infection in pregnant women in Rio de Janeiro","volume":"375","author":"Brasil","year":"2016","journal-title":"N Engl J Med"},{"issue":"10047","key":"10.1016\/j.jinf.2020.09.028_bib0004","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0140-6736(16)30883-2","article-title":"Pathology of congenital Zika syndrome in Brazil: a case series","volume":"388","author":"Martines","year":"2016","journal-title":"Lancet"},{"issue":"31","key":"10.1016\/j.jinf.2020.09.028_bib0005","first-page":"858","article-title":"Vital signs\u202f: Zika-associated birth defects and neurodevelopmental abnormalities possibly associated with congenital Zika Virus infection \u2014","volume":"67","author":"Rice Marion","year":"2018","journal-title":"Morb Mortal Wkly Rep, CDC"},{"issue":"642","key":"10.1016\/j.jinf.2020.09.028_bib0006","first-page":"1","article-title":"Transcriptome profiling reveals pro-inflammatory cytokines and matrix metalloproteinase activation in Zika virus infected human umbilical vein endothelial cells","volume":"10","author":"Svetlana","year":"2019","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.1016\/j.jinf.2020.09.028_bib0007","article-title":"Zika virus infection reprograms global transcription of host cells to allow sustained infection","volume":"6","author":"Kant","year":"2017","journal-title":"Emerg Microbes Infect"},{"issue":"1928","key":"10.1016\/j.jinf.2020.09.028_bib0008","article-title":"The transcriptional and protein profile from human infected neuroprogenitor cells is strongly correlated to zika virus microcephaly cytokines phenotype evidencing a persistent inflammation in the CNS","volume":"10","author":"Lima Morganna","year":"2019","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jinf.2020.09.028_bib0009","first-page":"1","article-title":"Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium","volume":"8","author":"Kumar","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jinf.2020.09.028_bib0010","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1469-7580.2008.01035.x","article-title":"Insulin and the IGF system in the human placenta of normal and diabetic pregnancies","volume":"215","author":"Ursula","year":"2009","journal-title":"J Anat"},{"issue":"3","key":"10.1016\/j.jinf.2020.09.028_bib0011","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000343995","article-title":"Insulin-like growth factor 2 in development and disease: a mini-review","volume":"59","author":"Daniel","year":"2013","journal-title":"Gerontology"},{"issue":"2266","key":"10.1016\/j.jinf.2020.09.028_bib0012","first-page":"1","article-title":"Zika virus infection at different pregnancy stages: Anatomopathological findings, target cells and viral persistence in placental tissues","volume":"9","author":"Lucia","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jinf.2020.09.028_bib0013","first-page":"1","article-title":"GAGE: Generally applicable gene set enrichment for pathway analysis","volume":"10","author":"Weijun","year":"2009","journal-title":"BMC Bioinformatics"},{"issue":"14","key":"10.1016\/j.jinf.2020.09.028_bib0014","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/bioinformatics\/btt285","article-title":"Pathview: an R\/Bioconductor package for pathway-based data integration and visualization","volume":"29","author":"Weijun","year":"2013","journal-title":"Bioinformatics"},{"issue":"7","key":"10.1016\/j.jinf.2020.09.028_bib0015","first-page":"1","article-title":"Genetic and biological characterization of zika virus isolates from different Brazilian regions","volume":"114","author":"Maria","year":"2019","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.jinf.2020.09.028_bib0016","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.actatropica.2016.09.030","article-title":"Isolation and characterization of a Brazilian strain of yellow fever virus from an epizootic outbreak in 2009","volume":"166","author":"Ricciardi","year":"2017","journal-title":"Acta Trop"},{"issue":"4","key":"10.1016\/j.jinf.2020.09.028_bib0017","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u0394\u0394CT method","volume":"25","author":"Livak Kenneth","year":"2001","journal-title":"Methods"},{"issue":"3","key":"10.1016\/j.jinf.2020.09.028_bib0018","first-page":"1","article-title":"Development and evaluation of a novel high-throughput image-based fluorescent neutralization test for detection of Zika virus infection","volume":"12","author":"Cristine","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"10.1016\/j.jinf.2020.09.028_bib0019","first-page":"1","article-title":"Tissue expression of retinoic acid receptor alpha and CRABP2 in metastatic nephroblastomas","volume":"13","author":"Paula","year":"2018","journal-title":"Diagn Pathol"},{"issue":"3","key":"10.1016\/j.jinf.2020.09.028_bib0020","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.prp.2016.12.011","article-title":"Immunoexpression of GADD45\u03b2 in the myocardium of newborns experiencing perinatal hypoxia","volume":"213","author":"Adalgisa","year":"2017","journal-title":"Pathol Res Pract"},{"issue":"5","key":"10.1016\/j.jinf.2020.09.028_bib0021","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1200\/JCO.1999.17.5.1474","article-title":"Estrogen receptor status by immunohistochemistry is superior to the Ligand-Binding assay for predicting response