{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:40:46Z","timestamp":1784133646586,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["CD21\/00098"],"award-info":[{"award-number":["CD21\/00098"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["JR20\/00023"],"award-info":[{"award-number":["JR20\/00023"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["PI22\/001464"],"award-info":[{"award-number":["PI22\/001464"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014139","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","doi-asserted-by":"publisher","award":["MICIU\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MICIU\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100014139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Spain Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["FJC2021-046546-I"],"award-info":[{"award-number":["FJC2021-046546-I"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI22\/001464"],"award-info":[{"award-number":["PI22\/001464"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["JR20\/00023"],"award-info":[{"award-number":["JR20\/00023"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["CD21\/00098"],"award-info":[{"award-number":["CD21\/00098"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["CM22\/00196"],"award-info":[{"award-number":["CM22\/00196"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PMP22\/00092"],"award-info":[{"award-number":["PMP22\/00092"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jinf.2024.106268","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T02:51:55Z","timestamp":1726195915000},"page":"106268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Survival of infection with TEM \u03b2-lactamase-producing Escherichia coli with Pan-\u03b2-lactam resistance"],"prefix":"10.1016","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-9724","authenticated-orcid":false,"given":"\u00c1ngel","family":"Rodr\u00edguez-Villodres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Ortiz de la Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"G\u00e1lvez-Ben\u00edtez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-0944","authenticated-orcid":false,"given":"Mar\u00eda Luisa","family":"Gasc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-6230","authenticated-orcid":false,"given":"Germ\u00e1n","family":"Pe\u00f1alva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Dorado Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos S.","family":"Casimiro-Soriguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rodr\u00edguez Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Amaya Villar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5001-672X","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Cisneros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Lepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jinf.2024.106268_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Antimicrobial Resistance Collaborators","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jinf.2024.106268_bib2","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/cid\/cix893","article-title":"Carbapenemase-producing organisms: a global scourge","volume":"66","author":"Bonomo","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2024.106268_bib3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/jpids\/piz002","article-title":"Defining the role of novel \u03b2-lactam agents that target carbapenem-resistant gram-negative organisms","volume":"8","author":"Tamma","year":"2019","journal-title":"J Pediatric Infect Dis Soc"},{"key":"10.1016\/j.jinf.2024.106268_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1089\/mdr.2021.0095","article-title":"Defining baseline mechanisms of cefiderocol resistance in the Enterobacterales","volume":"28","author":"Simner","year":"2022","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.jinf.2024.106268_bib5","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3201\/eid1308.070071","article-title":"Risk factors for colonization with extended-spectrum beta-lactamase-producing bacteria and intensive care unit admission","volume":"13","author":"Harris","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jinf.2024.106268_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/cid\/ciab888","article-title":"Progressive development of cefiderocol resistance in Escherichia coli during therapy is associated with an increase in blaNDM-5 copy number and gene expression","volume":"75","author":"Simner","year":"2022","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jinf.2024.106268_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10096-023-04697-4","article-title":"Deciphering mechanisms affecting cefepime-taniborbactam in vitro activity in carbapenemase-producing Enterobacterales and carbapenem-resistant Pseudomonas spp. isolates recovered during a surveillance study in Spain","volume":"43","author":"Hern\u00e1ndez-Garc\u00eda","year":"2024","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jinf.2024.106268_bib8","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1093\/jac\/dkz330","article-title":"Emergence of ceftazidime\/avibactam resistance in KPC-3-producing Klebsiella pneumoniae in vivo","volume":"74","author":"G\u00f6ttig","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jinf.2024.106268_bib9","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1093\/jac\/dkac100","article-title":"Dynamic evolution of imipenem\/relebactam resistance in a KPC-producing Klebsiella pneumoniae from a single patient during ceftazidime\/avibactam-based treatments","volume":"77","author":"Gaibani","year":"2022","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jinf.2024.106268_bib10","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3390\/antibiotics10050536","article-title":"Epidemiology of meropenem\/vaborbactam resistance in KPC-producing Klebsiella pneumoniae causing bloodstream infections in Northern Italy, 2018","volume":"10","author":"Gaibani","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.jinf.2024.106268_bib11","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 14.0; 2024. https:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Breakpoint_tables\/v_14.0_Breakpoint_Tables.pdf."