{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:13:23Z","timestamp":1793229203113,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jinf.2022.04.035","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T04:43:59Z","timestamp":1650861839000},"page":"770-776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Sex differences in sepsis hospitalisations and outcomes in older women and men: A prospective cohort study"],"prefix":"10.1016","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2304-8931","authenticated-orcid":false,"given":"Kelly J","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R","family":"Finfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9800-5296","authenticated-orcid":false,"given":"Mark","family":"Woodward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Neil F","family":"Leong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bette","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jinf.2022.04.035_bib0001","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"10219","key":"10.1016\/j.jinf.2022.04.035_bib0002","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jinf.2022.04.035_bib0003","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1056\/NEJMp1707170","article-title":"Recognizing sepsis as a global health priority - a WHO resolution","volume":"377","author":"Reinhart","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jinf.2022.04.035_bib0004","doi-asserted-by":"crossref","unstructured":"Antequera A., L\u00f3pez-Alcalde J., Stallings E., Muriel A., Fern\u00e1ndez-F\u00e9lix B.M., del Campo R., et\u00a0al. Evaluation of the role of sex as a prognostic factor in critically ill adults with sepsis: a systematic review and meta-analysis. 2020.","DOI":"10.21203\/rs.3.rs-86997\/v1"},{"issue":"3","key":"10.1016\/j.jinf.2022.04.035_bib0005","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/jnu.12295","article-title":"Systematic review of gender differences in sepsis management and outcomes","volume":"49","author":"Failla","year":"2017","journal-title":"J Nursing Scholarship"},{"issue":"5","key":"10.1016\/j.jinf.2022.04.035_bib0006","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/nicc.12280","article-title":"Systematic review of gender- dependent outcomes in sepsis","volume":"22","author":"Papathanassoglou","year":"2017","journal-title":"Nurs Crit Care"},{"issue":"11","key":"10.1016\/j.jinf.2022.04.035_bib0007","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1001\/archsurg.133.11.1200","article-title":"Gender differences in human sepsis","volume":"133","author":"Schroder","year":"1998","journal-title":"Arch Surgery"},{"issue":"10","key":"10.1016\/j.jinf.2022.04.035_bib0008","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1097\/01.CCM.0000239114.50519.0E","article-title":"The role of infection and comorbidity: factors that influence disparities in sepsis","volume":"34","author":"Esper","year":"2006","journal-title":"Crit Care Med"},{"issue":"12","key":"10.1016\/j.jinf.2022.04.035_bib0009","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1503\/cmaj.071112","article-title":"Sex-and age-based differences in the delivery and outcomes of critical care","volume":"177","author":"Fowler","year":"2007","journal-title":"CMAJ"},{"issue":"5","key":"10.1016\/j.jinf.2022.04.035_bib0010","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/ije\/dym184","article-title":"Cohort profile: the 45 and Up Study","volume":"37","author":"Banks","year":"2008","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jinf.2022.04.035_bib0011","unstructured":"Australian Government. Quarterly Population Estimates, by State\/Territory, Sex and Age. 2021."},{"issue":"7","key":"10.1016\/j.jinf.2022.04.035_bib0012","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.jinf.2022.04.035_bib0013","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0895-4356(92)90133-8","article-title":"Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases","volume":"45","author":"Deyo","year":"1992","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"10.1016\/j.jinf.2022.04.035_bib0014","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1001\/archpsyc.60.2.184","article-title":"Screening for serious mental illness in the general population","volume":"60","author":"Kessler","year":"2003","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"10.1016\/j.jinf.2022.04.035_bib0015","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/aje\/kwq433","article-title":"Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries","volume":"173","author":"Quan","year":"2011","journal-title":"Am J Epidemiol"},{"issue":"9","key":"10.1016\/j.jinf.2022.04.035_bib0016","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-048982","article-title":"Sex as a prognostic factor for mortality in critically ill adults with sepsis: a systematic review and meta-analysis","volume":"11","author":"Antequera","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.jinf.2022.04.035_bib0017","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2147\/IJGM.S294229","article-title":"Sex differences in short- and long-term survival among critically ill patients with sepsis","volume":"14","author":"Lin","year":"2021","journal-title":"Int J Gen Med"},{"issue":"3","key":"10.1016\/j.jinf.2022.04.035_bib0018","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/acel.12326","article-title":"How sex and age affect immune responses, susceptibility to infections, and response to vaccination","volume":"14","author":"Giefing-Kr\u00f6ll","year":"2015","journal-title":"Aging Cell"},{"issue":"10","key":"10.1016\/j.jinf.2022.04.035_bib0019","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nature Rev Immunol"},{"issue":"1","key":"10.1016\/j.jinf.2022.04.035_bib0020","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1186\/s12879-021-06378-z","article-title":"High risk groups for severe COVID-19 in a whole of population cohort in Australia","volume":"21","author":"Liu","year":"2021","journal-title":"BMC Infect. Dis."},{"issue":"123","key":"10.1016\/j.jinf.2022.04.035_bib0021","article-title":"Sex differences on clinical characteristics, severity, and mortality in adult patients with COVID-19: a multicentre retrospective study","volume":"8","author":"Sha","year":"2021","journal-title":"Front Med (Lausanne)"},{"issue":"10227","key":"10.1016\/j.jinf.2022.04.035_bib0022","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/S0140-6736(20)30526-2","article-title":"COVID-19: the gendered impacts of the outbreak","volume":"395","author":"Wenham","year":"2020","journal-title":"The Lancet"},{"issue":"13","key":"10.1016\/j.jinf.2022.04.035_bib0023","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012","volume":"311","author":"Kaukonen","year":"2014","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.jinf.2022.04.035_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001601","article-title":"Long-term survival and dialysis dependency following acute kidney injury in intensive care: extended follow-up of a randomized controlled trial","volume":"11","author":"Gallagher","year":"2014","journal-title":"PLoS Med"},{"key":"10.1016\/j.jinf.2022.04.035_bib0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.22374\/ijmsch.v4i1.48","article-title":"Men's health promotion in waiting rooms: an observational study","volume":"4","author":"Whitehead","year":"2021","journal-title":"Int J Mens Soc Commun Health"},{"issue":"5","key":"10.1016\/j.jinf.2022.04.035_bib0026","doi-asserted-by":"crossref","first-page":"e98960","DOI":"10.1172\/jci.insight.98960","article-title":"Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial","volume":"3","author":"Francois","year":"2018","journal-title":"JCI Insight"},{"issue":"7781","key":"10.1016\/j.jinf.2022.04.035_bib0027","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41586-019-1657-6","article-title":"Sex and gender analysis improves science and engineering","volume":"575","author":"Tannenbaum","year":"2019","journal-title":"Nature"},{"issue":"7837","key":"10.1016\/j.jinf.2022.04.035_bib0028","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/d41586-020-03459-y","volume":"588","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jinf.2022.04.035_bib0029","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2288-10-26","article-title":"Investigation of relative risk estimates from studies of the same population with contrasting response rates and designs","volume":"10","author":"Mealing","year":"2010","journal-title":"BMC Med Res Methodol"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445322002171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445322002171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:34:42Z","timestamp":1759008882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445322002171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0163445322002171"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2022.04.035","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differences in sepsis hospitalisations and outcomes in older women and men: A prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2022.04.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}