{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T01:00:57Z","timestamp":1793926857123,"version":"4.8.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["2021YFC2302500"],"award-info":[{"award-number":["2021YFC2302500"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1303500"],"award-info":[{"award-number":["2022YFA1303500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2017ZX10201301-003-002"],"award-info":[{"award-number":["2017ZX10201301-003-002"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770010"],"award-info":[{"award-number":["81770010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.jinf.2023.09.004","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T18:16:43Z","timestamp":1694283403000},"page":"373-384","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Single-cell RNA-sequencing reveals heterogeneity and intercellular crosstalk in human tuberculosis lung"],"prefix":"10.1016","volume":"87","author":[{"given":"Lin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangfei","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laiyi","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8356-5880","authenticated-orcid":false,"given":"Ka-Wing","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jinf.2023.09.004_bib1","first-page":"365","article-title":"Pathogenesis of post primary tuberculosis: immunity and hypersensitivity in the development of cavities","volume":"44","author":"Hunter","year":"2014","journal-title":"Ann Clin Lab Sci"},{"issue":"1","key":"10.1016\/j.jinf.2023.09.004_bib2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/imr.12252","article-title":"Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses","volume":"264","author":"Lenaerts","year":"2015","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jinf.2023.09.004_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/307631","article-title":"Immunopathology of postprimary tuberculosis: increased T-regulatory cells and DEC-205-positive foamy macrophages in cavitary lesions","volume":"2011","author":"Welsh","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.jinf.2023.09.004_bib4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/s41590-021-01121-x","article-title":"The immunoregulatory landscape of human tuberculosis granulomas","volume":"23","author":"McCaffrey","year":"2022","journal-title":"Nat Immunol"},{"issue":"265","key":"10.1016\/j.jinf.2023.09.004_bib5","doi-asserted-by":"crossref","first-page":"265ra166","DOI":"10.1126\/scitranslmed.3009501","article-title":"PET\/CT imaging correlates with treatment outcome in patients with multidrug-resistant tuberculosis","volume":"6","author":"Chen","year":"2014","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1016\/j.jinf.2023.09.004_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49057-5","article-title":"18F-FDG positron-emission tomography\/computed tomography findings of radiographic lesions suggesting old healed pulmonary tuberculosis and high-risk signs of predicting recurrence: a retrospective study","volume":"9","author":"Ji","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jinf.2023.09.004_bib7","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2967\/jnumed.119.233783","article-title":"(18)F-FDG PET\/CT as a noninvasive biomarker for assessing adequacy of treatment and predicting relapse in patients treated for pulmonary tuberculosis","volume":"61","author":"Lawal","year":"2020","journal-title":"J Nucl Med"},{"issue":"10","key":"10.1016\/j.jinf.2023.09.004_bib8","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/nm.4177","article-title":"Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure","volume":"22","author":"Malherbe","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.jinf.2023.09.004_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijid.2020.02.030","article-title":"Validating the surgical indication value of the LTB-S classification system for drug resistant tuberculosis","volume":"95","author":"Lin","year":"2020","journal-title":"Int J Infect Dis"},{"issue":"10","key":"10.1016\/j.jinf.2023.09.004_bib10","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210469","article-title":"Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice","volume":"218","author":"Bohrer","year":"2021","journal-title":"J Exp Med"},{"issue":"28","key":"10.1016\/j.jinf.2023.09.004_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1972","article-title":"Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis","volume":"6","author":"Habermann","year":"2020","journal-title":"Sci Adv"},{"issue":"5","key":"10.1016\/j.jinf.2023.09.004_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nbt.4091","article-title":"Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors","volume":"36","author":"Haghverdi","year":"2018","journal-title":"Nat Biotechnol"},{"issue":"7847","key":"10.1016\/j.jinf.2023.09.004_bib13","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41586-020-03148-w","article-title":"Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia","volume":"590","author":"Grant","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jinf.2023.09.004_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22164-6","article-title":"Single-cell analyses of Crohn\u2019s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions","volume":"12","author":"Jaeger","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jinf.2023.09.004_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22975-7","article-title":"Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation","volume":"12","author":"Mijnheer","year":"2021","journal-title":"Nat Commun"},{"issue":"23","key":"10.1016\/j.jinf.2023.09.004_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.10.023","article-title":"COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas","volume":"184","author":"Ren","year":"2021","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.jinf.2023.09.004_bib17","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/ajt.13115","article-title":"The molecular landscape of antibody-mediated kidney transplant rejection: evidence for NK involvement through CD16a Fc receptors","volume":"15","author":"Venner","year":"2015","journal-title":"Am J Transpl"},{"issue":"4","key":"10.1016\/j.jinf.2023.09.004_bib18","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41596-020-0292-x","article-title":"CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes","volume":"15","author":"Efremova","year":"2020","journal-title":"Nat