{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:55:23Z","timestamp":1791644123613,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000855","name":"University of Birmingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jinf.2024.01.014","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T18:59:47Z","timestamp":1706813987000},"page":"106115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["IgG glycosylation associates with risk of progression from latent to active tuberculosis"],"prefix":"10.1016","volume":"88","author":[{"given":"Julie G.","family":"Burel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Wuhrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Dedicoat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam F.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew K.","family":"O\u2019Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jinf.2024.01.014_bib1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nrd2804","article-title":"Glycosylation as a strategy to improve antibody-based therapeutics","volume":"8","author":"Jefferis","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jinf.2024.01.014_bib2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev.immunol.25.022106.141702","article-title":"The impact of glycosylation on the biological function and structure of human immunoglobulins","volume":"25","author":"Arnold","year":"2007","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"10.1016\/j.jinf.2024.01.014_bib3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nri.2017.106","article-title":"Beyond binding: antibody effector functions in infectious diseases","volume":"18","author":"Lu","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10.1016\/j.jinf.2024.01.014_bib4","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1084\/jem.167.5.1731","article-title":"Age-related galactosylation of the N-linked oligosaccharides of human serum IgG","volume":"167","author":"Parekh","year":"1988","journal-title":"J Exp Med"},{"issue":"10","key":"10.1016\/j.jinf.2024.01.014_bib5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrrheum.2017.146","article-title":"Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?","volume":"13","author":"Seeling","year":"2017","journal-title":"Nat Rev Rheuma"},{"issue":"1","key":"10.1016\/j.jinf.2024.01.014_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12495-0","article-title":"Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health","volume":"7","author":"Plomp","year":"2017","journal-title":"Sci Rep"},{"issue":"31","key":"10.1016\/j.jinf.2024.01.014_bib7","doi-asserted-by":"crossref","first-page":"12669","DOI":"10.1073\/pnas.1108455108","article-title":"Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose","volume":"108","author":"Ferrara","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jinf.2024.01.014_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/srep28207","article-title":"IgG1 Fc N-glycan galactosylation as a biomarker for immune activation","volume":"6","author":"de Jong","year":"2016","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.jinf.2024.01.014_bib9","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.014563","article-title":"Changes in antigen-specific IgG1 Fc N-glycosylation upon influenza and tetanus vaccination","volume":"11","author":"Selman","year":"2012","journal-title":"Mol Cell Proteom"},{"key":"10.1016\/j.jinf.2024.01.014_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104678","article-title":"IFN-gamma independent markers of Mycobacterium tuberculosis exposure among male South African gold miners","volume":"93","author":"Davies","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jinf.2024.01.014_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.679973","article-title":"Antibody subclass and glycosylation shift following effective TB treatment","volume":"12","author":"Grace","year":"2021","journal-title":"Front Immunol"},{"issue":"12","key":"10.1016\/j.jinf.2024.01.014_bib12","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1093\/infdis\/jiz643","article-title":"Antibody Fc glycosylation discriminates between latent and active tuberculosis","volume":"222","author":"Lu","year":"2020","journal-title":"J Infect Dis"},{"issue":"6","key":"10.1016\/j.jinf.2024.01.014_bib13","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/s41591-019-0441-3","article-title":"IFN-gamma-independent immune markers of Mycobacterium tuberculosis exposure","volume":"25","author":"Lu","year":"2019","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.jinf.2024.01.014_bib14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1164\/rccm.202011-4239PP","article-title":"Latent tuberculosis: two centuries of confusion","volume":"204","author":"Behr","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jinf.2024.01.014_bib15","article-title":"Tuberculosis","volume":"2","author":"Pai","year":"2016","journal-title":"Nat Rev Dis Prim"},{"issue":"2","key":"10.1016\/j.jinf.2024.01.014_bib16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/aje\/kwt246","article-title":"Estimated rate of reactivation of latent tuberculosis infection in the United States, overall and by population subgroup","volume":"179","author":"Shea","year":"2014","journal-title":"Am J Epidemiol"},{"issue":"4","key":"10.1016\/j.jinf.2024.01.014_bib17","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1093\/infdis\/jit494","article-title":"Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy","volume":"209","author":"Naranbhai","year":"2014","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jinf.2024.01.014_bib18","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-014-0120-7","article-title":"The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life","volume":"12","author":"Naranbhai","year":"2014","journal-title":"BMC Med"},{"issue":"10035","key":"10.1016\/j.jinf.2024.01.014_bib19","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/S0140-6736(15)01316-1","article-title":"A blood RNA signature for tuberculosis disease risk: a prospective cohort study","volume":"387","author":"Zak","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jinf.2024.01.014_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.tube.2021.102127","article-title":"Distinct blood transcriptomic signature of treatment in latent tuberculosis infected individuals at risk of developing active disease","volume":"131","author":"Burel","year":"2021","journal-title":"Tuberc (Edinb)"},{"key":"10.1016\/j.jinf.2024.01.014_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103957","article-title":"Immunoglobulin G1 Fc glycosylation as an early hallmark of severe COVID-19","volume":"78","author":"Pongracz","year":"2022","journal-title":"EBioMedicine"},{"issue":"7","key":"10.1016\/j.jinf.2024.01.014_bib22","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1021\/acs.jproteome.6b00171","article-title":"LaCyTools: a targeted liquid chromatography-mass spectrometry data processing package for relative quantitation of