{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:12:15Z","timestamp":1791558735027,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009032","name":"Pfizer Ltd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","journalofinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Infection"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jinf.2024.106277","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T20:14:50Z","timestamp":1726776890000},"page":"106277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia"],"prefix":"10.1016","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-4618","authenticated-orcid":false,"given":"Louise","family":"Lansbury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia M.","family":"McKeever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Pick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6470-5726","authenticated-orcid":false,"given":"Vadsala","family":"Baskaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rochelle C.","family":"Edwards-Pritchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Ashton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamira","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-0553","authenticated-orcid":false,"given":"David","family":"Litt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2151-6706","authenticated-orcid":false,"given":"Seyi","family":"Eletu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanshi","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen L.","family":"Sheppard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamez","family":"Ladhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Trotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Shen","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.jinf.2024.106277_bib1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1586\/erv.12.53","article-title":"The fundamental link between pneumococcal carriage and disease","volume":"11","author":"Simell","year":"2012","journal-title":"Expert Rev Vaccin"},{"issue":"1","key":"10.1016\/j.jinf.2024.106277_bib2","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000000335","article-title":"A cross-sectional observational study of pneumococcal carriage in children, their parents, and older adults following the introduction of the 7-valent pneumococcal conjugate vaccine","volume":"94","author":"Hamaluba","year":"2015","journal-title":"Medicine"},{"issue":"5","key":"10.1016\/j.jinf.2024.106277_bib3","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1086\/381547","article-title":"Nasopharyngeal carriage of Streptococcus pneumoniae by adults and children in community and family settings","volume":"38","author":"Regev-Yochay","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"3","key":"10.1016\/j.jinf.2024.106277_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090974","article-title":"Low prevalence of pneumococcal carriage and high serotype and genotype diversity among adults over 60 years of age living in Portugal","volume":"9","author":"Almeida","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jinf.2024.106277_bib5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/00365548.2011.652162","article-title":"Nasopharyngeal carriage of Streptococcus pneumoniae and pneumococcal urine antigen test in healthy elderly subjects","volume":"44","author":"Palmu","year":"2012","journal-title":"Scand J Infect Dis"},{"issue":"29","key":"10.1016\/j.jinf.2024.106277_bib6","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1016\/j.vaccine.2018.05.107","article-title":"Effect of prior vaccination on carriage rates of Streptococcus pneumoniae in older adults: a longitudinal surveillance study","volume":"36","author":"Branche","year":"2018","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.jinf.2024.106277_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119875","article-title":"Carriage of Streptococcus pneumoniae in aged adults with influenza-like-illness","volume":"10","author":"Krone","year":"2015","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.jinf.2024.106277_bib8","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1093\/infdis\/jiaa558","article-title":"Dynamics of pneumococcal carriage in adults: a new look at an old paradigm","volume":"223","author":"Almeida","year":"2021","journal-title":"J Infect Dis"},{"issue":"10","key":"10.1016\/j.jinf.2024.106277_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140112","article-title":"Clinical and microbiological factors associated with high nasopharyngeal pneumococcal density in patients with pneumococcal pneumonia","volume":"10","author":"Alpkvist","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jinf.2024.106277_bib10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1136\/thoraxjnl-2019-213725","article-title":"Pneumococcal serotype trends, surveillance and risk factors in UK adult pneumonia, 2013-18","volume":"75","author":"Pick","year":"2020","journal-title":"Thorax"},{"issue":"9","key":"10.1016\/j.jinf.2024.106277_bib11","doi-asserted-by":"crossref","first-page":"e2680","DOI":"10.1093\/cid\/ciaa1551","article-title":"Influenza-like Illness exacerbates pneumococcal carriage in older adults","volume":"73","author":"Miellet","year":"2021","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10.1016\/j.jinf.2024.106277_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgph.0000327","article-title":"Factors associated with pneumococcal nasopharyngeal carriage: a systematic review","volume":"2","author":"Neal","year":"2022","journal-title":"PLoS Glob Public Health"},{"issue":"32","key":"10.1016\/j.jinf.2024.106277_bib13","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1016\/j.vaccine.2021.06.035","article-title":"Impact of private use of the 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal carriage among Portuguese children living in urban and rural regions","volume":"39","author":"F\u00e9lix","year":"2021","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.jinf.2024.106277_bib14","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/infdis\/jiac376","article-title":"Nasopharyngeal carriage of pneumococcus in children in England up to 10 years after 13-valent pneumococcal conjugate vaccine introduction: persistence of serotypes 3 and 19A and emergence of 7C","volume":"227","author":"Tiley","year":"2023","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.jinf.2024.106277_bib15","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/14760584.2020.1750378","article-title":"Upper respiratory tract colonization with Streptococcus pneumoniae in