to Adjuvant Endocrine therapy in breast cancer","volume":"17","author":"Harvey Jennet","year":"1999","journal-title":"J Clin Oncol"},{"issue":"1\u20132","key":"10.1016\/j.jinf.2020.09.028_bib0022","first-page":"141","article-title":"Human colon carcinoma cells ( CaCo-2) synthesize IGF-II and express IGF-I receptors and IGF-II\/M6P receptors","volume":"101","author":"Andreas","year":"1994","journal-title":"Mol Cell Endocrinol"},{"issue":"6","key":"10.1016\/j.jinf.2020.09.028_bib0023","article-title":"Zika virus detection in amniotic fluid and Zika-associated birth defects","volume":"222","author":"Marcela","year":"2020","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.jinf.2020.09.028_bib0024","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1473-3099(16)00095-5","article-title":"Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study","volume":"16","author":"Guilherme","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"10.1016\/j.jinf.2020.09.028_bib0025","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1590\/0074-02760160085","article-title":"Zika virus damages the human placental barrier and presents marked fetal neurotropism","volume":"111","author":"Lucia","year":"2016","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"6","key":"10.1016\/j.jinf.2020.09.028_bib0026","first-page":"2015","article-title":"Evidence of Zika virus infection in brain and placental tissues from two congenitally infected newborns and two fetal losses - Brazil, 2015","volume":"65","author":"Brasil","year":"2016","journal-title":"Morb Mortal Wkly Rep"},{"issue":"3","key":"10.1016\/j.jinf.2020.09.028_bib0027","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1055\/s-0031-1275515","article-title":"Placental Dysfunction and fetal programming: the importance of placental size, shape, histopatology, and molecular composition","volume":"29","author":"Longtine","year":"2013","journal-title":"Semin Reprod Medeical J"},{"issue":"1","key":"10.1016\/j.jinf.2020.09.028_bib0028","doi-asserted-by":"crossref","first-page":"43","DOI":"10.5858\/arpa.2016-0401-OA","article-title":"Placental pathology of zika virus: Viral infection of the placenta induces villous stromal macrophage (Hofbauer Cell) proliferation and hyperplasia","volume":"141","author":"Rosenberg Avi","year":"2017","journal-title":"Arch Pathol Lab Med"},{"issue":"11","key":"10.1016\/j.jinf.2020.09.028_bib0029","first-page":"1","article-title":"Immunological observations and transcriptomic analysis of trimester-specific full-term placentas from three Zika virus-infected women","volume":"8","author":"Moon","year":"2019","journal-title":"Clin Transl Immunol"},{"issue":"3","key":"10.1016\/j.jinf.2020.09.028_bib0030","first-page":"129","article-title":"The IGF axis and placental function: a mini review","volume":"69","author":"Karen","year":"2008","journal-title":"Horm Res"},{"issue":"1","key":"10.1016\/j.jinf.2020.09.028_bib0031","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/jog.12853","article-title":"Role and mechanism of insulin-like growth factor 2 on the proliferation of human trophoblasts in vitro","volume":"42","author":"Huiyue","year":"2016","journal-title":"J Obstet Gynaecol Res"},{"issue":"2","key":"10.1016\/j.jinf.2020.09.028_bib0032","first-page":"247","article-title":"An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: Interaction between genotype and epigenotype","volume":"13","author":"Adele","year":"2004","journal-title":"Hum Mol Genet"},{"issue":"10","key":"10.1016\/j.jinf.2020.09.028_bib0033","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1523\/JNEUROSCI.4248-11.2012","article-title":"Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis","volume":"32","author":"Oliver","year":"2012","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.jinf.2020.09.028_bib0034","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.yfrne.2012.06.002","article-title":"Neurodevelopmental effects of insulin-like growth factor signaling","volume":"33","author":"John","year":"2012","journal-title":"Front Neuroendocrinol"},{"issue":"4","key":"10.1016\/j.jinf.2020.09.028_bib0035","article-title":"Vero Cell proteomic changes induced by Zika virus infection","volume":"19","author":"Glover Kathleen","year":"2019","journal-title":"Proteomics"},{"issue":"2","key":"10.1016\/j.jinf.2020.09.028_bib0036","first-page":"1","article-title":"Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes","volume":"14","author":"Raj","year":"2019","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jinf.2020.09.028_bib0037","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3390\/v12060608","article-title":"Reduced-Beclin1-expressing Mice Infected with Zika-R103451 and viral-associated pathology during pregnancy","volume":"12","author":"Muthu","year":"2020","journal-title":"Viruses"},{"issue":"7","key":"10.1016\/j.jinf.2020.09.028_bib0038","first-page":"2680","article-title":"The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface","volume":"81","author":"Han V","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.jinf.2020.09.028_bib0039","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.placenta.2012.09.007","article-title":"Revisiting the housekeeping genes of human placental development and insufficiency