},{"key":"10.1016\/j.jinf.2024.106268_bib12","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jinf.2023.07.005","article-title":"Role of blaTEM and OmpC in the piperacillin-tazobactam resistance evolution by E. coli in patients with complicated intra-abdominal infection","volume":"87","author":"G\u00e1lvez-Ben\u00edtez","year":"2023","journal-title":"J Infect"},{"key":"10.1016\/j.jinf.2024.106268_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13059-019-1727-y","article-title":"Performance of neural network basecalling tools for Oxford Nanopore sequencing","volume":"20","author":"Wick","year":"2019","journal-title":"Genome Biol"},{"key":"10.1016\/j.jinf.2024.106268_bib14","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jinf.2024.106268_bib15","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41587-019-0072-8","article-title":"Assembly of long, error-prone reads using repeat graphs","volume":"37","author":"Kolmogorov","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jinf.2024.106268_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112963","article-title":"Pilon: an integrated tool for comprehensive microbial variant detection and genome assembly improvement","volume":"9","author":"Walker","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2024.106268_bib17","doi-asserted-by":"crossref","first-page":"8365","DOI":"10.1038\/srep08365","article-title":"RASTtk: a modular and extensible implementation of the RAST algorithm for building custom annotation pipelines and annotating batches of genomes","volume":"5","author":"Brettin","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jinf.2024.106268_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123690","article-title":"The carbapenem inactivation method (CIM), a simple and low-cost alternative for the Carba NP test to assess phenotypic carbapenemase activity in gram-negative rods","volume":"10","author":"Van der Zwaluw","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jinf.2024.106268_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jinf.2024.106268_bib20","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1093\/jac\/dkl426","article-title":"Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF)","volume":"59","author":"Bohnert","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jinf.2024.106268_bib21","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1093\/infdis\/jit386","article-title":"Association of the outer membrane protein Omp33 with fitness and virulence of Acinetobacter baumannii","volume":"208","author":"Smani","year":"2013","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jinf.2024.106268_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/1749-4877.12637","article-title":"Characteristics of the multiple replicon plasmid IncX1-X1 in multidrug-resistant Escherichia coli from Malayan pangolin (Manis javanica)","volume":"18","author":"Ji","year":"2023","journal-title":"Integr Zool"},{"key":"10.1016\/j.jinf.2024.106268_bib23","article-title":"Occurrence of high levels of cefiderocol resistance in carbapenem-resistant Escherichia coli before its approval in China: a report from China CRE-Network","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jinf.2024.106268_bib24","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1128\/AAC.33.9.1451","article-title":"Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae","volume":"33","author":"Quinn","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jinf.2024.106268_bib25","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1128\/AAC.46.3.646-653.2002","article-title":"Mutant TEM beta-lactamase producing resistance to ceftazidime, ampicillins, and beta-lactamase inhibitors","volume":"46","author":"Vakulenko","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jinf.2024.106268_bib26","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1128\/AAC.01585-15","article-title":"Role of the outer membrane and porins in susceptibility of \u03b2-lactamase-producing Enterobacteriaceae to ceftazidime-avibactam","volume":"60","author":"Pag\u00e8s","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jinf.2024.106268_bib27","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1128\/AAC.04238-14","article-title":"Unexpected challenges in treating multidrug-resistant Gram-negative bacteria: resistance to ceftazidime-avibactam in archived isolates of Pseudomonas aeruginosa","volume":"59","author":"Winkler","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jinf.2024.106268_bib28","doi-asserted-by":"crossref","first-page":"dlab197","DOI":"10.1093\/jacamr\/dlab197","article-title":"Activity of cefepime\/taniborbactam and comparators against whole genome sequenced ertapenem-non-susceptible Enterobacterales clinical isolates: CANWARD 2007-19","volume":"4","author":"Golden","year":"2022","journal-title":"JAC Antimicrob Resist"},{"key":"10.1016\/j.jinf.2024.106268_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01281-22","article-title":"In vitro activity of cefepime-taniborbactam and comparators against clinical isolates of gram-negative Bacilli from 2018 to 2020: results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program","volume":"67","author":"Karlowsky","year":"2023","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jinf.2024.106268_bib30","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/cid\/ciab511","article-title":"Rapid development of cefiderocol resistance in carbapenem-resistant Enterobacter cloacae during therapy is associated with heterogeneous mutations in the catecholate siderophore receptor cirA","volume":"74","author":"Klein","year":"2022","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445324002020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445324002020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:00:52Z","timestamp":1777492852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445324002020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0163445324002020"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2024.106268","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Survival of infection with TEM \u03b2-lactamase-producing Escherichia coli with Pan-\u03b2-lactam resistance","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2024.106268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association.","name":"copyright","label":"Copyright"}],"article-number":"106268"}}