adults","volume":"19","author":"Arguedas","year":"2020","journal-title":"Expert Rev Vaccines"},{"issue":"1","key":"10.1016\/j.jinf.2024.106277_bib16","doi-asserted-by":"crossref","first-page":"8373","DOI":"10.1038\/s41598-020-65399-x","article-title":"Re-evaluation of Streptococcus pneumoniae carriage in Portuguese elderly by qPCR increases carriage estimates and unveils an expanded pool of serotypes","volume":"10","author":"Almeida","year":"2020","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jinf.2024.106277_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060520","article-title":"Superiority of trans-oral over trans-nasal sampling in detecting Streptococcus pneumoniae colonization in adults","volume":"8","author":"Trzci\u0144ski","year":"2013","journal-title":"PLoS One"},{"issue":"pagination","key":"10.1016\/j.jinf.2024.106277_bib18","article-title":"Streptococcus pneumoniae carriage studies in adults: importance, challenges, and key issues to consider when using quantitative PCR-based approaches","volume":"14","author":"Miellet","year":"2023","journal-title":"Front Microbiol"},{"issue":"6","key":"10.1016\/j.jinf.2024.106277_bib19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/INF.0b013e31828692be","article-title":"Selection of distinctive colony morphologies for detection of multiple carriage of Streptococcus pneumoniae","volume":"32","author":"Valente","year":"2013","journal-title":"Pediatr Infect Dis J"},{"issue":"10","key":"10.1016\/j.jinf.2024.106277_bib20","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1093\/infdis\/jiu326","article-title":"High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia","volume":"210","author":"Wolter","year":"2014","journal-title":"J Infect Dis"},{"issue":"8","key":"10.1016\/j.jinf.2024.106277_bib21","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-005953","article-title":"Pneumococcal colonisation density: a new marker for disease severity in HIV-infected adults with pneumonia","volume":"4","author":"Albrich","year":"2014","journal-title":"BMJ Open"},{"issue":"4","key":"10.1016\/j.jinf.2024.106277_bib22","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrmicro3231","article-title":"The co-pathogenesis of influenza viruses with bacteria in the lung","volume":"12","author":"McCullers","year":"2014","journal-title":"Nat Rev Microbiol"},{"issue":"7","key":"10.1016\/j.jinf.2024.106277_bib23","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.jiph.2023.05.007","article-title":"Pneumococcal carriage among high-risk adults in a country with nonmandatory pneumococcal vaccination during the coronavirus disease 2019 pandemic","volume":"16","author":"Ngamprasertchai","year":"2023","journal-title":"J Infect Public Health"},{"issue":"2","key":"10.1016\/j.jinf.2024.106277_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S2213-2600(13)70165-6","article-title":"Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions","volume":"2","author":"Krone","year":"2014","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jinf.2024.106277_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2022.900028","article-title":"Immune senescence, immunosenescence and aging","volume":"3","author":"Lee","year":"2022","journal-title":"Front Aging"},{"issue":"8","key":"10.1016\/j.jinf.2024.106277_bib26","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.3201\/eid2808.212440","article-title":"Characterization of emerging serotype 19A pneumococcal strains in invasive disease and carriage, Belgium","volume":"28","author":"Desmet","year":"2022","journal-title":"Emerg Infect Dis"},{"issue":"49","key":"10.1016\/j.jinf.2024.106277_bib27","doi-asserted-by":"crossref","first-page":"7756","DOI":"10.1016\/j.vaccine.2020.10.045","article-title":"Evaluating post-vaccine expansion patterns of pneumococcal serotypes","volume":"38","author":"Phillips","year":"2020","journal-title":"Vaccine"},{"issue":"12","key":"10.1016\/j.jinf.2024.106277_bib28","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1093\/cid\/ciy920","article-title":"Effectiveness of 13-valent pneumococcal conjugate vaccine against invasive disease caused by serotype 3 in children: a systematic review and meta-analysis of observational studies","volume":"68","author":"Sings","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.jinf.2024.106277_bib29","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1093\/cid\/cit428","article-title":"Comparative immunogenicity and efficacy of 13-valent and 7-valent pneumococcal conjugate vaccines in reducing nasopharyngeal colonization: a randomized double-blind trial","volume":"57","author":"Dagan","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"32","key":"10.1016\/j.jinf.2024.106277_bib30","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1016\/j.vaccine.2019.06.071","article-title":"Effectiveness of the seven-valent and thirteen-valent pneumococcal conjugate vaccines in England: the indirect cohort design, 2006-2018","volume":"37","author":"Andrews","year":"2019","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.jinf.2024.106277_bib31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/14760584.2021.1873136","article-title":"Circulating clonal complexes and sequence types of Streptococcus pneumoniae serotype 19a worldwide: the importance of multidrug resistance: a systematic literature review","volume":"20","author":"Ruiz Garc\u00eda","year":"2021","journal-title":"Expert Rev Vaccines"},{"issue":"3","key":"10.1016\/j.jinf.2024.106277_bib32","doi-asserted-by":"crossref","DOI":"10.1099\/acmi.0.000094","article-title":"Re-validation and update of an extended-specificity multiplex assay for detection of Streptococcus pneumoniae capsular serotype\/serogroup-specific antigen and cell-wall polysaccharide in urine specimens","volume":"2","author":"Eletu","year":"2020","journal-title":"Access Microbiol"}],"container-title":["Journal of Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445324002111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0163445324002111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T14:02:23Z","timestamp":1733148143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0163445324002111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0163445324002111"],"URL":"https:\/\/doi.org\/10.1016\/j.jinf.2024.106277","relation":{},"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia","name":"articletitle","label":"Article Title"},{"value":"Journal of Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jinf.2024.106277","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association.","name":"copyright","label":"Copyright"}],"article-number":"106277"}}