glycopeptides","volume":"15","author":"Jansen","year":"2016","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jinf.2024.01.014_bib23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-6493-2_4","article-title":"High-throughput analysis of IgG Fc glycopeptides by LC-MS","volume":"1503","author":"Falck","year":"2017","journal-title":"Methods Mol Biol"},{"issue":"16","key":"10.1016\/j.jinf.2024.01.014_bib24","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1093\/bioinformatics\/btm311","article-title":"beadarray: R classes and methods for Illumina bead-based data","volume":"23","author":"Dunning","year":"2007","journal-title":"Bioinformatics"},{"issue":"13","key":"10.1016\/j.jinf.2024.01.014_bib25","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/bioinformatics\/btn224","article-title":"lumi: a pipeline for processing Illumina microarray","volume":"24","author":"Du","year":"2008","journal-title":"Bioinformatics"},{"issue":"6","key":"10.1016\/j.jinf.2024.01.014_bib26","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jinf.2024.01.014_bib27","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinforma"},{"issue":"6","key":"10.1016\/j.jinf.2024.01.014_bib28","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cell.2018.10.022","article-title":"Impact of genetic polymorphisms on human immune cell gene expression","volume":"175","author":"Schmiedel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jinf.2024.01.014_bib29","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3389\/fimmu.2014.00520","article-title":"IgG subclasses and allotypes: from structure to effector functions","volume":"5","author":"Vidarsson","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.jinf.2024.01.014_bib30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tube.2015.11.001","article-title":"Detection of IgG1 antibodies against Mycobacterium tuberculosis DosR and Rpf antigens in tuberculosis patients before and after chemotherapy","volume":"96","author":"Mattos","year":"2016","journal-title":"Tuberc (Edinb)"},{"key":"10.1016\/j.jinf.2024.01.014_bib31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tube.2017.10.010","article-title":"IgG subclasses' response to a set of mycobacterial antigens in different stages of Mycobacterium tuberculosis infection","volume":"108","author":"de Araujo","year":"2018","journal-title":"Tuberc (Edinb)"},{"issue":"6","key":"10.1016\/j.jinf.2024.01.014_bib32","doi-asserted-by":"crossref","first-page":"R193","DOI":"10.1186\/ar2892","article-title":"Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study","volume":"11","author":"van de Geijn","year":"2009","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"10.1016\/j.jinf.2024.01.014_bib33","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/s41590-023-01544-8","article-title":"Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy","volume":"24","author":"Nimmerjahn","year":"2023","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jinf.2024.01.014_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02436","article-title":"Comparative glycomics of immunoglobulin A and G from saliva and plasma reveals biomarker potential","volume":"9","author":"Plomp","year":"2018","journal-title":"Front Immunol"},{"issue":"33","key":"10.1016\/j.jinf.2024.01.014_bib35","doi-asserted-by":"crossref","first-page":"13980","DOI":"10.1073\/pnas.0901720106","article-title":"Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics","volume":"106","author":"Abu-Raddad","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jinf.2024.01.014_bib36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev-publhealth-031912-114431","article-title":"Prospects for tuberculosis elimination","volume":"34","author":"Dye","year":"2013","journal-title":"Annu Rev Public Health"},{"issue":"12","key":"10.1016\/j.jinf.2024.01.014_bib37","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrmicro2236","article-title":"The spectrum of latent tuberculosis: rethinking the biology and intervention strategies","volume":"7","author":"Barry","year":"2009","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"10.1016\/j.jinf.2024.01.014_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00021-18","article-title":"Incipient and subclinical tuberculosis: a clinical review of early stages and progression of infection","volume":"31","author":"Drain","year":"2018","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jinf.2024.01.014_bib39","doi-asserted-by":"crossref","first-page":"k2738","DOI":"10.1136\/bmj.k2738","article-title":"Revisiting the timetable of tuberculosis","volume":"362","author":"Behr","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.jinf.2024.01.014_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103928","article-title":"Mind the gap - managing tuberculosis across the disease spectrum","volume":"78","author":"Esmail","year":"2022","journal-title":"EBioMedicine"},{"issue":"10","key":"10.1016\/j.jinf.2024.01.014_bib41","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.it.2022.08.001","article-title":"Afucosylated IgG responses in humans - structural clues to the regulation of humoral immunity","volume":"43","author":"Oosterhoff","year":"2022","journal-title":"Trends Immunol"},{"issue":"6532","key":"10.1016\/j.jinf.2024.01.014_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.abc8378","article-title":"Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity","volume":"371","author":"Larsen","year":"2021","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jinf.2024.01.014_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-26118-w","article-title":"Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination","volume":"12","author":"Larsen","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.jinf.2024.01.014_bib44","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cell.2016.08.072","article-title":"A functional role for antibodies in tuberculosis","volume":"167","author":"Lu","year":"2016","journal-title":"Cell"},{"issue":"7720","key":"10.1016\/j.jinf.2024.01.014_bib45","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41586-018-0439-x","article-title":"A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes","volume":"560","author":"Roy Chowdhury","year":"2018","journal-title":"Nature"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445324000331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445324000331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:37:06Z","timestamp":1759009026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445324000331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0163445324000331"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2024.01.014","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IgG glycosylation associates with risk of progression from latent to active tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2024.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association.","name":"copyright","label":"Copyright"}],"article-number":"106115"}}