Protoc"},{"issue":"1","key":"10.1016\/j.jinf.2023.09.004_bib19","article-title":"Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution","volume":"12","author":"Liu","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.jinf.2023.09.004_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102686","article-title":"Single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis","volume":"53","author":"Cai","year":"2020","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.jinf.2023.09.004_bib21","first-page":"1517","article-title":"Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis","volume":"199","author":"Reyfman","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"7309","key":"10.1016\/j.jinf.2023.09.004_bib22","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature09247","article-title":"An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis","volume":"466","author":"Berry","year":"2010","journal-title":"Nature"},{"issue":"7309","key":"10.1016\/j.jinf.2023.09.004_bib23","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/S0140-6736(15)01316-1","article-title":"A blood RNA signature for tuberculosis disease risk: a prospective cohort study","volume":"387","author":"Zak","year":"2016","journal-title":"Lancet"},{"issue":"527","key":"10.1016\/j.jinf.2023.09.004_bib24","article-title":"Immunometabolic signatures predict risk of progression to active tuberculosis and disease outcome","volume":"10","author":"Duffy","year":"2019","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.jinf.2023.09.004_bib25","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/eji.201445000","article-title":"The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation","volume":"45","author":"Cousin","year":"2015","journal-title":"Eur J Immunol"},{"issue":"24","key":"10.1016\/j.jinf.2023.09.004_bib26","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1093\/infdis\/jiab558","article-title":"IL-4i1 regulates immune protection during Mycobacterium tuberculosis infection","volume":"224","author":"Hlaka","year":"2021","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.jinf.2023.09.004_bib27","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.immuni.2014.02.012","article-title":"Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses","volume":"40","author":"Joller","year":"2014","journal-title":"Immunity"},{"issue":"14","key":"10.1016\/j.jinf.2023.09.004_bib28","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.137858","article-title":"Pulmonary Mycobacterium tuberculosis control associates with CXCR3- and CCR6-expressing antigen-specific Th1 and Th17 cell recruitment","volume":"5","author":"Shanmugasundaram","year":"2020","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.jinf.2023.09.004_bib29","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00109-021-02116-9","article-title":"CD27 expression on Treg cells limits immune responses against tumors","volume":"100","author":"Muth","year":"2021","journal-title":"J Mol Med"},{"issue":"24","key":"10.1016\/j.jinf.2023.09.004_bib30","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122167","article-title":"OX40L\/OX40 axis impairs follicular and natural Treg function in human SLE","volume":"3","author":"Jacquemin","year":"2018","journal-title":"JCI Insight"},{"issue":"23","key":"10.1016\/j.jinf.2023.09.004_bib31","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1073\/pnas.1621280114","article-title":"CCR8(+)FOXp3(+) Treg cells as master drivers of immune regulation","volume":"114","author":"Barsheshet","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"10.1016\/j.jinf.2023.09.004_bib32","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1164\/rccm.200508-1294OC","article-title":"Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis","volume":"173","author":"Guyot-Revol","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jinf.2023.09.004_bib33","article-title":"CTLA-4 blockade reverses the Foxp3+ T-regulatory-cell suppression of anti-tuberculosis T-cell effector responses","author":"Shao","year":"2020","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.jinf.2023.09.004_bib34","doi-asserted-by":"crossref","first-page":"E62","DOI":"10.1073\/pnas.1711373114","article-title":"In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis","volume":"115","author":"Gautam","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jinf.2023.09.004_bib35","article-title":"A spatial map of human macrophage niches links tissue location with function","author":"Matusiak","year":"2022","journal-title":"bioRxiv"},{"issue":"Pt 12","key":"10.1016\/j.jinf.2023.09.004_bib36","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1093\/brain\/aww254","article-title":"IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation","volume":"139","author":"Psachoulia","year":"2016","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.jinf.2023.09.004_bib37","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/cei.13488","article-title":"Emerging patterns of regulatory T cell function in tuberculosis","volume":"202","author":"Ahmed","year":"2020","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"10.1016\/j.jinf.2023.09.004_bib38","first-page":"85","article-title":"Immune complex injury of the lung","volume":"97","author":"Ward","year":"1979","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.jinf.2023.09.004_bib39","doi-asserted-by":"crossref","first-page":"E964","DOI":"10.1073\/pnas.1711853115","article-title":"Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis","volume":"115","author":"Esmail","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jinf.2023.09.004_bib40","article-title":"Immune deposit and vasculopathy in metabolic-active lung tissues of patients with pulmonary tuberculosis","author":"Ma","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.jinf.2023.09.004_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111144","article-title":"Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection","volume":"40","author":"Bohrer","year":"2022","journal-title":"Cell Rep"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445323005066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445323005066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:36:31Z","timestamp":1759008991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445323005066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0163445323005066"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2023.09.004","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell RNA-sequencing reveals heterogeneity and intercellular crosstalk in human tuberculosis lung","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2023.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association.","name":"copyright","label":"Copyright"}]}}