syndromes","volume":"33","author":"Drewlo","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.jinf.2020.09.028_bib0040","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.placenta.2010.03.006","article-title":"Sex differences in the mRNA levels of housekeeping genes in human Placenta","volume":"31","author":"Cleal","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.jinf.2020.09.028_bib0041","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.placenta.2016.10.017","article-title":"Identification of genes for normalization of real-time RT-PCR data in placental tissues from intrahepatic cholestasis of pregnancy","volume":"48","author":"Yanli","year":"2016","journal-title":"Placenta"},{"issue":"6352","key":"10.1016\/j.jinf.2020.09.028_bib0042","doi-asserted-by":"crossref","first-page":"eaan2507","DOI":"10.1126\/science.aan2507","article-title":"A pathology atlas of the human cancer transcriptome","volume":"357","author":"Mathias","year":"2017","journal-title":"Science (80- )"},{"issue":"6","key":"10.1016\/j.jinf.2020.09.028_bib0043","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.3892\/ijo.2012.1666","article-title":"The insulin-like growth factor (IGF) signaling axis and hepatitis C virus-associated carcinogenesis (Review)","volume":"41","author":"Aldona","year":"2012","journal-title":"Int J Oncol"},{"issue":"35","key":"10.1016\/j.jinf.2020.09.028_bib0044","doi-asserted-by":"crossref","first-page":"56944","DOI":"10.18632\/oncotarget.10922","article-title":"Kim Bo Yeon, Yu Dae Yeul. IGF-II induced by hepatitis B virus X protein regulates EMT via SUMO mediated loss of E- cadherin in mice","volume":"7","author":"Lin","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.jinf.2020.09.028_bib0045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000489744","article-title":"Serum from Chronic Hepatitis B Patients promotes growth and proliferation via the IGF-II\/IGF-IR\/MEK\/ERK Signaling Pathway in Hepatocellular Carcinoma Cells","volume":"47","author":"Yuanyuan","year":"2018","journal-title":"Cell Physiol Biochem"},{"issue":"6","key":"10.1016\/j.jinf.2020.09.028_bib0046","first-page":"1","article-title":"HPV16 Down-regulates the insulin-like growth factor binding Protein 2 to promote Epithelial Invasion in organotypic cultures","volume":"11","author":"Adam","year":"2015","journal-title":"PLoS Pathog"},{"issue":"3","key":"10.1016\/j.jinf.2020.09.028_bib0047","first-page":"2003","article-title":"Birth outcomes following west nile virus infection of pregnant women in the United States: 2003-2004","volume":"117","author":"O'Leary Daniel","year":"2006","journal-title":"Pediatrics"},{"issue":"8","key":"10.1016\/j.jinf.2020.09.028_bib0048","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/bdra.23523","article-title":"Prospective study of pregnancy and newborn outcomes in mothers with West nile illness during pregnancy","volume":"106","author":"Gabriella","year":"2016","journal-title":"Birth Defects Res Part A - Clin Mol Teratol"},{"issue":"426","key":"10.1016\/j.jinf.2020.09.028_bib0049","first-page":"1","article-title":"Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice","volume":"10","author":"Platt Derek","year":"2018","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jinf.2020.09.028_bib0050","article-title":"Yellow fever vaccine and risk of developing serious adverse events: a systematic review","volume":"42","author":"Ruben","year":"2018","journal-title":"Rev Panam Salud P\u00fablica"},{"issue":"8","key":"10.1016\/j.jinf.2020.09.028_bib0051","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1210\/en.2011-0240","article-title":"Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice","volume":"152","author":"Sferruzzi-Perri Amanda","year":"2011","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.jinf.2020.09.028_bib0052","doi-asserted-by":"crossref","first-page":"eaaw6284","DOI":"10.1126\/sciadv.aaw6284","article-title":"Congenital Zika syndrome is associated with maternal protein malnutrition","volume":"6","author":"Barbeito-Andr\u00e9s","year":"2020","journal-title":"Sci Adv"},{"issue":"11","key":"10.1016\/j.jinf.2020.09.028_bib0053","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1056\/NEJMoa1709481","article-title":"Pregnancy outcomes after ZIKV infection in French territories in the Americas","volume":"378","author":"Bruno","year":"2018","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jinf.2020.09.028_bib0054","first-page":"1","article-title":"Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes","volume":"10","author":"Flores","year":"2020","journal-title":"Sci Rep"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445320306344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445320306344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:31:24Z","timestamp":1759008684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445320306344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0163445320306344"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2020.09.028","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Downregulation of IGF2 expression in third trimester placental tissues from Zika virus infected women in Brazil","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2020.09.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association.","name":"copyright","label":"Copyright"}]}}